MEGAResFrom MEG, the Microbial Ecology Group


The glycopeptide antibiotic class contain antibiotics whose chemical structure is defined by a heptapeptide scaffold to which various functional groups are attached. The mechanism of action of the glycopeptides is to bind to the D-ala-D-ala N-acyl terminus of the peptidoglycan cell wall component and Lipid II, inhibiting cell proliferation by the sequestration of these required components for cell wall synthesis. Common drugs in the glycopeptide class include vancomycin, teicoplanin, and telavancin. Additionally, bleomycin is a glycopeptide antibiotic, however its mechanism of action involves the cutting of DNA and is unrelated to the other glycopeptide antibiotics in terms of its target.





Download Sequences