MEGAResFrom MEG, the Microbial Ecology Group

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APH3-PRIME

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(3') phosphotransferases modify the 3 prime hydroxyl group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-phosphotransferases

Sequences

Download Sequences

>>MEG_1059|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
atggataaacttccaaatttcatatttgaaaactatagtgacttaaaaattgaacgagatactgagggttggtctccggc
tgaggtatatagtgttacaaccaagaaaaaaaggtggtttctaaaaagaagtcatacgagatacaataaaactacatata
atgtaagaagagagaaagaaattattgaatgggcctatccaaagtttagagtaccacaaataatacattatgaagaagca
aaagaatataattcattactaatgaatcacattggcggctctagccttgaaatgcttggtccatcaattactttagagaa
atatatcgattactatgtacaatccttaaaattaatgcagtccattaacatcgaaaactgtccatacaataattgtataa
agaatagaataatcgaattagaatatttattagagaatgatctagcagatattaattcaaataactgggaagaagatacg
cgtgagcatttcagaaacggtaaagacttatttaattatatagtaaataataagccaaatgaagacttagttttctcaca
tggagatatgacaaactctaacatatttattgaaaacgaagaagttggatttatagatctcggtcgatgtggattagctg
ataagtgggttgatattgcattttgtgttagagatataagagaaataagtaatgaaaataaatggataaagatgttattt
gataaattagaaatagtacccaattgggataaaatgagatactacattttgttagatgagctgttctaa

>>MEG_1060|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
GTGGACGAGTTGGAGCAGTTTTATCAATTAGGGTGGACACTTGATTCAGCAGGTGGTGCATCTGGTGAAGCATATATGGC
TGAACAAGATGGACAAAAGTTGTTTTTAAAACGAAATTCAAATCCATTTATTGCGGCATTATCAGCAGAAGGTATTGTGC
CCAAATTAGTATGGACGAAACGCATAGAAACAGGCGAGGTTGTTACAGCACAACATTGGAAAAATGGGCGTGAACTATCT
TCAAACGAAATGAAGCAAACAAGAGTTGCACATTTATTAAAGAAGATACACAATTCTAGACCTTTATTAAGTATGTTAAA
GCGTATGGAAATGGAACCTATTACTCCTGAGATTATGCTTAATAAAATTAATGCCTCTTTATCAAGAGAAGTTTTAACAC
ATCATATTGTGAGAAAATCATTAACCTATTTAGAAGAGCATATACCGAGTTTAGATTCGCGTTTTTTCACTGTTGTACAT
GGTGATGTGAATCATAATAATTGGTTATTATCCGATCGAGATGAACTATTTTTAGTTGATTGGGAAGGTGCAATGATTGC
AGACCCGGCAATTGATATCGGAATGCTGCTTTACAACTATGTTCCACAACAACAATGGTCTGAATGGCTTGAAACATATG
GTGTTCAAGAGAGCTTGAATTTAAATAAACGTATGAAATGGTATACGGTAATTCAATCTATAGGTCTTGTTCAATGGTAT
GAAGAGCAAAAAAGATATAAGGATATGAACACTTGGCTTAAATTCCTAAATGAAGTTATGAATAGTAACATGTTTATTTA
A

>>MEG_1061|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAA
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTC
TGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAAATGGTCAGACTAAACTGGCTGACGGAATTTATGCCT
CTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATT
CCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGA
TTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTG
GTTGATGCGAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAAGCTTTTGCC
ATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTT
GTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCT
CCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCT
CGATGAGTTTTTCTAA

>>MEG_1062|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGTCACCACCATCCCCGGTGCTGAAGAATTTCGAAGCATGGACGATGCGTTGCGTGCACTGCGGGGTCGGTATCCCGGT
TGTGAGTGGGTTGTTGTGGAGGATGGGGCCTCGGGGGCTGGTGTTTATCGGCTTCGGGGTGGTGGGCGGGAGTTGTTTGT
CAAGGTGGCAGCTCTGGGGGCCGGGGTGGGCTTGGGTGAGGCTGAGCGGCTGGTGTGGTTGGCGGAGGTGGGGATTCCCG
TACCTCGTGTTGTGGAGGGTGGTGGGGACGAGAGGGTCGCCTGGTTGGTCACCGAAGCGGTTCCGGGGCGTCCGGCCAGT
GCGCGGTGGCCGCGGGAGCAGCGGCTGGACGTGGCGGTGGCGCTCGCGGGGATCGCTCGTTCGCTGCACGGCGCTGGACT
GGGAGCGGTGTCCGTTCGATCGCAGTCTCGCGGTGACGGTGCCGCAGGCCCGTGCTGTCGCTGAAGGGAGCGTCGACTTG
GAGGATCTGACGAGGAGCGGAAGGGGTGGTCGGGGGAGCGGCTTCTCGCCGAGCTGGAGCGGACTCGGCCTGCGGACGAG
GATCTCGGTTTGCCACGGTGACCTGTGCCCGGACAACGTGCTGCTCGACCCTCGTACCTGCGAGGTGACCGGGCTGATCG
ACTGGGGCGGGTCGGCCGTGCGGACCGGCACTCCGATCTCGCGCGGTGCTGGCGTCGCGCGAGCTGCGCGGGTGGGTCGG
GGGCGGTGCAATCGGAGGAAAAGCTGCGTTTACCGGCTGTTGGACGAGTTCTTCTGA

>>MEG_1063|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAATTGCCCAATATTATTCAACAATTTATTGGAAACAGCGTTTTAGAGCCAAATAAAATTGGTCAGTCGCCATCGGA
TGTTTATTCTTTTAATCGAAATAATGAAACTTTTTTTCTTAAGCGATCTAGCACTTTATATACAGAGACCACATACAGTG
TCTCTCGTGAAGCGAAAATGTTGAGTTGGCTCTCTGATAAATTAAAGGTGCCTGAACTCATCATGACTTTTCAGGATGAG
CAGTTTGAATTCATGATCACTAAAGCGATCAATGCAAAATCAATTTCAGCGCTTTTTTTAACAGAGCAAGAATTGCTTGC
TATCTATAAGGAAACACTCAATCAGTTAAATGCAGTTGCTATTATTGATTGCCCATTTATTTCAAGCATTGATCATCGGT
TAAAAGAGTCAAAATTTTTTATTGATAACCAACTCCTTGACGAGATAGATCAAGATGATTTTGAGGCTGAATTATGGGGA
GACCATAAAACTTACATAAGTCTTTGGAATGAGTTAAATGAGACTCGTGTTGAAGAAAGATTGGTTTTTTCTCATGGCGA
TATCACGGATAGTAATATTTTTATAGATAAATCTGGTGAAATTTACTTTTTAGATCTTGGTCGTGCTGGATTAGCAGATG
AATTTGTAGATATATCTTTTGTTGAACGTTGCCTAAGAGAGGATGTATCTGAGGAAACTGCTAAAATATTTTTAAAGCAT
TTAAAAAACGATATGCCTGACAAAAGGAATTATTTTTTAAAACTTGATGAATTGAATTGA

>>MEG_1064|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGACAGTCGCCCTCGACGAAGTATCTGAACTAAAGAATTTGCTTTCACCCTTGTTGGATGAATGCACTTTTGAAGAAGT
TGAGTATGGTCAGTCAGATGCTCGAGTGATTCGAGTTCTATTTCCTGATCGCAATACCGCGTATCTAAAGTACGCCTCCG
GATCTTCTGCTCAAGAAATTCTTCAAGAGCATCAGCGCACTAGATGGCTCAGAACACGAGCTCTCGTACCGGAAGTGATC
TCATATGTCTCGACTTCAACTGTCACCATCCTGTTGACAAAAGCATTGATTGGCCACAATGCCGCTGACGCCGCAGATGC
AGATCCAGTTATTGTTGTTGCAGAGATGGCACGAGCGTTACGCGACCTCCATTCGATCTCGCCTGACGATTGCCCATTCG
ACGAAAGGCTCCACCTGCGACTGAAGCTGGCTTCGGGCCGTTTGGAAGCCGGGTTAGTTGATGAGGAGGACTTTGATCAC
GCAAGGCAAGGCATGCTGGCGCGGGATGTTTACGAGCAACTTTTTATACAAATGCCTGGAGCGGAGCAGCTGGTAGTCAC
ACATGGCGACGCCTGTCCCGAGAACTTCATCTTCCAAGGTAATGCCTTCGTCGGCTTCATAGACTGCGGTCGGGTCGGGC
TTGCCGATAAGTATCAAGACCTGGCGCTTGCATCGAGAAACATTGACGCGGTATTTGGACCAGAACTCACTAACCAGTTC
TTCATCGAGTATGGAGAGCCAAATCCGAACATAGCTAAGATTGAGTACTACCGGATCTTGGATGAGTTCTTCTAA

>>MEG_1065|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAATTGCCCAATATTATTCAACAATTTATCGGAAACAGCGTTTTAGAGCCAAATAAAATTGGTCAGTCGCCATCGGA
TGTTTATTCTTTTAATCGAAATAATGAAACTTTTTTTCTTAAGCGATCTAGCACTTTATATACAGAGACCACATACAGTG
TCTCTCGTGAAGCGAAAATGTTGAGTTGGCTCTCTGAGAAATTAAAGGTGCCTGAACTCATCATGACTTTTCAGGATGAG
CAGTTTGAATTCATGATCACTAAAGCGATCAATGCAAAACCAATTTCAGCGCTTTTTTTAACAGACCAAGAATTGCTTGC
TATCTATAAGGAGGCACTCAATCTGTTAAATTCAATTGCTATTATTGATTGTCCATTTATTTCAAACATTGATCATCGGT
TAAAAGAGTCAAAATTTTTTATTGATAACCAACTCCTTGACGATATAGATCAAGATGATTTGGACACTGAATTATGGGGA
GACCATAAAACTTACCTAAGTCTATGGAATGAGTTAACCGAGACTCGTGTTGAAGAAAGATTGGTTTTTTCTCATGGCGA
TATCACGGATAGTAATATTTTTATAGATAAATTCAATGAAATTTATTTTTTAGATCTTGGTCGTGCTGGGTTAGCAGATG
AATTTGTAGATATATCCTTTGTTGAACGTTGCCTAAGAGAGGATGCATCGGAGGAAACTGCGAAAATATTTTTAAAGCAT
TTAAAAAATGATAGACCTGACAAAAGGAATTATTTTTTAAAACTTGATGAATTGAATTGA

>>MEG_1066|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGACGATGCGTTGCGTGCACTGCGGGGTCGGTATCCCGGTTGTGAGTGGGTTGTTGTGGAGGATGGGGCCTCGGGGGC
TGGTGTTTATCGGCTTCGGGGTGGTGGGCGGGAGTTGTTTGTCAAGGTGGCAGCTCTGGGGGCCGGGGTGGGCTTGTTGG
GTGAGGCTGAGCGGCTGGTGTGGTTGGCGGAGGTGGGGATTCCCGTACCTCGTGTTGTGGAGGGTGGTGGGGACGAGAGG
GTCGCCTGGTTGGTCACCGAAGCGGTTCCGGGGCGTCCGGCCAGTGCGCGGTGGCCGCGGGAGCAGCGGCTGGACGTGGC
GGTGGCGCTCGCGGGGCTCGCTCGTTCGCTGCACGCGCTGGACTGGGAGCGGTGTCCGTTCGATCGCAGTCTCGCGGTGA
CGGTGCCGCAGGCGGCCCGTGCTGTCGCTGAAGGGAGCGTCGACTTGGAGGATCTGGACGAGGAGCGGAAGGGGTGGTCG
GGGGAGCGGCTTCTCGCCGAGCTGGAGCGGACTCGGCCTGCGGACGAGGATCTGGCGGTTTGCCACGGTGACCTGTGCCC
GGACAACGTGCTGCTCGACCCTCGTACCTGCGAGGTGACCGGGCTGATCGACGTGGGGCGGGTCGGCCGTGCGGACCGGC
ACTCCGATCTCGCGCTGGTGCTGCGCGAGCTGGCCCACGAGGAGGACCCGTGGTTCGGGCCGGAGTGTTCCGCGGCGTTC
CTGCGGGAGTACGGGCGCGGGTGGGATGGGGCGGTATCGGAGGAAAAGCTGGCGTTTTACCGGCTGTTGGACGAGTTCTT
CTGA

>>MEG_1067|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAAGCTTCCAATCCCTTCACTGATGGCCTGCGGCTGCCGCGCGCATGGCAGGAAGCGTTGGCCGATGCGCACATCGA
GCGGCAGTCGATCGGCGTGTCGCGCGCGGATGTCGCGCGGGTGCATCGTCCCGGGCAGACCGACGCCTTCCTGAAATCGG
AAGTGATCGATGCCTTCAGTGAACTGGGTGATGAGATCGCCCGGCTGCGTTGGCTGCAGGCGCAGGGGCAGTCGGCGCCG
ACGGTGATTGCCACGACCGAGGAGGGCGGTCGGCGCTGGTTGTTGATGAGCGCGTTGCCCGGCCGCGACTTGGCCTCCTC
GCCGGAGCTCGCGCCGAGACGGGTGGCAGAACTGCTGGCTGACGCACTGCGTGGCCTGCATGCCGTGCCTGTAGCCAACT
GCCCGTTCGACCAGCAGTTGGCATCGCGCCTGCAGGCCGCACAGGCACGCGTCGAGGCGGGGCTGGTCGATGCCGATGAC
TTCGACGACGAGCGGCTGGGCCAGAGCCCGCAGCAGGTTTTCGCCGAGCTGCGCGCTACCCGGCCCGCTCATGAAGACCT
GGTGGTCAGTCAGGGCGATGCCTGCCTGCCCAACCTGACGGTGACCGATGGGCGGTTCACTGGCTTCATCGATTGTGGCC
GGTTGGGCGTGGCCGACCGCTATCAGGACCTGGCCCTGGCCGCGCGCAGCCTGGTCCACAATTTCGGGGAGAGCCGCTGT
GTCGCCGCGCTGTTCCAGCGCTACGGTGCGGTCCCTGATGAGCGGCGGCTTGCATTCTATCGGTTGCTTGACGAGTTTTT
CTGA

>>MEG_1068|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGACGACAGCACGTTGCGCCGGAAGTACCCGCACCACGAGTGGCACGCAGTGAACGAAGGAGACTCGGGCGCCTTCGT
CTACCAGCTCACCGGCGGCCCCGAGCCCCAGCCCGAGCTCTACGCGAAGATCGCCCCCCGCGCCCCCGAGAACTCCGCCT
TCGACCTGTCCGGCGAGGCCGACCGGCTGGAGTGGCTCCACCGCCACGGGATCCCCGTCCCCCGCGTCGTCGAGCGCGGT
GCCGACGACACCGCCGCGTGGCTCGTCACGGAGGCCGTCCCCGGCGTCGCGGCGGCCGAGGAGTGGCCCGAGCACCAGCG
GTTCGCCGTGGTCGAGGCGATGGCGGAGCTGGCCCGCGCCCTCCACGAGCTGCCCGTGGAGGACTGCCCCTCCGACCGGC
GCCTCGACGCGGCGGTCGCCGAGGCCCGGCGGAACGTCGCCGAGGGCTTGGTGGACCTCGACGACCTGCAGGAGGAGCGG
GCCGGGTGGACCGGCGACCAGCTCCTGGCGGAGCTCGACCGCACCCGTCCCGAGAAGGAGGACCTGGTCGTCTGCCATGG
CGACCTGTGCCCCAACAACGTCCTGCTCGACCCCGGGACCTGCCGGGTCACCGGCGTGATCGACGTCGGCCGCCTCGGGG
TCGCCGACCGCCACGCCGACATCGCCTTGGCCGCCCGCGAGCTGGAGATCGACGAGGACCCCTGGTTCGGCCCCGCCTAC
GCCGAGCGGTTCCTGGAGCGGTACGGCGCCCACCGCGTCGACAAGGAGAAGCTGGCCTTCTACCAGCTTCTCGACGAGTT
CTTCTAG

>>MEG_1069|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAATTGCCCAATATTATTCAACAATTTATTGGAAACAGCGTTTTAGAGCCAAATAAAATTGGTCAGTCGCCATCGGA
TGTTTATTCTTTTAATCGAAATAATGAAACTTTTTTTCTTAAGCGATCTAGCACTTTATATACAGAGACCACATACAGTG
TCTCTCGCGAAGCGAAAATGTTGAGTTGGCTCTCTGAGAAATTAAAGGTGCCTGAACTCATCATGACTTTTCAGGATGAG
CAGTTTGAATTAATGATCACTAAAGCGATCAATGCAAAACCAATTTCAGCGCTTTTTTTAACAGACCAAGAATTGCTTGC
TATCTATAAGGAGGCACTCAATCTGTTAAATTCAGTTGCTATTATTGATTGTCCATTTATTTCAAACATTGATCATCGGT
TAAAAGAGTCAAAATTTTTTATTGATAACCAACTCCTTGACGATATAGATCAAGATGATTTTGACGCTGAATTATGGGGA
GACCATAGAACTTACCTAAGTCTATGGAATGAGTTAACTGAGACTCGTGTTGAAGAAAGATTGGTTTTTTCTCATGGCGA
TATCACGGATAGTAATATTTTTATAGATAAATTCAATGAAATTTACTTTTTAGATCTTGGCCGTGCTGGGTTAGCTGATG
AATTTGTAGATATATCCTTTGTTGAACGTTGCCTAAGAGAGGATGCCTCGGAGGAAACTGCTAAAATATTTTTAAAGCAT
TTAAAAAATGATAGACCTGACAAAAGGAATTATTTTTTAAAACTTGATGAATTGAATTGA

>>MEG_1070|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
GTGAACGATATTGATCGAGAAGAGCCCTGCGCAGCCGCTGCCGTGCCCGAGAGCATGGCGGCTCACGTGATGGGATACAA
ATGGGCGCGTGATAAGGTTGGTCAGTCCGGCTGCGCGGTCTATCGGCTGCATAGCAAGTCAGGCGGCTCCGACTTGTTTC
TGAAGCACGGCAAAGATGCTTTTGCCGACGACGTGACTGATGAAATGGTGAGATTGCGTTGGCTGGCGGGGCACATTTCT
GTGCCCTCCGTTGTAAGCTTCGTTCGCACGCCCAATCAGGCATGGCTCCTGACAACAGCAATACATGGAAAAACGGCATA
TCAAGTGCTGAAATCGGATTTCGGAGCCCGTCTCGTTGTTGTTGACGCATTGGCGGCGTTCATGCGCCGACTGCATGCGA
TCCCAGTGAGCGAATGCTCCGTTCAACAGTGGACCACGCATGCAGGCTTGCCCGAGCGCGGGAGTATCGAGGCGGGGGTT
GTTGATGTCGATGACTTCGATAAGGAGCGCGAAGGGTGGACGGCCGAACAGGTTTGGGAGGCGATGCATCGCCTCCTACC
GCTCGCGCCGGACCCAGTCGTGACGCACGGCGATTTTTCACTCGATAATCTACTTATCGTCGAAGGTAAGGTAGTCGGCT
GCATCGACGTTGGGCGGGCTGGTATTGCTGATCGATACCAAGACCTTGCCGTGTTATGGAACTGTCTTGAGGAGTTCGAA
CCTTCGCTTCAGGAGAGGCTTGTTGCGCAATATGGCATTGCCGATCCGGATAGGCGCAAGCTGCAATTTCATCTCCTGCT
GGACGAACTTTTCTAA

>>MEG_1071|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAAAGCACGTTGCGCCGGACATACCCGCACCACACTTGGCACCTCGTGAACGAAGGAGACTCGGGCGCCTTCGTCTA
CCGCCTCACCGGACACGGGCCCGAGCTCTACGCGAAGATCGCCCCCCGCACCCCCGAGAACTCCGCCTTCCACCTCGACG
GCGAGGCCGACCGCCTCGACTGGCTCGCCCGCCATGGCATCTCGGTCCCCCGTGTCGTCGAGCGCGGTGCCGACGACACC
ACCGCCTGGCTCGTCACCGAGGCCGTGCCCGGCGCCGCGGCCTCCGAGGAGTGGCCCGAGGACGAGCGGGCGGCCGTTGT
CGACGCGATCGCCGAAATGGCCCGCACCCTCCATGAACTCCCCGTGTCCGAGTGCCCCTTCGACCGCCGCCTCGACGTCA
CCGGCGAGGCCCGGCACAACGTCCGCGAGGGCCTGGTCGACCTCGACGACCTCCAGGAGGAGCCGGCCGGCTGGACCGGC
GACCAACTCCTGGCCGAACTCGACCTGACGCGGCCCGAGAAGGAGGACTTGGTCGTCTGCCATGGCGACCTGTGCCCCAA
CAACGTGCTGCTCGACCCCGAGACCCACCGGATCACCGGGCTGATCGACGTCGGCCGCCTCCGGCTCGCCACCTGCCACG
CCGACCTCGCCCTCGCCGCCCGCGAACTGGCGATCGACGAGGACCCGTGGTTCGGCCCCGCATACGCCGAACGGTTCCTC
GAACGGTACGGGGCCCACCACGTCGACCAGGAGAAGATGGCCTTCTACCAGCTGCTCGACGAGTTCTTCTAG

>>MEG_1072|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGAAATATATCGATGAAATTCAAATTCTGGGAAAATGTTCAGAGGGTATGTCTCCAGCAGAAGTATATAAATGCCAGCT
TAAAAATACTGTATGCTATCTGAAAAAAATTGACGATATATTTTCAAAAACCACATACAGCGTGAAAAGAGAAGCTGAGA
TGATGATGTGGTTATCCGATAAACTGAAAGTACCAGATGTAATCGAATACGGAGTACGAGAACATTCAGAATATTTGATC
ATGAGTGAGTTAAGGGGGAAACACATAGATTGCTTTATTGATCATCCAATAAAATATATTGAGTGCTTGGTAAACGCACT
TCATCAGCTACAAGCAATAGATATAAGAAACTGCCCATTTTCATCCAAAATAGATGTTCGATTAAAAGAACTAAAATATC
TTTTGGATAACAGAATTGCCGATATTGATGTATCGAATTGGGAAGATACAACAGAATTTGATGATCCAATGACGTTATAT
CAGTGGCTTTGCGAAAATCAACCTCAAGAAGAACTGTGTCTCTCTCATGGAGATATGAGCGCTAATTTTTTTGTATCTCA
TGATGGAATATATTTTTATGATTTGGCAAGATGTGGAGTTGCAGACAAATGGTTGGATATAGCATTTTGTGTCAGAGAGA
TTCGAGAATATTATCCTGATTCTGATTATGAAAAATTCTTTTTTAACATGTTGGGACTTGAACCGGATTATAAAAAAATT
AACTATTACATTTTATTAGATGAGATGTTTTAG

>>MEG_1073|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGTACGCCATGTTGCGCCGGAAATACCAGCACTACGAATGGACCTCCGTGAACGAAGGAGATTCGGGCGCCTCCGTTTA
CCGCCTCGCCGGACAGCAGCCCGAGCTCTATGTGAAATTCGCTCCGCGCGAACCGGAAAATTCCGCGTTCGACCTGGCGG
GCGAGGCCGACCGGCTCACCTGGCTCACCCGCCACGGCATCCCGGTTCCGTGCATTGTCGAGTGCGGCGGCGACGACACC
TCGGTTTTCCTCGTCACCGAGGCCGTCACCGGCGTATCGGCCGCCGAGGAGTGGCCGGAGCACCAGCGCTTCGCCGTCGT
CGAGGCGATGGCCGACCTCGCCCGCACCCTGCACGAACTGCCCGTTGGTGGCTGCCCCTTCGATCGCAGCCTGGCGGTGA
CGGTTGCCGAAGCCCGCCACAACCTACGCGAGGGCCTCGTGGACCTGGACGACCTCCAAGAGGAGCACGCCAACTGGTCC
GGTGACCAGCTTCTCGCCGAGCTCGACCGAACGCGGCCCGAGAAAGAGGATCTGGTCCTCTGCCACGGGGACCTGTGCCC
CAACAACGTGCTGCTCGATCCCGAGACATGCCGAGTCACCGGAATGATCGATGTGGGCCGCCTCGGCCGCGCCGATCGCC
ACGCCGACCTGGCCCTCGCCGCCCGCGAGCTGGAGATCGACGAGGATCCCTGGTTTGGCCCCGAGTACGCCCAGCGGTTC
CTCGAACGCTACGGCGCGCACCACGTCGACGAGAACAAGATGGCCTTTTACCAGCTGCTCGACGAGTTTTTCTAG

>>MEG_1074|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGAACGAAAGTACGCGTAATTGGCCGGAGGAACTTCTTGAGCTTCTCGGGCAGACGGAACTAACCGTCAACAAAATCGG
ATATTCCGGAGATCACGTCTATCACGTGAAAGAGTACAGGGGCACCCCCGCATTTCTGAAAATCGCCCCCAGTGTATGGT
GGAGAACGCTCCGGCCCGAAATTGAAGCGCTCGCTTGGCTGGACGGGAAGCTCCCGGTTCCCAAAATTTTGTACACGGCC
GAACACGGCGGGATGGACTACTTGCTGATGGAGGCGCTAGGCGGAAAAGACGGCTCCCACGAAACGATCCAGGCGAAGCG
GAAACTGTTTGTGAAGCTGTACGCGGAAGGGCTCCGAAGCGTGCATGGCCTCGATATCCGCGAATGTCCGCTGTCGAACG
GGCTGGAGAAGAAGCTCCGGGATGCGAAAAGAATAGTCGATGAGAGCCTGGTGGACCCGGCCGATATAAAAGAGGAGTAC
GATTGCACGCCGGAGGAATTGTACGGGCTATTGCTTGAGAGTAAGCCGGTAACCGAAGATCTGGTTTTTGCGCACGGAGA
TTACTGTGCTCCGAATCTGATTATCGACGGTGAGAAGCTGTCGGGATTTATCGATCTCGGACGTGCGGGCGTGGCGGACC
GTTATCAGGACATCAGCCTGGCGATCCGCAGCCTCCGGCACGATTACGGCGACGACCGCTACAAAGCGCTCTTCCTGGAA
CTTTACGGGCTGGACGGGCTTGACGAGGACAAGGTCCGGTATTACATCCGGCTGGATGAATTTTTTTGA

>>MEG_1075|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAATTGCCCAATATTATTCAACAATTTATCGGAAACAGCGTTTTAGAGCCAAATAAAATTGGTCAGTCGCCATCGGA
TGTTTATTCTTTTAATCGAAATAATGAAACTTTTTTTCTTAAGCGATCTAGCACTTTATATACAGAGACCACATACAGTG
TCTCTCGTGAAGCGAAAATGTTGAGTTGGCTCTCTGAGAAATTAAAGGTGCCTGAACTCATCATGACTTTTCAGGATGAG
CAGTTTGAATTCATGATCACTAAAGCGATCAATGCAAAACCAATTTCAGCGCTTTTTTTAACAGACCAAGAATTGCTTGC
TATCTATAAGGAGGCACTCAATCTGTTAAATTCAATTGCTATTATTGATTGTCCATTTATTTCAAACATTGATCATCGGT
TAAAAGAGTCAAAATTTTTTATTGATAACCAACTCCTTGACGATATAGATCAAGATGATTTTGACACTGAATTATGGGGA
GACCATAAAACTTACCTAAGTCTATGGAATGAGTTAACCGAGACTCGTGTTGAAGAAAGATTGGTTTTTTCTCATGGCGA
TATCACGGATAGTAATATTTTTATAGATAAATTCAATGAAATTTATTTTTTAGATCTTGGTCGTGCTGGGTTAGCAGATG
AATTTGTAGATATATCCTTTGTTGAACGTTGCCTAAGAGAGGATGCATCGGAGGAAACTGCGAAAATATTTTTAAAGCAT
TTAAAAAATGATAGACCTGACAAAAGGAATTATTTTTTAAAACTTGATGAATTGAATTGA

>>MEG_1076|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGCATGATGCAGCCACCTCCATGCCGCCGCAGGCTCCCTCAACCTGGGCCGACTACCTTGCCGGCTACCGCTGGCGAGG
GCAGGGCGAAGGATGTTCCGCGGCCACGGTCCACCGCCTGGAGGCTGCGCGGCGGCCGACCCTGTTCGTCAAGCAGGAAG
TGCTGTCCGCACATGCCGAGCTGCCCGCCGAAATCGCCCGCCTGCGCTGGCTGCACGGTGCCGGCATCGACTGCCCGCAG
GTGCTGAACGAAACCCAGAGCGACGGCCGGCAATGGCTGCTGATGAGCGCAATGCCGGGGGACACGCTGTCCGCGCTGGC
GCAGCGCGACGAGCTGGAGCCCGAGCGCCTGGTGCGCCTGGTGGCCGCCGCCCTGCGCCGGCTGCACGATCTCGATCCGG
CCGCCTGTCCCTTCGATCATCGCCTGGAACGGCGTCTGGACACCGTGCGCCAGCGGGTCGAGGCCGGGCTGGTGGACGAG
GCGGACTTCGACGACGACCATCGCGGTCGCAGCGCCACGGAGCTGTACCGCCTGCTGCTCGACCGGCGTCCGGCGGTCGA
AGACCTGGTGGTCGCCCACGGCGACGCCTGCCTGCCCAACCTCTTGGCGGAGGGCCGGCGCTTCAGCGGCTTCATCGATT
GCGGGCGGCTCGGCGTCGCCGACCGGCACCAGGACCTGGCCCTGGCCGCGCGGGACATCGAGGCCGAACTCGGCGCGGCC
TGGGCCGAGGCCTTCCTCGTCGAATACGGCGGCGATATCGACGGCGAACGGCTGGCGTACTTCAGGCTATTGGACGAGTT
CTTCTAG

>>MEG_1077|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
TCACTTCTCCGCCAGCGCCTCCAGGGCCATGCGGGCGACTGTCTCGTCGATATCGGCCGGGTCGCCGTCATCCCTGAACC
ACACTGCCGACAGCGCAGTGCTGGCCGCGATCCAGCGCAGCAGGCGTGTGCGTTCCAGTTCGGACAGCGCACAGACCTGC
TCAAGGCGGATCGCAAACCGCTCGGGCCGCGTCGCAACGTGGATGCCCGGACCACAGAGGTCCGGGTTGCTGAACATCGT
CGTGTAATCGAACGCACGGTCCCCCAGCAGTCGCTTCGGGTCGATCGCCAACCAGCCGCGCGGGCCGAAATCCAGCACAT
TGTCATGATGCAGGTCGCCGTGCAGCGGGCGGATCTCCTGTTCGTCATGCAGCAGCCCCTCCGCCAGTGATCTGCACTGT
TCCAGCAGTGGCGGCAGGACAGCCCTTGGCTGCAGCAGGTCGGCGAACCATGTTCGCAGGCAGACCAGTTCCGCTGGCGG
CGCGCTCCGTGGCCGGTGCAGCCGCTGCAGGACCTGGCACAGGATCGCGGTGCAGGCGTCATCGTCGCCCTCGATCGAGC
GTTGCCGCAGCGAGTCACCGCGGGCACGCTCGATCAGGATCGCAGGCCCCTCGTGGGCCAGCAGGCGGGCGGCGCCATCG
CCGTTCCACCAGCGTAGCAGGCGATGACTGTTCTGCTCCTCGGTCTCGCTGCTGATCTTCAGCATCGCTGGCTCGCCCGC
AGCGGTCAGCACCGGCCAGAGCCGGGCGTGGGGCGTACGGAGGGCCGGGCCATCACGCCGCAATCGCCAGCGGCTCAGGT
AGGGTTCGCTCAT

>>MEG_1078|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACTTGGATGCTGATTTATATGGGTATAG
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCAATGCGCCAGAGTTGTTTC
TGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGACTAAACTGGCTGACGGCATTTATGCCT
CTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATT
CCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGA
TTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTG
GTTGATGCTAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAAGCTTTTGCC
ATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTT
GTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCT
CCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCT
CGATGAGTTTTTCTGA

>>MEG_1079|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAA
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCGATGCGCCAGAGTTGTTTC
TGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGACTAAACTGGCTGACGGAATTTATGCCT
CTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATT
CCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGA
TTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTG
GTTGATGCGAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAAGCTTTTGCC
ATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTT
GTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCT
CCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCT
CGATGAGTTTTTCTAA

>>MEG_1080|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACA
GACAATCGGCTGCTCTGATGGCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGT
CCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTG
CTCGACGTTGTAACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCT
TGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCG
ACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAA
GAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGAC
CCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTG
TGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTC
CTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGA

>>MEG_1081|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-PRIME
ATGGAATTGCCCAATATCATTCAACAATTTATTGGAAACAGCGTTTTAGAGCCAAATAAAATTGGTCAGTCGCCATCGGA
TGTTTATTCTTTTAATCGAAATAATGAAACTTTTTTTCTTAAGCGATCTAGCACTTTATATACAGAGACCACATACAGTG
TCTCTCGCGAAGCGAAAATGTTGAGTTGGCTCTCTGAGAAATTAAAGGTGCCTGAACTCATCATGACTTTTCAGGATGAG
CAGTTTGAATTCATGATCACTAAAGCGATCAATGCAAAACCAATTTCAGCGCTTTTTTTAACAGACCAAGAATTGCTTGC
TATCTATAAGGAGGCACTTAATCTGTTAAATTCAATTGCTATTATTGATTGTCCATTTATTTCAAACATTGATCATCGGT
TAAAAGAGTCAAAATTTTTTATTGATAACCAACTCCTTGACGATATAGATCAAGATGATTTTGACGCTGAATTATGGGGA
GACCATAAAACTTACCTAAGTCTATGGAATGAGTTAACTGAGACTCGTGTTGAAGAAAGATTGGTTTTTTCTCATGGCGA
TATCACGGATAGTAATATTTTTATAGATAACTTTAATGAAATTTATTTTTTAGATCTTGGCCGTGCTGGGTTAGCAGATG
AATTTGTAGATATATCCTTTGTTGAACGTTGCCTAAGAGAGGATGCATCGGAGGAAACTTCTAAAATATTTTTAAAGCAT
TTAAAAAATGATAGACCTGACAAAAGGAATTATTTTTTAAAACTTGATGAATTGAATTGA