MEGAResFrom MEG, the Microbial Ecology Group

DFRA

The dfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

Other Groups in Dihydrofolate reductase

Sequences

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>CARD|phgb|AM403715|302-854|ARO:3002857|dfrA26|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGGCTGATGAAGAATACGACCCGCTACTCGATGACGACATGGAAGATGCCAAAGTCGCCGTCATTGCTGCCCGTGCGCA
AAACGGTTGCATTGGTCGCCACGGCAAGCTGCCGTGGAAGCTGCCCGGTGACCTGAAATACTTCCGTGAGCGCACCTGGG
GCAAGCCCATCATCATGGGGCGCAAAACCTGGGAATCACTCAATGGTGCCTTGCCGGGGCGCACCAACATCGTGGTAACG
CGTCAACAAGGTTATGAAGCCGAAGGTGCTCGCGTGGTCGATAGCATCGAAGAAGCCATTAGCTTGGCACAGTCTATCGC
CTTAATCGAAGCCGTTGATGAAATCATGGTGCTGGGCGGCGGCGAAATCTATACCCAAGCCTTACCGCAAGCCGACATTC
TCTATCTCACCGAAGTACACGCCTCGGTCGACGGCGATGCCTTCTTCCCCGACGTGGACCTCAGCCAATATCAAGAAACC
CAACGCCAGGACTTCGAGCCATCGGGCGGCAACCCTTACCCGTTTAGCTTTGTGGTCTATCAGCGGACGTAGA

>CARD|phgb|NC_010410|3676915-3677389|ARO:3002854|dfrA1|Trimethoprim|Dihydrofolate_reductase|DFRA
TTAACCCTTTTGCCAGATTTGGTAACTATAATTTATGTTAGAGGCGAAGTCTTGGGTAAAAACTGGCCTAAAATTGCTGG
GGATTTCAGGAAAGTAAACATCACCTTCCGGCTCGATGTCTATTGTAGATATATGTAGTGTATCTACTTGATCGATCAGG
CTTTTGTATATCTCCCCACCACCTGAAACAATGACATGATCCGTTATTTTCTTTAGGTTGGTTAAAGCATCTTTAATTGA
TGGAAAGATCAATACGTTCTCATTGTCAGATGTAAAACTTGAACGTGTTACGACCGCATACTTTCGGTTGGGTAATGCTC
CCATTGATTCAAAAGTCTTGCGTCCAACCAACAGCCATTGGTTATAGGTAATAGCTTTAAACAGGAGCTGTTCACCTTTG
GCACTCCATGGAATATCAGGGCCATTCCCGATAACTCCATTCTTCGATATAGCTACCATTAGTGATAGTTTCACA

>CARD|phgb|KF976462|111558-112122|ARO:3003011|dfrA10|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAATATATCACTTATCTTTGCCAATGAATTAATTACCAGAGCATTCGGTAATCAAGGCAAATTACCTTGGCAATTCAT
TAAAGAAGATATGCAGTTCTTCCAGAAGACTACAGAAAATTCTGTAGTCGTTATGGGATTAAATACATGGAGATCTCTAC
CTAAGATGAAGAAGCTTGGTAGAGACTTCATTGTCATATCTTCAACTATCACAGAGCACGAAGTGCTCAACAATAATATC
CAAATATTCAAATCATTTGAGAGCTTCTTAGAAGCATTCAGAGACACAACCAAACCAATCAATGTCATTGGTGGTGTTGG
TTTATTATCTGAAGCGATAGAACATGCTAGCACTGTTTACATGAGTTCTATTCATATGGTTAAACCTGTTCATGCTGATG
TGTATGTACCGGTAGAACTAATGAATAAACTCTATAGTGATTTCAAATATCCAGAAAATATTCTATGGGTAGGTGATCCA
ATAGATTCTGTGTATAGCTTGTCTATTGATAAGTTTGTTAGACCAGCTTCGCTGGTTGGGGTGCCAAATGATATTAATAC
GTGAT

>CARD|phgb|AJ746361|6742-7303|ARO:3003019|dfrA23|Trimethoprim|Dihydrofolate_reductase|DFRA
TTACGGCCGAGCGCGCTCATATGTGATGAACTTCACGGGATGGGTCTCACCATCTACCGCAGTTTGAATGGTGATAGACC
CTTGACCTGCAACAAACTTTTTGTCGATGTATGACATCGGCAACGTCCGATCGCAGTTATATGGCTTGTGCATTACCGTC
ATGTGGACTTTTGTGGCAGATGCGAGGGCTTGCACGTACAGCTTTTCTCCACCAATGACAGCTATTCGTTGATCGCTGTC
GTGATATTGATTGAGCACCGCACGTAGGTCCGGAACTACCGTGGCTCCAATGACGTCCTCGGGCTTCAAAGTCGAGGACA
CGACGTAAGATTCGCGCTCCGGAAGAATTCCCTTCTCTTTGATTCGTTCTTCAGCGCCTTCCTTCTTCATTTGCATATCG
AGCATGTCTTTGTATGTGTTCTTCCCCATCACACACACTCGAATCTCTTTGGATATGGTGGTGAAGCGCTTCATGTCTTC
CTTGCACGTCCAAGGGATTTGGCCATTCCGGCCAAATCCCCCAACAGGATCAACTGCAACAATAATCTCAACTGTTGGCA
TT