MEGAResFrom MEG, the Microbial Ecology Group

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DFRA

The dfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/6985448

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Other Groups in Dihydrofolate reductase

Sequences

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>>MEG_2482|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccgagacttcgcctctaacataaattatagttacccaatctggcaaaagggttaa

>>MEG_2483|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttatcggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacatcggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggaactgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggcgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2484|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagattcttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2485|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaataaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcatgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2486|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgtgttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggccgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactaccacacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2487|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggattaaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2488|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgagctcggaatctgtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
tttgtttcaacgctgtcggacgctatcgatttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacaaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2489|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgagtcacccacaacttgagctaatagtcgctgtggattctaagttgggattcgggaaaggcggcaagattccatggaa
atgcaaagaagacatggcgcgatttacgcggatttctaaagagatccgcgtgtgcgttatggggaaacacacgtatactg
acatgcgtgacatgcagttagaaaaggatggcgccgaggagcgaatcaaggagaaaggaattctccccgaacgcgaatcg
ttcgtgatctcctcgacgttaaaacaagaagatgtcataggcgctactgtcgttcctgatcttcgtgctgtgatcaacct
gtatgagaataccgatcaacgcattgctgtcattggtggggagaagttgtacattcaagctctttcatcagcaacgaaac
tgcacatgaccataattccaagagagttcgactgtgatcgatttattcctgttgatccgatccagaacaattttcacatt
gattccagtgccagcgagactgtggaggcaaccgttgatgagactcaagagcgcattcactttgctacttacgtgcgtaa
caatcagtaa

>>MEG_2490|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgatcacagcatgtgtagcgatcgatagcgatggcggttttggtgcccaggggacgcttccatgggcaataccagaaga
atttgctttttaccaagagcatgtcaggggtggtatctgtataattggcggcagatcgtttaatgatctagttcacttat
cgctatcaccaaagggtggtttgtataaaaaatgtctactccggaccacgccacatatcgtagtatcatcatcacacgaa
ttggtgtacgatccgtcgataatggcacttatagaggctgacaggagacatcttgatctgtacttcgtgaacaccgtgga
cgctgctgttaaactcgcaaaagggttaggtggaatgcacgcgaataaagatatccatttcattggcggtaaacgcatat
atgatgccggtctcgattattgtgacgaggtatacacctcaatattaccggctgtgtatcttaactgcgacacattcttt
cctgtagaaaaactgtcgcgcatgtttacaccagaattatacaagacgattcctaaccaagttcatgcggatattcctgt
aattaaatggacccgcaagcgcgcataa

>>MEG_2491|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgatttcaatcgtcgtagccaaatccgccaatcacgtcatcggggtagacaatcaattaccgtggcgattgccgtccga
tctgaagtggtttaaagaaacgaccactggtggggtagttgttatgggacgcaagacatttgaatccatcggtaagccat
tgccggatcgaatcaatgtgatcatttctaaacaaccagtgccgatcgaatgggcaagtaaggtagtttgggttaactcg
atccagcaagcgatggactatgttcgcggtctggatgggatgatcaaaacatttattattggcgggagtgagatttatcg
ccaatttatctcattggtcgatcaggtgtatcttaccgaagtaggtgccgaaatagaaggcgacgcgacgtttcagccgt
tagacgaacatgaatggacgctcaaaacttggtgggtggttccagaccaatcatccaaagatcaattccgttaccaacgt
aagctctacgtgaggaaggtgttagatgaatga

>>MEG_2492|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggcagcaatttcgaagaatggagttatcggaaatggtccggatattccatggagtgccaaagg
ggaacaattactcttcaaagcgattacctataatcagtggcttttggtaggccgaaagactttcgagtcaatgggggctt
tacccaaccgaaaatatgccgttgtaactcgttcaagcttcacttccagtgatgagaatgtattggtatttccatctatc
gatgaagcgctaaatcatctgaagacgacaacggatcatgtgattgtgtctggtggtggtgaaatatacaaaagcctgat
cgataaagttgatactttacatatttcaacaatcgacattgagccagaaggtgatgtctattttccagaaatccccagta
gttttaggccagtttttagccaagacttcgtgtctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2493|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgcttaaagctattacctataaccagtggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2494|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatacggtcgtaacacgttcaagttttacatctgacaatgagaacgtagtgacctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2495|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcgatcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2496|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgcaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2497|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagctttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttacccaaccgaaagtatgcggtcgtaacacgttcaagctttacatctgacaatgagaacgtattgatctt
tccatcaattaaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatataca
aaagcctgatcgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaa
atccccagcaattttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaaggg
ttaa

>>MEG_2498|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtagtgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaataatagttaccaattctggcaaaagggttaa

>>MEG_2499|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
atcttaggccagtccttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2500|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggaaaaagggttaa

>>MEG_2501|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggaggtatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2502|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggttcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2503|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaagtatcattaatggctgcaaaagcgaaaaacggagtgattggttgcggtccacacataccctggtccgcgaaagg
agagcagctactctttaaagccttgacgtacaaccagtggcttttggtgggccgcaagacgttcgaatctatgggagcac
tccctaataggaaatacgcggtcgttactcgctcagcctggacggccgataatgacaacgtaatagtattcccgtcgatc
gaagaggccatgtacgggctggctgaactcaccgatcacgttatagtgtctggtggcggggagatttacagagaaacatt
gcccatggcctctacgctccatatatcgacgattgatattgagccggaaggagatgttttctttccgaatattcccaata
ccttcgaagttgtttttgagcaacgctttagctcaaacattaactattgctatcaaatttggcaaaagggttag

>>MEG_2504|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaagttatcactaatggctgccaagtcgaagaacggtattatcggtaatggaccagatattccatggagcgccaaagg
cgagcaacttctatttaaggcaattacatataatcaatggcttttagttggacgcaaaacttttgagtcaatgggcgctc
tcccaaatcgaaagtatgcagttgtaactcgctctaatttttctacgaatgatgagggtgtaatggttttctcctcaatt
caggatgccttaataaatttagaggaaatcacgggtcatgttatcgtttctggtggtggtgaaatatacaaaagcttgat
ttccaaagtagatactttgcatatttcaacagtcgacatcgagcgagatggagacatagtttttcctgaaatcccagata
cattcaagttggtatttgagcaagatttcgagtctaacattaactattgttatcaaatctggcaaaagagttaa

>>MEG_2505|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaatgtatcattaatggctgcaaaagcgaaaaaaggagggattggttgcggtccacacataccctggtccgcgaaagg
agagcagctactctttaaagccttgacgtacaaccagtggcttttggtgggccgcaagacgttcgaatctatgggagcac
tccctaataggaaatacgcggtcgttactcgctcagcctggacggccgataatgacaacgtaatattattcccgtcgatc
gaagaggccatgtacgggctggctgaactcaccgatcacgttatagtgtctggtggcggggagatttacagagaaacatt
gcccatggcctctacactccatatatcgacgattgatattgagccggaaggaaatgttttctttccgaatattcccaata
ccttcgaagttgtttttgagcaacactttaactcaaacattaactattgctatcaaatttggcaaaagggttaa

>>MEG_2506|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaagatgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2507|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcccgttgaagtcgaaggagatatcaaattccctataatgcctgaaa
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2508|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaacacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2509|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaagtggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2510|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcatttatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2511|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatttcattgatttctgcaacgtcagaaaatggcgtaatcggtaatggccctgatatcccatggtcagcaaaagg
tgagcagttactctctaaagcgctcacatataatcagtggctccttgttggaaggaaaacatttgactctatgggtgttc
ttccaaatcgaaaatatgcagtagtgtcgaggaaaggaatttcaagctcaaatgaaaatgtattagtctttccttcaata
gaaatcgcttcgcaagaactatcgaaaattacagatcatttatatgtctctggtggcggtcaaatctacaatagtcttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaggttgaaggtgatatcaattttcctaaaattccagaga
atttcaatttggtttttgagcagttttttttgtctaatataaattacacatatcagatttggaaaaaaggctaa

>>MEG_2512|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatttcattgatttctgcaacgtcagaaaatggcgtaatcggtaatggccctgatatcccatggtcagcaaaagg
tgagcagttactctttaaagcgctcacatataatcagtggctccttgttggaaggaaaacatttgactatatgggtgttc
ttccaaatcgaaaatatgcagtagtgtcgaggaaaggaatttcaagctcaaatgaaaatgtattagtctttccttcaata
gaaatcgctttgcaagaactatcgaaaattacagatcatttatatgtctctggtggcggtcaaatctacaatagtcttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaggttgaaggtgatatcaattttcctaaaattccagaga
atttcaatttggtttttgagcagttttttttgtctaatataaattacacatatcagatttggaaaaaaggctaa

>>MEG_2513|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatttcattgatttctgcaacgtcagaaaatggcgtaatcggtaatggccctgatatcccatggtcagcaaaagg
tgagcagttactctttaaagcgctcacatataatcagtggctccttgttggaaggaaaacctttgactctatgggtgttc
ttccaaatcgaaaatatgcagtagtgtcgaggaaaggaatttcaagctcaaatgaaaatgtattagtctttccttcaata
gaaatcgctttgcaagaactatcgaaaattacagatcatttatatgtctctggtggcggtcaaatctacaatagtcttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaggttgaaggtgatatcaattttcctaaaattccagaga
atttcaatttggtttttgagcagttttttttgtctgatataaattacacatatcagatttggaaaaaaggctaa

>>MEG_2514|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatttcattgatttctgcaacgtcagaaaatggcgtaatcggtaatggccctgatattccatggagtgccaaagg
tgagcagctcctgtttaaagctatcacatataaccaatggctccttgttggaaggaaaacatttgactctatgggtgttc
ttccaaatcgaaaatatgcagtagtgtcgaggaaaggaatttcaagctcaaatgaaaatgtattagtctttccttcaata
gaaatcgctttgcaagaactatcgaaaattacagatcatttatatgtctctggtggcggtcaaatctacaatagtcttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaggttgaaggtgatatcaattttcctaaaattccagaga
atttcaatttggtttttgagcagttttttttgtctaatataaattacacatatcagatttggaaaaaaggctaa

>>MEG_2515|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatttctttaatcgcagctcagtcagaaaacggtgttattggtaatggcccagatattccatggtcagcaaaagg
ggagcagttacttttcaaagcgctaacatataatcagtggcttcttgtcggaagaaaaacatttgagtcaatgggtattc
ttcctaatcgaaagtatgctgttctttcaaaaaatggaatttcacaccttcctgaaaacgtactagttttttcgtctata
gaaaatgcattatatgaactggctaaggtaacagaccatttatatatttctggcggtggtcaaatatataatagtcttat
tgaaagtgctgataccatccacttatctatcatccacaaagaggtagaaggtgaagtaaggtttcccaaaatacctccta
attacaagttggtatttgagcaatattattcttcaaatattaattacacttatcaaatttggcaaaaaggttaa

>>MEG_2516|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaagtatcattgatagctgcgaaacgaaaaaacggcgtgattggttgcggtccagacataccgtggtccgcgaaagg
ggagcagctactttttaaagcattgacctacaatcagtgtcttctggtgggtcgcaagacgtttgaatctatgggcgcac
tccccaataggaaatacgcggtcgttacccgctcaggttggacatcaaatgatgacaatgtagttgtatttcagtcaatc
gaagaggccatggacaggctagctgaattcaccggtcacgttatagtgtctggtggcggagaaatttaccgagaaacatt
acccatggcctctacgctccacttatcgacgatcgacatcgagccagagggggatgttttcttcccgagtattccaaata
ccttcgaagttgtttttgagcaacactttacttcaaacattaactattgctatcaaatttggaaaaagggttaa

>>MEG_2517|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaagtatcattgatagctgcgaaagcgaaaaacggcgtgattggttgcggtccagacataccctggtccgcgaaagg
ggagcagctactttttaaagcattgacctacaatcagtggcttctggtgggtcgcaagacgtttgaatctatgggcgcac
tccccaataggaaatacgcggtcgttacccgctcaggttggacatcaaatgatgacaatgtagttgtatttcagtcaatc
gaagaggccatggacaggctagctgaattcaccggtcacgttatagtgtctggtggcggagaaatttaccgagaaacatt
acccatggcctctacgctccacttatcgacgatcgacatcgagccagagggggatgttttcttcccgagtattccaaata
ccttcgaagttgtttttgagcaacactttacttcaaacattaactattgctatcaaatttggaaaaagggttaa

>>MEG_2518|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaagtatcattgatagctgcgaaagcgaaaaacggcgtgattggttgcggtccagacatatcctggtccgcgaaagg
ggagcagctactttttaaagcattgacctacaatcagtggcttctggtgggtcgcaagacgtttgaatctatgggcgcac
tccccaataggaaatacgcggtcgttacccgctcaggttggacatcaaatgatgacaatgtagttgtatttcagtcaatc
gaagaggccatggacaggctagctgaattcaccggtcacgttatagtgtctggtggcggagaaatttaccgagaaacatt
acccatggcctctacgctccacttatcgacgatcgacatcgagccagagggggatgttttcttcccgagtattccaaata
ccttcgaagttgtttttgagcaacactttacttcaaacattaactattgctatcaaatttggaaaaagggttaa

>>MEG_2519|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaacccggaatcggtccgcatttatctggtcgctgccatgggtgccaatcgggttattggcaatggccctgatatccc
ttggaatatccctggtgagcaaaagatttttcgcaggctcaccgagggcaaagtggtcgttatgggccgcaagacgtttg
agtccataggcaagcccttaccaaaccgtcgcacagtggtgctctcgcgccaagctagttatagcgctgctggttgtgca
gttgtttcaacgctgtcgcaggctattgccatcgcagccgaacacggcaaggaactctacgtggccggcggagccgaggt
atatgcactggcactacctcgtgccgatggcgtctttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
cagtgctcgacgcagcagaattcgacgttgtctcagccgaaaccgttcaagccacaattacgtacacgcactccgtctat
gcacgtcgtaacggctaa

>>MEG_2520|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaacccggaattggtccgcatttatctggtcgctgccatgggtgccaatcgggttattggcaatggccccgatattcc
ctggaaaatcccgggtgagcaaaagatctttcgcaggctcaccgagggcaaagtggtcgttatgggccgcaagacgtttg
agtccataggcaagcccttaccaaaccgccgcacagtggtgctctcgcgccaagccagttatagcgctgctggttgtgca
gttgtttcaacgctgtcgcaggctattgccatcgcagccgaacacggcaaagagctctacgtggccggcggagccgaggt
atatgcactggcactacctcgtgccgacggcgtctttctatatgaggtacatcaaaccttcgagggtgacgccttcttcc
ctgtgctcgacgaagcagaattcgaggttgtctcagccgaaaccgttcaagccacaatcacgtacacgcactccgtctat
gcacgtcgtaacggctaa

>>MEG_2521|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaaccgggaatcggtccgcatttatctggtcgctgccatgggtgccaatcgggttattggcaatggccccgacatccc
ctggacaatcccaggtgagcagaagatttttcgcaggctcaccgagggcaaagtggtcgtgatgggtcgtaagacatttg
agtccataggaaagcccttaccaagccgccgcacagtggtgctctcccgccaagctggttatagcgctgctggttgtgca
gttgtttcaacgctgtcgcaggctattgccatcgcagccgaacacggcaaagaactctacgtagccggcggagccgaggt
atatgcactggcactacctcatgccgacggcgtctttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
ctgtgctcaacgcagcagaattcgaggttgtctcagccgaaaccgttcaagccactatcacgtacacgcactccgtctat
gcacgtcgtaacggctaa

>>MEG_2522|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcattgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2523|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagacttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggtaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2524|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcccgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2525|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgagggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcaagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgagat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacagaattcgagcttgcctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2526|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttattggcaatggtcctaatatccc
ctggaaaattccgggtgagcagaagatttttcgcagactcactgatggaaaagtcgttgtcatggggcgaaagacctttg
agtctatcggcgagcctctaccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctacgtcgcgggcggagctgaaat
atacactctggcactacctcacgcccacggcgtgtttctatctgaggtacatcaaaccttcgagggtgacgccttcttcc
caatgctcaacgaaacaaaattcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

>>MEG_2527|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacgatgagaacgtattgatctttccatcaatt
aaagatgctttaacccacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2528|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacagctcctgtttaaggctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtagtgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2529|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgatattccatggagtgccaaagg
tgaacggctcctgtttaaagctattacctataaccaatggctgttggttggacgcaagacttttgaatcaatgggagcat
tacccaaccgaaagtatgcggtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggggagatatacaaaagcctgat
cgatcaagtagatacactacatatatctacaatagacatcgagccggaaggtgatgtttactttcctgaaatccccagca
attttaggccagtttttacccaagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

>>MEG_2530|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaaagtatcattaacggctgcaaaagcgaaaaacggagtgattggttgcggtccacacataccctggtccgcgaaagg
agagcagctactctttaaagccttgacgtacaaccagtggcttttggtgggccgcaagacgttcgaatctatgggagcac
tccctaataggaaatacgcggtcgttactcgctcagcctggacggccgataatgacaacgtaatagtattcccgtcgatc
gaagaggccatgtacgggctggctgaactcaccgatcacgttatagtgtctggtggcggggagatttacagagaaacatt
gcccatggcctctacgctccatatatcgacgattgatattgagccggaaggagatgttttctttccgaatattcccaata
ccttcgaagttgtttttgagcaacactttagctcaaacattaactattgctatcaaatttggcaaaagggttaa

>>MEG_2531|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
gtgaagttatcactaatggctgccaagtcgaagaacggtattatcggtaatggaccagatattccatggagcgccaaagg
cgagcaacttctatttaaggcaattacatataatcaatggcttttagttggacgcaaaacttttgagtcaatgggcgctc
tcccaaatcgaaagtatgcagttgtaactcgctctaatttttctacgaatgatgagggtgtaatggttttctcctcaatt
caggatgccttaataaatttagaggaaatcacggatcatgttatcatttctggtggtggtgaaatatacaaaagcttgat
ttccaaagtagatactttgcatattgcaacagtcgacatcgagcgagatggagacatagtttttcctgaaatcccagata
cattcaagttggtatttgagcaagatttcgagtctaacattaactattgttatcaaatctggcaaaagagttaa

>>MEG_2532|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattaatttctgcagtgtcagaagatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2533|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgccagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2534|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgcggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagcttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2535|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggcgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2536|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtccgagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2537|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctaccaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2538|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctgacgggggtcaaatctataatagccttat
tgaaaaagcagatataattcatttgtctactgttcacgttgaagtcgaaggtgatatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2539|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaaatatcattgatttctgcagtgtcagaaaatggcgtaatcggtagtggtcctgatatcccgtggtcagtaaaagg
tgagcaactactctttaaagcgctcacatataatcaatggctccttgtcggaagaaaaacatttgactctatgggtgttc
ttccaaatcgcaaatatgcagtagtgtcaaagaacggaatttcaagctcaaatgaaaacgtcctagtttttccttcaata
gaaaatgctttgaaagagctatcaaaagttacagatcatgtatatgtctctggcgggggtcaaatctataataaccttat
tgaaaaagcaataacaattcatttgtctactgatcacgttgaagtccaaggtgctatcaaattccctataatgcctgaga
atttcaatttggtttttgaacagttttttatgtctaatataaattatacataccagatttggaaaaaaggctaa

>>MEG_2540|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ttgaaagtatcattgatggctgcaagagcgaaaaatggcgtaatcggttgcggtcctgacattccttggtctgccaaagg
ggaacagcttcttttcaaagcactgacctataaccaatggcttttggtagggcgcaaaacatttgagtctatggggccgc
tgcccaataggaaatacgcggttgttacccgctcaaactggacagcggctaatgaaaacgtagtggttttcccgtcgatt
gacgaagcgatgggtagattaggcgagatcactgaccatgtcatcgtcgccggtggtggagaaatctaccatgaaacgat
acccatggcctctactctgcatgtgtcgacaatcgacgttgagccagagggagacgttttctttccgaacattcctggga
agtttgatgtcgtttttgagcaacaatttacatcaaacattaactattgctatcaaatctggcaaaagggttaa

>>MEG_2541|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAGTCACCCACAACTTGAGCTAATAGTCGCTGTGGATTCTAAGTTGGGATTCGGGAAAGGCGGCAAGATTCCATGGAA
ATGCAAAGAAGACATGGCGCGATTTACGCGGATTTCTAAAGAGATCCGCGTGTGCGTTATAGGGAAACACACGTATACTG
ACATGCGTGACATGCAGTTAGAAAAGGATGGCGCCGAGGAGCGAATCAAGGAGAAAGGAATTCTCCCCGAACGCGAATCG
TTCGTGATCTCCTCGACGTTAAAACAAGAAGATGTCATAGGCGCTACTGTCGTTCCTGATCTTCGTGCTGTGATCAACCT
GTATGAGAATACCGATCAACGCATTGCTGTCATTGGTGGGGAGAAGTTGTACATTCAAGCTCTTTCATCAGCAACGAAAC
TGCACATGACCATAATTCCAAGAGAGTTCGACTGTGATCGATTTATTCCTGTTGATCCGATCCAGAACAATTTTCACATT
GATTCCAGTGCCAGCGAGACTGTGGAGGCAACCGTTGATGAGACTCAAGAGCGCATTCACTTTGCTACTTACGTGCGTAA
CAATCAGTAA

>>MEG_2542|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGGCTGATGAAGAATACGACCCGCTACTCGATGACGACATGGAAGATGCCAAAGTCGCCGTCATTGCTGCCCGTGCGCA
AAACGGTTGCATTGGTCGCCACGGCAAGCTGCCGTGGAAGCTGCCCGGTGACCTGAAATACTTCCGTGAGCGCACCTGGG
GCAAGCCCATCATCATGGGGCGCAAAACCTGGGAATCACTCAATGGTGCCTTGCCGGGGCGCACCAACATCGTGGTAACG
CGTCAACAAGGTTATGAAGCCGAAGGTGCTCGCGTGGTCGATAGCATCGAAGAAGCCATTAGCTTGGCACAGTCTATCGC
CTTAATCGAAGCCGTTGATGAAATCATGGTGCTGGGCGGCGGCGAAATCTATACCCAAGCCTTACCGCAAGCCGACATTC
TCTATCTCACCGAAGTACACGCCTCGGTCGACGGCGATGCCTTCTTCCCCGACGTGGACCTCAGCCAATATCAAGAAACC
CAACGCCAGGACTTCGAGCCATCGGGCGGCAACCCTTACCCGTTTAGCTTTGTGGTCTATCAGCGGACGTAG

>>MEG_2543|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGTCCCGATATCCC
CTGGAAAATCCCAGGTGAGCAGAAGATTTTTCGCAGGCTCACCGAGAGCAAAGTGGTCGTTATGGGCCGCAAGACATTTG
AGTCCATAGGCAAGCCCTTACCAAACCGCCACACAGTGGTGCTCTCGCGCCAAGCTCGTTATAGCGCTCCTGGTTGTGCA
GTTGTTTCAACGCTGTCACAGGCTATCGCCATCGCAGCCGAACACGGCAAAGAACTCTACGTAGCCGGCGGAGCCGAGGT
ATATGCGCTGGCGCTACCGCATGCCAACGGCGTCTTTCTATCTGAGGTACATCAAACCTTTGAGGGTGACGCCTTCTTCC
CAGTGCTTAACGCAGCAGAATTCGAGGTTGTCTCATCCGAAACCATTCAAGGCACAATCACGTACACGCACTCCGTCTAT
GCGCGTCGTAACGGCTAA

>>MEG_2544|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
CTATCGCTCATACGTCGTCGCGATAGTGAAACTGCCGTTTTCGATAATGTGGCCTCTGGACGTTACGCGCCATTGTCGGC
CTTCAGTGTCGTATCCGGGACTTTCCCAGAATACGTCTACGTGAGTATCCGCTGCAGGATACGCCCTCAACACCTTCGTT
TCAAAAACCTTCGTAATGACGTCTTTGTGCAGATTATAGATTTCAGCACCGCCCGCCACGATGATCTCAGTAACGCCCAG
GTGTTCGGCCACTTCAAACAGATGGCAGCTATTCCCCCACGCTACAAAGGTGCCGTCTCCACGTTCGGTTATATCCGCTT
TATCGTAAGGCTCGCGTGTGAGCACGATGACGTTGCGTCCGGGCAGGCCATTGGGGATGCTCTCAAAGGTCTTTCTGCCC
ATGACGAGTGTCTTACCCATAGTGATCGCTTTGAAGCGTTTGAGGTCTTCTTTCAACCGAACTCCTTCGACATGCCAAGG
CAAGTCGCCGTCCTGACCAATCTCACCGTTTACACCACGCGCTACAATCATTGAAAATTGAATTTCTTTATTCAT

>>MEG_2545|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGACTAAACAAGCAATATTTGCCGTAGCCGAGAACCTAGCCTTCGGGCTAGGTGGGGGTCTCCCTTGGGATACGCTGAA
AGACGACTTACAATTCTTTAAGAGGCTAACTGAAGGGACTGACTTAGTAATGGGAGCCTCCACGTACAGAACGCTGCCAT
TGTTACCAACCAATAACAGACAGTTTATTGTGGTAAGCAATACTGAGGAGCCTAGCCTTAATGTTCATGTGGTATCTCCA
GAACACTTCAAGGCTTTCCTTAGCAAAACTTCCAGAAACCTTACTATTATCGGGGGCAGCTCGTTACTAACGGTAGATAT
ATTATCAAAAATGGATAAGATAATTATGACTACGGTGTATGGAAGTTTTGATGCAGATGTATACTTACCTACTGAAGTAG
TAAGTTATGTTACTGGCAAAGCTTCAAACGCCACATTATTTAATAACTCGGACGCAAAGATGGCAGTTTATTATGGATAA

>>MEG_2546|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
GTGAAAGTATCATTAATGGCTGCAAAAGCGAAAAACGGAGTGATTGGTTGCGGTCCACACATACCCTGGTCCGCGAAAGG
AGAGCAGCTACTCTTTAAAGCCTTGACGTACAACCAGTGGCTTTTGGTGGGCCGCAAGACGTTCGAATCTATGGGAGCAC
TCCCTAATAGGAAATACGCGGTCGTTACTCGCTCAGCCTGGACGGCCGATAATGACAACGTAATAGTATTCCCGTCGATC
GAAGAGGCCATGTACGGGCTGGCTGAACTCACCGATCACGTTATAGTGTCTGGTGGCGGGGAGATTTACAGAGAAACATT
GCCCATGGCCTCTACGCTCCATATATCGACGATTGATATTGAGCCGGAAGGAGATGTTTTCTTTCCGAATATTCCCAATA
CCTTCGAAGTTGTTTTTGAGCAACACTTTAGCTCAAACATTAACTATTGCTATCAAATTTGGCAAAAGGGTTAA

>>MEG_2547|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
TTGAAAATATCATTGATTTCTGCAGTGTCAGAAAATGGCGTAATCGGTAGTGGTCCTGATATCCCGTGGTCAGTAAAAGG
TGAGCAACTACTCTTTAAAGCGCTCACATATAATCAATGGCTCCTTGTCGGAAGAAAAACATTTGACTCTATGGGTGTTC
TTCCAAATCGCAAATATGCAGTAGTGTCAAAGAACGGAATTTCAAGCTCAAATGAAAACGTCCTAGTTTTTCCTTCAATA
GAAAATGCTTTGAAAGAGCTATCAAAAGTTACAGATCATGTATATGTCTCTGGCGGGGGTCAAATCTATAATAGCCTTAT
TGAAAAAGCAGATATAATTCATTTGTCTACTGTTCACGTTGAAGTCGAAGGTGATATCAAATTCCCTATAATGCCTGAGA
ATTTCAATTTGGTTTTTGAACAGTTTTTTATGTCTAATATAAATTATACATACCAGATTTGGAAAAAAGGCTAA

>>MEG_2548|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
TTGAAAATTTCATTGATTTCTGCAACGTCAGAAAATGGCGTAATCGGTAATGGCCCTGATATCCCATGGTCAGCAAAAGG
TGAGCAGTTACTCTTTAAAGCGCTCACATATAATCAGTGGCTCCTTGTTGGAAGGAAAACATTTGACTCTATGGGTGTTC
TTCCAAATCGAAAATATGCAGTAGTGTCGAGGAAAGGAATTTCAAGCTCAAATGAAAATGTATTAGTCTTTCCTTCAATA
GAAATCGCTTTGCAAGAACTATCGAAAATTACAGATCATTTATATGTCTCTGGTGGCGGTCAAATCTACAATAGTCTTAT
TGAAAAAGCAGATATAATTCATTTGTCTACTGTTCACGTTGAGGTTGAAGGTGATATCAATTTTCCTAAAATTCCAGAGA
ATTTCAATTTGGTTTTTGAGCAGTTTTTTTTGTCTAATATAAATTACACATATCAGATTTGGAAAAAAGGCTAA

>>MEG_2549|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAAAATATCCATTATGGCAGCTGTTTCCGAGAATGGAGTAATTGGCTCTGGATTGGATATACCTTGGCATGTATATGG
TGAGCAGCTCCTGTTCAAAGCTATGACTTACAATCATTGGCTTTTAGTCGGTCGTAAAACTTTCGACTCAATGGGTAAAC
TTCCGAATAGGAAATATGCTGTGGTTACTCGTACTGAAATGGTCTCGAATGATCCTGATGTTGTTTATTTCACAAGCGTT
GAATCGGCATTAGCTTACTTAGACCACACGACAACACATGTCTTTGTTTCTGGTGGTGGTGAAATTTACAAAGCATTAAT
CGAACAAGCAGATGTTATCCATCTTTCAGTGATTCATAAGCACATCTCTGGCGACGTGTTTTTCCCTTCAGTTCCACAGA
GTTTCAAGCAAACATTTGAGCAAAGTTTCAGTTCAAATATTGATTACACGTACCAAATTTGGACAAAGGGCTAA

>>MEG_2550|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
GTGAAAATATCACTAATGGCTGCAAAAGCAAGAAATGGGGTTATTGGCTGCGGCTCTGATATCCCTTGGAACGCTAAAGG
CGAGCAGCTGCTTTTTAAAGCAATAACTTACAATCAGTGGCTTTTAGTCGGCCGCAAAACATTTGAGGCAATGGGGGCTC
TCCCAAATAGAAAGTATGCAGTTGTCAGCCGCTCAGGATCGGTAGCTACTAACGATGATATGGTTGTGTTTCCATCTATA
GAAGCAGCAATGGGTAAGCTAAAGACTCTTACGAACCATGTTGTTGTTTCTGGTGGTGGAGAGATCTATAAGAGTCTGAT
CGCCCATGCCGACACGCTACATATTTCGACAATAGATTCCGAGCCAGAGGGCAATGTTTTCTTTCCGGAAATCCCCAAAG
ATTTCAATGTGGTGTTCGAGCAGGAATTTCATTCAAATATAAATTATCGATATCAAATCTGGCAAAGGGGTTAA

>>MEG_2551|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAACTCGGAATCAGTACGCATTTATCTCGTTGCTGCGATGGGAGCCAATCGGGTTATTGGCAATGGTCCTAATATCCC
CTGGAAAATTCCGGGTGAGCAGAAGATTTTTCGCAGACTCACTGAGGGAAAAGTCGTTGTCATGGGGCGAAAGACCTTTG
AGTCTATCGGCAAGCCTCTACCGAACCGTCACACATTGGTAATCTCACGCCAAGCTAACTACCGCGCCACTGGCTGCGTA
GTTGTTTCAACGCTGTCGCACGCTATCGCTTTGGCATCCGAACTCGGCAATGAACTCTACGTCGCGGGCGGAGCTGAGAT
ATACACTCTGGCACTACCTCACGCCCACGGCGTGTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCC
CAATGCTCAACGAAACAGAATTCGAGCTTGTCTCAACCGAAACCATTCAAGCTGTAATTCCGTACACCCACTCCGTTTAT
GCGCGTCGAAACGGCTAA

>>MEG_2552|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGAATATATCACTTATCTTTGCCAATGAATTAATTACCAGAGCATTCGGTAATCAAGGCAAATTACCTTGGCAATTCAT
TAAAGAAGATATGCAGTTCTTCCAGAAGACTACAGAAAATTCTGTAGTCGTTATGGGATTAAATACATGGAGATCTCTAC
CTAAGATGAAGAAGCTTGGTAGAGACTTCATTGTCATATCTTCAACTATCACAGAGCACGAAGTGCTCAACAATAATATC
CAAATATTCAAATCATTTGAGAGCTTCTTAGAAGCATTCAGAGACACAACCAAACCAATCAATGTCATTGGTGGTGTTGG
TTTATTATCTGAAGCGATAGAACATGCTAGCACTGTTTACATGAGTTCTATTCATATGGTTAAACCTGTTCATGCTGATG
TGTATGTACCGGTAGAACTAATGAATAAACTCTATAGTGATTTCAAATATCCAGAAAATATTCTATGGGTAGGTGATCCA
ATAGATTCTGTGTATAGCTTGTCTATTGATAAGTTTGTTAGACCAGCTTCGCTGGTTGGGGTGCCAAATGATATTAATAC
GTGA

>>MEG_2553|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGATCGAGCTTCATGCCATTTTAGCTGCCACCGCCAATGGTTGCATTGGGAAGGACAACGCACTTCCCTGGCCACCACT
AAAAGGCGATCTGGCCAGATTCAAAAAATTGACCATGGGGAAGGTGGTCATTATGGGGCGCAAGACCTATGAGAGCTTGC
CCGTCAAATTAGAAGGTCGCACCTGCATCGTTATGACGCGCCAAGCGCTGGAGCTTCCGGGTGTTCGTGACGCTAACGGC
GCTATCTTCGTGAACAACGTCAGCGACGCCATGCGGTTCGCTCAAGAAGAGAGCGTGGGCGATGTGGCCTACGTCATTGG
TGGCGCTGAGATATTCAAGCGACTTGCCTTGATGATCACGCAGATTGAATTGACCTTTGTTAAGCGACTGTACGAAGGCG
ACACCTACGTTGATCTGGCCGAAATGGTCAAAGACTACGAGCAGAATGGCATGGAAGAACATGACCTTCACACTTACTTC
ACTTACCGTAAAAAGGAGCTTACAGAATGA

>>MEG_2554|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
GTGAAAATATCACTAATGGCTGCAAAAGCAAGAAATGGGGTTATTGGCTGCGGCTCGGATATCCCGTGGAACGCTAAAGG
TGAGCAGCTGCTTTTTAAAGCAATAACTTACAATCAATGGCTCTTAGTCGGCCGTAAAACATTTGAGGCAATGGGGGCTC
TCCCAAATAGAAAGTATGCAGTTGTCAGCCGCTCAGGATCGGTAGCTACTAACGATGATGTGGTTGTGTTTCCATCTATA
GAAGCAGCAATGAGGGAGCTAAAGACTCTTACGAACCATGTTGTTGTTTCTGGTGGTGGAGAGATCTACAAGAGTCTGAT
CGCCCATGCCGACACGCTACATATCTCGACAATAGATTCCGAGCCAGAGGGCAATGTTTTCTTTCCGGAAATCCCCAAAG
AGTTCAATGTGGTGTTCGAGCAGGAATTTCATTCAAATATAAATTATCGCTATCAAATCTGGCAAAGGGGTTAA

>>MEG_2555|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGGCTGCAAGAGCGAAAAATGGCGTAATCGGTTGCGGTCCTAACATTCCTTGGTCTGCCAAAGGGGAACAGCTTCTTTT
CAAAGCACTGACCTATAACCAATGGCTTTTGGTAGGGCGCAAAACATTTGAGTCTATGGGGCCGCTGCCCAATAGGAAAT
ACGCGGTTGTTACCCGCTCAAACTGGACAGCGGCTAATGAAAACGTAGTGGTTTTCCCGTCGATTGACGAAGCGATGGGT
AGATTAGGCGAGATCACTGACCATGTCATCGTCGCCGGTGGTGGAGAAATCTACCATGAAACGATACCCATGGCCTCTAC
TCTGCATGTGTCGACAATCGACGTTGAGCCAGAGGGAGACGTTTTCTTTCCGAACATTCCTGGGAAGTTTGATGTCGTTT
TTGAGCAACAATTTACATCAAACATTAACTATTGCTATCAAATCTGGCAAAAGGGTTAA

>>MEG_2556|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRA
ATGGCTTCTCTAAACATGATTGTCGCTGTCAATAAGACAGGAGGTATCGGATTTGAAAATCAGATTCCGTGGCATGAACC
AGAAGATTTAAAACACTTCAAAGCTGTTACAATGAACTCAGTTTTGATTATGGGTAGAAAAACTTTTGCCTCACTGCCTA
AAGTGCTGCCCGGACGACTTCATGTGGTAGTCAGTAAAACAGTACCACCCACCCAGAACACTGATCAAGTTGTGTATGTA
AGTACATACCAGATCGCAGTAAGAACTGCAAGCTTGTTGGTTGACAAACCAGAGTATTCTCAAATTTTTGTAATTGGTGG
GAAGAGTGCGTACGAGAACTTAGCTGCCTACGTGGACAAACTCTACTTAACTAGAGTACAGCTCAACACACAACAAGACA
CTGAACTGGATTTATCCCTATTCAAGTCATGGAAACTCGTATCTGAGGTCCCGACCATTACTGAAAACAAAACAAAACTT
ATTTTCCAAATTTGGATTAACCCTAACCCTATTAGTGAGGAACCCACATGTTAG