MEGAResFrom MEG, the Microbial Ecology Group

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ERM42

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

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Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_2779|Drugs|MLS|23S_rRNA_methyltransferases|ERM42
atgaataaaaacactaaaataaaaaacaaaaatttcaacattaaagactcacagaattttttgcataatactaaattagt
cgaagatttgctttttaaaagcaatataactaaggaggattttgttgttgagattgggcctggaaaaggcataataacca
aggcattaagcaaaatctgcaaagccgttactgctattgagttcgatagtgtattggctgataagttgacccatgaattt
aaaagttcaaatgtgtctattattgaagccgattttttaaaatacaatttaccagaccataattataaagttttttcaaa
cattccatttaacataacggcaagtattttaaataaattgttagatagtgagaacccacccttagatacttttttaatta
tgcaatatgaaccttttttaaagtatgcgggtgcaccatcttacaaggagtcttataaatctttattatataaaccattt
ttcaaaactaacatattgcatagctttagcaaatttgattttaagccagctccaaacgcaaacattattttgggccaatt
ttcttataaagactttacagatataaaccttgaagacaggcatgcttggaaagattttttagcctttgtctttttagaaa
agggagttacatttaaagaaaaaacaaaacgaatttttagttataagcaacaaaaaataattttaaaagaaagccgaatt
aatgatgattcaaatataagtaattggagttatgaattttggctaaaaatgtttaaactctataattcgaacatggtaag
caaggataaaaaagttttagttaacaattcgtataaaagaatgttagaacatgagtctagtttagaaaagattcatagaa
atagaaagcaaaataacagaaaatag

>>MEG_2780|Drugs|MLS|23S_rRNA_methyltransferases|ERM42
ATGAATAAAAACACTAAAATAAAAAACAAAAATTTCAACATTAAAGACTCACAGAATTTTTTGCATAATACTAAATTAGT
CGAAGATTTGCTTTTTAAAAGCAATATAACTAAGGAGGATTTTGTTGTTGAGATTGGGCCTGGAAAAGGCATAATAACCA
AGGCATTAAGCAAAATCTGCAAAGCCGTTAATGCTATTGAGTTCGATAGTGTATTGGCTGATAAGTTGAGCCATGAATTT
AAAAGTTCAAATGTGTCTATTATTGAAGCCGATTTTTTAAAATACAATTTACCAGACCATAATTATAAAGTTTTTTCAAA
CATTCCATTTAACATAACGGCAAGTATTTTAAATAAATTGTTAGATAGTGAGAACCCACCCTTAGATACTTTTTTAATTA
TGCAATATGAACCTTTTTTAAAGTATGCGGGTGCACCATCTTACAAGGAGTCTTATAAATCTTTATTATATAAACCATTT
TTCAAAACTAACATATTGCATAGCTTTAGCAAATTTGATTTTAAGCCAGCTCCAAACGCAAACATTATTTTGGGCCAATT
TTCTTATAAAGACTTTACAGATATAAACCTTGAAGACAGGCATGCTTGGAAAGATTTTTTAGCCTTTGTCTTTTTAGAAA
AGGGAGTTACATTTAAAGAAAAAACAAAACGAATTTTTAGTTATAAGCAACAAAAAATAATTTTAAAAGAAAGCCGAATT
AATGATGATTCAAATATAAGTAATTGGAGTTATGAATTTTGGCTAAAAATGTTTAAACTCTATAATTCGAACATGGTAAG
CAAGGATAAAAAAGTTTTAGTTAACAATTCGTATAAAAGAATGTTAGAACATGAGTCTAGTTTAGAAAAGATTCATAGAA
ATAGAAAGCAAAATAACAGAAAATAG

>>MEG_2781|Drugs|MLS|23S_rRNA_methyltransferases|ERM42
ATGGATATGAATAAAAACACTAAAATAAAAAACAAAAATTTCAACATTAAAGACTCACAGAATTTTTTGCATAATACTAA
ATTAGTCGAAGATTTGCTTTTTAAAAGCAATATAACTAAGGAGGATTTTGTTGTTGAGATTGGGCCTGGAAAAGGCATAA
TAACCAAGGCATTAAGCAAAATCTGCAAAGCCGTTACTGCTATTGAGTTCGATAGTGTATTGGCTGATAAGTTGACCCAT
GAATTTAAAAGTTCAAATGTGTCTATTATTGAAGCCGATTTTTTAAAATACAATTTACCAGACCATAATTATAAAGTTTT
TTCAAACATTCCATTTAACATAACGGCAAGTATTTTAAATAAATTGTTAGATAGTGAGAACCCACCCTTAGATACTTTTT
TAATTATGCAATATGAACCTTTTTTAAAGTATGCGGGTGCACCATCTTACAAGGAGTCTTATAAATCTTTATTATATAAA
CCATTTTTCAAAACTAACATATTGCATAGCTTTAGCAAATTTGATTTTAAGCCAGCTCCAAACGCAAACATTATTTTGGG
CCAATTTTCTTATAAAGACTTTACAGATATAAACCTTGAAGACAGGCATGCTTGGAAAGATTTTTTAGCCTTTGTCTTTT
TAGAAAAGGGAGTTACATTTAAAGAAAAAACAAAACGAATTTTTAGTTATAAGCAACAAAAAATAATTTTAAAAGAAAGC
CGAATTAATGATGATTCAAATATAAGTAATTGGAGTTATGAATTTTGGCTAAAAATGTTTAAACTCTATAATTCGAACAT
GGTAAGCAAGGATAAAAAAGTTTTAGTTAACAATTCGTATAAAAGAATGTTAGAACATGAGTCTAGTTTAGAAAAGATTC
ATAGAAATAGAAAGCAAAATAACAGAAAATAG