The lipopeptide class of antibiotics are characterized by a sequence of peptides, cyclic or linear, that are effective against multi-drug resistant bacteria. For this reason, resistance against the lipopeptides is of high importance and concern. The proposed mechanism of action of the lipopeptides is the rapid depolarization of the bacterial outer membrane. Drugs in this class include colistin, amphomycin, and daptomycin, among others.
- Colistin phosphoethanolamine transferase
- Daptomycin-resistant beta-subunit of RNA polymerase RpoB
- Daptomycin-resistant beta-subunit of RNA polymerase RpoC
- Daptomycin-resistant cls
- Daptomycin-resistant liaFSR
- Daptomycin-resistant pgsA
- Phosphotidylglycerol lysyltransferase