MEGAResFrom MEG, the Microbial Ecology Group

VanI-type regulator

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The regulator proteins include VanRS (and optionally VanU). These genes are part of a sensor-kinase two-component system. The VanI resistance cluster is characterized by its lack of VanH-like D-lactate dehydrogenase and so is unique. Its terminal product is D-ala-D-lac.

References

Other Mechanisms in Glycopeptides

Groups

Sequences

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