MEGAResFrom MEG, the Microbial Ecology Group

Aminoglycosides

The aminoglycoside antibiotics are derived from Streptomyces and Micromonospora bacteria. Their method of action is disruption of bacterial protein translation via binding of the 16S rRNA of the 30S subunit of the bacterial ribosome. To reach the ribosome, they must first be actively transported into the cell by transporters on the cell wall. Common drugs in the aminoglycoside class include gentamicin, amikacin, streptomycin, and tobramycin.

References

Mechanisms

Sequences

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