Penicillin binding protein regulator
Penicillin binding proteins (PBPs) are the target of beta-lactam antibiotics. Down-regulation of the production of PBPs reduces the concentration of targets for beta-lactam binding, resulting in resistance due to evasion of the mechanism of action of the beta-lactams.
References
- http://www.ncbi.nlm.nih.gov/pubmed/12591921