MEGAResFrom MEG, the Microbial Ecology Group

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Mutant porin proteins

In order for beta-lactam antibiotics to inhibit bacterial growth, they must pass through the bacterial cell wall using pore-forming porins. Resistance to beta-lactamases can develop via mutations in these porin proteins that no longer allow beta-lactam antibiotics to penetrate the cell wall.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696358/

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Other Mechanisms in betalactams

Groups

Sequences

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