MEGAResFrom MEG, the Microbial Ecology Group

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DFRB

The dfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/6985448

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Other Groups in Dihydrofolate reductase

Sequences

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>>MEG_2557|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atgaatgaaggaaaaaatgaggtcagtacttcagctgctggccggttcgcattcccatcaaacgccacgtttgccttggg
ggatcgcgtacgcaagaagtctggcgctgcttggcaggggcgcattgtcgggtggtactgcacaacacttacccctgaag
gctacgccgtcgagtccgaatctcacccagactcagtccagatttatcccatgactgcgcttgaacgggtggcctga

>>MEG_2558|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atggaacgaagtagcaatgaagtcagtaatccagttgctggcaattttgtattcccatcgaacgccacgtttggtatagg
agatcgcgtgcgcaagaaatccggcgccgcctggcaaggtcagattgtcggctggtactgcacaaatttgacccccgaag
gctacgccgtcgagtctgaggctcacccaggctcagtacagatttatcctgttgcggcgcttgagcgcatcaactga

>>MEG_2559|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atgaatcaaagtagcaattgcatcagcactccagttgttggacagtttgcgctgccatttcaacccacgttcggcctggg
agatcgcgtacgcaagaagtctggcgccgcttggcaaggtaaagttgtcggctggtactgcacaaaattaacccctgaag
gctacgcggtcgagtccgaagctcatccaggctcagtgcagatttatcctgtggctgcgcttgaacgcgtggcctaa

>>MEG_2560|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atgaatgaaggaaaaaatgaggtcagtacttcagctgctggccggttcgcattcccatcaaacgccacgtttgcctgggg
ggatcgcgtacgcaagaagtctggcgctgcttggcaggggcgcattgtcgggtggtactgcacaacacttacccctgaag
gctacgccgtcgagtccgaatctcacccaggctcagtccagatttatcccatgactgcgcttgaacgggtggcctga

>>MEG_2561|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atggaacgaagtagcaatgaagtcagtaatccagttgctggcaattttgtattcccatcgaacgccacgtttggtatggg
agatcgcgtgcgcaagaaatccggcgccgcctggcaaggtcagattgtcgggtggtactgcacaaatttgacccccgaag
gctacgccgtcgagtctgaggctcacccaggctcagtacagatttatcctgttgcggcgcttgaacgcatcaactga

>>MEG_2562|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
atgggtcaaagtagccatgaagccaacgctcccgttgcagggcagtttgcacttcccctgagtgccacctttggcttcgg
agatcgcgtacgcaagaaatctggtgccgcttggcagggtcaagtcgtcggttggtattgcacaaaactcactcctgaag
gctatgcggtcgagtccgaatcccacccaggctcagtgcaaatttatcctgtggctgcacttgaacgtgtggcctaa

>>MEG_2563|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGACCAAGGCAGAAGTGAAGTCAGTAATCCAGTTGCTGGCCAGTTTGCGTTCCCTTCAAACGCCGCGTTCGGAATGGG
AGATCGCGTGCGCAAGAAATCTGGCGCCGCTTGGCAAGGCCAGATTGTCGGGTGGTACTGCACAAAATTGACCCCTGAAG
GGTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCACTGGAACGCATCAACTGA

>>MEG_2564|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGCAGCGTGTCGTCGGGCCACATAGAACACCTAGAAGTTCACAAGAAAGGTCGGAAATGGAACGAAGTAGCAATGAAGT
CAGTAATCCAGTTGCTGGCAATTTTGTATTCCCATCGAACGCCACGTTTGGTATGGGAGATCGCGTGCGCAAGAAATCCG
GCGCCGCCTGGCAAGGTCAGATTGTCGGGTGGTACTGCACAAATTTGACCCCCGAAGGCTACGCCGTCGAGTCTGAGGCT
CACCCAGGCTCAGTACAGATTTATCCTGTTGCGGCGCTTGAACGCATCAACTGA

>>MEG_2565|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGGTCAAAGTAGCGATGAAGCCAACGCTCCCGTTGCAGGGCAGTTTGCGCTTCCCCTGAGTGCCACCTTTGGCTTAGG
GGATCGCGTACGCAAGAAATCTGGTGCCGCTTGGCAGGGTCAAGTCGTCGGTTGGTATTGCACAAAACTCACTCCTGAAG
GCTATGCGGTCGAGTCCGAATCCCACCCAGGCTCAGTGCAAATTTATCCTGTGGCTGCACTTGAACGTGTGGCCTAA

>>MEG_2566|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGACCAACACAACAATGGAGTCAGTACTCTAGTTGCTGGCCAGTTTGCGCTCCCATCGCACGCCACGTTTGGCCTGGG
AGATCGCGTGCGCAAGAAATCTGGCGCCGCTTGGCAGGGTCAAGTTGTCGGGTGGTACTGCACAAAACTGACCCCTGAAG
GCTATGCCGTCGAGTCCGAGTCTCACCCCGGTTCAGTACAGATTTATCCTGTGGCTGCGCTTGAACGCGTGGCCTGA

>>MEG_2567|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGACCAAGGTAGCAATGAAGTCATTAATCCAGTCGCTGGCCAGTTTGCGTCCCCATCGAACGCCACGTTTGGTATGGG
AGATCGCGTGCGCAAGAAATCTGGCGCCGCCTGGCAAGGTCAGATTGTCGGGTGGTACAGCACAAAGTTGACCCCTGAAG
GCTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTGCAGATTTATCCTGTTGCCGCGCTTGAACGCGTCAACTGA

>>MEG_2568|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGACCAAGGTAGCAATGAAGTCGGTAATCCAGTTGCGGGCCAGTTTTCGTTCCCATCGAACGCCGCGTTTAGTATGGG
AGATCGCGTGCGCAAGAAATCGGGCGCCGCTTGGCAAGGTCAGATTGTCGGGTGGTACTGCACAAAGTTGACCCCTGAAG
GCTACGCTGTCGAGTCTGAGGCTCACCCTGGCTCGGTACAGATTTATCCTGTTGCGGCGCTTGAACGCATCAACGGAGTT
CAAGGTTGA

>>MEG_2569|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGAATGAAGGAAAAAATGAGGTCAGTACTTCAGCTGCTGGCCGGTTCGCATTCCCATCAAACGCCACGTTTGCCTTGGG
GGATCGCGTACGCAAGAAGTCTGGCGCTGCTTGGCAGGGGCGCATTGTCGGGTGGTACTGCACAACACTTACCCCTGAAG
GCTACGCCGTCGAGTCCGAATCTCACCCAGGCTCAGTCCAGATTTATCCCATGACTGCGCTTGAACGGGTGGCCTGA

>>MEG_2570|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGACCAACACAACAATGGAGTCAGTACTCTAGTTGCTGGCCAGTTTGCGCTCCCATCGCACGCCACGTTTGGCCTGGG
AGATCGCGTGCGCAAGAAATCTGGCGCCGCTTGGCAGGGTCAAGTTGTCGGGTGGTACTGCACAAAACTGACCCCTGAAG
GCTATGCCGTCGAGTCCGAGTCTCACCCCGGTTCAGTACAGATTTACCCTGTGGCTGCGCTTGAACGCGTGGCCTGA

>>MEG_2571|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRB
ATGGATCAAAGTAGTAAGGAAGTCAGTTCTCCAGCTACTGACCAGTTTGCGCTCCCATTCCGCGCCACGTTTGGCCTGGG
AGATCGCGTACGCAAGAAATCTGGCGCCGCTTGGCAGGGTCAAGTTGTCGGCTGGTACAGCACAAAACTAACCCCAGAAG
GCTATGCCGTCGAGTCCGAGTCTCATCCGGGCTCTGTACAAATCTATCCTGTTGCCGCGCTTGAACGCGTGGCCTAA