Trimethoprim is a drug commonly used in conjunction with sulfamethoxazole. Its mechanism of action is to block the conversion of dihydrofolate to tetrahydrofolate (active folic acid), which is a limiting factor for bacterial proliferation. Therefore, trimethoprim is a bacteriostatic drug. Common forms of resistance to trimethoprim involve resistant forms of dihydrofolate reductase, the target of the trimethoprim antibiotics.
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