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MEGAResFrom MEG, the Microbial Ecology Group


The tetracycline class of antibiotics are comprised of a linear tetracyclic nucleus (rings A, B, C, D) that contain multiple functional groups. Their mechanism of action is to inhibit the bacterial ribosome and therefore protein synthesis. They are bacteriostatic and their mechanism of action is reversible. Resistance to tetracycline antibiotics occurs via active efflux, ribosomal protection, and drug inactivation.


  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC99026/


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