Rifampin inhibits the bacterial ribosome by complexing with the beta-subunit encoded by the rpoB gene. Resistance to rifampin is mediated by specific mutations in the beta-subunit of the rRNA polymerase or less commonly by drug inactivation and drug binding.

References

• http://www.ncbi.nlm.nih.gov/pubmed/6356275

Mechanisms

• Monooxygenase
• Rifampin ADP-ribosyltransferase Arr
• Rifampin glycosyltransferase
• Rifampin phosphotransferase
• Rifampin-resistant beta-subunit of RNA polymerase RpoB
• RNA-polymerase binding protein

Sequences

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