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MEGAResFrom MEG, the Microbial Ecology Group


This class includes the macrolides, lincosamides, and streptrogramin A and B (MLS) drugs. Macrolides contain a lactone ring with 12 or more components and are used at antibiotics, immunomodulators, and antifungals; their mechanism of action as antibiotics is still unclear, though they are known to bind to the large ribosomal subunit. Lincosamides do not have a lactone ring, but are related to macrolides. Streptogramin A antibiotics are macrolactones and streptogramin B antibiotics are cyclic hexapeptides. Both inhibit bacterial protein synthesis via action on the ribosome.


  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901655/,http://cid.oxfordjournals.org/content/34/4/482.full,http://www.ncbi.nlm.nih.gov/pubmed/10798011


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