Fosfomycin is a bactericidal antibiotic that inhibits UDP-(N-acetyl)glucosamine-3-enolpyruvyl transferase (MurA), an enzyme responsible for early stage synthesis of the peptidoglycan component of the bacterial cell wall. It is most commonly used to treat urinary tract infections, however interest in using it in the treatment of multidrug resistant bacteria has grown in recent years.
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- Fosfomycin MFS efflux pump
- Fosfomycin phosphorylation
- Fosfomycin target mutation
- Fosfomycin thiol transferases