MEGAResFrom MEG, the Microbial Ecology Group

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EF-Tu inhibition

Elongation Factor Tu (EF-Tu) is the primary target of the elfamycins. Resistance to the elfamycin class can occur via mutations in EF-Tu, which evade the mechanism of action of the elfamycin drugs. These mutations must be present for the EF-Tu to be resistant, therefore screening for these mutations is required to detect resistance via this mechanism.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/16876786

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Other Mechanisms in Elfamycins

Groups

Sequences

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