MEGAResFrom MEG, the Microbial Ecology Group

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APH9

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(9) phosphotransferases modify the 9 hydroxyl group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>>MEG_1099|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH9
atgctaagaaataacattccggatcaacacctcattgcgcttttgaaagtctattatggaattgatattcatactgtaca
actcatcgtgggtggtgctgatatgaatgcctttggatataaagcggattcagaatccaattcttatttcgtaaagctga
aatacggccatcatgatgaaattaatttatcaatcattcgcctcttgcatgattctggaataaaagaaattatttttcct
atctacacacgtgatacaaaattatttcagcaaatagatcattttaaaataatagtgtatccatttattaatgcgcccaa
tggcttcactcaaaatttaacagaaaaacagtggcaccagcttggaaaagtattaagacaaattcatgaaacttctgttc
ccaccgctattcagcaacgattaaggaaagaaacttattcgcctaaatggcgtgaaatggttagatctttttataacaaa
attggatttgatgattcagatgatcaaattactactgacttcaaaactttttttaatcaaaatatcgattcaattcatcg
attagtcgattcttcagaagaactatctaaaaaaattcaacccgatttagataaatatgtactgtgtcattctgatgtac
atgcgggcaatgtattggtcgttaatgaggaatctatttacattattgattgggatgagcccatgttagcgccaaaagag
tgtgatttgatgttcattggcggtggcattggtaatgtatggaataaacaccatgaaatcaattatttttatgaaggtta
tggtaaaacaaacgttgataaaataattttatcttattacagacatgaacgaattgtcgaagatatagctgtatatggac
aagacttactttcacgtgatcaaaacgacgagtccagacttgaaagttttaaacattttaaatcgatgtttactccaaat
gatgttgttgaaatagctttttcttcggattaa

>>MEG_1100|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH9
ATGGAAGATCTTCCTGAGAACCTGGACCAGGAAAGCCTATTTCAGGGACTACGAGAATTCGGTATCTCCACGACCAGTGC
GTCGTACGCGCCGCTCGGCTTCGGCGACTATCACTGGCACATCACCGGTGACGACGGGCAGCGGTGGTTCGCCACCGTCT
CCGACCTCGAACACAAGGAGCACTGCGGGCACGGTGCCCCGGCGGCACTGCGAGGTCTGCGGAGAGCCATGGACACCGCG
GTGCACTTGCGTGAGCAGGGCGGCCTGCCGTTCGTGGTGGCACCCCGGACCACGAGTGACGGCGCTTCACTGGTCCCGCT
GGACTCGCGGTACGCGTTGACCGTATTTCCCCATGTCTCGGCCCGACCCGGGGAGTTCGGCCAGAAGCTGACGGAGCGGG
AGCGGGACCAGGTGCTGGTGCTGCTCGCAGAATTGCACGGCCAGGCACCGCCGAAGTGCACCCCGACCACCGACATGGTG
CCGACCGGACTGGATGGCGTGCACACCGCGCTGGCCGAGCCGTCCGGAACCTGGACGGGCGGGCCGTTCTCCGAGCCGGC
CCGCGAGTTGCTGGCCGAGCACGAGGCGACGCTCCGCGGGCGGATGGCGGAGTTCGGCGAACTGGTGGCGCGGGTACGGG
GCCGCGGCGCCCCGCTGGTCGTCACACACGGCGAGCCGCACCCGGGGAACCTGATCCTTGGTGAGGACGGCTATGTGCTG
GTGGACTGGGACACGGTGGGCCTCGCGATACCCGAACGGGACCTCTCCCTGATCTCGGACGACCCGGCAGCTCTCGCCCG
CTACACCGAACTGACCGGGCACACGCCCGACCCGGCCGCGCTGGCGCTCTACCGGCTGCGGTGGAGCCTGCTGGACGTCG
CCGAGTTCGTCGAGTGGTTCCGCGGGGAACACCAGCGCACCTCCGACACCGAAGCCGCTTGGCAGAGCTTCGCCGAGACT
CTCGACCATCTGAACTCCGAAGTACCGAGCTGA

>>MEG_1101|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH9
ATGCTAAAACAACCAATTCAAGCTCAACAACTTATCGAACTTTTGAAAGTGCATTATGGAATTGATATTCATACAGCACA
ATTCATCCAGGGTGGTGCTGATACGAATGCATTTGCATATCAAGCAGATTCAGAATCCAAGTCTTATTTCATAAAGCTAA
AATACGGCTATCATGATGAAATTAATTTATCGATAATCCGTCTTTTACATGATTCTGGAATAAAAGAAATTATTTTTCCT
ATCCATACACTTGAAGCAAAATTATTCCAGCAACTAAAGCATTTTAAAATAATTGCGTATCCATTTATTCATGCGCCCAA
TGGTTTCACCCAAAATTTAACAGGAAAACAGTGGAAACAGCTTGGAAAAGTATTAAGACAAATTCATGAAACATCAGTTC
CCATCTCGATTCAACAACAATTAAGAAAAGAAATATACTCCCCTAAATGGCGTGAAATAGTCAGATCCTTTTATAATCAA
ATTGAATTTGATAATTCAGATGATAAGCTCACGGCTGCCTTTAAATCTTTTTTTAACCAAAATAGTGCTGCAATTCATCG
ATTAGTTGATACTTCAGAAAAACTATCTAAAAAAATTCAACCTGATTTAGATAAATACGTACTATGTCATTCTGATATAC
ATGCGGGCAATGTGTTAGTCGGTAATGAAGAGTCGATTTACATTATTGATTGGGATGAGCCTATGTTAGCTCCAAAAGAA
CGTGATTTGATGTTCATAGGTGGTGGCGTTGGTAATGTATGGAATAAACCCCATGAAATCCAATATTTTTATGAAGGTTA
TGGTGAAATAAATGTCGATAAAACAATTTTGTCTTATTACAGGCATGAACGAATTGTCGAAGATATCGCAGTATACGGGC
AAGACTTGCTTTCACGTAATCAAAACAATCAGTCCAGACTTGAAAGTTTTAAATATTTTAAAGAAATGTTTGATCCAAAC
AACGTTGTTGAAATAGCTTTTGCTACAGAGCAGTAA