MEGAResFrom MEG, the Microbial Ecology Group

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APH3-DPRIME

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(3'') phosphotransferases modify the 3 double prime hydroxyl group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-phosphotransferases

Sequences

Download Sequences

>>MEG_1019|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atcagaaaactgaaggaacctccattgaatcgaactaatattttttttggtgaatcgcattctgactggttgcctgtcag
aggcggagaatctggtgattttgtttttcgacgtggtgacgggcatgccttcgcgaaaatcgcacctgcttcccgccgcg
gtgagctcgctggagagcgtgaccgcctcatttggctcaaaggtcgaggtgtggcttgccccgaggtcatcaactggcag
gaggaacaggagggtgcatgcttggtgataacggcaattccgggagtaccggcggctgatctgtctggagcggatttgct
caaagcgtggccgtcaatggggcagcaacttggcgctgttcacagcctatcggttgatcaatgtccgtttgagcgcaggc
tgtcgcgaatgttcggacgcgccgttgatgtggtgtcccgcaatgccgtcaatcccgacttcttaccggacgaggacaag
agtacgccgcagctcgatcttttggctcgtgtcgaacgagagctaccggtgcggctcgaccaagagcgcaccgatatggt
tgtttgccatggtgatccctgcatgccgaacttcatggtggaccctaaaactcttcaatgcacgggtctgatcgaccttg
ggcggctcggaacagcagatcgctatgccgatttggcactcatgattgctaacgccgaagagaactgggcagcgccagat
gaagcagagcgcgccttcgctgtcctattcaatgtattggggatcgaagcccccgaccgcgaacgccttgccttctatct
gcgattggaccctctgacttggggttga

>>MEG_1020|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgacagtcgccctcgacgaagtatctgaactaaagaatttgctttcacccttgttggatgaatgcacttttgaagaagt
tgagtatggtcagtcagatgctcgagtgattcgagttctatttcctgatcgcaataccgcgtatctaaagtacgcctccg
gatcttctgctcaagaaattcttcaagagcatcagcgcactagatggctcagaacacgagctctcgtaccggaagtgatc
tcatatgtctcgacttcaactgtcaccatcctgttgacaaaagcattgattggccacaatgccgctgacgccgcacatgc
agatccagctattgttgttgcagagatggcacgagcgttacgcgacctccattcgatctcgcctgacgattgcccattcg
acgaaaggctccacctgcgactgaagctggcttcgggccgtttggaagccgggttagttgatgaggaggactttgatcac
gcaaggcaaggcatgctggcgcgggatgtttacgagcaactttttttacaaatgcctggagcggagcagctggtagtcac
acatggcgacgcctgtcccgagaacttcatcttccaaggtaatgccttcgtcggcttcatagactgcggtcgggtcgggc
ttgccgataagtatcaagacctggcgcttgcatcgagaaacattgacgcggtatttggaccagaactcactaaccagttc
tttatcgagtatggagagccaaatccgaacatagctaagattgagtactaccggatcttggatgagttcttctaa

>>MEG_1021|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgaccgcgacaacaaatccgccggacgcgatgcttgtgccgccacaactgcaagctctcgtcgcgggctacagctggaa
ccgcgatgcgctcggctgttccgatgcgcaggttttcatgctgcaaggcgaaggcttgccccggctcttcatcaaggtcg
aagccgttagcccttacggtgagttgcccgatgaggcggtgcggcttcgctggctgtcctcccgtgatatgccctgcccc
gatgttctcttcgagggcgcccatgctggccgcttctggctgttgatgagcggggttcctggtgaagatcttgcctcggc
cggttcgttgtccatcgaaacgcgtatccggatttttgccggggcgctgcgccagttgcatgcgcttgatcccgcgacct
gtccgttcgatcaccggcttgacgggcgcattgaagcggcgcgggcccgcatgcaggccgggctggtggacgagacggat
ttcgacgacgatatgctgggaaagacgacatctgaccttttcagccggctggcggccgaaaagccgatggttggagatgt
ggttgttacccacggcgatgcctgcctgccgaatttcatggccgataaaggcatcttcaccggctatatcgactgcggcc
ggcttggtcttgccgatcgctaccaggatattgggctggcgtgccgcagcattgcggataatttcggtgacgaaagggtg
aagctttttctggattgctacggcctgatgcaggccgatccggcaaagctggcttattaccggctgctcgacgagttttt
ctga

>>MEG_1022|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacatcttgctcgaggccgcgattaaattcaaatctggatgctgatctatatgggtatag
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcgtggttactcaccactgcgatccccgggaaaacagcatt
ccaggcattagaagaataccctgattcacgtgaaaatattgttgatgctctggcagcgttcctgcgccggttgcattcga
ttcctctttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctgtcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgaattttca
ccttcattacaaaaacggctttttcataaatatggcattgataaccctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctaa

>>MEG_1023|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggcagcgattaaattccaacctggatgctgatttatatgggtataa
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggaatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagcgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgatgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataatcttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccattctatggaactgcctcggtgaattttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctga

>>MEG_1024|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacatggatgctgatttatatgggtataa
atgggctcgcgataatgtcgggcaatcaggtgcgacaatcgatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggatgacggaatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagtgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcgtccaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgagttttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttactttgatgct
cgatgagtttttctaa

>>MEG_1025|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacatggatgctgatttatatgggtataa
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggaatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccmngtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagtgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgagttttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctaa

>>MEG_1026|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacctggatgctgatttatatgggtataa
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgctccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagcgttcctgcgccggttgcattcga
ttcctgttagtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcgtgccatcctatggaactgcctcggtgaattttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctga

>>MEG_1027|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacctggatgctgatttatatgggtataa
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgctccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagcgttcctgcgccggttgcattcga
ttcctgttagtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgaattttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctga

>>MEG_1028|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacctggatgctgatttatatgggtatag
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccaatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaataatgttgatgcgctggcagtgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgctagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgagttttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctga

>>MEG_1029|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggaaacgtcttgctcgaggccgcgattaaattccaacctggatgttgatttatatgggtatag
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagcgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgagttttct
ccttcattacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctaa

>>MEG_1030|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagccatattcaacgggagacgtcttgctcgaggccgcgattaaattccaacctggatgctgatttatatgggtatag
atgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttc
tgaaacatggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggcatttatgcct
cttccgaccatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccgggaaaacagcatt
ccaggtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagcgttcctgcgccggttgcattcga
ttcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctcactcaggcgcaatcacgaatgaataacggtttg
gttgatgcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgcc
attctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt
gtattgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgaattttca
ccttcattacagaaacggtttttttataaatatggcattgataatcctgatatgaataaattgcagtttcatttgatgct
cgatgagtttttctga

>>MEG_1031|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagtgagtggcgacgacagcaagtctgtgcacctattcccatgcctgcgagcatggcaaccagtctggaaggatacca
atgggcgcctatcacaattggtgaatccggcagcaatgtttatcgactttatgggaaaccaaaagctcctgatttgtttt
tgaagcgaggtaagtacgacgttgctgatgatgtgaccgatgaaatggtcaggctacgctggcttgccgaacgtatccct
gtgccaaccgtcgtcaactttgttcgcaccctcgacgaagcgtggttgctgacaacggcaatgcctggcaggacggtcta
cgaagagctggaggcgaatcccgatgcttgccttgccatcgcagacgcgctagctgatttcttgcgccgcctgcatgaga
tcccaacgattgaatgccctttcaacagcaatcacatctacagacttgctcttgcgcgcaaacgcatcgaagcgggcatg
gtcgaggtcgatgactttgatgacgaacggaaaggctgggcggctgagcaggtatgggatgcgatgcataatcttcttcc
gttcacgcccgatcctgtcacaacgcacggagattctgctctcgagaatctcttcgttcgcgaaggcaaggtgactggtt
gcattgatgttggaagatcaggcgttgcagatcgataccaggacatagccatactctggaaccgtctaggtgagtttggc
tctttgccccaggaacgattcgtggagcaatatggcatcgctgatgtagatcgacggaagctgtcatttcacttgatgct
ggatgagctgttttga

>>MEG_1032|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagtgatcaccccgggccgggggccgtcacgccggagctgttcggcgtgggcggcgactggctggccgtcaccgcggg
cgaatcgggcgcctccgtctttcgcgccgcggacgccacccggtacgccaagtgcgtgcccgccgcggacccggccggtc
ttgaggcggaacgcgaccggatcgcctggctgagcgggcagggcgtaccgggcccccgcgtcctcgactggtacgccggt
gacgcgggcgcctgcctggtcacccgtgccgtccccggcgtacccgctgatcgggtgggcgccgatgaccttcgcactgc
ctggggggccgtcgcggacgcggtccgtcggctgcacgaggtacccgtggcctcgtgtccgttccgccgggggctggact
ccgtggtcgacgccgcccgtgacgtggtggcccgtggcgcggtgcatccggagttcctgccggtggagcagcggctcgct
cccccggcggagctgctggcccggctcaccggggagctcgcccgtcggcgcgatcaggaggccgccgacacggtcgtctg
ccacggtgatctctgcctgcccaacatcgtcctccatccggagaccctggaggtgtcgggcttcatcgacctgggacggc
tcggggcggccgaccgccacgccgacctggcgctgctgctggccaacgcgcgcgagacctgggtggacgaggagcgggcg
cggttcgccgacgcggcgttcgccgagcgctacggcatcgccccggacccggaacggctgcgcttctacctccatctcga
tccgctcacctggggctag

>>MEG_1033|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgagtgatcaccccgggccgggggccgtcacgccggagctgttcggcgtgggcggcgactggctggccgtcaccgcggg
cgaatcgggcgcctccgtctttcgcgccgcggacgccacccggtacgccaagtgcgtgcccgccgcggacgcggccggtc
ttgaggcggaacgcgaccggatcgcctggctgagcgggcagggcgtaccgggcccccgcgtcctcgactggtacgccggt
gacgcgggcgcctgcctggtcacccgtgccgtccccggcgtacccgctgatcgggtgggcgccgatgaccttcgcactgc
ctggggggccgtcgcggacgcggtccgtcggctgcacgaggtacccgtggcctcgtgtccgttccgccgggggctggact
ccgtggtcgacgccgcccgtgacgtggtggcccgtggcgcggtgcatccggagttcctgccggtggagcagcggctcgct
cccccggcggagctgctggcccggctcaccggggagctcgcccgtcggcgcgatcaggaggccgccgacacggtcgtctg
ccacggtgatctctgcctgcccaacatcgtcctccatccggagaccctggaggtgtcgggcttcatcgacctgggacggc
tcggggcggccgaccgccacgccgacctggcgctgctgctggccaacgcgcgcgagacctgggtggacgaggagcgggcg
cggttcgccgacgcggcgttcgccgagcgctacggcatcgccccggacccggaacggctgcgcttctacctccatctcga
tccgctcacctggggctag

>>MEG_1034|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgcatgatgcagccacctccatgccgccgcaggctccctcaacctgggccgactaccttgccggctaccgctggcgagg
gcagggcgaaggatgttccgcggccacggtccaccgcctggaggctgcgcggcggccgaccctgttcgtcaagcaggaag
tgctgtccgcacatgccgagctgcccgccgaaatcgcccgcctgcgctggctgcacggtgccggcatcgattgcccgcag
gtgctgaacgaaacccagagcgacggccggcaatggctgctgatgagcgcagtgccgggggacacgctgtccgcgctggc
gcagcgcggcgagctggagcccgagcgcctggtgcgcctggtggccgccgccctgcgccggctgcacgatctcgatccgg
ctgcctgtcccttcgaccatcgcctggagcggcgtctggacaccgtgcgccagcgggtcgaggccgggctggtggacgag
gcggacttcgacgacgaccatcgcggtcgcagcgccacggagctgtaccgcctgctgctcgaccggcgtccggcggtcga
agacctggtggtcgcccatggcgacgcctgcctgccaaatctgctggcggaggggcggcgcttcagcggcttcatcgatt
gcgggcggctcggcgtcgccgaccggcaccaggacctggccctggccgcgcgggacatcgaggccgaactcggcgcggcc
tgggccgaggccttcctcgtcgaatacggcggcgatatcgacggcgaacggctggcgtacttcaggctattggacgagtt
cttctag

>>MEG_1035|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggaaagcacgttgcgccggacatacccgcaccacacttggcacctcgtgaacgaaggagactcgggcgccttcgtcta
ccgcctcaccggacacgggcccgagctctacgcgaagatcgccccccgcacccccgagaactccgccttccacctcgacg
gcgaggccgaccgcctcgactggctcgcccgccatggcatctcggtcccccgtgtcgtcgagcgcggtgccgacgacacc
accgcctggctcgtcaccgaggccgtgcccggcgccgcggcctccgaggagtggcccgaggacgagcgggcggccgttgt
cgacgcgatcgccgaaatggcccgcaccctccatgaactccccgtgtccgagtgccccttcgaccgccgcctcgacgtca
ccgtcggcgaggcccggcacaacgtccgcgagggcctggtcgacctcgacgacctccaggaggagcgcgccggctggacc
ggcgaccaactcctggccgaactcgaccgtacccggcccgagaaggaggacctggtcgtctgccatggcgacctgtgccc
caacaacgtgctgctcgaccccgagacccaccggatcaccgggctgatcgacgtcggccgcctcggcgtcgccgaccgcc
acgccgacctcgccctcgccgcccgcgaactggcgatcgacgaggacccgtggttcggccccgcatacgccgaacggttc
ctcgaacggtacggggcccaccacgtcgaccaggagaagatggccttctaccagctgctcgacgagttcttctag

>>MEG_1036|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggaagcacccaatcccttcactgatggcatgccgctaccgtgggcatggcaggaagcgttggccgatgcgcgcgtcga
gcggcagtcgatcggcgtgtcgcgcgcggatgtagcccgtgtgcaacggccggggcaggccgatgccttcgtgaagtcgg
aagtgatcgacgccttcagtgagctcggtgatgagatcgcgcgcctgcgctggctgcaggaacagggacaaccggcacca
acggtaattgccaccgccgaagaagcgggccggcgctggttgctgatgagcgcgctgcccggccgcgacctggcttcgtc
gccggaactcgcgccgcagcagttggtggaactgctggccgacgcgctgcgcgggctgcatgcgttgccgctggcagcct
gtccgtttgaccagcgactgcacttgcgactgcaagccgcgcaggcacgggtcgaggcggggttggtggatgccgatgac
ttcgatgacgaacgcctgggccagagtccgcagcaggtcttcgccgaactgtgcagtacccggcccgatcatgaagacct
ggtggtcagccatggcgatgcctgcttgccgaacctgatggtggtcgaggggcgtttcagcggtttcatcgactgtgggc
gactgggtgttgccgaccgctaccaggacctggcgctggccgcgcgcagcctggtccacaacttcggcgacacgcgttgg
gtggcgccgttgttccagcgctacggcgcggtggccgacgagcgccggctcgcgttctaccggctgctcgacgagttctt
ctga

>>MEG_1037|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggacgacagcacgttgcgccggaagtacccgcaccacgagtggcacgcagtgaacgaaggagactcgggcgccttcgt
ctaccagctcaccggcggccccgagccccagcccgagctctacgcgaagatcgccccccgcgcccccgagaactccgcct
tcgacctgtccggcgaggccgaccggctggagtggctccaccgccacgggatccccgtcccccgcgtcgtcgagcgcggt
gccgacgacaccgccgcgtggctcgtcacggaggccgtccccggcgtcgcggcggccgaggagtggcccgagcaccagcg
gttcgccgtggtcgaggcgatggcggagctggcccgcgccctccacgagctgcccgtggaggactgccccttcgaccggc
gcctcgacgcggcggtcgccgaggcccggcggaacgtcgccgagggcctggtggacctcgacgacctgcaggaggagcgg
gccgggtggaccggcgaccagctcctggcggagctcgaccgcacccgtcccgagaaggaggacctggtcgtctgccatgg
cgacctgtgccccaacaacgtcctgctcgaccccgggacctgccgggtcaccggcgtgatcgacgtcggccgcctcgggg
tcgccgaccgccacgccgacatcgccctggccgcccgcgagctggagatcgacgaggacccctggttcggccccgcctac
gccgagcggttcctggagcggtacggcgcccaccgcgtcgacaaggagaagctggccttctaccagcttctcgacgagtt
cttctga

>>MEG_1038|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggctaaaatgagaatatcaccggaattgaaaaaactgatcgaaaaataccgctgcgtaaaagatacggaaggaatgtc
tcctgctaaggtatataagctggtgggagaaaatgaaaacctatatttaaaaatgacggacagccggtataaagggacca
cctatgatgtagaacgggaaaaggacatgatgctatggctggaaggaaagctgcctgttccaaaggtcctgcactttgaa
cggcatgatggctggagcaatctgctcatgagtgaggccgatggcgtcctttgctcggaagagtatgaagatgaacaaag
ccctgaaaagattatcgagctgtatgcggagtgcatcaggctctttcactccatcgacatatcggattgtccctatacga
atagcttagacagccgcttagccgaattggattacttactgaataacgatctggccgatgtggattgcgaaaactgggaa
gaagacactccatttaaagatccgcgcgagctgtatgattttttaaagacggaaaagcccgaagaggaacttgtcttttc
ccacggcgacctgggagacagcaacatctttgtgaaagatggcaaagtagtggctttattgattcttgggagaagcggca
gggcggacaagtggtatgacattgccttctgcatccggttgatcagggaggatatcggggaagaacagtatgtcgagcta
ttttttgacttactggggatcaagcctgattgggagaaaataaaatattatattttactggatgaattgttttag

>>MEG_1039|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggctaaaatgagaatatcaccggaattgaaaaaactgatcgaaaaataccgctgcgtaaaagatacggaaggaatgtc
tcctgctaaggtatataagctggtgggagaaaatgaaaacctatatttaaaaatgacggacagccggtataaagggacca
cctatgatgtggaacgggaaaaggacatgatgctatggctggaaggaaagctgcctgttccaaaggtcctgcactttgaa
cggcatgatggctggagcaatctgctcatgagtgaggccgatggcgtcctttgctcggaagagtatgaagatgaacaaag
ccctgaaaagattatcgagctgtatgcggagtgcatcaggctctttcactccatcgacatatcggattgtccctatacga
atagcttaaacagccgcttagccgaattggattacttactgaataacgatctggccgatgtggattgcgaaaactgggaa
gaagacactccatttaaagatccgcgcgagctgtatgattttttaaagacggaaaagcccgaagaggaacttgtcttttc
ccacggcgacctgggagacagcaacatctttgtgaaagatggcaaagtaagtggctttattgatcttgggagaagcggca
gggcggacaagtggtatgacattgccttctgcgtccggtcgatcagggaggatatcggggaagaacagtatgtcgagcta
ttttttgacttactggggatcaagcctgattgggagaaaataaaatattatattttactggatgaattgttttag

>>MEG_1040|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atggctaaaatgagaatatcaccggaattgaaaaaactgatcgaaaaataccgctgcgtaaaagatacggaaggaatgtc
tcctgctaaggtatataagctggtgggagaaaatgaaaacctatatttaaaaatgacggacagccggtataaagggacca
cctatgatgtggaacgggaaaaggacatgatgctatggctggaaggaaagctgcctgttccaaaggtcctgcactttgaa
cggcatgatggctggagcaatctgctcatgagtgaggccgatggcgtcctttgctcggaagagtatgaagatgaacaaag
ccctgaaaagattatcgagctgtatgcggagtgcatcaggctctttcactccatcgacatatcggattgtccctatacga
atagcttagacagccgcttagccgaattggattacttactgaataacgatctggccgatgtggattgcgaaaactgggaa
gaagacactccatttaaagatccgcgcgagctgtatgattttttaaagacggaaaagcccgaagaggaacttgtcttttc
ccacggcgacctgggagacagcaacatctttgtgaaagatggcaaagtaagtggctttattgatcttgggagaagcggca
gggcggacaagtggtatgacattgccttctgcatccggtcgatcagggaggatatcggggaagaacagtatgtcgagcta
ttttttgacttactggggatcaagcctgattgggagaaaataaaatattatattttactggatgaattgttttag

>>MEG_1041|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgggtaaggaaaagactcacgtttcgaggccgcgattaaattccaacatggatgctgatttatatgggtataaatgggc
tcgcgataatgtcgggcaatcaggtgcgacaatctatcgattgtatgggaagcccgatgcgccagagttgtttctgaaac
atggcaaaggtagcgttgccaatgatgttacagatgagatggtcagactaaactggctgacggaatttatgcctcttccg
accatcaagcattttatccgtactcctgatgatgcatggttactcaccactgcgatccccggcaaaacagcattccaggt
attagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagtgttcctgcgccggttgcattcgattcctg
tttgtaattgtccttttaacagcgatcgcgtatttcgtctcgctcaggcgcaatcacgaatgaataacggtttggttgat
gcgagtgattttgatgacgagcgtaatggctggcctgttgaacaagtctggaaagaaatgcataagcttttgccattctc
accggattcagtcgtcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggttgtattg
atgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactgcctcggtgagttttctccttca
ttacagaaacggctttttcaaaaatatggtattgataatcctgatatgaataaattgcagtttcatttgatgctcgatga
gtttttctaa

>>MEG_1042|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
atgttacgcagcagggcagtcgccctcgacgaagtatctgaactaaagaatttgctttcacccttgttggatgaatgcac
ttttgaagaagttgagtatggtcagtcagatgctcgagtgattcgagttctatttcctgatcgcaataccgcgtatctaa
agtacgcctccggatcttctgctcaagaaattcttcaagagcatcagcgcactagatggctcagaacacgagctctcgta
ccggaagtgatctcatatgtctcgacttcaactgtcaccatcctgttgacaaaagcattgattggccacaatgccgctga
cgccgcagatgcagatccagttattgttgttgcagagatggcacgagcgttacgcgacctccattcgatctcgcctgacg
attgcccattcgacgaaaggctccacctgcgactgaagctggcttcgggccgtttggaagccgggttagttgatgaggag
gactttgatcacgcaaggcaaggcatgctggcgcgggatgtttacgagcaactttttatacaaatgcctggagcggagca
gctggtagtcacacatggcgacgcctgtcccgagaacttcatcttccaaggtaatgccttcgtcggcttcatagactgcg
gtcgggtcgggcttgccgataagtatcaagacctggcgcttgcatcgagaaacattgacgcggtatttggaccagaactc
actaaccagttcttcatcgagtatggagagccaaatccgaacatagctaagattgagtactaccggatcttggatgagtt
cttctaa

>>MEG_1043|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
gtgaacgatattgatcgagaagagccctgcgcagccgctgccgtgcccgagagcatggcggctcacgtgatgggatacaa
atgggcgcgtgataaggttggtcagtccggctgcgcggtctatcggctgcatagcaagtcaggcggctccgacttgtttc
tgaagcacggcaaagatgcttttgccgacgacgtgactgatgaaatggtgagattgcgttggctggcggggcacatttct
gtgccctccgttgtaagcttcgttcgcacgcccaatcaggcatggctcctgacaacagcaatacatggaaaaacggcata
tcaagtgctgaaatcggatttcggagcccgtctcgttgttgttgacgcattggcggcgttcatgcgccgactgcatgcga
tcccagtgagcgaatgctccttcaacagtgaccacgcatgcaggcttgcccgagcgcgggagcgtatcgaggcgggggtt
gttgatgtcgatgacttcgataaggagcgcgaagggtggacggccgaacaggtttgggaggcgatgcatcgcctcctacc
gctcgcgccggacccagtcgtgacgcacggcgatttttcactcgataatctacttatcgtcgaaggtaaggtagtcggct
gcatcgacgttgggcgggctggtattgctgatcgataccaagaccttgccgtgttatggaactgtcttgaggagttcgaa
ccttcgcttcaggagaggcttgttgcgcaatatggcattgccgatccggataggcgcaagctgcaatttcatctcctgct
ggacgaacttttctaa

>>MEG_1044|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACCTGGATGCTGATTTATATGGGTATAG
ATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGATTGTATGGGAAGCCCAATGCGCCAGAGTTGTTTC
TGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGACTAAACTGGCTGACGGCATTTATGCCT
CTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATT
CCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGA
TTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTG
GTTGATGCTAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAAGCTTTTGCC
ATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTT
GTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCT
CCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCT
CGATGAGTTTTTCTGA

>>MEG_1045|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGT
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1046|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGT
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATTGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1047|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGATCAATGATATGAAAATTTCACTTCCGCAAAGTCTTAAAAGTTTTATTGGAAATCAACCATTACAAAAAGATAAAGT
GGGACAATCCCCTTCTGATGTGTATTCTTTTACCAAAAATAATGAAAAATACTATTTAAAAACCACTGAGCTAATTTATG
CTCAAACAACTTATAGTATCATACGTGAAGCAAAAATACTCGACTGGCTAGATGGAAAGCTCAATGTTCCAGAGCTAGTT
TTAATGGATACCGACCATGAAAATGAGTACATGATCAGCAAGGCAGTCCCCGCAAAACCCTTACAAGATTTCACAGGAAA
AAGTGATCAATTTTTCATAGATATTTATACAGATGCTTTGGCACAATTACAGTCTATTTCAATAAAAAACTGTCCATTTA
TATCCAATAAAAAATTTCGATTAGCTGAGGCGGAATTCTTTATTGAAAATGGCTTACTTGATGAATTGGATGATGATGAA
AAAGATCTAAAGCTTTGGTCCAGTTATCAAAATTTTGCTGAATTCTTAGATGATCTAAAACAGCAAAATTTCCAAGAAGA
ATATGTATTTAGTCATGGTGACCTAACCGACAGCAATGTATTTTTAAGTCATGATGCACAAATCTACTTTTTAGATGTCG
GACGTGCTGGTATCGCAGATCGATTTGTAGATATTGCCTTTATTGAACGTAGTCTACGAGAAGATTGCTCTGAGGATGCT
GCACTTCAATTTTTAAATCATTTAGCAGAAGACGATTCTTTTAAACGGAATTATTTTCTAAAATTGGATGAGTTAAATTG
A

>>MEG_1048|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGAAACTACCTCAGAAAATTAGAAATTTTATTGGAAATAATCGATTAATCGTTAACAAAGTTGGTCAATCACCTTCTGA
TGTATATTGCTTTGAACGAAATCGGGAAACGTTCTTCTTAAAAGTGTCTAGTGTGCAATATGCAACAACAACTTATAGTG
TTGCGCGTGAAGCACAGATGATGCTTTGGTTAGCTGATAAGATTAACGTACCTGAGTTAGTATTCAGTGAAATAGATCAA
AATTTTGAGTATATGTTAAGCAAGTCTATTGATGCTCAACCTATATCAGATTTGTCCTTAGCTCAATCCGAATTAATCAT
GCTTTATCAAGATGTATTAAGCCAGTTACGATCAGTACCTGTACAAAATTGTCCATTTAATTCAGATATCAATAGCCGTT
TACAAGAATCCCAATACTTTATGGAGATTGGGTTGTTAAATCAGGTTGATGATGAAAATATTGATATAGAGCTATGGGGT
GAGCATCAGAGTTATCTAGAACTGTGGACAGAGTTAAACAATCATCGTGTGAAAGAAAATTTAGTGTTTACACATGGAGA
TATTACTGACAGTAATATTTTCGTTGATCAGTCAAATAAGATTTATTTTTTGGACTTAGGACGCGCTGGCTTGGCAGATG
AGTTTGTAGATATTGCCTTTGTTGAACGTTGTCTTCGTGAAGATGGTTCTGAAGAGAGTGCTCAGAAGTTTCTCAAACAA
TTAAGTTTTGATGACCTATCCAAACGTCAATATTTTCTAAAACTTGATGAGTTAAATTGA

>>MEG_1049|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
GTGACCGAGTGGCTGCCCGTCACACGCGGTGAATCCGGTGCCGGGGTCTTCAGGAACTCCGACGGTTCGAGCTACGCGAA
GGTGGTCGACGCCGCGGCGGTGGCAGACCTGGCCGCGGAGCGTGACCGGGTGTCCTGGGCCCACAGGCACGGTGTCCCCG
GGCCCGCGGTCATCGACTGGCGTGTCACCGAAGACGGCGGCGCGTGCTTGATCACGAGCACTGTGCGCGGTGTCGCTGCC
GATCGGCTTTCCGAATCGGCGCTGCGGGCGGCCTGGCCGGCGATTGTGGAGGCGGTCCGGACACTGCACGCCCTTCCGGC
CGACGGTTGTCCCTACCGGCGCGATCTCGACGACATGCTGGCCCGGGCCCGCGCGGTCGTCGGCGCCGGTGCCGTGAACC
CGGAGTTCCTGTCCGACGAGGACCGCGAGGTACCGGCGGAGGCGCTGCTGGACCGAGTCGAACGGGAAGCCGATCTACGT
CGTCGGGAGGAGGCCGCCGACTGGGTGGTGTGCCACGGCGATCTGTGCCTGCCGAACATTTTGGTCGACCCCGACCGTCA
CACCGTCGAGGGATTCATCGATCTGGGCAGGCTGGGGCTGGCCGACCGGCACGCCGACCTGGCACTGCTGCTGGCCAATA
CGGCTGATACCGTTCCGGGCTTCGCCGAGGAGGCCACGGCGGGGTTGGCCGCGGGGTATCCGGCGCAGGTGGATCCGGAG
CGGCTGCGGTTCTATCTCGCGCTCGATCCGCTGACCTGGGGATGA

>>MEG_1050|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACA
GACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGT
CCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTG
CTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCT
TGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCG
ACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAA
GAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGAC
CCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTG
TGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTC
CTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGA

>>MEG_1051|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGAGTGATCACCCCGGGCCGGGGGCCGTCACGCCGGAGCTGTTCGGCGTGGGCGGCGACTGGCTGGCCGTCACCGCGGG
CGAATCGGGCGCCTCCGTCTTTCGCGCCGCGGACGCCACCCGGTACGCCAAGTGCGTGCCCGCCGCGGACGCGGCCGGTC
TTGAGGCGGAACGCGACCGGATCGCCTGGCTGAGCGGGCAGGGCGTACCGGGCCCCCGCGTCCTCGACTGGTACGCCGGT
GACGCGGGCGCCTGCCTGGTCACCCGTGCCGTCCCCGGCGTACCCGCTGATCGGGTGGGCGCCGATGACCTTCGCACTGC
CTGGGGGGCCGTCGCGGACGCGGTCCGTCGGCTGCACGAGGTGCCCGTGGCCTCGTGTCCGTTCCGCCGGGGGCTGGACT
CCGTGGTCGACGCCGCCCGTGACGTGGTGGCCCGTGGCGCGGTGCATCCGGAGTTCCTGCCGGTGGAGCAGCGGCTCGTT
CCCCCGGCGGAGCTGCTGGCCCGGCTCACCGGGGAGCTCGCCCGTCGGCGCGATCAGGAGGCCGCCGACACGGTCGTCTG
CCACGGTGATCTCTGCCTGCCCAACATCGTCCTCCATCCGGAGACCCTGGAGGTGTCGGGCTTCATCGACCTGGGACGGC
TCGGGGCGGCCGACCGCCACGCCGACCTGGCGCTGCTGCTGGCCAACGCGCGCGAGACCTGGGTGGACGAGGAGCGGGCG
CGGTTCGCCGACGCGGCGTTCGCCGAGCGTTACGGCATCGCCCCGGACCCGGAACGGCTGCGCTTCTACCTCCATCTCGA
TCCGCTCACCTGGGGCTAG

>>MEG_1052|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGAGCGAACCCTACCTGAGCCGCTGGCGATTGCGGCGTGATGGCCCGGCCATCCGTACGCCCCACGCCCGGCTCTGGCC
GGTGCTGACCGCTGCGGGCGAGCCAGCGATGCTGAAGATCAGCAGCGAGACCGAGGAGCAGAACAGCCATCGCCTGCTAC
GCTGGTGGAACGGCGATGGCGCCGCCCGCCTGCTGGCCCACGAGGGGCCTGCGATCCTGATCGAGCGTGCCCGCGGTGAC
TCGCTGCGGCAACGCTCGATCGAGGGCGACGATGACGCCTGCACCGCGATCCTGTGCCAGGTCCTGCAGCGGCTGCACCG
GCCACGGAGCGCGCCGCCAGCGGAACTGGTCTGCCTGCGTAGATGGTTCGCCGACCTGCTGCAGCCAAGGGCTGTGCTGC
CGCCACTGCTGGAACAGTGCAGATCACTGGCGGAGGGGCTGCTGCGTGACGAACAGGAGATCCGGCCGCTGCACGGCGAC
CTGCATCATGACAATGTGCTGGATTTCGGCCCGCGCGGCTGGTTGGCGATCGACCCGAAGCGACTGCTGGGGGACCGTGC
GTTCGATTACGCGACGATGTTCAGCAACCCGGACCTCTGTGGTCCGGGCATCCACGTTGCGACGCGGCCCGAGCGGTTTG
CGATCCGCCTTGAGCAGGTCTGTGCGCTGGCCGAACTGGAACGCACACGCCTGCTGCGCTGGATCGCGGCCAGCACTGCG
CTGTCGGCAGTGTGGTTCAGGGATGACGGCGACCCGGCCGATATCGACGAGACAGTCGCCCGGATGGCCCTGGAGGCGCT
GGCGGAAGCGTGA

>>MEG_1053|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGT
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1054|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGG
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTGATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1055|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGT
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTCATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCTGCACGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1056|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
CATCGCCGCGGTCGGGTGCGTGCTGAGCTGGATCGCCGCGGCGACGACGATCGAGGTGGCGCCCGTGCTGGAAGGCGAGC
CGGCCACCACGGCGATCAGCTACTCGTCGCCGCTGTTGGTATTGGCGCTGGCCCTGGCGGGTCTGGCCGGCGTGCTGGCG
GTGTTGGGTATTGCCCGGTTGCGTCGCTGATCCGTGACCGAGTGGCTGCCCGTCACACGCGGTGAATCCGGTGCCGGGGT
CTTCAGGAACTCCGACGGTTCGAGCTACGCGAAGGTGGTCGACGCCGCGGCGGTGGCAGACCTGGCCGCGGAGCGTGACC
GGGTGTCCTGGGCCCACAGGCACGGTGTCCCCGGGCCCGCGGTCATCGACTGGCGTGTCACCGAAGACGGCGGCGCGTGC
TTGATCACGAGCACTGTGCGCGGTGTCGCTGCCGATCGGCTTTCCGAATCGGCGCTGCGGGCGGCCTGGCCGGCGATTGT
GGAGGCGGTCCGGACACTGCACGCCCTTCCGGCCGACGGTTGTCCCTACCGGCGCGATCTCGACGACATGCTGGCCCGGG
CCCGCGCGGTCGTCGGCGCCGGTGCCGTGAACCCGGAGTTCCTGTCCGACGAGGACCGCGAGGTACCGGCGGAGGCGCTG
CTGGACCGAGTCGAACGGGAAGCCGATCTACGTCGTCGGGAGGAGGCCGCCGACTGGGTGGTGTGCCACGGCGATCTGTG
CCTGCCGAACATTTTGGTCGACCCCGACCGTCACACCGTCGAGGGATTCATCGATCTGGGCAGGCTGGGGCTGGCCGACC
GGCACGCCGACCTGGC

>>MEG_1057|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
TTGAATCGAACTAATATTTTTTTTGGTGAATCGCATTCTGACTGGTTGCCTGTCAGAGGCGGAGAATCTGGTGATTTTGT
TTTTCGACGTGGTGACGGGCATGCCTTCGCGAAAATCGCACCTGCTTCCCGCCGCGGTGAGCTCGCTGGAGAGCGTGACC
GCCTCATTTGGCTCAAAGGTCGAGGTGTGGCTTGCCCCGAGGTCATCAACTGGCAGGAGGAACAGGAGGGTGCATGCTTG
GTGATAACGGCAATTCCGGGAGTACCGGCGGCTGATCTGTCTGGAGCGGATTTGCTCAAAGCGTGGCCGTCAATGGGGCA
GCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGGACGCGCCG
TTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCGATCTTTTG
GCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGATCCCTGCAT
GCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGCAGATCGCT
ATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCTTCGCTGTC
CTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTGACTTGGGG
TTGA

>>MEG_1058|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH3-DPRIME
ATGGGGCAGCAACTTGGCGCTGTTCACAGCCTATCGGTTGATCAATGTCCGTTTGAGCGCAGGCTGTCGCGAATGTTCGG
ACGCGCCGTTGATGTGGTGTCCCGCAATGCCGTCAATCCCGACTTCTTACCGGACGAGGACAAGAGTACGCCGCAGCTCG
ATCTTTTGGCTCGTGTCGAACGAGAGCTACCGGTGCGGCTCGACCAAGAGCGCACCGATATGGTTGTTTGCCATGGTGAT
CCCTGCATGCCGAACTTCATGGTGGACCCTAAAACTCTTCAATGCACGGGTCTGATCGACCTTGGGCGGCTCGGAACAGC
AGATCGCTATGCCGATTTGGCACTCATGATTGCTAACGCCGAAGAGAACTGGGCAGCGCCAGATGAAGCAGAGCGCGCCT
TCGCTGTCCTATTCAATGTATTGGGGATCGAAGCCCCCGACCGCGAACGCCTTGCCTTCTATCTGCGATTGGACCCTCTG
ACTTGGGGTTGA