MEGAResFrom MEG, the Microbial Ecology Group

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AAC2-PRIME

Aminoglycoside N-acetyltransferases modify a specific amino group on the aminoglycoside molecule by transferring an acetyl group from acetyl-CoA to the aminoglycoside drug; the type of N-acetyltransferase is named after which amino group it modifies. AAC(2') aminoglycosides modify the 2 prime amino group.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/18710261,http://www.ncbi.nlm.nih.gov/pubmed/9159528

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Other Groups in Aminoglycoside N-acetyltransferases

Sequences

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>>MEG_13|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
GTGCACACCCAGGTACACACGGCCCGCCTGGTCCACACCGCCGATCTTGACAGCGAGACCCGCCAGGACATCCGTCAGAT
GGTCACCGGCGCGTTTGCCGGTGACTTCACCGAGACCGACTGGGAGCACACGCTGGGTGGGATGCACGCCCTGATCTGGC
ATCACGGGGCGATCATCGCGCATGCCGCGGTGATCCAGCGGCGACTGATCTACCGCGGCAACGCGCTGCGCTGCGGGTAC
GTCGAAGGCGTTGCGGTGCGGGCGGACTGGCGGGGCCAACGCCTGGTGAGCGCGCTGTTGGACGCCGTCGAGCAGGTGAT
GCGCGGCGCTTACCAGCTCGGAGCGCTCAGTTCCTCGGCGCGGGCCCGCAGACTGTACGCCTCACGCGGCTGGCTGCCCT
GGCACGGCCCGACATCGGTACTGGCACCAACCGGTCCAGTCCGTACACCCGATGACGACGGAACGGTGTTCGTCCTGCCC
ATCGACATCAGCCTGGACACCTCGGCGGAGCTGATGTGCGATTGGCGCGCGGGCGACGTCTGGTAA

>>MEG_14|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
ATGAAAGACAGATCCCATGACGACTCAATGGCCGAGGTCTGTCGGAACACCTCTGAGAACCACTGGCTGAAGACCGATTA
TCGGACGTTGTTTCGGCTGTGCCCCGACGGTCGGATCGAGCGCGAGAATGATCCGGACTGCTCGCCGGGGCCGCGTTTCT
GGTTGGCTGGCTGTTCGGAAGGCAACGTGTTCGGCGTACGTGCCGATGTGCCCGATGACATAGCACTAAAGCTCGAAGAA
CTCGCCAGCGTCGAGCCTCCGTTCACACCCCCGGCGATACCGAAGCATCTTGAACGTTATCTTTCACTGCTCGGCAGTGA
TGGCCCTGTTACCCACGATCTTGGTCTGATTTACGAGTTGCCGCACGCGCAGCAGTACCCGAGCAAGGCCCGGCTCATCG
GCAGCGGTTCCGAGGAGGGCGAGAGTCTGATGCAGTCTTGGGCGGAGGACAGAGTACCGGAAGCTTTGTTTGAGCTTGGC
TTCCGTGAGGTGGCGGACTTCTGGACGCCTTGGTGCGCGGCAGTTGTCGATGGTGAAGTCGCTTCAATCGCCTTTGCAGC
GCGTCTCGCGGATGCCGGTGCCGAACTCGGGTTGGTAACGGCGAAGGCATTCAGAGGACAGGGGTTCGCCGCCGCTGCGA
CGGCTGGTTGGTCCCGGCTCTCCGCTCTTCGTTCCCGCACGCTGTTCTACAGCACGGACCGAGACAACATTTCATCGCAG
CGCGTTGCCGCCCGCCTTGGTCTCCGGCTTCGTGGAGCCAGCTTGCGAATATCACGCGCCTGA

>>MEG_15|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
ATGGATACCCACCACGTACATACCGCCCGCCTGGTTCATACCGCCGATCTCGACGGCGAGACTCTCCGGCGCCTCCAGCA
GATGGTCACCGACGCTTTCGCCGGAGACTTCGACGAGACCGACTGGGAACACGCATTGGGCGGGATGCACGCCCTGATCT
GGCGGCACGGCACAATCATTGCGCACGCCGCGGTCGTTCAGCGGCGACTATTCTACCACGGCAACGCGTTGCGTTGCGGT
TACCTCGAAGGTGTCGCGGTACGGAAGGACTGCCGGGGCCGCGGACTTGTACATGCGCTGCTGGACGCTATCGAGCAAGT
GATACGCGGCGCCTATCAATTCGGTGCCTTGAGTTCCTCGGACCGAGCCCGTCGGGTGTATATGTCGCGCGGGTGGTTAC
CATGGCTCGGCCCGACGTCAGTGCTGGCTCCTACCGGTGTGATCCGTACGCCCGATGATGACGGCTCGGTGTTTGTCCTT
CCGGTCGGCATCAACCCGGACACCTCCTCGGGGTTGATGTGCGATTGGCGCGCAGGCAACGTGTGGTAA

>>MEG_16|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
ATGAACCATAGGAAAGGTAACGAGCCAACCGCTGCGGCACTGATGGAATTGCATGTTCTGGCGATGTTTACGCATGACGG
GAATATGCAAATTCGCACCATCAACGAGCCTTGGCCGGGAGAGGAGCTTGCCCCGAGGTTTTTCATGGGTCGAACGATAG
ACGGCTCTTCGATCTGCAGGTTTCGTCATGATGTTCCCGAAGGAATTGCCGGGCAATTGAGGGCTTTGGTTGAAGATGAG
CCTATCGTTACTGAAGAGGTTCTGACGAGGCCTAAACATTTTGCAGCTTATATGAACCTCCTTCGCGCTGAGCACTATAC
GAGCGGACCTTGTTATCGGATACCTGATCAAACAACGCAGGCCAAACAGACGGTAAGGATCACACCGGGAAATATTCGCG
AATATTCGCTCACCGGTTTTGAATGGCTGACCACGGAAATTGATTATGACCAGCCTTGTGTTGCGCTCATTCATGAGAAT
AGGGTGGTGTCGGTTTGCCGCAGCGTCCGGATTACTGAACGAGCTCACGAAGCTGGGCTTGAAACGTCAGAGGAATTTCG
TGGAAGAGGTTATGCGGCTGCTGTTGTTGCCGGATGGGCCATAGAGGTGCAAAAAATGGGCGCGCTGGCGTTGTACAGTA
CTTTATGGGGAAATAGCTCTTCCCGGAGAGTAGCAAATAAATTAGGGTTGTCCTATTACGGAGTTAACTTCACGATCAGT
TGA

>>MEG_17|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
ATGGGCATAGAATACCGCAGTCTGCATACCAGCCAATTGACACTGAGTGAAAAAGAAGCGCTTTACGATTTATTAATTGA
AGGTTTTGAAGGCGATTTTTCGCATGACGATTTCGCGCACACTTTAGGTGGAATGCACGTCATGGCTTTTGATCAACAAA
AATTGGTTGGTCATGTTGCAATTATTCAACGCCATATGGCCCTAGATAATACGCCTATCTCTGTAGGGTATGTTGAAGCG
ATGGTAGTTGAACAAAGTTATCGTCGCCAAGGTATTGGGCGGCAATTGATGCTGCAAACCAATAAAATTATAGCTTCGTG
TTATCAATTAGGGCTGCTGTCGGCTTCAGATGATGGACAAAAATTGTATCATTCGGTTGGATGGCAAATCTGGAAAGGTA
AGTTGTTTGAATTGAAACAAGGGAGCTATATCCGTTCTATTGAAGAAGAAGGCGGAGTCATGGGCTGGAAAGCGGATGGT
GAGGTTGATTTTACCGCTTCGCTTTACTGTGATTTTCGTGGCGGTGATCAGTGGTAA

>>MEG_18|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
GTGCCTTTCCAGGATGTCAGCGCGCCCGTTCGAGGCGGGATCCTGCACACCGCTCGACTCGTCCACACCTCCGATCTCGA
TCAGGAGACTCGAGAGGGCGCCCGCCGCATGGTCATCGAGGCGTTCGAGGGTGATTTCAGCGACGCCGACTGGGAGCACG
CGCTCGGTGGCATGCACGCCTTCATCTGTCACCACGGCGCTCTGATCGCGCATGCCGCGGTGGTCCAGCGCCGGCTGCTC
TACCGCGACACCGCGCTGCGCTGCGGGTACGTGGAAGCCGTGGCGGTGCGCGAAGATTGGCGCGGCCAAGGCCTGGCCAC
CGCCGTCATGGACGCGGTCGAACAGGTGCTGCGCGGCGCCTACCAGCTCGGCGCCCTCAGTGCGTCCGACACAGCCAGAG
GCATGTACCTCTCTCGCGGGTGGCTGCCGTGGCAGGGGCCGACCTCGGTGCTGCAGCCGGCCGGCGTGACGCGTACACCC
GAGGACGACGAGGGACTGTTCGTGCTGCCCGTCGGTCTCCCGGCGGGAATGGAACTCGACACCACAGCCGAGATCACCTG
CGACTGGCGCGACGGGGACGTCTGGTAA

>>MEG_19|Drugs|Aminoglycosides|Aminoglycoside_N-acetyltransferases|AAC2-PRIME
GTGCTCACCCAGCATGTCAGTGAGGCTCGCACGCGCGGTGCGATCCACACCGCGCGTCTGATCCACACCTCCGATCTGGA
CCAGGAAACCCGCGACGGCGCGCGCCGCATGGTGATCGAGGCGTTCCGCGATCCGTCCGGAGACAGTGATTTCACCGACG
ATTTCACCGACGACGACTGGGACCACGCGCTCGGCGGCATGCACGCGCTGATCTCTCACCACGGTGCGCTCATCGCGCAC
GGCGCCGTCGTCCAACGTCGGTTGATGTACCGGGGACCCGACGGTAGAGGTCACGCGCTGCGCTGCGGTTACGTCGAGGC
CGTCGCGGTGCGCGAGGACCGGCGGGGCGACGGTCTGGGCACCGCCGTGCTCGACGCGCTCGAGCAGGTGATCCGCGGCG
CCTATCAGATCGGCGCGCTGAGCGCGTCGGACATCGCCCGGCCGATGTACATTGCCAGGGGCTGGCTGTCGTGGGAGGGT
CCGACATCGGTGCTGACCCCCACCGAGGGCATCGTTCGCACCCCTGAGGACGACCGGTCGCTGTTCGTCCTGCCGGTCGA
TCTCCCGGACGGCCTCGAGTTGGACACCGCGCGCGAGATCACGTGCGACTGGCGCTCCGGCGACCCCTGGTGA