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MEGARes
MEGAResFrom MEG, the Microbial Ecology Group

Aminocoumarins

The aminocoumarin antibiotics are derived from Streptomycetes bacteria. Their method of action is the competitive inhibition of bacterial DNA topoisomerases (typically the ATP-binding subunit), which are vital enzymes for cellular function. Common drugs in the Aminocoumarin class (coumarin glycosides) include novobiocin, clorobiocin, and coumermycin A1.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/22644392,http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189412/

Mechanisms


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Sequences

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