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OMP36
The Omp36 porin is similar to OmpC and can harbor mutations resulting in a decreased porin conductance due to narrowing of the lumen. These mutations result in beta-lactam resistance, specifically to cefepime, cefpirome and imipenem. This porin has also been implicated in multi-drug resistance.
References
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696358/
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Other Groups in Mutant porin proteins
Sequences
>>MEG_4279|Drugs|betalactams|Mutant_porin_proteins|OMP36|RequiresSNPConfirmation
ATGAAAGTTAAAGTACTGTCCCTCCTGGTACCAGCACTGCTGGTAGCGGGCGCAGCAAATGCGGCTGAAATTTATAACAA
AGACGGCAACAAATTAGACCTGTACGGTAAAATCGACGGTCTGCACTACTTCTCTTCCGACGACAGCGTCGACGGCGACC
AGACCTACATGCGTATCGGCGTGAAAGGCGAAACCCAGATCAACGACCAGCTGACCGGTTACGGCCAGTGGGAATACAAC
GTTCAGGCGAACAACACTGAAAGCTCCAGCGACCAGGCGTGGACTCGTCTGGCCTTCGCGGGTCTGAAATTCGGCGACGC
GGGTTCTTTCGACTACGGTCGTAACTACGGCGTTGTTTACGACGTAACTTCCTGGACCGACGTTCTGCCGGAATTCGATG
GCGACACCTACGGTTCCGACAACTTCCTGCAGTCCCGTGCTAACGGCGTTGCCACCTACCGTAACTCTGACTTCTTCGGT
CTGGTTGACGGCCTGAACTTTGCTCTGCAGTACCAGGGTAAAAACGGCAGCGTGAGCGGCGAAGATCAGACCAACAACGG
TCGCGGCTTCCAGAAACAGAACGGCGAAGGCTTCGGCACCTCCGTGACTTATGAGATCTGGGACGGCATCAGCGCTGGTT
TCGCGTACTCCAGCTCTAAACGTACCGATGAGCAGAACAACTCTACTTATTTTTCTAAGTCCTATCAGCGTACATACGGT
GTTCTGGGTGAAGGCGATCACGCTGAAACCTATACCGGTGGTCTGAAATATGACGCCAACAACATTTACCTGGCGACTCA
GTACACCCAGACCTACAACGCAACTCGCACTGGCGACATCGGTTTTGCTAACAAAGCGCAGAACTTCGAAGTGGTTGCTC
AGTACCAGTTCGACTTCGGTCTGCGTCCGTCCGTGGCTTACCTGCAGTCTAAAGGTAAAGACATGGGCCGTTACGGCGAC
CAGGACATCCTGAAATATGTTGACCTGGGTGCGACCTACTACTTCAACAAAAACATGTCCACCTACGTTGATTACAAAAT
CAACCTGCTGGACGACAACAAGTTCACTAAAGATGCAAGCATCTCTACTGACAACGTTGTGGCTCTGGGCCTGGTTTACC
AGTTCTAA
>>MEG_4280|Drugs|betalactams|Mutant_porin_proteins|OMP36|RequiresSNPConfirmation
ATGAAAGTTAAAGTACTGTCCCTCCTGGTACCAGCACTGCAGGTAGCGGGCGCAGCATATGCGGCTGAAATTTATAACAA
AGACGGCAACAAATTAGACCTGTACGGTAAAATCGACGGTCTGCACTACTTCTCTTCCGACGACAGCGTCGACGGCGACC
AGACCTACATGCGTATCGGCGTGAAAGGCGAAACCCAGATCAACGACCAGCTGACCGGTTACGGCCAGTGGGAATACAAC
GTTCAGGCGAACAACACTGAAAGCTCCAGCGACCAGGCATGGACTCGTCTGGCCTTCGCGGGTCTGAAATTCGGCGACGC
GGGTTCTTTCGACTACGGTCGTAACTACGGCGTTGTTTACGACGTAACTTCCTGGACCGACGTTCTGCCGGAATTCGGTG
GCGACACCTACGGTTCCGACAACTTCCTGCAGTCCCGTGCTAACGGTGTTGCCACCTACCGTAACTCTGACTTCTTCGGT
CTGGTTGACGGCCTGAACTTTGCTCTGCAGTACCAGGGTAAAAACGGCAGCGTAAGCGGCGAAGATCAGACCAACAACGG
TCGCGGCTACCAGAAACAGAACGGCGAAGGCTTCGGCACCTCCGTGACTTATGATATCTGGGACGGCATCAGCGCTGGTT
TCGCGTACTCCAGCTCTAAACGTACCGATGAGCAGAACAGCGTTAACACTCGTTATACTGACTCCAACGGTGTTTCCCGT
CGCGTACTGGGTGAAGGCGATCACGCTGAAACCTACACCGGTGGTCTGAAATACGACGCCAACAACATCTACCTGGCGAC
TCAGTACACCCAGACCTACAACGCAACCCGCACCGGTATCATCGGTTTTGCTAACAAAGCGCAGAACTTCGAAGTAGTTG
CTCAGTACCAGTTCGACTTCGGTCTGCGTCCGTCCGTGGCTTACCTGCAGTCTAAAGGTAAAGACATGGGCCGTTACGGC
GACCAGGACATCCTGAAATATGTTGACCTGGGTGCGACTTACTACTTCAACAAAAACGTGTCCACGTACGTTGATTACAA
AATCAACCTGCTGGACGACAACTGTTTCACTAAAGATGCAAGCATCTCTACTGACAACGTTGTGGCTCTGGGCCTGGTTT
ACCAGTTCTAA
>>MEG_4281|Drugs|betalactams|Mutant_porin_proteins|OMP36|RequiresSNPConfirmation
ATGAAAGTTAAAGTACTGTCCCTCCTGGTACCAGCACTGCTGGTAGCGGGCGCAGCAAATGCGGCTGAAATCTACAACAA
AGACGGCAACAAATTAGACCTGTACGGTAAAATCGACGGTCTGCACTACTTCTCTTCCGACGACAGCGTCGACGGCGACC
AGACCTACATGCGTATCGGCGTGAAAGGCGAAACCCAGATCAACGACCAGCTGACCGGTTACGGCCAGTGGGAATACAAC
GTTCAGGCGAACAACACTGAAAGCTCCAGCGACCAGGCGTGGACTCGTCTGGCCTTCGCGGGTCTGAAATTCGGCGACGC
GGGTTCTTTCGACTACGGTCGTAACTACGGCGTTGTTTACGACGTAACTTCCTGGACCGACGTTCTGCCGGAATTCGGTG
GCGACACCTACGGTTCCGACAACTTCCTGCAGTCCCGTGCTAACGGCGTTGCCACCTACCGTAACTCTGACTTCTTCGGT
CTGGTTGACGGCCTGAACTTTGCTCTGCAGTACCAGGGTAAAAACGGCAGCGTGAGCGGCGAAGATCAGACCAACAACGG
TCGCGGCTTCCAGAAACAGAACGGCGAAGGCTTCGGCACCTCCGTGACTTATGAGATCTGGGACGGCATCAGCGCTGGTT
TCGCGTACTCCAGCTCTAAACGTACCGATGAGCAGAACAACTCTACTTATTTTTCTAAGTCCTATCAGCGTACATACGGT
GTTCTGGGTGAAGGCGATCACGCTGAAACCTATACCGGTGGTCTGAAATATGACGCCAACAACATTTACCTGGCGACTCA
GTACACCCAGACCTACAACGCAACTCGCACTGGCGACATCGGTTTTGCTAACAAAGCGCAGAACTTCGAAGTGGTTGCTC
AGTACCAGTTCGACTTCGGTCTGCGTCCGTCCGTGGCTTACCTGCAGTCTAAAGGTAAAGACATGGGCCGTTACGGCGAC
CAGGACATCCTGAAATATGTTGACCTGGGTGCGACCTACTACTTCAACAAAAACATGTCCACCTACGTTGATTACAAAAT
CAACCTGCTGGACGACAACAAGTTCACTAAAGATGCAAGCATCTCTACTGACAACGTTGTGGCTCTGGGCCTGGTTTACC
AGTTCTAA
>>MEG_4282|Drugs|betalactams|Mutant_porin_proteins|OMP36|RequiresSNPConfirmation
ATGAAAGTTAAAGTACTGTCCCTCCTGGTACCAGCACTGCTGGTAGCGGGCGCAGCAAATGCGGCTGAAATTTATAACAA
AGACGGCAACAAATTAGACCTGTACGGTAAAATCGACGGTCTGCACTACTTCTCTTCCGACGACAGCGTCTACGGCGACC
AGACCTACATGCGTATCGGCGTGAAAGGCGAAACCCAGATCAACGACCAGCTGACCGGTTACGGCCAGTGGGAATACAAC
GTTCAGGCGAACAACACTGAAAGCTCCAGCGACCAGGCGTGGACTCGTCTGGCCTTCGCGGGTCTGAAATTCGGCGACGC
GGGTTCTTTCGACTACGGTCGTAACTACGGCGTTGTTTACGACGTAACTTCCTGGACCGACGTTCTGCCGGAATTCGATG
GCGACACCTACGGTTCCGACAACTTCCTGCAGTCCCGTGCTAACGGTGTTGCCACCTACCGTAACTCTGACTTCTTCGGT
CTGGTTGACGGCCTGAACTTTGCTCTGCAGTACCAGGGTAAAAACGGCAGCGTGAGCGGCGAAGATCAGACCAACAACGG
TCGCGGCTTCCAGAAACAGAACGGCGAAGGCTTCGGCACCTCCGTGACTTATGAGATCTGGGACGGCATCAGCGCTGGTT
TCGCGTACTCCAGCTCTAAACGTACCGATGAGCAGAACAACTCTACTTACTTTTCTAAGTCCTATCGTCGTACATACGGT
GTTCTGGGTGAAGGCGATCACGCTGAAACCTATACCGGTGGTCTGAAATATGACGCCAACAACATTTACCTGGCGACTCA
GTACACCCAGACCTACAACGCAACTCGCACTGGCGACATCGGTTTTGCTAACAAAGCGCAGAACTTCGAAGTGGTTGCTC
AGTACCAGTTCGACTTCGGTCTGCGTCCGTCCGTGGCTTACCTGCAGTCTAAAGGTAAAGACATGGGCCGTTACGGCGAC
CAGGACATCCTGAAATATGTTGACCTGGGTGCGACCTACTACTTCAACAAAAACATGTCCACCTACGTTGATTACAAAAT
CAACCTGCTGGACGACAACAAGTTCACTAAAGATGCAAGCATCTCTACTGACAACGTTGTGGCTCTGGGCCTGGTTTACC
AGTTCTAA