MEGAResFrom MEG, the Microbial Ecology Group

Mutant porin proteins

In order for beta-lactam antibiotics to inhibit bacterial growth, they must pass through the bacterial cell wall using pore-forming porins. Resistance to beta-lactamases can develop via mutations in these porin proteins that no longer allow beta-lactam antibiotics to penetrate the cell wall.,Porin proteins can confer resistance to multiple classes of antibiotics by blocking the transport of the antibiotic molecule into the bacterial cell, preventing the drug from reaching its target.


Other Mechanisms in betalactams



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