MEGAResFrom MEG, the Microbial Ecology Group

DHFR

The dhfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

Other Groups in Dihydrofolate reductase

Sequences

Download Sequences

>1389|FN561628.1|FN561628|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGGCTGCCAAGTCGAAGAACGGTATTATCGGTAATGGACCAGATATTCCATGGAGCGCCAAAGGCGAGCAACTTCTATT
TAAGGCAATTACATATAATCAATGGCTTTTAGTTGGACGCAAAACTTTTGAGTCAATGGGCGCTCTCCCAAATCGAAAGT
ATGCAGTTGTAACTCGCTCTAATTTTTCTACGAATGATGAGGGTGTAATGGTTTTCTCCTCAATTCAGGATGCCTTAATA
AATTTAGAGGAAATCACGGATCATGTTATCGTTTCTGGTGGTGGTGAAATATACAAAAGCTTGATTTCCAAAGTAGATAC
TTTGCATATTTCAACAGTCGACATCGAGCGAGATGGAGACATAGTTTTTCCTGAAATCCCAGATACATTCGAGTTGGTAT
TTGAGCAAGATTTCGAGTCTAACATTAACTATTGTTATCAAATCTGGCAAAGAGTTAACAAGCGCCTGCAATCTGACCTC
CGGTTACTGTCACCTTTTTTTGCGGTGGAGCTGCAAAAATGCGCCATTAACCTCCGGCAGTTGAGGCGGGCGTTAGATGC
ACTAGCACATAATTGCTCACAGCCAACTATCAGGTCAAGTCTGCTT

>Tmt|dfrA1_2_AJ419168|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTAGTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATCGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTCTACTTTTCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA30|AM997279|705-1178|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAAGTATCATTAATGGCTGCAAGAGCGAGAAACGGAGTGATCGGTTGCGGTCCACACATACCCTGGTCCGCGAAAGG
AGAGCAGCTACTCTTTAAAGCCCTGACGTACAACCAGTGGCTTTTGGTTGGCCGCAAGACGTTCGAATCAATGGGGGCGC
TCCCCAACAGGAAATACGCGGTCGTTACTCGCTCAGCCTGGACGGCCAATAATGACAACGTAGTAGTATTCCCGTCGATC
GAAGAGGCCATGGGCGGTCTAGCTAAACTCAACGGTCACGTTATAGTGTCTGGTGGCGGGGAGATTTACAGAGAAACGTT
GCCCATGGCCTCTACGCTCCATGTATCGACGATCGACATTGAGCCAGAAGGGGATGTTTTCTTCCCGAATATTCCCAACT
TCTTCGAAGTTGTTTTTGAGCAACATTTTAGTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGTTAA

>Tmt|Dfr22|AJ628423|325-822|498|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAACCCGGAATTGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGCCCCGATATTCC
CTGGAAAATCCCGGGTGAGCAAAAGATCTTTCGCAGGCTCACCGAGGGCAAAGTGGTCGTTATGGGCCGCAAGACGTTTG
AGTCCATAGGCAAGCCCTTACCAAACCGCCGCACAGTGGTGCTCTCGCGCCAAGCCAGTTATAGCGCTGCTGGTTGTGCA
GTTGTTTCAACGCTGTCGCAGGCTATTGCCATCGCAGCCGAACACGGCAAAGAGCTCTACGTGGCCGGCGGAGCCGAGGT
ATATGCACTGGCACTACCTCGTGCCGACGGCGTCTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCC
CTGTGCTCGACGAAGCAGAATTCGAGGTTGTCTCAGCCGAAACCGTTCAAGCCACAATCACGTACACGCACTCCGTCTAT
GCACGTCGTAACGGCTAA

>Tmt|DfrA27|EU675686|2543-3016|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAAATATCACTAATGGCTGCAAAAGCAAGAAATGGGGTTATTGGCTGCGGCTCGGATATCCCGTGGAACGCTAAAGG
TGAGCAGCTGCTTTTTAAAGCAATAACTTACAATCAATGGCTCTTAGTCGGCCGTAAAACATTTGAGGCAATGGGGGCTC
TCCCAAATAGAAAGTATGCAGTTGTCAGCCGCTCAGGATCGGTAGCTACTAACGATGATGTGGTTGTGTTTCCATCTATA
GAAGCAGCAATGAGGGAGCTAAAGACTCTTACGAACCATGTTGTTGTTTCTGGTGGTGGAGAGATCTACAAGAGTCTGAT
CGCCCATGCCGACACGCTACATATCTCGACAATAGATTCCGAGCCAGAGGGCAATGTTTTCTTTCCGGAAATCCCCAAAG
AGTTCAATGTGGTGTTCGAGCAGGAATTTCATTCAAATATAAATTATCGCTATCAAATCTGGCAAAGGGGTTAA

>Tmt|dfrA14_1_Z50805|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAGTATCATTGATAGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATACCGTGGTCCGCGAAAGG
GGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGTCTTCTGGTGGGTCGCAAGACGTTTGAATCTATGGGCGCAC
TCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTTCAGTCAATC
GAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCGAGAAACATT
ACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTATTCCAAATA
CCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGTTAA

>Tmt|Dfr16|AF077008|115-558|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAGTTATCACTAATGGCTGCCAAGTCGAAGAACGGTATTATCGGTAATGGACCAGATATTCCATGGAGCGCCAAAGG
GCAGCAACTTCTATTTAGGGCAATTATATATAATCAATGGCTTTTAGTTGGACGCAAAACTTTTGAGTCAATGGGCGCTC
TCCCAAATCGAAAGTATGCAGTTGTAACTCGCTCTAATTTTTCTACGAATGATGAGGGTGTAATGGTTTTCTCCTCAATT
CAGGATGCCTTAATAAATTTAGAGGAAATCACGGATCATGTTATCGTTTCTGGTGGTGGTGAAATATACAAAAGCTTGAT
TTCCAAAGTAGATACTTTGCATATTTCAACAGTCGACATCGAGCGAGATGGAGACATAGTTTTTCCTGAAATCCCAGATA
CATTCAAGTTGGTATTTGAGCAAGATTTCGAGTCTAACATTAACTATTGTTATCAAATCTGGCAAAAGAGTTAA

>Tmt|DfrA21|AY552589|1-498|498|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGTCCCGATATCCC
CTGGAAAATCCCAGGTGAGCAGAAGATTTTTCGCAGGCTCACCGAGAGCAAAGTGGTCGTTATGGGCCGCAAGACATTTG
AGTCCATAGGCAAGCCCTTACCAAACCGCCACACAGTGGTGCTCTCGCGCCAAGCTCGTTATAGCGCTCCTGGTTGTGCA
GTTGTTTCAACGCTGTCACAGGCTATCGCCATCGCAGCCGAACACGGCAAAGAACTCTACGTAGCCGGCGGAGCCGAGGT
ATATGCGCTGGCGCTACCGCATGCCAACGGCGTCTTTCTATCTGAGGTACATCAAACCTTTGAGGGTGACGCCTTCTTCC
CAGTGCTTAACGCAGCAGAATTCGAGGTTGTCTCATCCGAAACCATTCAAGGCACAATCACGTACACGCACTCCGTCTAT
GCGCGTCGTAACGGCTAA

>Tmt|DfrA15b|AJ867237|117-650|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGCAGCAATTTCGAAGAATGGAGTTATCGGAAATGGCCCAGATATTCCATGGAGTGCCAAAGG
GGAACAATTACTCTTCAAAGCGATTACCTATAATCAGTGGCTTTTGGTAGGCCGAAAGACTTTCGAGTCAATGGGGGCTT
TACCCAACCGAAAATATGCCGTTGTAACTCGTTCAAGCTTCACTTCCAGTGATGAGAATGTATTGGTATTTCCATCTATC
GATGAAGCGCTAAATCATCTGAAGACGATAACGGATCATGTGATTGTGTCTGGTGGTGGTGAAATATACAAAAGCCTGAT
CGATAAAGCTGATACTTTACATATTTCAACAATCGACATTGAGCCAGAAGGTGATGTCTATTTTCCAGAAATCCCCGGTA
GTTTTAGGCCAGTTTTTAGCAAAGACTTCGTGTCCAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA15_1_HM449019|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGCAGCAATTTCGAAGAATGGAGTTATCGGAAATGGCCCAGATATTCCATGGAGTGCCAAAGG
GGAACAATTACTCTTCAAAGCGATTACCTATAATCAGTGGCTTTTGGTAGGCCGAAAGACTTTCGAGTCAATGGGGGCTT
TACCCAACCGAAAATATGCCGTTGTAACTCGTTCAAGCTTCACTTCCAGTGATGAGAATGTATTGGTATTTCCATCTATC
GATGAAGCGCTAAATCATCTGAAGACGATAACGGATCATGTGATTGTGTCTGGTGGTGGTGAAATATACAAAAGCCTGAT
CGATAAAGTTGATACTTTACATATTTCAACAATCGACATTGAGCCAGAAGGTGATGTCTATTTTCCAGAAATCCCCAGTA
GTTTTAGGCCAGTTTTTAGCCAAGACTTCGTGTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA12|Z21672|310-807|498|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAACTCGGAATCAGTACGCATTTATCTCGTTGCTGCGATGGGAGCCAATCGGGTTATTGGCAATGGTCCTAATATCCC
CTGGAAAATTCCGGGTGAGCAGAAGATTTTTCGCAGACTCACTGAGGGAAAAGTCGTTGTCATGGGGCGAAAGACCTTTG
AGTCTATCGGCAAGCCTCTACCGAACCGTCACACATTGGTAATCTCACGCCAAGCTAACTACCGCGCCACTGGCTGCGTA
GTTGTTTCAACGCTGTCGCACGCTATCGCTTTGGCATCCGAACTCGGCAATGAACTCTACGTCGCGGGCGGAGCTGAGAT
ATACACTCTGGCACTACCTCACGCCCACGGCGTGTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCC
CAATGCTCAACGAAACAGAATTCGAGCTTGTCTCAACCGAAACCATTCAAGCTGTAATTCCGTACACCCACTCCGTTTAT
GCGCGTCGAAACGGCTAA

>Tmt|dfrA1_5_AJ238350|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTCCAAGTTTTACATCTGACAATGAGAACGTAGTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>1707|EU259884.2|EU259884|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTATTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA6|Z86002|336-809|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAAAATATCTCTTATGGCAGCTGTTTCCGAGAATGGAGTAATTGGCTCTGGATTGGATATACCTTGGCATGTACAAGG
CGAGCAGCTCCTATTCAAAGCCATGACTTACAATCAATGGCTTCTAGTTGGTCGTAAAACCTTCGACTCAATGGGTAAAC
TTCCGAATAGAAAATATGCAGTGGTTACTCGTTCTAAAATTATCTCGAATGACCCTGATGTTGTGTATTTCGCAAGTGTT
GAATCGGCATTAGCTTACCTAAACAATGCGACAGCACATATCTTTGTTTCTGGTGGTGGTGAAATATATAAAGCTTTAAT
CGATCAAGCAGATGTTATCCATCTTTCAGTGATTCACAAGCATATCTCTGGCGATGTGTTTTTTCCTCCAGTTCCACAGG
GCTTCAAGCAAACATTTGAGCAAAGTTTCAGTTCAAATATTGATTACACGTACCAAATTTGGGCAAAGGGCTAA

>Tmt|DfrA13|Z50802|718-1215|498|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGTCCCGATATCCC
CTGGAAAATCCCAGGTGAGCAGAAGATTTTTCGCAGGCTCACCGAGAGCAAAGTGGTCGTTATGGGCCGCAAGACATTTG
AGTCCATAGGCAAGCCCTTACCAAACCGCCACACAGTGGTGCTCTCGCGCCAAGCTGGTTATAGCGCTCCTGGTTGTGCA
GTTGTTTCAACGCTGTCACACGTATCGCCATCGACAGCCGAACACGGCAAAGAACTCTACGTAGCGCGCGGAGCCGAGGT
ATATGCGCTGGCGCTACCGCATGCCAACGGCGTCTTTCTATCTGAGGTACATCAAACCTTTGAGGGTGACGCCTTCTTCC
CAGTGCTTAACGCAGCAGAATTCGAGGTTGTCTCATCCGAAACCATTCAAGGCACAATCACGTACACGCACTCCGTCTAT
GCGCGTCGTAACGGCTAA

>1403|FM207631.1|FM207631|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGGAACACGTTCAAGTTTTACATCTGACAATGAGAACGTATTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA20|AJ605332|1304-1813|510|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGGGTATTAAATATAGCTTAATTGTTGCAATTGGGAAACACCGAGAAATGGGTGCTGACAATGATTTGCTTTGGCACTT
ACCAAGAGATATGCAATTTTTTAAGGAAACGACAACGGGTCACGCTGTTGTAATGGGAAGAAAAAGTTGGGAATCTATTC
CTCAGAAGTACAGACCGCTTCCAAATCGTTTAAACTTCGTTTTAACACGAGATAAAAACTATAGTGCAGAAGGTGCAACA
GTGATTTATGATTTAAAAGAAGTCGCACAACATCTTGAAGGAAAAAACTTAACATGCTTCATTATTGGTGGTGCTCAAAT
CTACCAACTGGCCTTAGAAACAGGACTTTTAAATGAAATGTATGTCACACAAGTACATAACACATTTGAAGAAGCTGACA
CCTTTTTCCCTTTTGTAAATTGGGGAGAATGGGAAGAAGAAGATATTTTAGAACAAGATAAAGATGAAAAACATCTTTAT
TCATTTAATATAAAGAAATTTACGCGTTAA

>939|U10186.1|ECU10186|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGATCGAGCTTCATGCCATTTTAGCTGCCACCGCCAATGGTTGCATTGGGAAGGACAACGCACTTCCCTGGCCACCACT
AAAAGGCGATCTGGCCAGATTCAAAAAATTGACCATGGGGAAGGTGGTCATTATGGGGCGCAAGACCTATGAGAGCTTGC
CCGTCAAATTAGAAGGTCGCACCTGCATCGTTATGACGCGCCAAGCGCTGGAGCTTCCGGGTGTTCGTGACGCTAACGGC
GCTATCTTCGTGAACAACGTCAGCGACGCCATGCGGTTCGCTCAAGAAGAGAGCGTGGGCGATGTGGCCTACGTCATTGG
TGGCGCTGAGATATTCAAGCGACTTGCCTTGATGATCACGCAGATTGAATTGACCTTTGTTAAGCGACTGTACGAAGGCG
ACACCTACGTTGATCTGGCCGAAATGGTCAAAGACTACGAGCAGAATGGCATGGAAGAACATGACCTTCACACTTACTTC
ACTTACCGTAAAAAGGAGCTTACAGAATGA

>Tmt|DfrA33|FM957884|88-585|498|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAACCCGGAATCGGTCCGCATTTATCTGGTCGCTGCCATGGGTGCCAATCGGGTTATTGGCAATGGCCCTGATATCCC
TTGGAATATCCCTGGTGAGCAAAAGATTTTTCGCAGGCTCACCGAGGGCAAAGTGGTCGTTATGGGCCGCAAGACGTTTG
AGTCCATAGGCAAGCCCTTACCAAACCGTCGCACAGTGGTGCTCTCGCGCCAAGCTAGTTATAGCGCTGCTGGTTGTGCA
GTTGTTTCAACGCTGTCGCAGGCTATTGCCATCGCAGCCGAACACGGCAAGGAACTCTACGTGGCCGGCGGAGCCGAGGT
ATATGCACTGGCACTACCTCGTGCCGATGGCGTCTTTCTATCTGAGGTACATCAAACCTTCGAGGGTGACGCCTTCTTCC
CAGCGCTCGACGCAGCAGAATTCGACGTTGTCTCAGCCGAAACCGTTCAAGCCACAATCACGTACACGCACTCCGTCTAT
GCACGTCGTAACGGCTAA

>1003|DQ267940.1|DQ267940|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGGCTGCAAGAGCGAAAAATGGCGTAATCGGTTGCGGTCCTGACATTCCTTGGTCTGCCAAAGGGGAACAGCTTCTTTT
CAAAGCACTGACCTATAACCAATGGCTTTTGGTAGGGCGCAAAACATTTGAGTCTATGGGGCCGCTGCCCAATAGGAAAT
ACGCGGTTGTTACCCGCTCAAACTGGACAGCGGCTAATGAAAACGTAGTGGTTTTCCCGTCGATTGACGAAGCGATGGGT
AGATTAGGCGAGATCACTGACCATGTCATCGTCGCCGGTGGTGGAGAAATCTACCATGAAACGATACCCATGGCCTCTAC
TCTGCATGTGTCGACAATCGACGTTGAGCCAGAGGGAGACGTTTTCTTTCCGAACATTCCTGGGAAGTTTGATGTCGTTT
TTGAGCAACAATTTACATCAAACATTAACTATTGCTATCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA5|X12868|1306-1779|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAAGTATCATTAATGGCTGCAAAAGCGAAAAACGGAGTGATTGGTTGCGGTCCACACATACCCTGGTCCGCGAAAGG
AGAGCAGCTACTCTTTAAAGCCTTGACGTACAACCAGTGGCTTTTGGTGGGCCGCAAGACGTTCGAATCTATGGGAGCAC
TCCCTAATAGGAAATACGCGGTCGTTACTCGCTCAGCCTGGACGGCCGATAATGACAACGTAATAGTATTCCCGTCGATC
GAAGAGGCCATGTACGGGCTGGCTGAACTCACCGATCACGTTATAGTGTCTGGTGGCGGGGAGATTTACAGAGAAACATT
GCCCATGGCCTCTACGCTCCATATATCGACGATTGATATTGAGCCGGAAGGAGATGTTTTCTTTCCGAATATTCCCAATA
CCTTCGAAGTTGTTTTTGAGCAACACTTTAGCTCAAACATTAACTATTGCTATCAAATTTGGCAAAAGGGTTAA

>Tmt|AJ605332.1|gene1|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
AAGGAAACAGAAATGGGTATTAAATATAGCTTAATTGTTGCAATTGGGAAACACCGAGAAATGGGTGCTGACAATGATTT
GCTTTGGCACTTACCAAGAGATATGCAATTTTTTAAGGAAACGACAACGGGTCACGCTGTTGTAATGGGAAGAAAAAGTT
GGGAATCTATTCCTCAGAAGTACAGACCGCTTCCAAATCGTTTAAACTTCGTTTTAACACGAGATAAAAACTATAGTGCA
GAAGGTGCAACAGTGATTTATGATTTAAAAGAAGTCGCACAACATCTTGAAGGAAAAAACTTAACATGCTTCATTATTGG
TGGTGCTCAAATCTACCAACTGGCCTTAGAAACAGGACTTTTAAATGAAATGTATGTCACACAAGTACATAACACATTTG
AAGAAGCTGACACCTTTTTCCCTTTTGTAAATTGGGGAGAATGGGAAGAAGAAGATATTTTAGAACAAGATAAAGATGAA
AAACATCTTTATTCATTTAATATAAAGAAATTTACGCGTTAA

>Tmt|dfrA14_1_DQ388123|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAGAACCTTGAAAGTATCATTGATAGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATATCCTGGTC
CGCGAAAGGGGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGGCTTCTGGTGGGTCGCAAGACGTTTGAATCTA
TGGGCGCACTCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTT
CAGTCAATCGAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCG
AGAAACATTACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTA
TTCCAAATACCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGT
TAA

>Tmt|DfrA14|GU726917|72-545|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAGTATCATTGATGGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATACCCTGGTCCGCGAAAGG
GGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGGCTTCTGGTGGGTCGCAAGACGTTTGAATCTATGGGCGCAC
TCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTTCAGTCAATC
GAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCGAGAAACATT
ACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTATTCCAAATA
CCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGTTAA

>986|AM237806.1|AM237806|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAATTTCTTTAATCGCAGCTCAGTCAGAAAACGGTGTTATTGGTAATGGCCCAGATATTCCATGGTCAGCAAAAGG
GGAGCAGTTACTTTTCAAAGCGCTAACATATAATCAGTGGCTTCTTGTCGGAAGAAAAACATTTGAGTCAATGGGTATTC
TTCCTAATCGAAAGTATGCTGTTCTTTCAAAAAATGGAATTTCACACCTTCCTGAAAACGTACTAGTTTTTTCGTCTATA
GAAAATGCATTATATGAACTGGCTAAGGTAACAGACCATTTATATATTTCTGGCGGTGGTCAAATATATAATAGTCTTAT
TGAAAGTGCTGATACCATCCACTTATCTATCATCCACAAAGAGGTAGAAGGTGAAGTAAGGTTTCCCAAAATACCTCCTA
ATTACAAGTTGGTATTTGAGCAATATTATTCTTCAAATATTAATTACACTTATCAAATTTGGCAAAAAGGTT

>1161|FR748153.1|FR748153|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTAGTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>1520|AF174129.3|AF174129|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAGTTATCACTAATGGCTGCCAAGTCGAAGAACGGTATTATCGGTAATGGACCAGATATTCCATGGAGCGCCAAAGG
CGAGCAACTTCTATTTAAGGCAATTACATATAATCAATGGCTTTTAGTTGGACGCAAAACTTTTGAGTCAATGGGCGCTC
TCCCAAATCGAAAGTATGCAGTTGTAACTCGCTCTAATTTTTCTACGAATGATGAGGGTGTAATGGTTTTCTCCTCAATT
CAGGATGCCTTAATAAATTTAGAGGAAATCACGGATCATGTTATCGTTTCTGGTGGTGGTGAAATATACAAAAGCTTGAT
TTCCAAAGTAGATACTTTGCATATTTCAACAGTCGACATCGAGCGAGATGGAGACATAGTTTTTCCTGAAATCCCAGATA
CATTCAAGTTGGTATTTGAGCAAGATTTCGAGTCTAACATTAACTATTGTTATCAAATCTGGCAAAAGAGTTAA

>894|unknown_id|unknown_name|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGCCAACAGTTGAGATTATTGTTGCAGTTGATCCTGTTGGGGGATTTGGCCGGAATGGCCAAATCCCTTGGACGTGCAA
GGAAGACATGAAGCGCTTCACCACCATATCCAAAGAGATTCGAGTGTGTGTGATGGGGAAGAACACATACAAAGACATGC
TCGATATGCAAATGAAGAAGGAAGGCGCTGAAGAACGAATCAAAGAGAAGGGAATTCTTCCGGAGCGCGAATCTTACGTC
GTGTCCTCGACTTTGAAGCCCGAGGACGTCATTGGAGCCACGGTAGTTCCGGACCTACGTGCGGTGCTCAATCAATATCA
CGACAGCGATCAACGAATAGCTGTCATTGGTGGAGAAAAGCTGTACGTGCAAGCCCTCGCATCTGCCACAAAAGTCCACA
TGACGGTAATGCACAAGCCATATAACTGCGATCGGACGTTGCCGATGTCATACATCGACAAAAAGTTTGTTGCAGGTCAA
GGGTCTATCACCATTCAAACTGCGGTAGATGGTGAGACCCATCCCGTGAAGTTCATCACATATGAGCGCGCTCGGCCGTA
A

>1500|AY339625.2|AY339625|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAGGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTAGTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>Tmt|DfrA31|AB200915|1832-2305|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAAAATATCCATTATGGCAGCAGTTTCTGAGAATGGAGTAATTGGCTCTGGATTGGATATACCTTGGCATGTACAAGG
TGAGCAGCTCCTGTTCAAAGCTATGACTTACAATCATTGGCTTTTAGTCGGTCGTAAAACTTTCGACTCAATGGGTAAAC
TTCCCAATAGGAAATATGCTGTGGTTACTCGCTCAGAAATGGTCTCGAATGATCCAGATGTTATTTATTTCACCAGCATT
GAATCGGCATTATCTTACTTAGACAATACGACAACACATGTCTTTGTTTCTGGTGGTGGTGAAATTTACAAAGCATTAAT
CGAACAAGCAGATGTTATCCATCTTTCAGTGATTCATAAGCACATCTCTGGCGACGTGTTTTTCCCTTCAGTTCCACAGA
GTTTCAAACAAACATTTGAGCAAAGTTTCAGTTCAAATATTGATTACACGTACCAAATTTGGGCAAAGGGCTAA

>1230|JX023441.1|JX023441|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAATTTCATTGATTTCTGCAACGTCAGAAAATGGCGTAATCGGTAATGGCCCTGATATCCCATGGTCAGCAAAAGG
TGAGCAGTTACTCTTTAAAGCGCTCACATATAATCAGTGGCTCCTTGTTGGAAGGAAAACATTTGACTCTATGGGTGTTC
TTCCAAATCGAAAATATGCAGTAGTGTCGAGGAAAGGAATTTCAAGCTCAAATGAAAATGTATTAGTCTTTCCTTCAATA
GAAATCGCTTTGCAAGAACTATCGAAAATTACAGATCATTTATATGTCTCTGGTGGCGGTCAAATCTACAATAGTCTTAT
TGAAAAAGCAGATATAATTCATTTGTCTACTGTTCACGTTGAGGTTGAAGGTGATATCAATTTTCCTAAAATTCCAGAGA
ATTTCAATTTGGTTTTTGAGCAGTTTTTTTTGTCTAATATAAATTACACATATCAGATTTGGAAAAAAGGCTAA

>Tmt|Dfr32|GU067642|535-1008|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAATTTCATTGATTTCTGCAGTGTCAGAAAATGGCGTAATCGGTAGTGGTCCTGATATTCCGTGGTCAGCAAAAGG
TGAGCAGCTAATCTTTAAGGCGCTCACATACAATCAGTGGCTTCTTGTTGGAAGGAAAACATTTGACTCTATGGGAGTTC
TTCCAAATCGCAAATATGCAGTAGTGTCAAAGAATGGAATTTCAGGGTCAAATGAAAACGTCTTGGTTTTTCCTTCAATA
GAAAATGCTTTGCAAGAACTATCTAAAATTACAGATCATGTATATATTTCGGGTGGGGGGCAAATCTATGAAAGCCTTAT
TGAAAAAGCAGATATAATTCATCTATCTACTATTCATGTTGAGGTTGAAGGTGATATTAAATTCCCTATATTACCTGAAG
GTTTCAACTTGGTTTTTGAACAGTTTTTTGTGTCTAATATAAATTATACATATCAAATTTGGAAAAAAGGCTAA

>903|AJ972619.1|AJ972619|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGACCTATCAGTTGGACGTGAGCAAAATTCTGTCGTTTGACCTGGAGGCCATCGTTGCTGCTACTGAGAACGGCGGCAT
CGGTTACAAAGGTGACCTCCCATGGCGTCTACAAGGCGATCTGAAGCGTTTTCGCGAAATCACCCAAGGCGGTATAGTCA
TCATGGGTGCAGGCACGTATAAGAGCCTCCCAAGTCCTCTGAAAGACCGCATCAATATCGTCATCACCAAGAAGTCAGAG
ATTTCTTGGACGGCTTGCTATGACGTGCGTGTGGTCAACAGTCCAGAAGACGCTTTGCGCATGGTTGGTCGCATTATCGA
CGAGAAAGAAGAGCAAGGTCGTGATCGACCTCGTGTATTCGTTATCGGCGGGGCTTCGATCTATCAGGCACTGATGCCTT
TCGTTTCTACGCTCCACTGGACTGAGGTGCATGTTGAACAACTGCCAGAGGAAATCGGTCTCGATACGTATATCGAAGAC
TTCCTTTCTCTGCGTGGGACTTCTACACCGAAGAGAAAGTCGAATCTGGTTTTACCACCCACACCTACCACACCCTGA

>Tmt|DfrA28|FM877476|116-589|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAAATATCACTAATGGCTGCAAAAGCAAGAAATGGGGTTATTGGCTGCGGCTCTGATATCCCTTGGAACGCTAAAGG
CGAGCAGCTGCTTTTTAAAGCAATAACTTACAATCAGTGGCTTTTAGTCGGCCGCAAAACATTTGAGGCAATGGGGGCTC
TCCCAAATAGAAAGTATGCAGTTGTCAGCCGCTCAGGATCGGTAGCTACTAACGATGATATGGTTGTGTTTCCATCTATA
GAAGCAGCAATGGGTAAGCTAAAGACTCTTACGAACCATGTTGTTGTTTCTGGTGGTGGAGAGATCTATAAGAGTCTGAT
CGCCCATGCCGACACGCTACATATTTCGACAATAGATTCCGAGCCAGAGGGCAATGTTTTCTTTCCGGAAATCCCCAAAG
ATTTCAATGTGGTGTTCGAGCAGGAATTTCATTCAAATATAAATTATCGATATCAAATCTGGCAAAGGGGTTAA

>Tmt|dfrA1_25_AJ844287|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGGGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTATTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>1396|AJ419170.1|AJ419170|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAATTTCATTGATTTCTGCAACGTCAGAAAATGGCGTAATCGGTAATGGCCCTGATCTCCCATGGTCAGCAAAAGG
TGAGCAGTTACTCTTTAAAGCGCTCACATATAATCAGTGGCTCCTTGTTGGAAGGAAAACATTTGACTCTATGGGTGTTC
TTCCAAATCGAAAATATGCAGTAGTGTCGAGGAAAGGAATTTCAAGCTCAAATGAAAATGTATTAGTCTTTCCTTCAATA
GAAATCGCTTTGCAAGAACTATCGAAAATTACAGATCATTTATATGTCTCTGGTGGCGGTCAAATCTACAATAGTCTTAT
TGAAAAAGCAGATATAATTCATTTGTCTACTGTTCACGTTGAGGTTGAAGGTGATATCAATTTTCCTAAAATTCCAGAGA
ATTTCAATTTGGTTTTTGAGCAGTTTTTTTTGTCTAATATCATTACACATATCAGATTTGGAAAAAAGGCTAACAAGTCG
TTCCAGCACCAGCCTGCGCTCCTTGGACAGTTTTTAAGTCGCGGTTTTATGGTTTTCTGCGCAAAAGTATTCCATAAAAC
CACAACTTAA

>Tmt|DfrA17|AB126604|98-571|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
TTGAAAATATCATTGATTTCTGCAGTGTCAGAAAATGGCGTAATCGGTAGTGGTCCTGATATCCCGTGGTCAGTAAAAGG
TGAGCAACTACTCTTTAAAGCGCTCACATATAATCAATGGCTCCTTGTCGGAAGAAAAACATTTGACTCTATGGGTGTTC
TTCCAAATCGCAAATATGCAGTAGTGTCAAAGAACGGAATTTCAAGCTCAAATGAAAACGTCCTAGTTTTTCCTTCAATA
GAAAATGCTTTGAAAGAGCTATCAAAAGTTACAGATCATGTATATGTCTCTGGCGGGGGTCAAATCTATAATAGCCTTAT
TGAAAAAGCAGATATAATTCATTTGTCTACTGTTCACGTTGAAGTCGAAGGTGATATCAAATTCCCTATAATGCCTGAGA
ATTTCAATTTGGTTTTTGAACAGTTTTTTATGTCTAATATAAATTATACATACCAGATTTGGAAAAAAGGCTAA

>Tmt|EU780012.1|gene2|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGAGAACCTTGAAAGTATCATTGATAGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATACCCTGGTC
CGCGAAAGGGGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGGCTTCTGGTGGGTCGCAAGACGTTTGAATCTA
TGGGCGCACTCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTT
CAGTCAATCGAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCG
AGAAACATTACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTA
TTCCAAATACCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGT
TAA

>Tmt|DfrA15|JN108895|93-551|474|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
ATGGCAGCAATTTCGAAGAATGGAGTTATCGGAAATGGCCCAGATATTCCATGGAGTGCCAAAGGGGAACAATTACTCTT
CAAAGCGATTACCTATAATCAGTGGCTTTTGGTAGGCCGAAAGACTTTCGAGTCAATGGGGGCTTTACCCAACCGAAAAT
ATGCCGTTGTAACTCGTTCAAGCTTCACTTCCAGTGATGAGAATGTATTGGTATTTCCATCTATCGATGAAGCGCTAAAT
CATCTGAAGACGATAACGGATCATGTGATTGTGTCTGGTGGTGGTGAAATATACAAAAGCCTGATCGATAAAGTTGATAC
TTTACATATTTCAACAATCGACATTGAGCCAGAAGGTGATGTCTATTTTCCAGAAATCCCCAGTAGTTTTAGGCCAGTTT
TTAGCCAAGACTTCGTGTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

>1848|AF156486.1|AF156486|Trimethoprim|Dihydrofolate_reductase|DHFR|RequiresSNPConfirmation
GTGAAACTATCACTAATGGCAGCAATTTCGAAGAATGGAGTTATCGGAAATGGCCCAGATATTCCATGGAGTGCCAAAGG
GGAACAATTACTCTTCAAAGCGATTACCTATAATCAGTGGCTTTTGGTAGGCCGAAAGACTTTCGAGTCAATGGGGGCTT
TACCCAACCGAAAATATGCCGTTGTAACTCGTTCAAGCTTCACTTCCAGTGATGAGAATGTATTGGTATTTCCATCTATC
GATGAAGCGCTAAATCATCTGAAGACGATAACGGATCATGTGATTGTGTCTGGTGGTGGTGAAATATACAAAAGCCTGAT
CGATAAAGCTGATACTTTACATATTTCAACAATCGACATTGAGCCAGAAGGTGATGTCTATTTTCCAGAAATCCCCGGTA
GTTTTAGGCCAGTTTTTAGCCAAGACTTCGTGTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA