MEGAResFrom MEG, the Microbial Ecology Group

DFRK

The dfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

Other Groups in Dihydrofolate reductase

Sequences

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>Tmt|dfrK_8_FN812951|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAATAGGGTATTAGGTAAAGAGAATGACATACCTTGGAGAATCCCAAA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGAAATATTATTCTGACAAGAGATAAGGGTTTCAGCTTTAATGGTTGTGAAATTGTCCATTCAATA
GAAGATGTTTTTGAGATATGTAATAACGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAGCGAAGTATCTGTTACACAAGGAATAACAGATGAAAAAAATCCTTATACATACTATTTTCATATTTATGAGCGA
AAAGCTTCTTGA

>Tmt|DfrK|FM207105|2788-3279|492|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAACAGGGTAATAGGTAAAGAGAATGACATACCTTGGAGAATCCCAGA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGGAATATTATTCTGACAAGAGATAAGGGGTTCAGCTTTAATGGTTGTGAAATCGTCCATTCAATA
GAAGATGTTTTTGAGTTATGTAATAGCGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAACGAAGTATCTGTTACACAAGGAATAACAAATGAAAAAAATCCTTATACATATTATTTTCATATTTATGAGCGA
AAAGCTTCTTGA

>Tmt|dfrK_4_FN677369|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAATAGGGTATTAGGTAAAGAGAATGACATACCTTGGAGAATCCCAAA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGAAATATTATTCTGACAAGAGATAAGGGTTTCAGCTTTAATGGTTGTGAAATTGTCCATTCAATA
GAAGATGTTTTTGAGATATGTAATAACGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAGCGAAGTATCTGTTACACAAGGAATAACAGATGAAAAAAATCCTTATACATACTATTTTCATATTTATGAACGA
AAAGCTTATTGA