MEGAResFrom MEG, the Microbial Ecology Group

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DFRK

The dfr genes in this category of resistance encode a dihydrofolate reductase enzyme that is less vulernable to trimethoprim than wild type.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/6985448

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Other Groups in Dihydrofolate reductase

Sequences

Download Sequences

>>MEG_2581|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAACAGGGTAATAGGTAAAGAGAATGACATACCTTGGAGAATCCCAGA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGGAATATTATTCTGACAAGAGATAAGGGGTTCAGCTTTAATGGTTGTGAAATCGTCCATTCAATA
GAAGATGTTTTTGAGTTATGTAATAGCGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAACGAAGTATCTGTTACACAAGGAATAACAAATGAAAAAAATCCTTATACATATTATTTTCATATTTATGAGCGA
AAAGCTTCTTGA

>>MEG_2582|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAATAGGGTATTAGGTAAAGAGAATGACATACCTTGGAGAATCCCAAA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGAAATATTATTCTGACAAGAGATAAGGGTTTCAGCTTTAATGGTTGTGAAATTGTCCATTCAATA
GAAGATGTTTTTGAGATATGTAATAACGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAGCGAAGTATCTGTTACACAAGGAATAACAGATGAAAAAAATCCTTATACATACTATTTTCATATTTATGAGCGA
AAAGCTTCTTGA

>>MEG_2583|Drugs|Trimethoprim|Dihydrofolate_reductase|DFRK
ATGAAAGTTTCTTTAATTGCTGCGATGGATAAGAATAGGGTATTAGGTAAAGAGAATGACATACCTTGGAGAATCCCAAA
GGATTGGGAGTATGTTAAAAATACTACAAAGGGATATCCAATTATATTAGGAAGGAAGAATCTTGAATCAATCGGAAGAG
CATTACCTGGAAGAAGAAATATTATTCTGACAAGAGATAAGGGTTTCAGCTTTAATGGTTGTGAAATTGTCCATTCAATA
GAAGATGTTTTTGAGATATGTAATAACGAAGAGGAAATTTTCATTTTCGGGGGAGAACAAATTTATAATTTGTTTCTACC
ATATGTTGAGAAAATGTACATTACAAAAATTCATTACGAATTTGAAGGAGATACATTCTTTCCAGAAGTGAATTATGAAG
AGTGGAGCGAAGTATCTGTTACACAAGGAATAACAGATGAAAAAAATCCTTATACATACTATTTTCATATTTATGAACGA
AAAGCTTATTGA