MEGAResFrom MEG, the Microbial Ecology Group

Dihydrofolate reductase

Dihydrofolate reductase catalyzes the conversion of dihydrofolate to tetrahydrofolate, the active form of folic acid. This enzyme is the target of trimethoprim, so resistance can develop when mutations arise in the dfr/dhfr genes that encode a more resistant form of the enzyme.

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