The tetracycline class of antibiotics are comprised of a linear tetracyclic nucleus (rings A, B, C, D) that contain multiple functional groups. Their mechanism of action is to inhibit the bacterial ribosome and therefore protein synthesis. They are bacteriostatic and their mechanism of action is reversible. Resistance to tetracycline antibiotics occurs via active efflux, ribosomal protection, and drug inactivation.
- Tetracycline inactivation enzymes
- Tetracycline resistance ABC efflux pumps
- Tetracycline resistance MFS efflux pumps
- Tetracycline resistance MFS efflux regulator
- Tetracycline resistance ribosomal protection proteins
- Tetracycline transcriptional repressor
- Tetracycline-resistant 16S ribosomal subunit protein