MEGAResFrom MEG, the Microbial Ecology Group

ARR

Resistance to rifampin can be mediated through ADP-ribosylation of the antibiotic molecule. The enzymes that catalyze this reaction are known as rifampin ADP-ribosyltransferases, and have been shown to be encoded by the ARR genes.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/12654674

Sequences

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>>MEG_1123|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
atggtaaaagattggattcccatctctcatgataattacaagcaggtgcaaggaccgttctatcatggaaccaaagccaa
tttggcgattggtgacttgctaaccacagggttcatctctcatttcgaggacggtcgtattcttaagcacatctactttt
cagccttgatggagccagcagtttggggagctgaacttgctatgtcactgtctggcctcgagggtcgcggctacatatac
atagttgagccaacaggaccgttcgaagacgatccgaatcttacgaacaaaagatttcccggtaatccaacacagtccta
tagaacctgcgaacccttgagaattgttggcgttgttgaagactgggaggggcatcctgttgaattaataaggggaatgt
tggattcgttggaggacttaaagcgccgtggtttacacatcattgaagactag

>>MEG_1124|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
atggtaaaagattggattcccatctctcatgataattacaagcaggtgcaaggaccgttctatcatggaaccaaagccaa
tttggcgattggtgacttgctaaccacagggttcatctctcatttcgaggacggtcgtattcttaagcacatctactttt
cagccttgatggagccagcagtttggggagctgaacttgctatgtcactgtctggcctcgagggtcgcggctacatatac
atagttgagtcaacaggaccgttcgaagacgatccgaatcttacgaacaaaagatttcccggtaatccaacacagtccta
tagaacctgcgaacccttgagaattgttggcgttgttgaagactgggaggggcatcctgttgaattaataaggggaatgt
tggattcgttggaggacttaaagcgccgtggtttacacgtcattgaagactag

>>MEG_1125|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
atggtaaaagattggattcccatctctcatgataattacaagcaggtgcaaggaccgttctatcatggaaccaaagccaa
tttggcgattggtgacttgctaaccacagggttcatctttcatttcgaggacggtcgtattcttaagcacatctactttt
cagccttgatggagccagcagtttggggagctgaacttgctatgtcactgtctggcctcgagggtcgcggctacatatac
atagttgagccaacaggaccgttcgaagacgatccgaatcttacgaacaaaaaatttcccggtaatccaacacagtccta
tagaacctgcgaacccttgagaattgttggcgttgttgaagactgggaggggcatcctgttgaattaataaggggaatgt
tggattcgttagaggacttaaagcgccgtggtttacacgtcattgaagactag

>>MEG_1126|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
atgtctgctaccgcaaccatgtttgcccagtcgttcttccatggaaccaaagccgctcttgcacccggtgatctgatcgc
cgtcggttatcgatcgaatttcacagacgcgaaatccctgtcgtgggtgtattttacaggcacgctcgatgcggcgatct
ggggcgccgaattggcgggtggcagcggaacggaacgaatttatgtcgtcgaaccgaccggcgccatcgaggaggatccg
aacctgacggataagaagttcccgggtaacccgaccctgtcttatcgctcccgcgatccattgcgcgtaattgctgaagt
gacgaagtggcaagcacacacggcccagcggctgcgggaaatgaaggagggcctggcgcgtctgaacgcagaaggtgccg
agatcatcgattaa

>>MEG_1127|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>>MEG_1128|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
GTGGTGGCGAATCCGCCGAAACCGTTCGAAGTGCACGAGTCCGGGGCCTATCTGCACGGCACCAAGGCCGACCTCAAGGT
GGGGGACCGACTGGTGCCCGGCCGCGAGTCCAACTTCGAGGCCGGGCGCATCATGAAGCACGTCTACATCACCCAGACGC
TGGACGCCGCGGTGTGGGGCGCCGAGCTTGCTGTCGGTGAGGGTCGCGGGCGGATTTACATCGTCGAACCCGAGGGCGAG
ATCGAAGACGACCCGAACGTCACCGACAAGAAGCTCCCCGGCAACCCGACCCGCTCCTACCGCACCCGTGAGCCCGTGCG
GATCGTCGGGGAGCTCACCGACTGGGAGGGGCATTCGCCGGAGCAGATCGCTGCCATGCGGGAGGGGCTCGAGGATCTAC
GGCGCAAGGGGCTCGCGGTCATCTATGACTAG

>>MEG_1129|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAAATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>>MEG_1130|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGACGAATGACTGGATTCCCACTTCGCATGACAACTGCTCGCAAGTAGCGGGGCCGTTCTATCACGGCACCAAAGCCAA
ACTCACGGTTGGTGACTTGCTTTCCCCAGGACACCCGTCTCACTTTGAGCAAGGTCGCAAGCTCAAACACATCTACTTTG
CCGCCCTGATGGAACCAGCCATCTGGGGAGCGGAGCTTGCGATGTCGCTGTCAAGCCTAGAGGGGCGCGGCCACATCTAC
ATCGTTGAACCGCTCGGCCCATTTGAGGACGACCCGAACCTTACAAACAAGAAATTCCCGGGAAATCCAACCAAGTCCTA
TCGCACCACTGAGCCGCTGCGGATTGTTGGGATCGTAGAAGACTGGCAAGGCCACTCACCGGAGGTGTTACAGGGCATGT
TGGCGTCTCTGGAGGATCTTCAGCGTCGTGGCCTCGCCATCATTGAGGACTAA

>>MEG_1131|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGACGGTAGACTGGATCCCCATTTCGCACGACAACTACCATCAAGTGCGTGGCCCGTTTTATCACGGAACAAAAGCCGA
ACTCGCCATTGGCGACTTAATTTCAACCGGATTTATTTCTCACTTTGAGCGGGACAGAGCACTAAAGCATGTGTACTTTT
CCGCGCTGATGGAGCCAGCAATCTGGGGGGCCGAGCTCGCTGTAGCACTCTCTGGCTCTGACGGGCCAGGCCATATTTAC
ATCATTGAGCCAACCGGCCCGTTTGAAGACGACCCCAATCTCACAAACAAACGATTCCCTGGCAATCCAACACAGTCCTA
TCGCACATGCCACCCACTTAAAATTGTTGGCATACTGCGGGAGTGGGAGCGCCATTCTCCTGAAGCATTGAAGACCATGC
TAGATTCTCTGGCAGACCTCAAGCGACGCGGCTTGGCCATCATTGAAGAATGA

>>MEG_1132|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTGGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>>MEG_1133|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGCCGAATGACTGGATTCCCACCTCGCACGAAAACTGCTCGCTCGTGCCGGGGCCGTTCTACCACGGCACCAAAGCAAA
ACTCGCAATAGGTGACTTGCTTTCGCCTGGACACCCGTCTCACTTTGAGCAAGGCCGTAGGCTCAAACACATCTATTTTG
CCGCACTGATGGAGCCAGCCATCTGGGGTGCTGAGCTTGCAATGTCATTGTCACGCCAAGAGGGGCGCGGTTACATTTAC
ATTGTTGAACCGCTCGGGCCGTTTGAGGACGACCCAAACCTTACAAACAAAAAATTTCCGGGCAATCCAACCAAGTCCTA
CCGCACCAGTGAGTCGCTACGGATTGTGGAGGTAGTAGAGGACTGGCAAGGCCACTCACCGGATGTGCTGCAGGGCATGT
TGGCATCACTGGAGGATCTTCAGCGTCGCGGCCTCGCAATCATTGAGGACTAG

>>MEG_1134|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGATTAAAGATTGGATTCCAACCACACATGAAAATTGTAAAAAAATGCAGGGACCGTTTTATCATGGCACCAAAGCTAA
ATTATCGGTAGGTGAACTCCTAACAACTGGGTTCAACACTCATTTTGAAGAGGGTCGCACACTCAAGCACGTTTATTTTT
CAGCTATGCTTGAGCCAGCAATTTGGGGGGCTGAACTCGCTGTTTCACTGTCTGGTCTAGATGGCCGGGGATACATATAC
TTAGTTGAACCAACTGGACCTTTCGAGGATGACCCGAATCTTACCAATAAAAAATTTCCAGGAAATCCAACAATGTCCTA
TCGAACTTCTGAGCCTCTCCAGATTGTGGGGGTCGTTGAAGAGTGGGAGGGACACTCCGCTGAAGCCCTGAAAGCGATGC
TGGATTCCTTGGAGAATCTAGAGCGCAATGGACTTCATGTCATATATGATTAA

>>MEG_1135|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTATGCAGCCAAATCCCAACAATTAA
GGGTCTTAAAATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAA
CCAAAGCCAATTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTTTCATTTCGAGGACGGTCGTATTCTTAAGCAC
ATCTACTTTTCAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGG
CTACATATACATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAAATTTCCCGGTAATCCAA
CACAGTCCTATAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATA
AGGGGAATGTTGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>>MEG_1136|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTCGAGTGACTGGACTCCCATCTCACATGAGAATTGCCAGCAGGTGCGTGGGCCGTTCTATCACGGCACCAAAGCCCA
TCTATCGATTGGCGACTTGATAACAACTGGGCATCTCTCCCACTTTGAAGATGGACGCGCTCTTAAACACGTCTACTTTT
CAGCTTTGATGGAGCCTGCCATTTGGGGGGCGGAACTTGCAATGTCGTTGTCACGCCTAGATGGCCGTGGCTACATATAC
ATCGTCGAACCAACTGGACCGTTTGAGGACGACCCGAATCTTACGAACAAAAGATTTCCTGGAAATCCAACAAAGTCCTA
TCGCACGTGCGATCCGCTACGAATTGTCGGGTCAGTCGAAGACTGGCAAGGGCATCCCGCTGATGTGCTGCAACAGATGT
TGGAGTCTTTAGAGGACCTAGAGCGCCGTGGTCTTGCCATCATCGAGGATTAG

>>MEG_1137|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTCGAGTGACTGGACTCCCATCTCACATGAGAATTGCCAGCAGGTGCGTGGGCCGTTCTATCACGGCACCAAAGCCCA
TCTATCGATTGGCGACTTGATAACAACTGGGCATCTCTCCCACTTTGAAGATGGACGCGCTCTTAAACACGTCTACTTTT
CAGCTTTGATGGAGCCTGCCATTTGGGGGGCGGAACTTGCAATGTCGTTGTCACGCCTAGATGGCCGTGGCTACATATAC
ATCGTCGAACCAACTGGACCGTTTGAGGACGACCCGAATCTTACGAACAAAAGATTTCCTGGAAATCCAACAAAGTCCTA
TCGCACGTGCGATCCGCTACGAATTGTCGGGTCAGTCGAAGACTGGCAAGGGCATCCCGCTGATGTGCTGCAACAGATGT
TGGAGTCTTTAGAGGACCTAAAGCGCCGTGGTCTTGCCATCATCGAGGATTAG

>>MEG_1138|Drugs|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGGCCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAGTTAATAAGGGGAATGT
TGGATTCGTTGGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG