MEGAResFrom MEG, the Microbial Ecology Group

ARR

Resistance to rifampin can be mediated through ADP-ribosylation of the antibiotic molecule. The enzymes that catalyze this reaction are known as rifampin ADP-ribosyltransferases, and have been shown to be encoded by the ARR genes.

References

Sequences

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>1004|KC199968.1|KC199968|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGATTAAAGATTGGATTCCAACCACACATGAAAATTGTAAAAAAATGCAGGGACCGTTTTATCATGGCACCAAAGCTAA
ATTATCGGTAGGTGAACTCCTAACAACTGGGTTCAACACTCATTTTGAAGAGGGTCGCACACTCAAGCACGTTTATTTTT
CAGCTATGCTTGAGCCAGCAATTTGGGGGGCTGAACTCGCTGTTTCACTGTCTGGTCTAGATGGCCGGGGATACATATAC
TTAGTTGAACCAACTGGACCTTTCGAGGATGACCCGAATCTTACCAATAAAAAATTTCCAGGAAATCCAACAATGTCCTA
TCGAACTTCTGAGCCTCTCCAGATTGTGGGGGTCGTTGAAGAGTGGGAGGGACACTCCGCTGAAGCCCTGAAAGCGATGC
TGGATTCCTTGGAGAATCTAGAGCGCAATGGACTTCATGTCATATATGATTAA

>Rif|ARR-6_1_FM955585|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTCGAGTGACTGGACTCCCATCTCACATGAGAATTGCCAGCAGGTGCGTGGGCCGTTCTATCACGGCACCAAAGCCCA
TCTATCGATTGGCGACTTGATAACAACTGGGCATCTCTCCCACTTTGAAGATGGACGCGCTCTTAAACACGTCTACTTTT
CAGCTTTGATGGAGCCTGCCATTTGGGGGGCGGAACTTGCAATGTCGTTGTCACGCCTAGATGGCCGTGGCTACATATAC
ATCGTCGAACCAACTGGACCGTTTGAGGACGACCCGAATCTTACGAACAAAAGATTTCCTGGAAATCCAACAAAGTCCTA
TCGCACGTGCGATCCGCTACGAATTGTCGGGTCAGTCGAAGACTGGCAAGGGCATCCCGCTGATGTGCTGCAACAGATGT
TGGAGTCTTTAGAGGACCTAGAGCGCCGTGGTCTTGCCATCATCGAGGATTAG

>Rif|Arr2|JQ639792|1050-1502|453|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAAATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>Rif|ARR-6_2_FM897214|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTCGAGTGACTGGACTCCCATCTCACATGAGAATTGCCAGCAGGTGCGTGGGCCGTTCTATCACGGCACCAAAGCCCA
TCTATCGATTGGCGACTTGATAACAACTGGGCATCTCTCCCACTTTGAAGATGGACGCGCTCTTAAACACGTCTACTTTT
CAGCTTTGATGGAGCCTGCCATTTGGGGGGCGGAACTTGCAATGTCGTTGTCACGCCTAGATGGCCGTGGCTACATATAC
ATCGTCGAACCAACTGGACCGTTTGAGGACGACCCGAATCTTACGAACAAAAGATTTCCTGGAAATCCAACAAAGTCCTA
TCGCACGTGCGATCCGCTACGAATTGTCGGGTCAGTCGAAGACTGGCAAGGGCATCCCGCTGATGTGCTGCAACAGATGT
TGGAGTCTTTAGAGGACCTAAAGCGCCGTGGTCTTGCCATCATCGAGGATTAG

>Rif|Arr4|EF660562|1672-2124|453|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGACGAATGACTGGATTCCCACTTCGCATGACAACTGCTCGCAAGTAGCGGGGCCGTTCTATCACGGCACCAAAGCCAA
ACTCACGGTTGGTGACTTGCTTTCCCCAGGACACCCGTCTCACTTTGAGCAAGGTCGCAAGCTCAAACACATCTACTTTG
CCGCCCTGATGGAACCAGCCATCTGGGGAGCGGAGCTTGCGATGTCGCTGTCAAGCCTAGAGGGGCGCGGCCACATCTAC
ATCGTTGAACCGCTCGGCCCATTTGAGGACGACCCGAACCTTACAAACAAGAAATTCCCGGGAAATCCAACCAAGTCCTA
TCGCACCACTGAGCCGCTGCGGATTGTTGGGATCGTAGAAGACTGGCAAGGCCACTCACCGGAGGTGTTACAGGGCATGT
TGGCGTCTCTGGAGGATCTTCAGCGTCGTGGCCTCGCCATCATTGAGGACTAA

>Rif|Arr3|JF806499|1353-1805|453|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTGGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>1402|FM207631.1|FM207631|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTATGCAGCCAAATCCCAACAATTAA
GGGTCTTAAAATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAA
CCAAAGCCAATTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTTTCATTTCGAGGACGGTCGTATTCTTAAGCAC
ATCTACTTTTCAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGG
CTACATATACATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAAATTTCCCGGTAATCCAA
CACAGTCCTATAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATA
AGGGGAATGTTGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>CARD|phgb|EF660563|392-845|ARO:3002850|arr-5|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGACGGTAGACTGGATCCCCATTTCGCACGACAACTACCATCAAGTGCGTGGCCCGTTTTATCACGGAACAAAAGCCGA
ACTCGCCATTGGCGACTTAATTTCAACCGGATTTATTTCTCACTTTGAGCGGGACAGAGCACTAAAGCATGTGTACTTTT
CCGCGCTGATGGAGCCAGCAATCTGGGGGGCCGAGCTCGCTGTAGCACTCTCTGGCTCTGACGGGCCAGGCCATATTTAC
ATCATTGAGCCAACCGGCCCGTTTGAAGACGACCCCAATCTCACAAACAAACGATTCCCTGGCAATCCAACACAGTCCTA
TCGCACATGCCACCCACTTAAAATTGTTGGCATACTGCGGGAGTGGGAGCGCCATTCTCCTGAAGCATTGAAGACCATGC
TAGATTCTCTGGCAGACCTCAAGCGACGCGGCTTGGCCATCATTGAAGAATGAA

>1014|AF001493.1|AF001493|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
GTGGTGGCGAATCCGCCGAAACCGTTCGAAGTGCACGAGTCCGGGGCCTATCTGCACGGCACCAAGGCCGACCTCAAGGT
GGGGGACCGACTGGTGCCCGGCCGCGAGTCCAACTTCGAGGCCGGGCGCATCATGAAGCACGTCTACATCACCCAGACGC
TGGACGCCGCGGTGTGGGGCGCCGAGCTTGCTGTCGGTGAGGGTCGCGGGCGGATTTACATCGTCGAACCCGAGGGCGAG
ATCGAAGACGACCCGAACGTCACCGACAAGAAGCTCCCCGGCAACCCGACCCGCTCCTACCGCACCCGTGAGCCCGTGCG
GATCGTCGGGGAGCTCACCGACTGGGAGGGGCATTCGCCGGAGCAGATCGCTGCCATGCGGGAGGGGCTCGAGGATCTAC
GGCGCAAGGGGCTCGCGGTCATCTATGACTAG

>Rif|HM015626.1|gene1|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGGCCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAGTTAATAAGGGGAATGT
TGGATTCGTTGGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG

>Rif|Arr7|FN397623|1189-1641|453|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGCCGAATGACTGGATTCCCACCTCGCACGAAAACTGCTCGCTCGTGCCGGGGCCGTTCTACCACGGCACCAAAGCAAA
ACTCGCAATAGGTGACTTGCTTTCGCCTGGACACCCGTCTCACTTTGAGCAAGGCCGTAGGCTCAAACACATCTATTTTG
CCGCACTGATGGAGCCAGCCATCTGGGGTGCTGAGCTTGCAATGTCATTGTCACGCCAAGAGGGGCGCGGTTACATTTAC
ATTGTTGAACCGCTCGGGCCGTTTGAGGACGACCCAAACCTTACAAACAAAAAATTTCCGGGCAATCCAACCAAGTCCTA
CCGCACCAGTGAGTCGCTACGGATTGTGGAGGTAGTAGAGGACTGGCAAGGCCACTCACCGGATGTGCTGCAGGGCATGT
TGGCATCACTGGAGGATCTTCAGCGTCGCGGCCTCGCAATCATTGAGGACTAG

>Rif|Arr6|JF922883|1-453|453|Rifampin|Rifampin_ADP-ribosyltransferase_Arr|ARR
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAA
TTTGGCGATTGGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTT
CAGCCTTGATGGAGCCAGCAGTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATAC
ATAGTTGAGCCAACAGGACCGTTCGAAGACGATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTA
TAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAAGACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGT
TGGATTCGTTAGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGACTAG