MEGAResFrom MEG, the Microbial Ecology Group

Pyrazinamide-resistant pncA

The pncA gene encodes a pyrazinamidase that converts pyrazinamide to its active form in Mycobacterium tuberculosis. Specific mutations in pncA can result in loss of typical function and therefore resistance to pyrazinamide.

References

Other Mechanisms in Mycobacterium tuberculosis-specific Drug

Groups

Sequences

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