MEGAResFrom MEG, the Microbial Ecology Group

Isoniazid-resistant kasA

The kasA gene encodes a beta-ketoacyl synthase that participates in fatty acid elongation in Mycobacterium tuberculosis. Isoniazid targets fatty acid elongation mechanisms that are essential to the bacteria, therefore specific mutations in kasA can result in resistance to isoniazid.

References

Other Mechanisms in Mycobacterium tuberculosis-specific Drug

Groups

Sequences

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