MEGAResFrom MEG, the Microbial Ecology Group

MLS23S

The MLS23S group of genes confer resistance to MLS through the mechanism, Macrolide-resistant 23S rRNA mutation.

Sequences

Download Sequences

>MEG_3978|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
AAGGCAGTGGTAGCGCTGAAGAATATTCGTGCAATTGTCGTTATTCATTATAAAAGGGCAGGTTTTAAAGGATATTTTAA
AATTTAAAACAAGCTTTTAAGAGCAGATGGCGGATGCCTTGCCAAAGAGAGGCGATGAAGGACGTACTAGACTGCGATAA
GCTATGCGGAGCTGTCAAGGAGCTTTGATGCGTAGATGTCCGAATGGGGCAACCCAACTAATAGAGATATTAGTTACTCT
AATTTAGAGAGCGAACCTAGTGAAGTGAAACATCTCAGTAACTAGAGGAAAAGAAATCAACGAGATTCCCTAAGTAGTGG
CGAGCGAACGGGGAAAAGGGCAAACCGAGTGCTTGCATTCGGGGTTGAGGACTGCAACATCCAAGAGAACGCTTTAGCAG
AGTTACCTGGAAAGGTAAGCCATAGAAAGTGATAGCCTTGTATGCGACAAGGCGTTCTTAGGTAGCAGGATCCAGAGTAG
GCCAGGACACGAGAAATCCAGGTTGAAGCTGGGGAGACCACTCTCCAACCCTAAATACTACTCTTTGAGCGATAGCGAAC
AAGTACCGTGAGGGAAAGGTGAAAAGAACCGCAGTGAGCGGAGTGAAATAGAACCTGAAACCATCTGCTTACAATCATTC
AGAGCCCTATGATTTATCAGGGTGATGGACTGCCTTTTGCATAATGATCCTGCGAGTTGTGGTATCTGGCAAGGTTAAGC
GGATGCGAAGCCGTAGCGAAAGCGAGTCTTAATAGGGCGGTTTAAGTCAGATGCTGCAGACCCGAAGCTAAGTGATCTAT
CCATGGCCAAGTTGAAACGCGTGTAATAGCGCGTGGAGGACTGAACTCGTACCCATTGAAACGGGTTGGGATGAGCTGTG
GATAGGGGTGAAAGGTCAAACAAACTTAGTGATAGCTGGTTCTCTTCGAAATATATTTAGGTATAGCCTCAAGTGATAAT
AAAAGGGGGTAGAGCTCTGATTGGGCTAGGGCTGCTCGCCGCGGTACCAAACCCTATCAAACTTCGAATACCTTTTATCG
TATCTTGGGAGTCAGGCGGTGGGTGATAAAATCAATCGTCAAAAGGGGAACAACCCAGACTACCAAATAAGGTCCCTAAG
TTCTATTCTGAGTGGAAAAAGATGTGTGGCTACTCAAACAACCAGGAGGTTGGCTTAGAAGCAGCCATCCTTTAAAGAAA
GCGTAACAGCTCACTGGTCTAGTGGTCATGCGCTGAAAATATAACGGGGCTAAGATAGACACCGAATTTGTAGATTGTGT
TAAACACAGTGGTAGAAGAGCGTTCATACCAGCGTTGAAGGTATACCGGTAAGGAGTGCTGGAGCGGTATGAAGTGAGCA
TGCAGGAATGAGTAACGATAAGATATATGAGAATTGTATCCGCCGTAAATCTAAGGTTTCCTACGCGATGGTCGTCATCG
TAGGGTTAGTCGGGTCCTAAGCCGAGTCCGAAAGGGGTAGGTGATGGCAAATTGGTTAATATTCCAATACCGACTCATGG
AGCGTGATGGGGGGACGCATAGGGTTAAGCGAGCTAGCTGATGGAAGTGCTAGTCTAAGGGCGTAGATTGGAGGGAAGGC
AAATCCACCTCTGTATTTGAAACCCAAACAGGCTCTTTGAGTCCTTTCAGGACAAAGGGAGAATCGCTGATACCGTCGTG
CCAAGAAAAGCCTCTAAGCATATCCATAGTCGTCCGTACCGCAAACCGACACAGGTAGATGAGATGAGTATTCTAAGGCG
CGTGAAAGAACTCTGGTTAAGGAACTCTGCAAACTAGCACCGTAAGTTCGCGATAAGGTGTGCCGCAGCAATGCGGTCTC
AGCAAAGAGTCCCTCCCGACTGTTTACCAAAAACACAGCACTTTGCCAACTCGTAAGAGGAAGTATAAGGTGTGACGCCT
GCCCGGTGCTCGAAGGTTAAGAGGATGCGTCAGTCGCAAGATGAAGCGTTGAATTGAAGCCCGAGTAAACGGCGGCCGTA
ACTATAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGTTAAATACCGACCTGCATGAATGGCGTAACGAGATGGGAGCTG
TCTCAACCAGAGATTCAGTGAAATTGTAGTGGAGGTGAAAATTCCTCCTACCCGCGGCAAGACGGAAAGACCCCGTGGAC
CTTTACTACAACTTAGCACTGCTAACGGGAATATCATGTGCAGGATAGGTGGGAGGCTTTGAAGTAAGGGCTTTGGCTCT
TATGGAGCCATCCTTGAGATACCACCCTTGATGTTTCTGTTAGCTAACTGGCCTGTGTTATCCACAGGCAGGACAATGCT
TGGTGGGTAGTTTGACTGGGGCGGTCGCCTCCTAAAAAGTAACGGAGGCTTGCAAAGGTTGGCTCATTGCGGTTGGAAAT
CGCAAGTTGAGTGTAATGGCACAAGCCAGCCTGACTGTAAGACATACAAGTCAAGCAGAGACGAAAGTCGGTCATAGTGA
TCCGGTGGTTCTGTGTGGAAGGGCCATCGCTCAAAGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTCCCCCAAGAG
CTCACATCGACGGGGAGGTTTGGCACCTCGATGTCGGCTCATCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTATGGCT
GTTCGCCATTTAAAGCGGTACGCGAGCTGGGTTCAGAACGTCGTGAGACAGTTCGGTCCCTATCTGCCGTGGGCGTAGGA
AAGTTGAGGAGAGCTGTCCCTAGTACGAGAGGACCGGGATGGACGTGTCACTGGTGCACCAGTTGTTCTGCCAAGAGCAT
CGCTGGGTAGCTACACACGGATGTGATAACTGCTGAAAGCATCTAAGCAGGAAGCCAACTCCAAGATAAACTTTCCCTGA
AGCTCGCACAAAGACTATGTGCTTGATAGGGTAGATGTGTAAGCGCAGTAATGCGTTTAGCTGACTACTACTAATAGAGC
GTTTGGCTTGTTTTT

>MEG_3979|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
AAGGTCAAAATCAAACGGCCTTTAGTATATCTCGGCTAAAGCCATTGCTGACTGTACACCTGATACCTATATAACGGCTT
GTCTAGCCGCGGCCTTAGAGAGCACTCATCTTGAGTTTAGCTTCCTACTTAGATGCTTTCAGCAGTTATCTATCCATGCG
TAGCTACCCAGCGTTTCCCATTGGAATGAGAACTGGTACACAATTGGCATGTCCTTTCAGGTCCTCTCGTACTATGAAAG
GCTACTCTCAATGCTCTAACGCCTACACCGGATATGGACCAAACTGTCTCACGCATGAAATTTTAAAGCCGAATAAAACT
TGCGGTCTTTAAAACTAACCCCTTTACTTTCGTAAAGGCATGGACTATGTCTTCATCCTGCTACTGTTAATGGCAGGAGT
CGGCGTATTATACTTTCCCACTCTCGAGAAAATATCCTATAAATCGAGCAACAATAAATAAATTGTATGTAAACATTCTT
TTAGAGATTGGCTAAATTTATAAAGTCTCTACGGGGACGATTTCTTTTTTTCACTTAAACTGTCTAGCACAGCACGAACG
GTTTCAGAAGTTGTTTTACGCGTCTTCGAATCATTCAGAGCTGCAATTTGATCCACCCATGTACAAACTTCTAAGAATTT
GTCCGGGGATTCTTTTGCTGACGGAAGCCGCCAAATAATTTTTAAAACTAAATTTGCTTGTTTTTGTTTTAGTTTTAGAA
AAGGTTGTAGTTGTGTTAAAAAATTATGCAAAGGCTTGATTTCGCTTAGAATATAATCCGAAACGCTACCCCTATCTCTT
ACATAACCAACCCCAATTTCATCCACTAATTTGTCTAAAAACCAACGTCTCTGTGTCTTTTGCGTGACTTGGAACGCGAG
TGATAGCTGATGCTTAAATTTATAAGACTGATTAGGCTTAATTTGAGCGATTATGCTACCGTCACCGTCTACAAACCCTG
CTAAGTAGAGTAAGAACTCTTTATTATATTTTGTATTCATAAGATGTTTTATTTAATTTATTGAATTATTAAACCAAAAA
GAAATGGTCTTCCCTCGGCGTTGCCATCTATTGCCCACGAATGTGGTTTATGCGACAGTTTGTACTTAAAACAATAGGAA
GGTTTCACCGATATAAGCCGATACTTTGCTTACATTACTGCAAGCACACGCAGTGTTATTTACGTTTTGAACCCAGCTCA
CGTACCACTTTAATGGGCGAACAGCCCAACCCTTCGGACCTACTACAGACCGAGGATGTGATGAGCCGACATCGAGGTGC
CAAACCTTCCCGTCGATGTGAACTCTTGGGGAAGATCAGCCTGTTATCCCTAGAGTAACTTTTATCCGTTGAGCGACGGC
CCTTCCACGCGGCACCGTCGGATCACTAAGGCCGGCTTTCGCCCCTGCTCGACTTGTAGGTCTTGCAGTCAAGCTCCCTT
TTGCCTTTACACTCAATGTCTGATTTCCGTCCAGACTGAGGGAACCTTTGCACGCCTCCGTTACCTTTTAGGAGGCATTC
GCCCCAAATAAACTGCCCACCTGAAACTGTCAAGGGTCCTGATTCAAGGATCCCCATTAGGATTCTAGCTCTTCCAGAGT
GGTCTCTCAATGACGGCTCTAATTACCCCGGAAGGTAATCTTCATAGCCTCCCACCTAGGCTGCGCAAGAAAAGCCCAAA
CCCAATTCCAAGATACAGTCAAGCTTCATAGGGTCTTTCTGTCCAGGTGTAGGTAGTCCGCATCTTCACGGGACAAGTCT
ATTTCACCGAGCCTCTCTCCGAGACAGCGCCCAGATCGTTACGCCTTTCGTGCAGGTCGAAACTTACTCGACAATGAATT
TCGCTACCTTAGGATCGTTATAGTTACGACCGCCGTTCACCGGGGCTTCGGTCGTCAGCTTTTTTCTTACGAAATAACCA
ACTTCCTTAACCTTCCGGCACTGGGCAGGCGTCAGCCCCCATATATTGTCTTACGACTTTGCGGAGACCTGTGTTTTTGG
TAAACAGTCGCCTGGGCCTGGTCACTGCGACCCACCTTGTTACGGATGGGTGCCCCTTCTTCCGAAGTTACGGGGCCAGT
TTGCCGAGTTCCTTAGAGAGAGTTCTCTCGCGCCCCTTGGTATTCTCTACCAACCTACCTGTGTCGGTTTCAGGTACAGG
TCATTAAATTATAAAGATGTATGAGCTTTTCTTGGAAGTATGACATCACTAGCTACTCGACGGCGAACCATCAAATAGGG
ATCACGTCTCCACTCAAGATAGCTTTTTTTCTATCTCTCAACGTCTAAACGCTTCCACTGCAATCCAAAAACAGTTCTAG
CTTAGCCTCCTTCGTCCCTCAGATCATAATTTAACTCGTACAGGAATATTAACCTGTTTTCCATCGACGACGCCGTTTGG
CCTAGTCTTAGGTCCTGACTAACCCCCCATGGACGAACCTAGTGGAGGAACCCTTAGGTTTTCGGGGCATTGGATTCTCA
CCAATGTTTTCGTTACTCAAGCCGACATTCTCACTTCCGCTTCGTCCATCCCCACTTACGTGAAAACTTCACCCGAGAGC
GGAACGCTCCCCTACCTATAATTTATATAATAAATTATATCACAGCTTCGGCAGGTCACTTAGTCCCGGCCATTATCGGC
GCAAGAACGCTTTACCAGTGAGCTATTACGCACTCTTTGAAGGGTGGCTGCTTCTAAGCAAACCTCCTGGTTGTTTCAGC
ATTCTCACATCCTTTTCCACTTAGTGACCATTTAGGGGCCTTAGCTGGTGATCTGGGCTGTTTCCCTCTTGACAATGAAG
CTTATCCCCCACTGTCTCACTGGTTTACGGAAGACATGTCTTGTATTCTGAGTTTGCCACGACTTGGTACCGCTTTCGCA
GCCCGCATCGAAACAGTAGCTTTACCCCAAGACAGTTCATCGTTACCGCTGCGCCTCAACGCATTTCGGGGAGATCCAGC
TAGCTCCGAGTTCGATTGGAATTTCTCCCCTATTCACAGCTCATCCGCCGATTTTTCAACATCGGTCGGTTCGGACCTCC
ACTTGGTGTTACCCAAGCTTCATCCTGGCCATGAATAGATCACCCGGGTTCGGGTCCATAAGAAGTGACCATTTGCGCCC
TATTCAGACTCGCTTTCGCTTGGGCTCCGGATTTTACTCCTTAACCCAGCCACTCCCTATAAGTCGCCGGCTCATTCTTC
AACAGGCACGCGGTCACAAGCATTCTTGCTCCCACTGCTTGTCAGCATACGGTTTCATGTTCTATTTCACTCCCCAACAG
GGGTTCTTTTCACCTTTCCCTCGTGGTACTATTTCGCTATCGGTCACTCAGGAGTATTTAGCCTTACGAGGTGGTCCTCG
CTGATTCACACGGGATTTCACGTGCCCCATGCTACTCGGGATT

>MEG_3980|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
ACAGTGGACGCGAGCATCTGTGGCCAAGTTTTTAAGGGCGCACGGTGGATGCCTTGGCACCAGGAACCGATGAAGGACGT
GGGAGGCCACGATAGTCCCCGGGGAGCCGTCAACCAGGCTTTGATCCGGGGGTTTCCGAATGGGGAAACCCGGCAGTCGT
CATGGGCTGTCACCCGCTGCTGAACACATAGGCAGTGTGGAGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGCAGGA
AGAGAAAACAACCGTGATTCCGGGAGTAGTGGCGAGCGAAACCGGATGAGGCCAAACCGTATACGTGTGAGACCCGGCAG
GGGTTGCGTGTGCGGGGTTGTGGGATCTCTCTTTCACAGTCTGCCGGCTGTGAGGCGAGTCAGAAACCGTTGATGTAGGC
GAAGGACATGCGAAAGGTCCGGCGTAGAGGGTAAGACCCCCGTAGTCGAAACATCAGCGGCTCGTTTGAGAGACACCCAA
GTAGCACGGGGCCCGAGAAATCCCGTGTGAATCTGGCGGGACCACCCGCTAAGCCTAAATATTCCCTGGTGACCGATAGC
GGATAGTACCGTGAGGGAATGGTGAAAAGTACCGCGGGAGCGGAGTGAAATAGTACCTGAAACCGTGTGCCTACAAGCCG
TGGGAGCGTCGGACATCAAGCTTGCTTGGTGTCTCGTGACTGCGTGCCTTTTGAAGAATGAGCCTGCGAGTTTGCGGTGT
GTTGCGAGGTTAACCCGAGTGGGGAAGCCGTAGCGAAAGCGAGTCCGAATAGGGCGTTTCAGTAGCACGCTCAAGACCCG
AAGCGGAGTGATCTAGCCATGGGCAGGTTGAAGCGGAGGTAAGACTTCGTGGAGGACCGAACCCACCAGGGTTGAAAACC
TGGGGGATGACCTGTGGTTAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGC
AGCGTCGTGTGTTTCTTGCCGGAGGTAGAGCACTGGATAGGCGATGGGCCCTACCGGGTTACTGACCTTAGCCAAACTCC
GAATGCCGGTAAGTGAGAGCGCGGCAGTGAGACTGTGGGGGATAAGCTCCATGGTCGAGAGGGAAACAGCCCAGAGCATC
GACTAAGGCCCCTAAGCGTACGCTAAGTGGGAAAGGATGTGGAGTCGCACAGACAACCAGGAGGTTGGCTTAGAAGCAGC
CACCCTTGAAAGAGTGCGTAATAGCTCACTGGTCTAGTGATTCCGCGCCGACAATGTAGCGGGGCTCAAGCGTACCGCCG
AAGTCGTGTCATTCATACAATAGGGCCAACGCCTGTATGGATGGGTAGGGGAGCGTCGTGTGCCGGGTGAAGCAGCCGCG
GAAGCGAGTTGTGGACGGTTCACGAGTGAGAATGCAGGCATGAGTAGCGATACAAACGTGAGAAACGTTTGCGCCGATTG
ACTAAGGGTTCCTGGGTCAAGCTGATCTGCCCAGGGTAAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGAT
AACCGGTTGATATTCCGGTACCCGCTGTGAAGCGTCAAACATCGAGCATCGTGATGCTAAGGCCGTGAAGCCGCCCTGAT
CTCTTCGGAGTTGAGGGGAGTGGTGGAGCCGCCGGACCAAGCGGTTAGTAGGTGAGTGATGGGGTGACGCAGGAAGGTAG
TCCATCCCGGGCGGTGGTTGTCCCGGGGTAAGGGTGTAGGACGTCAGGTAGGTAAATCCGCCTGGCAATAGTCTGAGACC
TGATGCCGAGCCGATTGTGGTGAAGTGGATGATCCTATGCTGTCGAGAAAAGCCTCTAGCGAGTTTCATGGCGGCCCGTA
CCCTAAACCGACTCAGGTGGTCAGGTAGAGAATACCGAGGCGTTCGGGTGAACTATGGTTAAGGAACTCGGCAAAATGCC
CCCGTAACTTCGGGAGAAGGGGGGCCACACCTGGTGATGATCTTTACGGTCTGAGCTGGGGGTGGCCGCAGAGACCAGCG
AGAAGCGACTGTTTACTAAAAACACAGGTCCGTGCGAAGCCGTAAGGCGATGTATACGGACTGACGCCTGCCCGGTGCTG
GAACGTTAAGGGGACCGGTTAGCTCCATTTCGGTGGGGCGAAGCTGAGAACTTAAGCGCCAGTAAACGGCGGTGGTAACT
ATAACCATCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCGACTGTCT
CAACCATAGGCCCGGTGAAATTGCACTACGAGTAAAGATGCTCGTTTCGCGCAGCAGGACGGAAAGACCCCGGGACCTTT
ACTACAGTTTGATATTGGTGTTCGGTTCGGCTTGTGTAGGATAGCTGGGAGACTTTGAAGCTCGCACGCCAGTGTGGGTG
GAGTCGTCGTTGAAATACCAGTCTGGTCGTGCTGGATGTCTAACCTGGGTCCGTGATCCGGATCAGGGACAGTGTCTGAT
GGGTAGTTTAACTGGGGCGGTTGCCTCCTAAAGAGTAACGGAGGCGCCCAAAGGTTCCCTCAGCCTGGTTGGCAATCAGG
TGTTGAGTGTAAGTGCACAAGGGAGCTTGACTGTGAGACCGACGGGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCCG
GCGGTGGCTTGTGGAAGCGCCGTCGCTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCA
TATCGACGGGATGGTTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGTCGGTCCCAAGGGTTGGGCTGTTC
GCCCATTAAAGCGGTACGCGAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCCCTATCCGCTGTGCGCGTAGGAGTCT
TGAGAAGGGCTGTCCCTAGTACGAGAGGACCGGGACGGACGAACCTCTGGTGTGCCAGTTGTCCTGCCAAGGGCATGGCT
GGTTGGCTACGTTCGGGAGGGATAACCGCTGAAAGCATCTAAGCGGGAAGCCTGCTTCGAGATGAGGACTCCCACCCCCT
TGAGGGGTTAAGGCTCCCAGTAGACGACTGGGTTGATAGGCCGGATCTGGAAGCACCGCAAGGTGTGGAGGTGACCGGTA
CTAATAGGCCGAGGGCTTGTCCTCAGTTG

>MEG_3981|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
ACCAATAAATTTATTAGTACTGGTCAGCTGAATGCATTGCTGCACTTACACCTCCAGCCTATCAACCTCATAGTCTATAA
GGAATTTTAAAGGGAATACTAATCTTTGAGGGGGCTTCCCGCTTAGATGCTTTCAGCGGTTATCCCTGCCGCACTTGGCT
ACCCAGCTATGCTTCTGGCGAAACAACTGGCACACCATCGGTGCGTCCACTCCGGTCCTCTCGTACTAAGAGTAGCTCTC
ATCAATATTCCAACGCCCACATCAGATAGGAACCAAACTGTCTCACGACGTTTTGAACCCAGCTCGCGTACCGCTTTAAT
GGGCGAACAGCCCAACCCTTGGAACCGACTCCAGCTCCAGGATGCGATGAGCCGACATCGAGGTGCCAAACCTTCCCGTC
GATGTGATCTCTTGGGAAAGATAAGCCTGTTATCCCCGGGGTAGCTTTTATCCGTTGAGCGACGGCCTTTCCACGAAGAA
CCGCCGGATCACTAAGTCCTGCTTTCGCACCTGCTCGACTTGTAGGTCTCACAGTCAATCACACTTCTACCTTTATGCTC
TTAGATACGGTTTCTGACCGTATTGAGTGTAACTTTGAACGCCTCCGTTACCCTTTAGGAGGCGACCGCCCCAGTCAAAC
TACCCACCACACACTGTCCTCTTCCCGGATAACGGGAACAAGTTAGAAGTTCAATGTAACAAGGGTGGTATTTCAACGGC
GACTACTCTTAAACTAGCGTTCAAGCATCAACGTCTCCCACCTATCCTACACATGTTAAATCAAACTCCAATATGAAGTT
ATAGTAAAGCTCCACGGGGTCTTTTCGTCTAGATGCGGGTCTCCGGCGTCTTCGCCGGAACCATAATTTCACCGAGTCTA
TTGTCGAGACAGTTAAGAGATAATTACTCCTTTCGTGCAGGTCAGTATTTAGCCGACAAGGAATTTCGCTACCTTAGGAC
CGTTATAGTTACGGCCGCCGTTCACCCGGGCTTCACATTAATGCTTCGCTAATGCTAACACCTCTGCTTAACCTTCGGGC
ACTGGGCAGGAGTCACCCCATATACATCATCTTACGACTTAGCATAGAGCTGTGTTTTTGATAAACAGTTCCCCCTTACT
ATTCACTGCGGCCCACATTTTATTGTGGGCATCCCTTCTTGCGAACTTACGGGATGAATTTGCAGAGTTCCTTGACAATA
GTTTTCTCGCTCGCCTTAGAATACTCATCTTGGGGACGTGTGTCCGTTCTCGGTACGGGTTTCCTAACACTTAATGTTAG
AAGCTTTTTTAAGAGGCATGAAATCATCTAATTCGCTACTCAGTTGCCCTTTTGCTATGCGTCGTAACTCCCAGTTAAGT
TATGCGGATTTGCCTACATAACCCAGTTGTTACTTACCCCACAATCCAATTAGTGGTAAAATTATCCTTCCCCGTCACTC
CATCACATGTTAAGAAAGTACAGGAATATTAACCTGTTGTCCATCGGCTACGCCTTTCGGCCTCGTCTTAGGACCCGACT
AACCCTGGGTGGACGAACCTTGCCCAGGAAACCTTCCCCAATAGGCGTCAGAGATTCTCACTCTGAATCGTTACTCATAC
CGGCATTCTCACTTGTAAGCGCTCCACCAGTCCTCACGGTCTGGCTTCTAAGCCCTTACAACGCTCTCCTAACGCATTTC
TGCCCGTAGCTTCGGTATTGTGTTTTAGTCCCGTTGAATTATCGGCACAAAGTCTCTCGACTAGTGAGCTATTACGCACT
CTTTAAACGGTGGCTGCTTCTAAGCCAACATCCTAGCTGTTTAAGAAACTTCACAACCTTTCTCACTTAACACAATTTTG
GGACCTTAGCTGACGATCTGGGTTGTTCCCCTCGCGTGCATCGACGTTATCACCGATGTACCGACTGCATAGTAATACAT
GATAGTATTCGGAGTTTGATTATAGTCAGTACGGCTAGGCGCCGCCATTCCATATTCAGTGCTCTACCCCCATCATTTAA
CACTACACGCTAGCCCTAAAGCTATTTCGGAGAGAACCAGCTATCTCCAAGTTCGATTGGAATTTCACCCCTACCCACAA
GTCATCCGGGCACTTTTTAGCGTACTGCGGTTCGGTCCTCCACTTAGTGTTACCTAAGTTTCAACCTGCTCATGGGTAGA
TCACCTGGTTTCGGGTCTATATCAACATACTAAATCGCCCTATTCAGACTCGATTTCTCTACGGCTTCGCTTTATTCTAC
TTAACCTCGCATGTTGACATAACTCGCCGGTCCATTCTGCAAGATGTACGCCATCACCCATTAACGGGCTCTGACTAACT
GTAAGTAATTGGTTTCAGAATCTATTTCACTCCCCTCCCGGGGTTCTTTTCACCTTTCCCTCACGGTACTAGTTCACTAT
CGGTGTCTGGTTAGTATTTAGCCTTACCGGGTGGTCCCGGCAAATTCAGACAGGGTTTCACGTGCCCCGCCCTACTCAGG
ATACTGCTAGGAGATTTATACATTTCGCTTACGGGAATTTCACCCTCTATGTTTAAGCGTTCCAACTTATTCTGCTATGT
ACAAATTCATTAATCCATGTCGCAGTCCTACAACCCCAACAACATGTGTTGGTTTGGGCTCTTCCCCGTTCGCTCGCCAC
TACTTAGGGAATCATTCTTTATTTTCTCTTCCTGCTGCTACTGAGATGTTTCAATTCACAGCGTGTCTCTTCATTCGACT
ATGAATTCATCGATATGATAATTGAGGATTAGCTCAATTAGGTTTCCCCATTCGGAAATCCCCGGATAACAGCTTATTTC
CAGCTAACCGAGGCTTATCGCAGGTAATCACGTCCTTCATCGACTTCCAGACCCAAGGCATCCACCAAAAACTCTTGCTT
GTTT

>MEG_3982|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
AGCTACTAAGAGCGAATGGTGGATGCCTTGACTGGTAAAGGCGATGAAGGACGTACTAGACTGCGATAAGCTACGGGGAG
CTGTCAAGAAGCTTTGATCCGTAGATTTCCGAATGGGGCAACCCAATGTATAGAGATATACATTACCTATATAGGAGCGA
ACGAGGGGAATTGAAACATCTTAGTACCCTCAGGAAAAGAAATCAATAGAGATTGCGTCAGTAGCGGCGAGCGAAAGCGC
AAGAGGGCAAACCCAGTGCTTGCACTGGGGGTTGTAGGACTGCAATGTGCAAGAGCTGAGTTTAGCAGAACATTCTGGAA
AGTATAGCCATAGAGGGTGATAGTCCCGTATGCGAAAAACAAAGCTTAGCTAGCAGTATCCTGAGTAGGGCGGGACACGA
GGAATCCTGTCTGAATCCGGGTCGACCACGATCCAACCCTAAATACTAATACCAGATCGATAGTGCACAAGTACCGTGAG
GGAAAGGTGAAAAGAACTGAGGTGATCAGAGTGAAATAGAACCTGAAACCATTTGCTTACAATCATTCAGAGCACTATGT
AGCAATACAGTGTGATGGACTGCCTTTTGCATAATGAGCCTGCGAGTTGTGGTGTCTGGCAAGGTTAAGCAAACGCGAAG
CCGTAGCGAAAGCGAGTCTGAATAGGGCGCTTAGTCAGATGCTGCAGACCCGAAACGAAGTGATCTATCCATGAGCAAGT
TGAAGCTAGTGTAAGAACTAGTGGAGGACTGAACCCATAGGCGTTGAAAAGCCCCGGGATGACTTGTGGATAGGGGTGAA
AGGCCAATCAAACTTCGTGATAGCTGGTTCTCTCCGAAATATATTTAGGTATAGCGTTGTGTCGTAATATAAGGGGGTAG
AGCACTGAATGGGCTAGGGCATACACCAATGTACCAAACCCTATCAAACTCCGAATACCTTATATGTAATCACAGCAGTC
AGGCGGCGAGTGATAAAATCCGTCGTCAAGAGGGAAACAACCCAGACTACCAGCTAAGGTCCCTAAATCTTACTTAAGTG
GAAAACGATGTGAAGTTACTTAAACAACCAGGAGGTTGGCTTAGAAGCAGCCATCCTTTAAAGAAAGCGTAATAGCTCAC
TGGTCTAGTGATTTTGCGCGGAAAATATAACGGGGCTAAAGTAAGTACCGAAGCTGTAGACTTAGTTTACTAAGTGGTAG
GAGAGCGTTCTATTTGCGTCGAAGGTATACCGGTAAGGAGTGCTGGAGCGAATAGAAGTGAGCATGCAGGCATGAGTAGC
GATAATTAATGTGAGAATCATTAACGCCGTAAACCCAAGGTTTCCTACGCGATGCTCGTCATCGTAGGGTTAGTCGGGTC
CTAAGTCGAGTCCGAAAGGGGTAGACGATGGCAAATTGGTTAATATTCCAATACCAACATTAGTGTGCGATGGAAGGACG
CTTAGGGCTAAGGGGGCTAGCGGATGGAAGTGCTAGTCTAAGGTCGTAGGAGGTTATACAGGCAAATCCGTATAACAATA
CTCCGAGAACTGAAAGGCTTTTTGAAGTCTTCGGATGGATAGAAGAACCCCTGATGCCGTCGAGCCAAGAAAAGTTTCTA
AGTTTAGCTAATGTTGCCCGTACCGTAAACCGACACAGGTGGGTGGGATGAGTATTCTAAGGCGCGTGGAAGAACTCTCT
TTAAGGAACTCTGCAAAATAGCACCGTATCTTCGGTATAAGGTGTGGTTAGCTTTGTATTAGGATTTACTCTGAAAGCAA
GGAAACTTACAACAAAGAGTCCCTCCCGACTGTTTACCAAAAACACAGCACTCTGCTAACTCGTAAGAGGATGTATAGGG
TGTGACGCCTGCCCGGTGCTCGAAGGTTAATTGATGGGGTTAGCATTAGCGAAGCTCTTGATCGAAGCCCGAGTAAACGG
CGGCCGTAACTATAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGTTAAATACCGACCTGCATGAATGGCGTAACGAGAT
GGGAGCTGTCTCAAAGAGGGATCCAGTGAAATTGTAGTGGAGGTGAAAATTCCTCCTACCCGCGGCAAGACGGAAAGACC
CCGTGGACCTTTACTACAGCTTGACACTGCTACTTGGATAAGAATGTGCAGGATAGGTGGGAGGCTTTGAGTATATGACG
CCAGTTGTATATGAGCCATTGTTGAGATACCACTCTTTCTTATTTGGGTAGCTAACCAGCTTGAGTTATCCTCAAGTGGG
ACAATGTCTGGTGGGTAGTTTGACTGGGGCGGTCGCCTCCCAAATAATAACGGAGGCTTACAAAGGTTGGCTCAGAACGG
TTGGAAATCGTTCGTAGAGTATAAAGGTATAAGCCAGCTTAACTGCAAGACATACAAGTCAAGCAGAGACGAAAGTCGGT
CTTAGTGATCCGGTGGTTCTGTGTGGAAGGGCCATCGCTCAAAGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTCC
CCCAAGAGCTCACATCGACGGGGAGGTTTGGCACCTCGATGTCGGCTCATCGCATCCTGGGGCTGGAGCAGGTCCCAAGG
GTATGGCTGTTCGCCATTTAAAGCGGTACGCGAGCTGGGTTCAGAACGTCGTGAGACAGTTCGGTCCCTATCTGCCGTGG
GCGTAAGAAGATTGAAGAGATTTGACCCTAGTACGAGAGGACCGGGTTGAACAAACCACTGGTGTAGCTGTTGTTCTGCC
AAGAGCATCGCAGCGTAGCTAAGTTTGGAAAGGATAAACGCTGAAAGCATCTAAGCGTGAAGCCAACTCTAAGATGAATC
TTCTCTAAGCTCTCTAGAAGACTACTAGTTTGATAGGCTGGGTGTGTAATGGATGAAAGTCCTTTAGCTGACCAGTACTA
ATAGAGCGTTTGGCTTATCTTTAATAAAGCAT

>MEG_3983|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
AGGTTAAGTTAATAAGGGCGCACGGTGGATGCCTTGGCACTAGGAGCCGACGAAGGACGTGACAAACGACGATATACCTT
GGGTAGCTGTAAGTAAGCGATGATCCAGGGATTTCCGAATGGGGGAACCCAACAGGTAATACCTGTTACCCACATCTGTT
AAGGATGTGAGGAGGAAGACGCAGTGAACTGAAACATCTAAGTAGCTGCAGGAAGAGAAAGCAAAAGCGATTGCCTTAGT
AGCGGCGAGCGAAACGGCAGAAGGGCAAACCGAAGAGTTTACTCTTCGGGGTTGTAGGACTGCAATGTGGACTCAAAGAT
TATAGAAGAATGATTTGGGAAGATCAGCCAAAGAGAGTAATAGCCTCGTATTTAAAATAGTCTTTGTACCTAGCAGTATC
CTGAGTACGGCGGGACACGTGAAATCCCGTCGGAATCTGGGAGGACCATCTCCCAACCCTAAATACTCCCTAGTGACCGA
TAGTGAACCAGTACCGTGAGGGAAAGGTGAAAAGCACCCCGGGAGGGGAGTGAAATAGAACCTGAAACCGTGTGCCTACA
ACAAGTTCGAGCCCGTTAATGGGTGAGAGCGTGCCTTTTGTAGAATGAACCGGCGAGTTACGTTATGATGCGAGGTTAAG
TTGAAGAGACGGAGCCGTAGGGAAACCGAGTCTGAACAGGGCGAATTAGTATCATGACGTAGACCCGAAACCATGTGACC
TACCCATGAGCAGGTTGAAGGTGCGGTAAGACGCACTGGAGGACCGAACCAGGGCACGTTGAAAAGTGCTTGGATGACTT
GTGGGTAGCGGAGAAATTCCAAACGAACTTGGAGATAGCTGGTTCTCTCCGAAATAGCTTTAGGGCTAGCGTCGACATTA
GAGATTCTTGGAGGTAGAGCACTGTTTGGGTGAGGGGTCCATCCCGGATTACCAATCTCAGATAAACTCCGAATGCCAAT
GAATTATGGTCGGCAGTCAGACTGCGAGTGCTAAGATCCGTAGTCGAAAGGGAAACAGCCCAGACCACCAGCTAAGGTCC
CAAAATAATTGTTAAGTGGAAAAGGATGTGGGGTTGCACAGACAACTAGGATGTTAGCTTAGAAGCAGCTATTCATTCAA
AGAGTGCGTAATAGCTCACTAGTCGAGTGACCCTGCGCCGAAAATGTACCGGGGCTAAAACAATTTACCGAAGCTGTGGA
TACCTTTATAGGTATGGTAGGAGAGCGTTCTATGTGTGATGAAGGTATACCGTGAGGAGTGCTGGAACGCATAGAAGTGA
GAATGCCGGTATGAGTAGCGAAAGACAGGTGAGAATCCTGTCCACCGTAAGACTAAGGTTTCCAGGGGAAGGCTCGTCCG
CCCTGGGTTAGTCGGGACCTAAGGAGAGACCGAAAGGTGTATCCGATGGACAACAGGTTGATATTCCTGTACTAGAGTAT
GTAGTGATGGAGGGACGCAGTAGGCTAACTAAAGCAGACGATTGGAAGAGTCTGTCTAAGCAGTGAGGTGTGAATTGAGT
CAAATGCTTAATTCTATAACATTGAGCTGTGATGGGGAGCGAAGTTTAGTAGCGAAGTTAGTGACGTCACACTGCCAAGA
AAAGCTTCTAGCGTTTAAACATACTCTACCCGTACCGCAAACCGACACAGGTAGTCGAGGCGAGTAGCCTCAGGTGAGCG
AGAGAACTCTCGTTAAGGAACTCGGCAAAATGACCCCGTAACTTCGGGAGAAGGGGTGCTGACTTTAGGTCAGCCGCAGT
GAATAGGCCCAAGCAACTGTTTATCAAAAACACAGCTCTCTGCTAAATCGTAAGATGATGTATAGGGGGTGACGCCTGCC
CGGTGCTGGAAGGTTAAGAGGAGTGCTTAGCGTAAGCGAAGGTATGAATTGAAGCCCCAGTAAACGGCGGCCGTAACTAT
AACGGTCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCCGCACGAAAGGCGTAATGATTTGGGCACTGTCTCA
ACGAGAGACTCGGTGAAATTTTAGTACCTGTGAAGATGCAGGTTACCCGCGACAGGACGGAAAGACCCCATGGAGCTTTA
CTGCAGTTTGATATTGAGTGTCTGTACCACATGTACAGGATAGGTAGGAGTCTAAGAGATCGGGACGCCAGTTTCGAAGG
AGACGCTGTTGGGATACTACCCTTGTGTTATGGCCACTCTAACCCAGATAGGTGATCCCTATCGGAGACAGTGTCTGACG
GGCAGTTTGACTGGGGCGGTCGCCTCCTAAAAGGTAACGGAGGCGCCCAAAGGTTCCCTCAGAATGGTTGGAAATCATTC
GCAGAGTATAAAGGTATAAGGGAGCTTGACTGCGAGAGCTACAACTCGAGCAGGGACGAAAGTCGGGCTTAGTGATCCGG
TGGTTCCGTATGGAAGGGCCATCGCTCAACGGATAAAAGCTACCCTGGGGATAACAGGCTTATCTCCCCCAAGAGTTCAC
ATCGACGGGGAGGTTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGTAGTCGGTCCCAAGGGTTGGGCTGTTCG
CCCATTAAAGCGGCACGCGAGCTGGGTTCAGAACGTCGTGAGACAGTTCGGTCCCTATCCGTCGCGGGCGTAGGAAATTT
GAGAGGATCTGCTCCTAGTACGAGAGGACCAGAGTGGACTTACCGCTGGTGTACCAGTTGTCTTGCCAAAGGCATCGCTG
GGTAGCTATGTAGGGAAGGGATAAACGCTGAAAGCATCTAAGTGTGAAACCCACCTCAAGATGAGATTTCCCATGATTAT
ATATCAGTAAGAGCCCTGAGAGATGATCAGGTAGATAGGTTAGAAGTGGAAGTGTGGCGACACATGTAGCGGACTAATAC
TAATAGCTCGAGGACTTATCCAAA

>MEG_3984|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
ATATGGTCAAGTCATTGGTCTGATTAGTGCTGCTCAGCTGAACAGGTATTTCTTCCCTGCTTACACTTGCAGTCTATCAA
CGTCGTAGTCTCCAACGAAACTCATAGGGAAAGTTAATCTTGAAGGAGGCTTCCCACTTAGATGCTTTCAGCGGTTATCC
CGTCCGCACATAGCTACTCTGCGATGCTCTTGGCAGAACAACAGATACACCAGCGGTGCGTTCATTCCGGTCCTCTCGTA
CTAAGAATGACTCTTCTCAACTTTCCAACGCCCACAACGGATAGGGACCAAACTGTCTCACGACGTTCTGAACCCAGCTC
GCGTACCGCTTTAATTGGCGAACAGCCAAACCCTTGGGACCTGCTCCAGCCCCAGGATGCGATGAGCCGACATCGAGGTG
CCAAACCTCCCCGTCGATATGAACTCTTGGGGGAGATAAGCCTGTTATCCCCGGAGTACCTTTTGTCCGTTTAGCGATGG
CCCTTCCACTCGGGACCACCGGATCACTAAAACCTACTTTCGTACCTGCTCGAGATGTCTCTCTCGCAGTCAAGCCACCT
TATGCCTTTATACTCTACTACCGATTTCTATTCGGTTTGAGGTGACCTTTGCACGCCTCCGTTACTCTTTAGGAGGCGAC
CGCCCCAGTCAAACTACCCGCCTGACAATGTCCGACTGCCGGATAACGGCTAATCGTTAGAATCCCATTTTGCGAAGGAT
GGTATTTCAACGATGGCTCCATGAAAGCTGGCGCTCCCACTTCAAAGCCTCCCATCTATCCTACACATCACAAAACAAAA
CTCAATGTCAAGTTATAGTAAAGGTTCACGGGGTCTTTCCGTCCTGTTGCGGGTAATCAGCATCTTCACTGATAATTCAA
TTTCACCGAGTTCTTCCCCGAGACAGTGCCCGGATCGTTACACCATTCGTGCAGGTCGGAACTTACCCGACAAGGAATTT
CGCTACCTTAGGACCGTCATAGTTACGGCCGCCGTTTACTGGGGCTTCAATTCGAAGCTTCGCTTACGCTAACCTCTCCT
TTTAACCTTCCAGCACTGGGCAGGTGTCAATCCCTATACATCCATTTACATGTTTGCAGAGATCTGTGTTTTTGTTAAAC
AGTCGGCCAGGCCTTTTCACTGCGACTCTCCTCTCAATATTGCTACCAAGATTCAAGCGTCTCTTTTTCCGAAGTTACAA
GACTAATTTGCAGAGTTCCTTAGGGAAGATTATCTCGAGCGCCTTAGAATACTCATCTCACCCACCTGTGTCGGTTTGCG
GTACGATTATGACATGCCTAACCTTAGAAATTATTTCTCGACAGCCTAGCTCATGCAACTTCCTGAACCCGAAAGCCCAG
TCACTATCCAGCCTCAACCTTAAAGAAGCAAGCATTTGACTCACCTCAAGTCTAAACTGTTTGACGTTATCTACCAATCT
AACGCGTACATAAACAATCTGTGTCATTCCATCGAAACATATCATAGTACAGGAATATTTACCTGTTTCCCATCGACTAC
GCTTTTCAGCCTCATCTTAGGGGTCGACTAACCCTAGGCAGATTAGCTTTACCTAGGAAACCTTGGGTTTGCGGCGAACG
GGTTTCTCACCCGTTTTCTCGTTACTCATGCCTGCATCCTCACTTCTTATACCTCCAGCCCACCTCACGATGAACCTTCG
ACGGCTTAAAGAACGCTCTCCTACCAATTATAGATTAACTCTATAATTCCCTAGCTTCGGTACTATGTTTGAGCCCCGTT
ACATTTTCGGCGCAAGAACACTCGACCAGTGAGCTGTTACGCACTCTTTAAAGGAATGGCTGCTTCTAAGCCAACCTCCT
GGCTGTTTAAGTATTCTCACATCCTTTCCCACTTAACATAGATTTTGGGACCTTAGCTGAGGATCTGGGCTGTTTCCCTT
TTGACAATGACGCTTATCCGCCGCTGTCTAACTGCCATGTTCTTAACTTACGGTATTCGGAGTTTAGTTGGGTTTGGTAC
TCGGTTAGGAGCCCTAGTCCATTTAGTGCTCTACCCCCGCAAGTAAACACATAACGCTGCCCCTAAAGACATTTCGGAGA
GAACCAGCTATCTCCAAGTTTGATTAGCCTTTCACTCCTACCCACAAGTCATCCAAAGCCTTTTCACGGCCACTGGTTCG
CACCTCCATTCGATGTTACTCGAGTTTCGCGCTGCTCATAGGTAGATCACTTGGCTTCGGGTCGTATAGCATGCAACTAA
TTTCGCCCTATTAAGGCTCGCTTTCACTACGACTACAAGGCTATTACCTCTTAATCTTGCTACATACTATAAGTCGCAGG
CTCATTCTACAAAAGGCACGCCATCAGGCCATCTACTATTGCTAGCAGGGTACCCTCTGACTACTTGTAAGCTTAAGGTT
TCAGGTTCTATTTAATAACCCTCAACGGGAGACTTTTCACCTTTCCCTCACGGTACTCTACACTATTGGTCACTGGTTAG
TATTTTGCCTTGGATAGTGGTCTACCCAGATTCAAACAGGGTTTCACGTGCCCCGCCCTACTCAGGAACGATAAAACCTT
GTCTATATGATTTCGTGTACAGGACTATCACCCACTATGGTCTGCTTTTCCAAAACAGTTCCACTATCATATAAAGCAAA
GTCGATGCATGCAAGTACATCGCTTACCGCCCTACAACACCATAATAACAACGCCTTGCAGCTTGACATTATTAAGGTTT
AGGCTCTTCCCCTTTCGCTCGCCACTACTTAGGGAATCTCAATTTTGATTACTCTTCCTCCAGGTACTTAGATGTTTCAG
TTCCCTGGGTGTCGCCTCATACACCTATGGATTCAGTGTATGATATAGAAGGTTTACTTCTATAGGTTTTCCCATTCGGT
GATCTACGGATCATAGAATATTTGCTTCTCCCCGTAGCTTATCGCAGCTTGTCACGACCTTCATCGCCTTCCAGTGCCTA
GGCATCCACCTTAAGCCCTTACTTACTTGACCATAT

>MEG_3985|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
ATGGTCAAGCCAAACGAGCAATTAGTATTGGTTAGCTACATGTATCACTACACTTCCACACCCAACCTATCAACGTCGTC
GTCTACAACGGCTCTTTAGGGAAATCTTATCTTGAGGTGGGCTTCCCGCTTAGATGCTTTCAGCGGTTATCCCATCCGAA
CATAGCTACTCGGCAATGCCACTGGCGTGACAACCGAAACACCAGAGGTTCGTCCACTCTGGTCCTCTCGTACTAGGAGC
AGATCCTCTCAAATTTCCAACGCCCACGGTAGATAGGGACCGAACTGTCTCACGACGTTCTAAACCCAGCTCGCGTACCT
CTTTAAATGGCGAACAGCCATACCCTTGGGACCTGCTTCAGCCCCAGGATGAGATGAGCCGACATCGAGGTGCCAAACAC
CGCCGTCGATATGAACTCTTGGGCGGTATCAGCCTGTTATCCCCAGAGTACCTTTTATCCGTTGAGCGATGGCCCTTCCA
TACAGAACCACCGGATCACTAAGACCTACTTTCGTACCTGCTCGACTTGTGGGTCTCGCAGTTAAGCGCGCTTTTGCCTT
TATACTCTTTGAACGATTTCCGACCGTTCTGAGCGCACCTTCGTACTCCTCCGTTACTCTTTAGGAGGAGACCGCCCCAG
TCAAACTACCCACCATACATTGTCCTTGGATTTGTTGATCCTAAGTTAGAACCCCAACATAACCAGGGTGGTATTTCAAG
GTTGGCTCCACAAATACTGGCGTATCTGCTTCAAAGCCTCCCACCTATCCTACACAAGTTAGGTCAAAGTTCAATGTAAA
GCTGTAGTAAAGGTTCACGGGGTCTTTCCGTCTAGCCGCGGGTACACAGCATCTTCACTGCGATTTCGATTTCACTGAGT
CTCTGCTGGAGACAGCGCTGCCATCATTATGCCATTCGTGCAGGTCGGAACTTACCCGACAAGGAATTTCGCTACCTTAG
GACCGTTATAGTTACGGCCGCCGTTTACTGGGGCTTCGATCAAGAGCTTCGCTTACGCTAACCCCATCAATTAACCTTCC
AGCACCGGGCAGGCATCACACCCTATACGTCCACTTTCGTGTTTGCAGAGTGCTGTGTTTTTAATAAACAGTTGCAGCAG
CCTGGTATCTGCGACTGCCAACAGCTCAAAGAGCAAGTCTTATCACCATCGGCAGCGTACCTTCTCCCGAAGTTACGGTA
CCATTTTGCCTAGTTCCTTCAGCAGAGTTCTCTCAAGCGCCTTGGTATTCTCTACCTGACCACCTGTGTCGGTTTCGGGT
ACGATTCGTTTATGACTATCGCTTAGAAGCTTTTCCTGGAAGCAGGGTATTTGCCACTTTGCCAGTAAACTGGCTTGCTA
TCAGATCTCATTAATAACCGAGCGGATTTGCCTACTCAGTCTAACTACATCCTTCCACCTGGACAACCATCGCCAGGCTG
GCATAACCTTCTCCGTCCCTCCATCGCATCATAAACAAGTATCGGAATATTAACCGATTTCCCATCGACTACGCCTTTCG
GCCTCGCCTTAGGGGTCGACTCACCCAGCCCCGATTAACGTTGGACTGGAACCCTTGGTCTTCCGGCGAACGGGCTTTTC
ACCCGTTTTGTCGTTACTCACGTCAGCATTCGCTCTTGTGATACCTCCAGCACACCTTACAGTGCACCTTCACAGGCTTA
CACAACGCTCCCCTACCACTTAATTGAAACAATTAAATCCGCAGCTTCGGCTCCTAGTTTGAGCCCCGTTACATCTTCCG
CGCAGGCCGACTCGACTAGTGAGCTATTACGCTTTCTTTAAAGGGTGGCTGCTTCTAAGCCAACCTCCTAGCTGTCTGTG
CCTTCCCACATCGTTTCCCACTTAACTAGGAATTTGGGGCCTTAGCTGGCGGTCTGGGTTGTTTCCCTCTTGACGACGGA
CGTTAGCACCCGCCGTCTGTCTCCCGGATATTACTCATCGGTATTCGGAGTTTGCATCGGTTTGGTAAGTCGGTGTGACC
CCCTAGCCGAAACAGTGCTCTACCCCCAATGGTATTCGTCCGAGGCGCTACCTAAATAGCTTTCGGGGAGAACCAGCTAT
CACCGAGTTTGATTAGCCTTTCACCCCTATCCACAAGTCATCCCCTGGCTTTTCAACGACAGTGGGTTCGGTCCTCCGGT
GCCTGTTACGGCACTTTCAACCTGCTCATGGATAGATCACTCGGTTTCGGGTCTATACCCTGCAACTCATTCGCCCTATT
AAGACTCGGTTTCCCTACGGCTCCCCTATTCGGTTAACCTTGCTACAGAATATAAGTCGCTGACCCATTATACAAAAGGT
ACGCCGTCACCCGACCACTTAATCGTTCTGATTGTCAAATTGTGATTTGACACGATTCATCAAGAAAGTTCTCATACGAC
CATTATTTTTTATGGTTCGCTCTCGTTTTCTTGCCACTTGTTCATTAATGTAGGCTTCACAATAAACAATACGCCATGTT
CTTGCTCTGGTTGAGTAAGTTGTGCCATTATTATGGTCATCAATTCTTTGTTTTAAACTGGTGGTAAAACCAACATAAAA
CTCATCATGATTATCCACGTTTTGTATGACATAGACGTAGTAAAAATTCATTGTTATCCTCAAAACGATTAAGTGGTCGG
GCTCCGACTGCTTGTATGCACACGGTTTCAGGTTCTATTTCACTCCCCTAACAGGGGTTCTTTTCGCCTTTCCCTCACGG
TACTGGTTCACTATCGGTCAGTCAGGAGTATTTAGCCTTGGAGGATGGTCCCCCCATCTTCAGACAGAATTTCTCGTGTT
CCGCCCTACTTAATATGTCGCTTAAACAGTTTCGCATACAGGACTATCACCTACTATGGTTGGCTTTCCCACGCCATTTT
GCTACTGTAAAATTGATCGGCTCCTCCGTGTTCGCTCGCCGCTACTTACGGAATCTCATTTGATGTCTTTTCCTCGGGGT
ACTGAGATGTTTCACTTCTCCCGGTTTGCCTTACACAGTAAACTGTGTAATAACCAACTTATGTTGGTTGGGTTTCCCCA
TTCAGAAATCGCCGGGTCACAGGATATTGCCACCTCACCGACGCTTATCGCAGGCTATCACGTCTTTCATCGCCTCTGAC
TGCCAAGGCATCCACCATGTGCACTTCATTACTTGA

>MEG_3986|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
CAATAAGTTACTAAGGGCTTATGGTGGATGCCTTGGCACTAATAGGCGATGAAGGACGTGTTAACCTGCGATAAGCTTCG
GGTAGGTGGTAAGAACCTCAGATCCGGAGATTTCCGAATGGAGCAATCCGGTAGTTGGAAACAGCTATCATTAATTGATG
AATAAATAGTCAATTAAAGCAATACGTGGTGAAGTGAAACATCTCAGTAGCCACAGGAAAAGAAAACGAATGTGATTCCG
TGTGTAGTGGCGAGCGAAAGCGGAACAGGCCAAACTTATCATTAGATAGGGGTTGTAGGGCTTGCAATGTGGACTTGAAA
ACGATAGAAGAAGCTGTTGGAAAGCAGCGCGCAAAAGGGTGATAGCCCCGTATTTGAAATTGTTTTCATACCTAGCGAGA
TCCCTGAGTAGCTCGGAAAACGTTATTTTGAGTGAATCTGCCCAGACCATTGGGTAAGCCTAAATACTAATTAGTGACCG
ATAGCGAAACAGTACCGTGAGGGAAAGGTGAAAAGAACCCAGAGATGGGAGTGAAATAGATTCTGAAACCATATGCCTAC
AACGTGTCAGAGCACATTAATGTGTGATGGCGTGCGTTTTGAAGTATGAGCCGGCGAGTTATGATAGCAAGCGTTAGTTA
ACCAGGAGATGGGGAGCTGTAGCGAAAGCGAGTTTTAAAAGAGCGTTTGTTTGTTATTATAGACCCGAAACGGGTTGAGC
TAGTCATGAGCAGGTTGAAGGTTGAGTAACATCAACTGGAGGACCGAACCGACTCTCGTTGAAACGATAGCGGATGACTT
GTGATTAGGGGTGAAATTCCAATCGAAATCCGTGATAGCTGGTTCTCGTCGAAATAGCTTTAAGGCTAGCGTGAGATCAC
AAATAAGTGGAGGTAAAGCTACTGAATGTATGATGGCGCCACCTAGGCGTACTGAATACAATTAAACTCTGAATGCCATT
TATTTTATTCTCGCAGTCAGACAGTGGGGGATAAGCTTCATTGTCAAGAGGGGAAGAGCCCAGATCATTAAATAAGGTCC
CCAAAATATACTAAGTGGAAAAGGATGTGAAAGTGCTAAAACAGCAAGGATGTTGGCTTAGAAGCAGCCATCGTTTAAAG
AGTGCGTAACAGCTCACTTGTCGAGTGTTTTTGCGCCGAAGATGTAACGGGGCTAAGTATATTACCGAATTTATGGATAA
GATTTATATCTTGTGGTAGACGAGCGTTGTATTGGAGTTGAAGTCAAAGCGTGAGCATTGGTGGATCCAATACAAGTGAG
AATGCCGGCATGAGTAACGCTTGGGAGTGAGAATCTCCCAAACCGATTGACTAAGGTTTCCTGGACCAGGGTCGTCCTTC
CAGGGTTAGTCTGGACCTAAGCTGAGGCTGAAAAGCGTAGGCGATGGACAACAGGTTAATATTCCTGTACTTACAGTTAG
ACTGATGGAGTGACAAAGAAGGTTTTCCACCCCCATAATTGGATTTGGGGATAAATCATAAGGTGGTACAATAGGCAAAT
CCGTTGTGCATAACATTGAGTGATGATGTCGAGTGAATGAGTGATCAAGTAGCGAAGGTGGTATTAATCATGCTTTCAAG
AAAAGCTTCTAGGGTTAATCTAGCTGTAACCAGTACCGAGAACGAACACACGTAGTCAAGGAGAGGATCCTAAGGTTAGC
GAGTGAACTATAGCCAAGGAACTCTGCAAATTAACCCCGTAAGTTAGCGAGAAGGGGTGCTTATGTAAAAGTAAGCCGCA
GTGAAGAACGAGGGGGGACTGTTTAACTAAAACACAACTCTATGCCAAACCGTAAGGTGATGTATATGGGGTGACACCTG
CCCAGTGCTGGAAGGTTAAAGAAGGAGGTTAGCGCAAGCGAAGCTTTTAACTGAAGCCCCAGTGAACGGCGGCCGTAACT
ATAACGGTCCTAAGGTAGCGAAATTCCTAGTCGGGTAAATTCCGTCCCGCTTGAATGGTGTAACCATCTCTTGACTGTCT
CGGCTATAGACTCGGTGAAATCCAGGTACGGGTGAAGACACCCGTTAGGCGCAACGGGACGGAAAGACCCCGTGAAGCTT
TACTGTAGCTTAATATTGATCAGGACATTATCATGTAGAGAATAGGTAGGAGCAATCGATGCAAGTTCGCTAGGACTTGT
TGATGCGAAAGGTGGAATACTACCCTTGGTTGTGTGCTGTTCTAATTGGTAACTGTTATCCAGTTTCAAGACAGTGTTAG
GTGGGCAGTTTGACTGGGGCGGTCGCCTCCTAAAAGGTAACGGAGGCGTACAAAGGTACCTTCAGTACGGTTGGAAATCG
TATGTAGAGTGTAATGGTGTAAGGGTGCTTGACTGTGAGACATACAGGTCGAACAGGTGAGAAATCAGGTCATAGTGATC
CGGTGGTCCAGTATGGAATGGCCATCGCTCAACGGATAAAAGCTACTCCGGGGATAACAGGCTGATACTGCCCAAGAGTT
CATATCGACGGCAGTGTTTGGCACCTCGATGTCGACTCATCTCATCCTCGAGCTGAAGCAGGTTCGAAGGGTTCGGCTGT
TCGCCGATTAAAGAGATACGTGAGTTGGGTTCAAACCGTCGTGAGACAGGTTGGTCCCTATCTATTGTGCCCGTAGGAAG
ATTGAAGAGTGTTGCTTCTAGTACGAGAGGACCGAAGCGAGGACACCTCTTATGCTCCAGTTGTAGCGCCAGCTGCACCG
CTGGGTAGTAACGTGTCTATTAGATAAACGCTGAAAGCATCTAAGTGTGAAACTATCTCAAAGATTAATCTTCCCATTTC
GCAAGAAAGTAAGAGCCGTCAAAGACGATGACGTTGATAGGTTACAGGTGTAAGCATAGTGATATGTTGAGCTGAGTAAT
ACTAATTGCTCGAGGACTTATTGGA

>MEG_3987|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
CAGACCAAGTTAATAAGAGCTATTGGTGGATGCCTTGGCATTGACAGGCGAAGAAGGACGCGAATACCTGCGAAAAGCTC
CGGCGAGCTGGTGATAAGCAAAGACCCGGAGGTATCCGAATGGGGAAACCCGGTAGAGTAATAGACTACCATTGCATGCT
GAATACATAGGTATGCAAAGCGACACCTGCCGAACTGAAACATCTTAGTAAGCAGAGGAAAAGAAATCGAAGAGATTCCC
TGTGTAGCGGCGAGCGAAAGGGGAATAGCCTAAACCGAGCTGATAAGGCTCGGGGTTGTAGGATTGAGGATAAAGGATCA
GGACTCCTAGTTGAACACATCTGGAAAGATGGATGATACAGGGTGATAGTCCCGTAGACGAAAGGAGAGAAAGACCGACC
TCAACACCTGAGTAGGACTAGACACGTGAAACCTAGTCTGAATCTGGGGAGACCACTCTCCAAGGCTAAATACTAGTCAA
TGACCGATAGTGAACCAGTACTGTGAAGGAAAGGCGAAAAGAACCCTTGTTAAGGGAGTGAAATAGAACCTGAAACCAGT
AGCTTACAAGCGGTCGGAGACCAATGGCCCGTAAGGGTCAAGGTTGACGGCGTGCCTTTTGCATGATGAGCCAGGGAGTT
AAGCTAAACGGCGAGGTTAAGGGATATACATTCCGGAGCCGGAGCGAAAGCGAGTTTTAAAAGAGCGAAGAGTCGTTTGG
TTTAGACACGAAACCAAGTGAGCTATTTATGACCAGGTTGAAGCATGGGTAAAACTATGTGGAGGACCGAACTAGTACCT
GTTGAAAAAGGTTTGGATGAGTTGTGAATAGGGGTGAAAGGCCAATCAAACTTGGAGATATCTTGTTCTCTCCGAAATAA
CTTTAGGGTTAGCCTCGGATAATAAGCTTTTGGGGGTAGAGCACTGAATTCTAGCGGGGGCCTACCGGCTTACCAACGGA
AATCAAACTCCGAATACCAGAAGCGAGTCCGGGAGATAGACAGCGGGGGCTAAGCTTCGTTGTCGAGAGGGGAACAGCCC
AGACCGCCGATTAAGGTCCCTAATTTTATGCTAAGTGGGTAAGGAAGTGATGATTCGAAGACAGTTGGAATGTTGGCTTA
GAGGCAGCAATCATTTAAAGAGTGCGTAACAGCTCACCAATCGAGAATCATTGCGCCGATAATAAACGGGACTAAGCATA
AAACCGACATCGCGGGTGTGTCGATAAGACACGCGGTAGGAGAGCGTAGTATTCAGCAGAGAAGGTGTACCGGAAGGAGC
GCTGGAGCGGATACTAGTGAAGATCCATGGCATAAGTAACGATAAAGGGAGTGAAAATCTCCCTCGCCGTAAGCCCAAGG
TTTCCAGGGTCAAGCTCGTCTTCCCTGGGTTAGTCGGCCCCTAAGTTGAGGCGTAACTGCGTAGACGATGGAGCAGCAGG
TTAAATATTCCTGCACCACCTAAAACTATAGCGAAGGAATGACGGAGTAAGTTAAGCACGCGGACGATTGGAAGAGTCCG
TAGAGCGATGAGAACGGTTAGTAGGCAAATCCGCTAACATAAGATCAGGTCGCGATCAAGGGGAATCTTCGGGGGAACCG
ATGGTGTGGAGCGAGGCTTTCAAGAAATAATTTCTAGCTGTTGATGGTGACCGTACCAAAACCGACACAGGTGGGCGAGA
TGAATATTCTAAGGCGCGCGAGATAACTTTCGTTAAGGAACTCGGCAAATTATCCCCGTAACTTCGGAATAAGGGGAGCC
TTTTAGGGTGACTATGGAACGATAGGAGCCCCGGGGGGCCGCAGAGAAATGGCCCAGGCGACTGTTTAGCAAAAACACAG
CACTATGCAAACCTCTAAGGGGAAGTATATGGTGTGACGCCTGCCCAATGCCAAAAGGTTAAAGGGATATGTCAGCTGCA
AAGCGAAGCATTGAACCTAAGCCCTGGTGAATGGCCGCCGTAACTATAACGGTGCTAAGGTAGCGAAATTCCTTGTCGGG
TAAGTTCCGACCTGCACGAATGGTGTAACGATCTGGGCACTGTCTCAACGAAAGACTCGGTGAAATTGTAGTAGCAGTGA
AGATGCTGTTTACCCGCGAAAGGACGAAAAGACCCCGTGAACCTTTACTGTACTTTGGTATTGATTTTTGGTTTGTTATG
TGTAGGATAGCCAGGAGACTAAGAACACTCTTCTTCAGGAGAGTGGGAGTCAACGTTGAAATACTGGTCTTAACAAGCTG
GGAATCTAACATTATTCCATGAATCTGGAAGATGGACATTGCCAGACGGGCAGTTTTACTGGGGCGGTATCCTCCTAAAA
AGTAACGGAGGAGCCCAAAGCTTATTTCATCGTGGTTGGCAATCACGAGTAGAGCGTAAAGGTATAAGATAGGTTGACTG
CAAGACCAACAAGTCGAGCAGAGACGAAAGTCGGGCTTAGTGATCCGGCGGTGGAAAGTGGAATCGCCGTCGCTTAACGG
ATAAAAGGTACTCCGGGGATAACAGGCTGATCGCCACCAAGAGTTCATATCGACGTGGCGGTTTGGCACCTCGATGTCGG
CTCATCGCATCCTGGGGCTGGAGAAGGTCCCAAGGGTTTGGCTGTTCGCCAATTAAAGCGGTACGCGAGCTGGGTTCAAA
ACGTCGTGAGACAGTTTGGTCTCTATCCTTCGTGGGCGCAGGATACTTGAGAGGAGCTGTTCCTAGTACGAGAGGACCGG
AATGGACGAACCAATGGTGTGTCGGTTGTTTTGCCAAGGGCATAGCCGGGTGGCTCACGTTCGGAAAGGATAAGCATTGA
AAGCATCTAAATGCCAAGCCTCCCTCAAGATAAGGTATCCCAATGAGACTCCATGTAGACTACGTGGTTGATAGGTTGGA
GGTGTAAGCACAGTAATGTGTTCAGCTAACCAATACTAATAAGTCCAAAGACTTGGTCTT

>MEG_3988|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
CTAAGTTCTTAAGGGCACATGGTGAATGCCTTGGCACTAGAAGCCGAAGAAGGACGTAGGAGGCTGCGATAAGCCTCGGG
GAGCTGCCAACCGAGCTTTGATCCGAGGATGTCCGAATGGGGAAACCCAGCACGAGTGATGTCGTGTTACCCACTGCTGA
ATATATAGGCTTTGGGAGGAAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAAGAGAAAACAACCGTGATTCCGTG
AGTAGTGGCGAGCGAAAGCGGAAGATGGCTAAACCGCATGCATGTGATACCTGGTAGGGGTTGTGTGTGCGGGGTTGTGG
GAGTTGTACTTGCCGGTTCTACCAGGCCGGCGGACAGTAAAAAAGTGTCGTGATTAGCGGAAGTGGTCTGGGACGGCCCG
CCGCAGACGGTGAGAGTCCGGTACGCGAAAATCCGACACCTGTCTCGTACTTCATCCCGAGTAGCAGCGGGCTCGTGGAA
TCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTAAATACTCTCTAGTGACCGATAGCGGATTAGTACCGTGAGGGAA
TGGTGAAAAGTACCCCGGGAGGGGAGTGAAATAGTACCTGAAACCATGTGCCTACAATCCGTCAAAGCCTCCTTGTGGGG
TGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACACGTCGCGAGGTTAACCCGTGAGGGGTAGCCGTAGCGA
AAGCGAGTCTGAATAGGGCGCCCATAGTGGCGTGTTCTGGACCCGAAGCGGAGTGATCTACCCATGGCCAGGGTGAAGCG
GCGGTAAGACGCCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGTGGGTAGGGGTGAAAGGCCAA
TCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCGCGTGTTTCTTATTGGAGGTAGAGCTACT
GGATGGCCGATGGGCCCTACTAGGTTACTGACGTCAGCCAAACTCCGAATGCCAATAAGTTAGAGCGCGGCAGTGAGACG
GCGGGGGAGAAGCTCCGTACGTCGAGAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCTAAGCGTGTACTAAGTGGAAA
AGGATGTGCAGTCGCAAAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGCGTAATAGCTCACTGGT
CAAGTGATTGTGCGCCGACAATGTAGCGGGGCTCAAGTACACCGCCGAAGCCGCGGCATTCATGCAATACATTCCCTTCG
GGGCAGTGGCATGGATGGGTAGGGGAGCGTCCTGCACCCAGCGAAGCTGCGGAGTAATCCAGCAGTGGAGGGTGCGGGAG
TGAGAATGCAGGCATGAGTAGCGACAGGCAAGTGAGAAACTTGCCCGCCGAATGACCAAGGGTTCCTGGGCCAGGCTAGT
CCTCCCAGGGTAAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCCGTG
TGTGCGCGCCCATGATGAATCATCGGTACTAACCACCCAAAAGGTTCTAGATCAATCTCTTCGGAGTGCGACGTGAACCC
GCTGCGTGGGACCTTCGGTGGTAGTAGTCAAGCGATGGGGTGACGCAGGAAGGTAGCTGTACCGGTTAGTGGTTATACCG
GAGCAAGCCCGTAGGGCGACGTCTAGGTAAATCCGGATGTCATTAAGCCTGAGAGGTGACGCATAGCCGATTGAGGCGAA
TTCAGTGATCCTATGCTGCCAAGAAAAGCCTCTAGTGAGTTCACACACGGCCCGTACCCCAAACCAACACAGGTGGTCAG
GTAGAGAATACTAAGGCGTACGAGATAACTATGGTTAAGGAACTCGGCAAAATACCCCCGTAACTTCGGGAGAAGGGGGA
CCTCGCTTGGTGACCGGACTTGCTCCGTGAGCTGAACGAGGTCGCAGAGACCAGTGAGAAGCGACTGTTTACTAAAAACA
CAGGTCCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCGTTAACC
CTTGGGTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTC
GGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCAACTGTCTCAACCATAGACTCGGCGAAATTGCACTACGAG
TAAAGATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTATAGCTTGGTATTGGCGTTTGGTTCGGTT
TGTGTAGGATAGGTGGGAGACTGTGAAGCAGGCACGCCAGTGTTTGTGGAGTCATCGTTGAAATACCACTCTGATCGTAT
TGAACCTCTAACCTCGGACCGTATATCCGGTCCAGGGACAGTGCCTGGTGGGTAGTTTAACTGGGGCGGTTGCCTCCCAA
AATGTAACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGTTGAGTGCAAGTGCACAAGGGAGCTTGAC
TGCGAGACTTACAAGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCATCTCTGAGTGGAAGGGATGTCGCTCAAC
GGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTC
GGCTCGTCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCTGGGTTTA
GAACGTCGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAACTTGAGGAAACCTGTCCCTAGTACGAGAGGACC
GGGACGGACGAACCTCTGGTGTACCAGTTGTTCCACCAGGAGCACGGCTGGATAGCTACGTTCGGACAGGATAACCGCTG
AAAGCATCTAAGCGGGAAACCTATTCCAAGACCAGGTTTCTTACCCTTTTAGAGGGATAAGGTCACCCACAGACTATGGG
TTCAATAGGCCAGACCTGTAAGCGTAGTAATACGTTCAGGGAACTGGCACTAATCGACCGAAAACTTACTAAT

>MEG_3989|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
CTAAGTTCTTAAGGGCGCATGGTGAATGCCTTGGCACTAGAAGCCGAAGAAGGACGTAGGAGGCTGCGATAAGCCTCGGG
GAGCTGCCAACCGAGCTTTGATCCGAGGATCTCCGAATGGGGAAACCCAGCACGAGTGATGTCGTGTTACCCACTGCTGA
ATATATAGGCTTTGGGAGGAAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAAGAGAAAACAACCGTGATTCCGTG
AGTAGTGGCGAGCGAAAGCGGAAGATGGCTAAACCGCATGCATGTGATACCTGGTAGGGGTTGTGTGTGCGGGGTTGTGG
GAGTTGTACTTGCCGGTTCTACCAGGCCGGCGGACAGTAAAAAAGTGTCGTGATTAGCGGAAGTGGTCTGGGACGGCCCG
CCGCAGACGGTGAGAGTCCGGTACGCGAAAATCCGACACCTGTCTCGTACTTCATCCCGAGTAGCAGCGGGCTCGTGGAA
TCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTAAATACTCTCTAGTGACCGATAGCGGATTAGTACCGTGAGGGAA
TGGTGAAAAGTACCCCGGGAGGGGAGTGAAATAGTACCTGAAACCATGTGCCTACAATCCGTCAAAGCCTCCTCGTGGGG
TGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACACGTCGCGAGGTTAACCCGTGTGGGGTAGCCGTAGCGA
AAGCGAGTCTGAATAGGGCGCCCATAGTGGCGTGTTCTGGACCCGAAGCGGAGTGATCTACCCATGGCCAGGGTGAAGCG
GCGGTAAGACGCCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGTGGGTAGGGGTGAAAGGCCAA
TCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCGCGTGTTTCTTGTTGGAGGTAGAGCTACT
GGATGGCCGATGGGCCCTACTAGGTTACTGACGTCAGCCAAACTCCGAATGCCAATAAGTTAGAGCGCGGCAGTGAGACG
GCGGGGGAGAAGCTCCGTACGTCGAGAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCTAAGCGTGTACTAAGTGGAAA
AGGATGTGCAGTCGCGAAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGCGTAATAGCTCACTGGT
CAAGTGATTGTGCGCCGACAATGTAGCGGGGCTCAAGTACACCGCCGAAGCCGCGGCATTCATGCAATACATTCCCTTCG
GGGCAGTGGCATGGATGGGTAGGGGAGCGTCCTGCACCCAGCGAAGCTGCGAAGTAATTCAGCAGTGGAGGGTGCGGGAG
TGAGAATGCAGGCATGAGTAGCGACAGGCAAGTGAGAAACTTGCCCGCCGAATGACCAAGGGTTCCTGGGCCAGGCTAGT
CCTCCCAGGGTAAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCCGTG
TGTGCGCGCCCATGATGAATCATCGGTACTAACCACCCAAAAGGTTCTAGATCAATCTCTTCGGAGTGCGACGTGAACCC
GCTGCGTGGGACCTTCGGTGGTAGTAGTCAAGCGATGGGGTGACGCAGGAAGGTAGCTGTACCGGTTAGTGGTTATACCG
GAGCAAGCCCGTAGGACGACATCTAGGCAAATCCGGATGTCATACGTCTGAGAGGTGACGCATAGCCGATTGAGGCGAAT
TCAGTGATCCTATGCTGCCAAGAAAAGCCTCTAGTGAGTTCACACACGGCCCGTACCCCAAACCAACACAGGTGGTCAGG
TAGAGAATACTAAGGCGTACGAGATAACTATGGTTAAGGAACTCGGCAAAATACCCCCGTAACTTCGGGAGAAGGGGGAC
CTCGCTTGGTGACCGGACTTGCTCCGTGAGCTGAACGAGGTCGCAGAGACCAGTGAGAAGCGACTGTTTACTAAAAACAC
AGGTCCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCGTTAACCC
TTGGGTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTCG
GGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCAACTGTCTCAACCATAGACTCGGCGAAATTGCACTACGAGT
AAAGATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTATAGCTTGGTATTGGCGTTTGGTTCGGTTT
GTGTAGGATAGGTGGGAGACTGTGAAGCAGGCACGCCAGTGTTTGTGGAGTCATCGTTGAAATACCACTCTGATCGTATT
GAACCTCTAACCTCGGACCGTATATCCGGTCCAGGGACAGTGCCTGGTGGGTAGTTTAACTGGGGCGGTTGCCTCCCAAA
ATGTAACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGTTGAGTGCAAGTGCACAAGGGAGCTTGACT
GCGAGACCTACAAGTCAAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCTCTGAGTGGAAGGGGTGTCGCTCAACG
GATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTCG
GCTCGTCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCTGGGTTTAG
AACGTCGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAACTTGAGGAAACCTGTCCCTAGTACGAGAGGACCG
GGACGGACGAACCTCTGGTGTACCAGTTGTTCCACCAGGAGCACGGCTGGATAGCTACGTTCGGACAGGATAACCGCTGA
AAGCATCTAAGCGGGAAACCTATTCCAAGACCAGGTTTCTTACCCTTTTAGAGGGATAAGGTCACCCACAGACTATGGGT
TCAATAGGCCAGACCTGCAAGCGTAGTAATACGTTCAGGGAACTGGCACTAATCGACCGAAAACTTACTAAT

>MEG_3990|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
CTTTTAAACCGATCGATTTATTAGTATTGGTCAGCTCAACGTATTACTACGCTTACACCTCCAACCTATCAACCTCATAG
TCTATAAGGAATCTCAAGGGAATACTTATCTCTGAGGAGGCTTCCCACTTAGATGCTTTCAGCGGTTATCCTTTCCGTAC
TTAGCTACCCAGCTATGCTCCTGGCGGAACAACTGGAACACCAGTGGTACGTCCACTCCGGTCCTCTCGTACTAAGAGCG
GCTCTCATCAATATTCCAACGCCCACATCAGATAGGGACCAAACTGTCTCACGACGTTTTGAACCCAGCTCGCGTACCGC
TTTAATGGGCGAACAGCCCAACCCTTGGAACCGACTCCAGCTCCAGGATGCGATGAGCCGACATCGAGGTGCCAAACCTT
GCCGTCGATGTGATCTCTTGGGCAAGATAAGCCTGTTATCCCCAGGGTAACTTTTATCCGTTGAGCGACTGCCATTCCAC
AATGTACAGCCGGATCACTAAGTCCTGCTTTCGCACCTGCTCGACTTGTAAGTCTCACAGTCAAGCACACTTCTACCTTT
GCGCTCTACATACGGTTTCTGACCGTACTGAGTGTACCTTTGAACGCCTCCGTTACTCTTTAGGAGGCGACCGCCCCAGT
CAAACTACCCGTCACGCACTGTCCACCCACCTGATGATGATGGCATGTTAGAAACTCAATATACCAAGGGTGGTATTTCA
AGGATGACTCCACGAGAACTAGCGTCCTCGCTTCAAAGTCTCCCACCTATCCTACACATGTTAGACCAAGTTCCAATACG
AAACTGTAGTAAAGCTCCATGGGGTCTTTTCGTCTTGATGCGGGTACCCAGCGTTTTCACTGGGACCATAATTTCACCGA
GTCTAGTGTTGAGACAGTTGAGAGATCATTGCGCCTTTCGTGCAGGTCAGTATTTAGCCGACAAGGAATTTCGCTACCTT
AGGACCGTTATAGTTACGGCCGCCGTTCACCCGGGCTTCATTTCAACGCTTCGCAAATGCTAACGCATCCACTTAACCTT
CGGGCACTGGGCAGGCTTCACCCCCTATACATCACCTTGCGGTTTAGCAGAGAGCTGTGTTTTTGATAAACAGTTGCCCC
TCATAATTTACTGTGGCCTAAGTGTTACCTTAGGCGCCCCTTCTTGCGAACTTACGGGGTCATTTTGCAGAGTTCCTTAA
CACTAGTTTTCTCGCTCGCCTTAGAATACTCATCTCGGGGACGTGTGTCCGTTCTCGGTACAGGTTTCCATAATATTAAG
TTTAGAAGCTTTTCTTGGAAGTGTGGAATCATCTAATTCGGTTTGACCCTATGCATCACGCCTCCCGGTTATAGACTGCG
GATTTGCCTACAGTCACCAGTGAACGCTTACCCCACAATCCAGTAAGTGGTAAGATTATCCTCCTCCGTCACTCCATCAC
TATTATAGAAAGTACAGGAATATTAACCTGTTGTCCATCGGCTACGCTTTTCAGCCTCGTCTTAGGTCCTGACTAACCCT
GGGTGGACGAACCTTGCCCAGGAAACCTTCCCCAATAGGCGTCGTAGATTCTCACTACGAATCGTTACTCATACCGGCAT
TCTCACTTCCTAGCGCTCCACCAGTCCTCACGGTCTGACTTCATTGCCCTAGGAACGCTCCTCTAACGTAAATATAATTA
CCCGCGGCTTCGGTATCGTGTTTTAGTCCCGTTAAATTGTTGGCGCAAGGTCTCTTGACTAGTGAGCTATTACGCACTCT
TTAAAAGGTGGCTGCTTCTGAGCCAACTTCCTAGTTGTTTATGAAACCTCACAACCTTTCTCACTTAACACGATTTTGGG
ACCTTAGCCGGCGATCTGGGTTGTTGCCCTCGCGAGCCGGGACGTTAGCACCCCGGTTCCGACTGCATAGCAATACATAG
CGGTATTCGGAGTTTGATTATAGTCAGTACCCCTAGGCGAGGCCATTCCATATTCAGTGCTCTACCACCACTACTTAACA
CTACACGCTAGCCCTAAAGCTATTTCGAGGAGAACCAGCTATCTCCAAGTTCGATTGGAATTTCTCCACTATTCACAAGT
CATCCGGGCACTTTTCAGCGTACTACGGTTCGGCCCTCCGCTTGGGGTTAGCCAAGTTTCAGCCTGCTCATGAATAGATC
ACATGGTTTCGGGTATATGACAACATACTAAGACGCCCTATTAAGACTCGATTTCTCTACGGCTCCGCTTTTTTCTGCTT
AACCTCGCATGCTGTCATAACTCGCCGGTCCATACTGCAAGATGTACGCCATCACCCATAAACGGGCTCTGACTAATTGT
AAGTAAGTGGTTTCAGAATCTATTTCACTCCCCTCTCGGGGTTCTTTTCACCTTTCCCTCACGGTACTAGTTCACTATCG
GTGTCTGATTAGTATTTAGCCTTACCGGGTGGTCCCGGCAGATTCAGACAGGGTTCCACGTGCCCCGCCCTACTCAGGAT
ACGATCAGAAGACTTAACAATTTCACATACGGGGGTATCACCCTCTATGCCGCTTCTTCCCAAAAGCTTCTGCTATCATT
AAGTTTTGTAACTTCATGTAGATCGTCCTACAACCCCCATTGCTGGGTTTGGGCTCTTTCTCGTTCGCTCGCCGCTACTA
AAGAAATCATTGTTTATTTTCTCTTCCTCTTGCTACTAAGATGTTTCAGTTCACAAGGTGTCTCACTCAAGTTCCTATGA
ATTCAGAACAAGGCAACTAGGCATTACCCTAGTTAGGTTTCCCCATTCGGAAATCCCCGTTTCATAGCATATTTCCGGCT
CCACGAGGCTTATCGCAGGTAATCACGTCCTTCATCGACTTTCAGACCCAAGGCATCCACCACAAACTCTTCCTTATTTA
AAAGTA

>MEG_3991|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
GTGACAAGCTACTAAGTGCGATCGGTGGATGCCTAGGCACCAAGAGCCGATGAAGGACGTTGTAACCTGCGATAAGCCCT
GGGGAGCTGGTAAACGAGCTTTGATCCGGGGATGTCCGAATGGGGAAACCTCGAAGGTGACCAGTTTAGCTACTGGCGAC
CGCCGCCTGAATGTATAGGGCGGTTGGAGGGAACGTGGGGAAGTGAAACATCTTAGTACCCACAGGAAGAGRAAACAACC
GTGAWTCCGTGAATATTGGCGAGCGAAAGCGGAAGAGGCCAAACCGGAGTGTGTGATAGCCGGCAGGTGTTGCATGTGCG
GGGTTGTGGGAAGCGTTTTGACTGAACTGCCGTGAGGTCGGAGAGTGATAAAGGATTGATGAAGCAGAAGCGTCTGGGAA
GGCGCGGCATAGATGGTGATACCCCTGTATGCGTAAGTTGATCTCTCTCTTAATGTTTTCCCAAGTAGTACGGAACCCCT
GAAATYCCGTACGAATCTGGCGGACCACCCGTTAAGCCTAAATACBCCTTGGTGACCGATMGCGGACAAGTACCCGTGAG
GGAAAGGGTGAAAATGTACCCCCGGGAGGGGAGTGAAATAGTMCCTGAAACCGATCGCATACAATCCGTCGGAGCCTGCC
CTTGTGGTGGGTGACGGCGTGCCTTTTGRAAGAATGAGCCTGCGAGTTAGTGGTGTGTGGCGAGGTTAACCCGTGTGGGG
AAGCCGTAGCGAAAGCGAGTCCGAATAGGGCGTTTGAGTCGCATGCTCTAGACCCGAAGCGGTGTGATCTATCCATGGCC
AGGGTGAAGCGACGGTAAGACGTCGTGGAGGCCCGAACCCACCAGGGTTGCAAACCTGGGGGATGAGCTGTGGATAGGGG
TGAAAGGCCAATCAAACACCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCATGTGTTTCTTGTCGGAG
GTAGAGCACTGGATGGTCTAGGGGGCTTACCAGCTTACCGAAATCAGCCAAACTCCGAATGCCGACAAGTGAGAGCATGG
CAGTGAGACGGCGGGGGATAAGCTTCGTCGTCGAGAGGGAAACAGCCCAGATCATCAGCTAAGGCCCCTAAGTGGTGACT
AAGTGGAAAAGGACGTGGAGTTGCGGAGACAACCAGGAGGTTGGCTTGGAAGCAGCCATCCTTGAAAGAGTGCGTAATAG
CTCACTGGTCAAGTGATTCTGCACCGACAATTTAGCGGGGCTCAAGTCATCCGCCGAAGCTGTGGCATCTACGCGTGTAT
CCGGCATCCTTTGGGGTGTCCAGGTGCGTGGATGGGTAGGGGAGCGTTGTGTGTGCGTTGAAGCGGCGGGGTGACCCGGT
CGTGGAGTGCACGCAAGTGAGAATGCAGGCATGAGTAGCGTATGACGGGTGAGAAACCCGTCCGCCGAATATCCAAGGGT
TCCAGGGTCAAGCTAATCTGCCCTGGGTGAGTCGGGTCCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTG
ATATTCCCGTACCGGCGCGAGAACGATCCTGCCGAGGTGAGTGATGCTAAGCATGCAAGGCGGTCGTGGGGGCTTCGGTT
CCCTGATCGTTGAGTCTGTAACCCGATCTTGTAGTAGGCAAGCTGCGGAGGGACGCAGGAAGGTAGTCTGGCACCGTATT
GGTTTGCGGTGTTAAGCCTGTAGGGTGTCTGGCCAGGTAAATCCGGTCGGACGTGTGCCTGAGAGGTGATGAGTGGTGCC
ACTTTTGTGGTACGTATCCGGATGATCCTATGCTGCCTAGAAAATCTTCGTGAGCGAGTTCTCGAGCTGCCCGTACCCCA
AACCGACACTGGTGGATAGGTAGAGAATACCAAGGCGATCGAGATAATCATGGTGAAGGAACTCGGCAAAATCCTCCCGT
AACTTCGGAATAAGGGAGACTGGAGGCGTGACGGCAGTTTACTTGTCGGTGCGTCGATAGTCGCAGAGAATAGGCCCAAG
CGACTGCTTACTAAAAGCACAGGTCCGTGCTAAGTCGAAAGACGATGTATACGGACTGACTCCTGCCCGGTGCTCKGAAG
GTTAAGGGGACGTGTTAGCACTTTTGTGCGAGGCACTGAACTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCC
TAAGGKAGCGAAATTCCTTGTCGGGKAAGTTCCGRCCTGSACGAATGGAGTAACGACTTGGGCGCTGTCTCCACCATGAA
CTCGGCGAAATTGCATTACGAGTAAAGATGCTCGTTACGCGCACAGGGACGGAAAGVNCCCGGGACCTTTACTATAGTTT
GGTATTGGTGATCGGTACGACTTGTGTAGGATAGGTGGGAGACTTTGAAGCGGTCACGCTAGTGATTGTGGAGTCATTGT
TGAAATACCACTCTGGTCGTTCTGGTTATCTAACCTAGGTCCGTGATCCGGATCAGGGACAGTGCCTGATGGGTAGTTTG
ACTGGGGCGGTCGCCTCCMAAAAGGTAACGGAGGCGCCCAAAGGTTCCCTCAGCCTGGTTGGTAATCAGGTGTTGAGTGT
AAGTGCACAAGGGAGCTTGACTGTGAGACAGACATGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCYTCTGGTGGATT
GTGGAATCGCCAGAACTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTTCCCGAGCGCTCACAGCGACGGA
ATGGNTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGTCGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAA
GCGGCACGCGARGCTGGGGKTAAGAACGTCGTGAGACAGTTCCGGKCCCTATACCGCTGCSCGTMGKATCTTGAGAGGGC
TGTCCTTAGTACGCAAGGACCGGGACGGACCAACCTCTGGTGTGCCAGTTGTTCCACCAGGAGCATGGCTGGTTGGCTAC
GTTGGGGAGTGATAACCGCTGAAAGCATCTAAGTGGGAAGCACGCTTCAAGATGAGGGTTCCTGCACAGTTAATGTGGTA
AGGCCCCCGGTAGACCACCGGGTGATAGGTCGGATGTGGAAGCATGGTGACATGTGGAGCTGACCGATACTAAGTGGCCG
AGGGCTTGTCCCACA

>MEG_3992|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
TAAGTGTTTAAGGGCGCATGGTGGATGCCTTGGCATCGAGAGCCGATGAAGGACGTGGGAGGCTGCGATATGCCTCGGGG
AGCTGTCAACCGAGCATTGATCCGAGGATTTCCGAATGGGGAAACCCAGCACGAGTGATGTCGTGTTACCCGCATCTGAA
TATATAGGGTGCGGGAGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAGAAGAAAACAATTGTGATTCCGTAA
GTAGTGGCGAGCGAACGCGGAACAGGCTAAACCGCACGCATGTGATACCGGGTAGGGGTTGTGTGTGCGGGGTTGTGGGA
GGATACATCTCAGCTCTACCTGGCTGAGGGGTAGTCAGAAAGTGTCGTGGTTAGCGGAAGTGGCCTGGGATGGTCTGCCG
TAGACGGTGAGAGCCCGGTACGCGAAAACCCGTCACCTACCTTGTATCAATTCCCGAGTAGCAGCGGGCCCGTGGAATCT
GCTGTGAATCTGCCGGGACCACCCGGTAAGCCTAAATACTTCTCGATGACCGATAGCGGATTAGTACCGTGAGGGAATGG
TGAAAAGTACCCCGGGAGGGGAGTGAAATAGTACCTGAAACCGTGTGCCTACAATCCGTCAGAGCCTCCTTGTGGGGTGA
TGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACACGTCGCGAGGTTAACCCGTGCGGGGTAGCCGCAGCGAAAG
CGAGTCTGAATAGGGCGCATCCCCTTTGGGGTGTAGTGGCGTGTTCTGGACCCGAAGCGGAGTGATCTACCCATGGCCAG
GGTGAAGCGCGGGTAAGACCGCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGTGGGTAGGGGTG
AAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTTGCGTGGTTCACCACGGAGGT
AGAGCTACTGGATGGCCGATGGGCCCTACTAGGTTACTGACGTCAGCCAAACTCCGAATGCCGTGGTGTAAAGCGTGGCA
GTGAGACGGCGGGGGATAAGCTCCGTACGTCGAAAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCTAAGCGTGTGCTA
AGTGGAAAAGGATGTGTAGTCGCAGAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGCGTAATAGC
TCACTGGTCAAGTGATTATGCGCCGATAATGTAGCGGGGCTCAAGCACACCGCCGAAGCCGCGGCACATTCACGTTTACG
TGGATGTGGGTAGGGGGAGCGTCCCTCATTCAGCGAAGCCTCCGGGTGACCGGTGGTGGAGGGTGGGGGAGTGAGAATGC
AGGCATGAGTAGCGATAAGGCAAGTGAGAACCTTGCCCGCCGTAAGACCAAGGGTTCCTGGGCCAGGCCAGTCCGCCCAG
GGTGAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCCGTGTATGGGCG
TCCCTGATGAATCAGCGGTACTAACCACCCAAAACCGGATCGACCATTCCCCTTCGGGGGCATGGAGTTTCGGGGCTGCG
TGGGACCTTCGCTGGTAGTAGTCAAGCAATGGGGTGACGCAGGAAGGTAGCCGTACCAGTCAGTGGTAATACTGGGGCAA
GCCTGTAGGGAGAGCGATAGGCAAATCCGTCGCTCATTAATCCTGAGAGGTGATGCATAGCCGATTGAGGTGAATTCGGT
GATCCTCTGCTGCCAAGAAAAGCCTCTAGCGAGCACATACACGGCCCGTACCCCAAACCAACACAGGTGGTCAGGTAGAG
AATACCAAGGCGTACGAGATAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGAGAAGGGGGGCCGGAA
TACCGTGAACACCCTTGCGGTGGGAGCGGGATCCGGCCGCAGAAACCAGTGGGTAGCGACTGTTTACTAAAAACACAGGT
CCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCGTTAACCGTAAG
GTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTCGGGTA
AGTTCCGACCTGCACGAATGGCGTAACGACTTCCCAACTGTCTCAACCATAGACTCGGCGAAATTGCACTACGAGTAAAG
ATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTACAACTTGGTATTGGTGTTCGGTACGGTTTGTGT
AGGATAGGTGGGAGACTGTGAAATACAGACGCCAGTTTGTATGGAGTCGTTGTTGAAATACCACTCTGATCGTATTGGAC
ACCTAACGTCGAACCCTTATCGGGTTCACGGACAGTGCCTGGCGGGTAGTTTAACTGGGGCGGTTGCCTCCTAAAATGTA
ACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGACGAGTGTAAGTGCACAAGGGAGCTTGACTGCGAG
ACTTACAAGTCAAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCCCCGAGTGGAAGGGGTGTCGCTCAACGGATAA
AAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTCGGCTCG
TCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCTGGGTTTAGAACGT
CGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAACTTGAGGAAACCTGTCCCTAGTACGAGAGGACCGGGACG
GACGAACCTCTGGTATACCAGTTGTTCCACCAGGAGCACGGCTGGATAGCCACGTTCGGACAGGATAACCGCTGAAAGCA
TCTAAGCGGGAAACCTTCTCCAAGATCAGGTTTCTCACCCTTTTAGAGGGATAAGGCCCCCCGCAGACCACGGGTTCGAT
AGGCTAGACCTGGAAGCTCAGCAATGAGTGCAGGGAACTGGCACTAACCGGCCGAAAACTTAC

>MEG_3993|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
TGGTCAAGTTATTAAGGGTGCAGGGCGGATGCCTTGGCACTAGGAGCCGATGAAGGACGTGATAAGCTGCGATAAGCTTC
GGGGAGTTGCACGTAAACTTTGATCCGAAGATTTCCGAATGAGGAAACTCACTTAGAGTAATGTCTAAGTATCATTAAGT
GAATACATAGCTTAATGAGGGGAACTCAGGGAACTGAAACATCTAAGTACCTGAAGGAAGAGAAAGAAATTCGATTCCGT
AAGTAGCGGCGAGCGAACGCGGATTAGCCCAAACCAATAAAGTTTTCTTTATTGGGGTTGAGGACATACCACATATAAGA
GGTCATTATAGACGAAGAAGTTTGGAAAAACTCATCATAGAAGGTAATAATCCTGTAGTCAAAATAATAATTCTTTAGGT
ATGATCCAGAGTACCACGGGACACGTGAAACCCTGTGGGAAGCAGGAGGGACCACCCTCCAAGGCTAAATACTACCTAGT
GACCGATAGCGTATAGTACCGTGAGGGAAAGGTGAAAAGAACCCCGGGAGGGGAGTGAAATAGAACCTGAAACCCTGCAC
TTACAAGCTGTGGAAGCACATTTCTTGTGTGACCGCGTACTTTTTGTAGAACGGGCCAACGAGTTACGTTAAGTAGCAAG
GTTAAGCACTTAAGGTGCGGAGCCGTAGCGAAAGCGAGTTTTAACTGAGCGTTCAGTTACTTGACGTAGACCCGAAACCG
GGCGACCTACCCATGAGCAGGATGAAGCGAAAGTAAAATTTCGTGGAGGTCCGAACCCACGAGCGTTGAAAAGCTCGGGG
ATGACTTGTGGGTAGCGGTGAAATTCCAATCGAGCCCGGAGATAGCTGGTTCTCCCCGAAATAGCTTTAGGGCTAGCCTC
AAGGTGAGAGATACGGAGGTAGAGCACTGAATGTCCTAGGGGGTATTGCACCTACCGAAGACTATCAAACTCCGAATGCC
GTCATCTTATACTTGGGAGTCAGACTGTGGGTGATAAGATTCATAGTCGAAAGGGCAACAGCCCAGATCGTCAGCTAAGG
TCCCTAAATGTAAGTTAAGTGGTAAAGGATGTGGGATTGCACAGACAACCAGGATGTTGGCTTAGAAGCAGCCACTCATT
CAAAGAGTGCGTAATAGCTCACTGGTCGAGTGATCCTGCGCCGAAGATTTCCGGGGCTAAAACTTACTACCGAAGCTACG
GCATCAGTAATGATGGGTAGGGGAGCTTCCCATACGGGTTGAAGCATGACCGTAAGGACATGTGGACAGTATGGGAGTGA
GAATGTTGGCATGAGTAGCGAGATGTGGGTGAGAATCCCACAGGCCGTAAACCCAAGGTTTCCAGGGGAAGGTTCGTCCG
CCCTGGGTTAGTCGGGACCTAAGCTGAGGCCGAAAGGCGTAGGTGATGGACAACAGGTTGATATTCCTGTACTACCGATA
ACCGTTTGAGAGAAGGGATGACACAGTAGGATAAGCTAAGCACACTGTTGGTTATGTGTGCCCAAGCATTGAGGCAGTCA
AAGTAGGCAAATCCGCTTTGATAATGCTGGGATGTGATGGGGAGCGAAATTTAGTAGCGAAGTAGCTGATTTCACACTGT
CAAGAAAAGTCTCTATCGAGGTTAAAGGTACCCGTACCGCAAACCGACACAGGTGGGTGAGGAGAGTATCCTAAGGCCAG
CGAGAGAACTGTTGTTAAGGAACTCGGCAAAATGACCCCGTAACTTAGGGATAAGGGGTGCCACCATCAGGTGGCCGCAG
AGAATAGGCCCAAGCGACTGTTTACCAAAAACATAGGTTTCTGCTAAGTCGCAAGACGATGTATAGGAGCTGACGCCTGC
CCGGTGCTGGAAGGTTAAGGGGATCTGTTAGAGCAATCGAAGCAGTGAACTTAAGCCCCAGTAAACGGCGGCCGTAACTA
TAACGGTCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCCGCACGAAAGGCGTAACGATTTGGGCACTGTCTC
AACAACAGACTCGGTGAAATTGTAATTCCGGTGAAGATGCCGGATACCTGCGACAGGACGGAAAGACCCCATGGAGCTTT
ACTGTAGCTTGACATTGGGTCTTGGTACTACATGTACAGGATAGGTGGGAGGCTTTGAAACCAGGACGCCAGTTTTGGCG
GAGCCATCCTTGGGATACCACCCTTGTAGTACTGGGACTCTAACCATAGGCCATGAATCTGGTCTTGGGACACTGTCAGG
TGGGCAGTTTGACTGGGGCGGTCGCCTCCCAAAAGGTAACGGAGGCGCTCAAAGGTTCTCTCAGTACGGTCGGAAATCGT
ACGTAGAGTGTAAAGGCAAAAGAGAGCTTGATTGCAAGACATACAGGTCGAGCAAGGATGAAAATCGGACTTAGTGATCC
GGTGGTTCTGCGTGGAAGGGCCATCGCTCAACGGATAAAAGCTACCCTGGGGATAACAGGCTTATCTCCCCCAAGAGTCC
ACATCGACGGGGAGGTTTGGCACCTCGATGTCGGCTCATCACATCCTGGGGCTGTAGTAGGTCCCAAGGGTTGGGCTGTT
CGCCCATTAAAGTGGTACGCGAGCTGGGTTCAGAACGTCGTGAGACAGTTCGGTCCCTATCCGTCGCAGGCGTAGGAAAT
TTGAGAAGACCTGTCCTTAGTACGAGAGGACCGGGATGGACGTACCTCTGGTGTACCAGTTGTCCTGCCAAGGGCATGGC
TGGGTAGCTATGTACGGAATGGATAAGCGCTGAAAGCATCTAAGCGCGAAGCCAACTTCAAGATAAGATTTCCCACCGCA
AGGGTAAGACCCCAGAAAGACTATCTGGTTGATAGGTCGAAGGTGTAAGTGCAGCAATGTATTTAGCTTATCGATACTAA
TAGGTCGAGGACTTGACCAA

>MEG_3994|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
TGTGTGTAAGTAAGTGTTTAAGGGCGCATGGTGGATGCCTTGGCATCGAGAGCCGATGAAGGACGTGGGAGGCTGCGATA
TGCCTCGGGGAGCTGTCAACCGAGCATTGATCCGAGGATTTCCGAATGGGGAAACCCAGCACGAGTGATGTCGTGTTACC
CGTATCTGAATATATAGGGTGCGGGAGGTAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAGAAGAAAACAATTGT
GATTCCGTCAGTAGTGGCGAGCGAACGCGGAACAGGCTAAACCGCATGCATGGACAACCGGGTAGGGGTTGTGTGTGCGG
GGTTGTGGGATTGATATGTCTCAGCTCTACCTGGCTGAGGGGTAGTCAGAAAGTGTCGTGGTTAGCGGAAGTGGCCTGGG
ACGGCCCGCCGTAGACGGTGAGAGCCCGGTACGCGAAAACCCGGCACCTGCCTTATATCAACACCCGAGTAGCAGCGGGC
CCGTGGAATCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTAAATACTTCTCGATGACCGATAGCGGATTAGTACCG
TGAGGGAATGGTGAAAAGTACCCCGGGAGGGGAGTGAAATAGTACCTGAAACCGTGTGCCTACAATCCGTCAGAGCCTCC
TCGTGGGGTGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACACGTCGCGAGGTTAACCCGTGCGGGGTAGC
CGCAGCGAAAGCGAGTCTGAATAGGGCGCATCCCCTTTGGGGTGTAGTGGCGTGTTCTGGACCCGAAGCGGAGTGATCTA
CCCATGGCCAGGGTGAAGCGCGGGTAAGACCGCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGT
GGGTAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTTGCGTGGTTC
ACCACGGAGGTAGAGCTACTGGATGGCCGATGGGCCCTACTAGGTTACTGACGTCAGCCAAACTCCGAATGCCGTGGTGT
AAAGCGTGGCAGTGAGACGGCGGGGGATAAGCTCCGTACGTCGAAAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCTA
AGCGTGTGCTAAGTGGAAAAGGATGTGTAGTCGCAGAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAG
TGCGTAATAGCTCACTGGTCAAGTGATTATGCGCCGATAATGTAGCGGGGCTCAAGCACACCGCCGAAGCCGCGGCACAT
TCATCTTTACGGTGGATGTGGGTAGGGGAGCGTCCCCCATTCAGCGAAGCCTCCGGGTGACCGGTGGTGGAGGGTGGGGG
AGTGAGAATGCAGGCATGAGTAGCGATAAGGCAAGTGAGAACCTTGCCCGCCGTAAGACCAAGGGTTCCTGGGCCAGGCC
AGTCCGCCCAGGGTGAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCC
GTGTATGGGCGTCCCTGATGAATCAGCGGTACTAACCACCCAAAACCGGATCGACCATTCCCCTTCGGGGGCGTGGCGAT
TCGGGGCTGCGTGGGACCTTCGCTGGTAGTAGTCAAGCAATGGGGTGACGCAGGAAGGCAGCCGTACCAGTCAGTGGTAA
TACTGGGGCAAGCCCGTAGGGAGAGCGATAGGCAAATCCGTCGCTCACTAATCCTGAGAGGTGATGCATAGCCGGTTGAG
GCGAATTCGGTGATCCTCTGCTGCCAAGAAAAGCCTCTAGCGAGCACATACACGGCCCGTACCCCAAACCAACACAGGTG
GTCAGGTAGAGAATACCAAGGCGTACGAGATAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGAGAAG
GGGGGCCGGAATACCGTGAACACCCTTGCGGTGGGAGCGGGATTCGGCCGCAGAAACCAGTGGGTAGCGACTGTTTACTA
AAAACACAGGTCCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCG
TTAACCCGTAAGGGTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAAT
TCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCCCAACTGTCTCAACCATAGACTCGGCGAAATTGC
ACTACGAGTAAAGATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTACAACTTGGTATTGGTGTTCG
GTACGGTTTGTGTAGGATAGGTGGGAGACTTTGAAGCACAGACGCCAGTTTGTGTGGAGTCGTTGTTGAAATACCACTCT
GATCGTATTGGACACCTAACGTCGAACCCTTATCGGGTTCACGGACAGTGCCTGGCGGGTAGTTTAACTGGGGCGGTTGC
CTCCTAAAATGTAACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGGCGAGTGTAAGTGCACAAGGGA
GCTTGACTGCGAGACTTACAAGTCAAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCCCCGAGTGGAAGGGGTGTC
GCTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCT
CGATGTCGGCTCGTCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCT
GGGTTTAGAACGTCGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAACTTGAGGAAACCTGTCCCTAGTACGA
GAGGACCGGGACGGACGAACCTCTGGTATACCAGTTGTCCCACCAGGGGCACGGCTGGATAGCCACGTTCGGACAGGATA
ACCGCTGAAAGCATCTAAGCGGGAAACCTTCTCCAAGATCAGGTTTCTCACCCTTTTAGAGGGATAAGGCCCCCCGCAGA
CCACGGGATTGATAGGCCAGACCTGGAAGCTCAGTAATGAGTGCAGGGAACTGGCACTAACCGGCCGAAAAC

>MEG_3995|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
TTGTAAGTGTCTAAGGGCGCATGGTGGATGCCTTGGCATCGAGAGCCGATGAAGGACGTGGGAGGCTGCGATAAGCCTCG
GGGAGCTGTCAACCGAGCGTGGATCCGAGGATTTCCGAATGGGGAAACCCAGCACGAGTGATGTCGTGTTACCCGCATCT
GAATATATAGGGTGCGGGAGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAGAAGAAAACAAAAGTGATTCCG
TAAGTAGTGGCGAGCGAACGCGGAACATGGCTAAACCGCACGCATGGGTAACCGGGTAGGGGTTGTGTGTGCGGGGTTGT
GGGATCGATACGTCTCAGCTCTACCCGGCTGAGGGGCAGTCAGAAAGTGTCGTGGTTAACGGAAGTGGCCTGGGATGGTC
TGCCGTAGACGGTGAGAGCCCGGTACGTGAAAACCCGGCACCTGCCTTGTATCAATTCCCGAGTAGCAGCGGGCCCGTGG
AATCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTAAATACTCCTCGATGACCGATAGCGGAATAGTACCGTGAGGG
AATGGTGAAAAGTACCCCGGGAGGGGAGTGAAAGAGTACCTGAAACCGTGTGCCTACAATCCGTCAGAGCCCTTTCGTGG
GGTGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACATGTCGCGAGGTTAACCCGTGCGGGGTAGCCGCAGC
GAAAGCGAGTCTGAATAGGGCGTATCGCGCGCGAGCGTGTGTAGTGGCGTGTTCTGGACCCGAAGCGGAGTGATCTACCC
ATGGCCAGGGTGAAGCGCGGGTAAGACCGCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGTGGG
TAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTTGCGTGTTTCACC
ACGGAGGTAGAGCTACTGGATGGCCGATGGGCCCCACTAGGTTACTGACGTCAGCCAAACTCCGAATGCCGTGGTGTATA
GCGTGGCAGTGAGACGGCGGGGGATAAGCTCCGTACGTCGAAAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCAAAGC
GTGTGCTAAGTGGGAAAGGATGTGCAGTCGCAGAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGC
GTAATAGCTCACTGGTCAAGTGATTGTGCGCCGATAATGTAGCGGGGCTCAAGCACACCGCCGAAGCCGCGACAACCGCA
AGGTTGGGTAGGGGAGCGTCCCTCATTCAGCGAAGCTGCCGGGTGACCGGTGGTGGAGGATGGGGGAGTGAGAATGCAGG
CATGAGTAGCGATAAGGCAAGTGAGAACCTTGCCCGCCGAAAGACCAAGGGTTCCTGGGCCAGGCCAGTCCGCCCAGGGT
GAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCCGTGTGTGGGCGCCC
GTGATGAATCAGCGGTACTAACCACCCAAAACCGGATCGATCACTCCCCTTCGGGGGCGTGGAGGTCTGGGGCTGCGTGG
AGCCTTCGCTGGTAGTAGTCAAGCGATGGGGTGACGCAGGAAGGCAGCCGTACCAGTCAGTGGTAATACTGGGGCAAGCC
AGTAGGGAGAGCGATAGGCAAATCCGTCGCTCACAAATCCTGAGAGGTGACGCATAGCCGATTGAGGCGAATTCGGTGAT
CCTCTGCTGCCAAGAAAAGCCTCTAGCGAGCACACACACGGCCCGTACCCCAAACCGACACAGGTGGTCAGGTAGAGAAT
ACCAAGGCGTACGAGATAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGAGAAGGGGGACCGGAATAC
CGTGAACACCCTTGCGGTGGGAGCGGGATTCGGTCGCAGAAACCAGTGAGAAGCGACTGTTTACTAAAAACACAGGTCCG
TGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCGTTAACCCGCAAGGG
TGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTCGGGTAA
GTTCCGACCTGCACGAATGGCGTAACGACTTCTCAACTGTCTCAACCATAGACTCGGCGAAATTGCACTACGAGTAAAGA
TGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTACAACTTGGTATTGGTGTTCGGTACGGTTTGTGTA
GGATAGGTGGGAGACTGTGAAACCTCAACGCCAGTTGGGGTGGAGTCGTTGTTGAAATACCACTCTGATCGTATTGGACA
CCTAACGTCGAACCCTGAATCGGGTTCACGGACAGTGCCTGGCGGGTAGTTTAACTGGGGCGGTTGCCTCCTAAAATGTA
ACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGGCGAGTGTAAGTGCACAAGGGAGCTTGACTGCGAG
ACCTACAAGTCAAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCTCTGAGTGGAAGGGGTGTCGCTCAACGGATAA
AAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTCGGCTCG
TCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCTGGGTTTAGAACGT
CGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAGCTTGAGGAAACCTGTCCCTAGTACGAGAGGACCGGGACG
GACGAACCTCTAGTGCACCAGTTGTCCCACCAGGGGCACCGCTGGATAGCTACGTTCGGACAGGATAACCGCTGAAAGCA
TCTAAGCGGGAAACCTTCTCCAAGATCAGGCTTCTCACCCACTTGGTGGGATAAGGCCCCCCGCAGAACACGGGTTCGAT
AGGCCAGACCTGGAAGCTCAGTAATGAGTGAAGGGAACTGGCACTAACCGGCCGAAAACTTACCAACACAAATAATCG

>MEG_3996|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
TTGTAAGTGTTTAAGGGCGCATGGTGGATGCCTTGGCACTGGGAGCCGATGAAGGACGTAGGAGGCTGCGATAAGCCTCG
GGGAGCTGTCAACCGAGCGTTGATCCGAGGATGTCCGAATGGGGAAACCCGGCACGAGTGATGTCGTGTCACCAGGCGCT
GAATATATAGGCGTCTGGGGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAAGAGAAAACAAAATGTGATTCC
GTGAGTAGTGGCGAGCGAAAGCGGAGGATGGCTAAACCGTATGCATGTGATACCGGGTAGGGGTTGTGTGTGCGGGGTTG
TGGGACCTATCTTTCCGGCTCTACCTGGCTGGAGGGCAGTGAGAAAATGTTGTGGTTAGCGGAAATGGCTTGGGATGGCC
TGCCGTAGACGGTGAGAGCCCGGTACGTGAAAACCCGACGTCTGTCTTGATGGTGTTCCCGAGTAGCAGCGGGCCCGTGG
AATCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTGAATACTTCCCAGTGACCGATAGCGGATTAGTACCGTGAGGG
AATGGTGAAAAGTACCCCGGGAGGGGAGTGAAAGAGTACCTGAAACCGTGCGCTTACAATCCGTCAGAGCCCTCGACGTG
TCGTGGGGTGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACATGTCGCGAGGTTAACCCGGGTGGGGTAGC
CGCAGCGAAAGCGAGTCTGAATAGGGCGTATCCACGCAACAGTGTGTGGTGTAGTGGTGTGTTCTGGACCCGAAGCGGAG
TGATCTACCCATGGCCAGGGTGAAGCGCGGGTAAGACCGCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGAT
GAGCTGTGGGTAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTTGC
GTGTTTCTTGCCGGAGGTAGAGCTACTGGATGGCCGATGGGCCCCACAGGGTTACTGACGTCAGCCAAACTCCGAATGCC
GGTAAGTCCAAGAGTGCGGCAGTGAGACGGCGGGGGATAAGCTCCGTGCGTCGAGAGGGAAACAGCCCAGATCGCCGGCT
AAGGCCCCTAAGCGTGTGCTAAGTGGAAAAGGATGTGCAGTCGCGAAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACC
CTTGAAAGAGTGCGTAATAGCTCACTGGTCAAGTGATTGTGCGCCGATAATGTAGCGGGGCTCAAGCACACCGCCGAAGC
CGCGGCAACGACCTTGTGTCGTTGGGTAGGGGAGCGTCCTGCATCCGGTGAAGCCGCCGAGTGATCGAGTGGTGGAGGGT
GTGGGAGTGAGAATGCAGGCATGAGTAGCGATTAGGCAAGTGAGAACCTTGCCCGCCGAAAGACCAAGGGTTCCTGGGCC
AGGCCAGTCCGCCCAGGGTGAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCG
TACCCGTGTATGTGCGTCCATGATGAATCAGCGGTACTAACCATCCAAAACCACCGTGACTGCACCTTTCGGGGTGTGGC
GTTGGTGGGGCTGCATGGGACCTTCGTTGGTAGTAGTCAAGCGATGGGGTGACGCAGGAAGGTAGCCGTACCGGTCAGTG
GTAATACCGGGGTAAGCCTGTAGGGAGTCAGATAGGTAAATCCGTCTGGCATATATCCTGAGAGGTGATGCATAGCCGAG
TGAGGCGAATTCGGTGATCCTATGCTGCCGAGAAAAGCCTCTAGCGAGGACATACACGGCCCGTACCCCAAACCAACACA
GGTGGTCAGGTAGAGAATACTAAGGCGTACGAGTGAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGA
GAAGGGGGACCCACATGGCGTGTAAGCCTTTACGGCCCAAGCGTGAGTGGGTGGCACAAACCAGTGAGAAGCGACTGTTT
ACTAAAAACACAGGTCCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGA
CCCGTTAACCCTTCGGGGTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCG
AAATTCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCAACTGTCTCAACCATAGACTCGGCGAAA
TTGCACTACGAGTAAAGATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTACAACTTGGTATTGGTG
CTCGATACGGTTTGTGTAGGATAGGTGGGAGACTGTGAAGCTCACACGCCAGTGTGGGTGGAGTCGTTGTTGAAATACCA
CTCTGATCGTATTGGGCCTCTAACCTCGGACCGTATATCCGGTTCAGGGACAGTGCCTGGTGGGTAGTTTAACTGGGGCG
GTTGCCTCCTAAAATGTAACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGTTGAGTGTAAGTGCACA
AGGGAGCTTGACTGCGAGACGGACATGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCTCTGAGTGGAAGGG
GTGTCGCTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGG
CACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGC
GAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAGCTTGAGGAAACCTGTCCCTAG
TACGAGAGGACCGGGACGGACGAACCTCTGGTATACCAGTTGTCCCACCAGGGGCACGGCTGGATAGCCACGTTCGGACA
GGATAACCGCTGAAAGCATCTAAGCGGGAAACCTCTTCCAAGACCAGGCTTCTCACCCTCTAGGAGGGATAAGGCCCCCC
GCAGACCACGGGATTGATAGACCAGACCTGGAAGCCTAGTAATAGGTGCAGGGAACTGGCACTAACCGGCCGAAAACTTA
CAACACCCCATAATCGTTGTAAGAAGAAAACATTGACGCACC

>MEG_3997|Drugs|MLS|Macrolide-resistant_23S_rRNA_mutation|MLS23S|RequiresSNPConfirmation
GGTTAAGCGACTAAGCGTACACGGTGGATGCCCTGGCAGTCAGAGGCGATGAAGGACGTGCTAATCTGCGATAAGCGTCG
GTAAGGTGATATGAACCGTTATAACCGGCGATTTCCGAATGGGGAAACCCAGTGTGTTTCGACACACTATCATTAACTGA
ATCCATAGGTTAATGAGGCGAACCGGGGGAACTGAAACATCTAAGTACCCCGAGGAAAAGAAATCAACCGAGATTCCCCC
AGTAGCGGCGAGCGAACGGGGAGGAGCCCAGAGCCTGAATCAGTGTGTGTGTTAGTGGAAGCGTCTGGAAAGGCGCGCGA
TACAGGGTGACAGCCCCGTACACAAAAATGCACATGCTGTGAGCTCGATGAGTAGGGCGGGACACGTGGTATCCTGTCTG
AATATGGGGGGACCATCCTCCAAGGCTAAATACTCCTGACTGACCGATAGTGAACCAGTACCGTGAGGGAAAGGCGAAAA
GAACCCCGGCGAGGGGAGTGAAAAAGAACCTGAAACCGTGTACGTACAAGCAGTGGGAGCATGCTTAGGCGTGTGACTGC
GTACCTTTTGTATAATGGGTCAGCGACTTATATTCTGTAGCAAGGTTAACCGAATAGGGGAGCCGAAGGGAAACCGAGTC
TTAACTGGGCGTTAAGTTGCAGGGTATAGACCCGAAACCCGGTGATCTAGCCATGGGCAGGTTGAAGGTTGGGTAACACT
AACTGGAGGACCGAACCGACTAATGTTGAAAAATTAGCGGATGACTTGTGGCTGGGGGTGAAAGGCCAATCAAACCGGGA
GATAGCTGGTTCTCCCCGAAAGCTATTTAGGTAGCGCCTCGTGAACTCATCTCCGGGGGTAGAGCACTGTTTCGGCAAGG
GGGTCATCCCGACTTACCAACCCGATGCAAACTGCGAATACCGGAGAATGTTATCACGGGAGACACACGGCGGGTGCTAA
CGTCCGTCGNGAAGAGGGAAACAACCCAGACCGCCAGCTAAGGTCCCAAAGTCATGGTTAAGTGGGAAACGATGTGGGAA
GGCCCAGACAGCCAGGATGTTGGCTTAGAAGCAGCCATCATTTAAAGAAAGCGTAATAGCTCACTGGTCGAGTCGGCCTG
CGCGGAAGATGTAACGGGGCTAAACCATGCACCGAAGCTGCGGCAGCGACGCTTATGCGTTGTTGGGTAGGGGAGCGTTC
TGTAAGCCTGTGAAGGTGTACTGTGAGGTATGCTGGAGGTATCAGAAGTGCGAATGCTGACATAAGTAACGATAAAGCGG
GTGAAAAGCCCGCTCGCCGGAAGACCAAGGGTTCCTGTCCAACGTTAATCGGGGCAGGGTGAGTCGACCCCTAAGGCGAG
GCCGAAAGGCGTAGTCGATGGGAAACAGGTTAATATTCCTGTACTTGGTGTTACTGCGAAGGGGGGACGGAGAAGGCTAT
GTTGGCCGGGCGACGGTTGTCCCGGTTTAAGCGTGTAGGCTGGTTTTCCAGGCAAATCCGGAAAATCAAGGCTGAGGCGT
GATGACGAGGCACTACGGTGCTGAAGCAACAAATGCCCTGCTTCCAGGAAAAGCCTCTAAGCATCAGGTAACATCAAATC
GTACCCCAAACCGACACAGGTGGTCAGGTAGAGAATACCAAGGCGCTTGAGAGAACTCGGGTGAAGGAACTAGGCAAAAT
GGTGCCGTAACTTCGGGAGAAGGCACGCTGATATGTAGGTGAAGCGACTTGCTCGTGGAGCTGAAATCAGTCGAAGATAC
CAGCTGGCTGCAACTGTTTATTAAAAACACAGCACTGTGCAAACACGAAAGTGGACGTATACGGTGTGACGCCTGCCCGG
TGCCGGAAGGTTAATTGATGGGGTTAGCGCAAGCGAAGCTCTTGATCGAAGCCCCGGTAAACGGCGGCCGTAACTATAAC
GGTCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAATGATGGCCAGGCTGTCTCCACC
CGAGACTCAGTGAAATTGAACTCGCTGTGAAGATGCAGTGTACCCGCGGCAAGACGGAAAGACCCCGTGAACCTTTACTA
TAGCTTGACACTGAACATTGAGCCTTGATGTGTAGGATAGGTGGGAGGCTTTGAAGTGTGGACGCCAGTCTGCATGGAGC
CGACCTTGAAATACCACCCTTTAATGTTTGATGTTCTAACGTTGACCCGTAATCCGGGTTGCGGACAGTGTCTGGTGGGT
AGTTTGACTGGGGCGGTCTCCTCCTAAAGAGTAACGGAGGAGCACGAAGGTTGGCTAATCCTGGTCGGACATCAGGAGGT
TAGTGCAATGGCATAAGCCAGCTTGACTGCGAGCGTGACGGCGCGAGCAGGTGCGAAAGCAGGTCATAGTGATCCGGTGG
TTCTGAATGGAAGGGCCATCGCTCAACGGATAAAAGGTACTCCGGGGATAACAGGCTGATACCGCCCAAGAGTTCATATC
GACGGCGGTGTTTGGCACCTCGATGTCGGCTCATCACATCCTGGGGCTGAAGTAGGTCCCAAGGGTATGGCTGTTCGCCA
TTTAAAGTGGTACGCGAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCCCTATCTGCCGTGGGCGCTGGAGAACTGAG
GGGGGCTGCTCCTAGTACGAGAGGACCGGAGTGGACGCATCACTGGTGTTCGGGTTGTCATGCCAATGGCACTGCCCGGT
AGCTAAATGCGGAAGAGATAAGTGCTGAAAGCATCTAAGCACGAAACTTGCCCCGAGATGAGTTCTCCCTGACTCCTTGA
GGGTCCTGAAGGAACGTTGAAGACGACGACGTTGATAGGCCGGGTGTGTAAGCGCAGCGATGCGTTGAGCTAACCGGTAC
TAATGAACCGTGAGGCTTAACCTT