MEGAResFrom MEG, the Microbial Ecology Group

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MYRA

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

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Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_4106|Drugs|MLS|23S_rRNA_methyltransferases|MYRA
GTGCACCCCGACCTGCTCCCCCACCTCCGCTGCCCGGTCTGCGGCCAGCCGCTGCACCAGGCCGACGCGGCACCACCACG
CGCCCTGCGCTGCCCGGCCGGGCACAGCTTCGACATCGCCCGACAGGGTTACGTCAACCTGCTCACGGGCCGGGCACCGC
ACGTCGGCGACACCGCCGAGATGATCGCCGCCAGGGAGGAGTTTCTGGCCGCCGGGCACTACGACCCGTTCTCGGCGGCA
CTCGCCACCGCGGCCGCGCGGGCGGTGCCACGTCGTGTCCGGCCCGGCGACGGCGTGGGCGAACCGGTGGCGTACCCGGA
TCTGGTGGTGGACGCCGGAGCCGGTACCGGCCGGCACCTCGCCGCAGTGCTCGACGCGGTGCCGACCGCCGTCGGCCTGG
CGCTGGACGTCTCGAAGCCCGCACTACGCCGGGCGGCCCGGGCGCATCCCCGGGCCGGCGCGGCCGTCTGCGACACCTGG
GGCCGGTTGCCGCTGGCCGATGCCACGGTCGCAGTACTGGTCAACGTCTTCGCCCCGCGCAACGGGCCGGAATTCCGTCG
GGTGCTCCGGCCGGACGGCGCCCTGCTCGTGGTGACACCGACCGCCGAACACCTGGTCGAGCTGGTGGACCGGCTGGGGC
TGCTGCGGGTCGACCCGGCCAAGGACGCCCGGGTGGCCGACAGCCTCACGAGACACTTCGAACCGGCCGGGCAGAGCACC
CACCGGCACCGGCTTCAGCTGACCCGGAAGGAGGTGCTGACCCTGGTTGGTATGGGGCCGAGCGCCTGGCACACCGACCC
GGCCCGGCTCACCGCGCGGGTCGCAGCCCTGTCCGAGCCGGTCACGGTCACCGCCGCTGTCCGGCTCGCCCGTTACCGCC
CGATCTGA

>>MEG_4107|Drugs|MLS|23S_rRNA_methyltransferases|MYRA
ATGTCAGCCCTGGCCGCACCTGGCCTCAGCGCTATCCGTGACTCACTCCGGTGCCCGATCTGCGCCGGTCGCCTCGAACT
GACACCGGGGGCACTGCGTTGTCGTCAGCGACACACCTTCAACATCGCTCGGCACGGCTACGTCAGCCTACTGTCTGGGA
CTAATGCGATCAGCGGGGATGATGCGCCGATGATCCAAGCTCGAGAACGTTTCCTCGCGACCGGCGCCTACGAGCCGATA
CGCCGGGCCGTCTCGACGATGGTGTCTCATACGATCCCTCGTGATGGCATAGTTCTCGATGTTGGCTGTGGTACCGGCTA
CTACCTCGCCGGTGCGCTCGACAAAGTGACCGGGGCTCGCGGCCTGGGGCTTGACTCCTCGGTGCGTGCGCTGCGGGTCG
CTGCGCGCGTCCACGAGCGAGCAGCCGCAGCGAGCTGGGACGTGTTCCGCCCGTATCCGTTGGCCGACCAGTCGGTGGAT
GCTGTGCTGAACATGTTCGCTCCGCGCAACCCCGGCGAGTTTCACCGGGTCCTCCGCCCGAACGGCAGCCTGATCGTGGT
GCGTCCGACGGTCGACCACCTGGCCGAGTTGCGCCGCGATGTGCCCGACTCGGTGACTATCGATGTTTCCAAGGAGCAAC
GCCTGCATGACGCCCTGGCACCGTTCTTCGAACAGGAGCGAGATCAACACGTCGGCTACATCGCAGAGATTGAACCGCAA
ACGGCTCGCGATCTGCTCGGAATGACGCCGAGTGCGCGGCACATCACCCCGGCAGAGGTCTCGGACGACGACCTGCCCGA
GCGAGTCACCATATCCGTGCTTGTCAGCTCATACCGGCTACGGGAGACTTGA