MEGAResFrom MEG, the Microbial Ecology Group

ERMX

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_2854|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
atgtctgcatacggacacggccgtcacgagaatggccaaaattttctcaccaaccacaagatcatcaactccatcatcga
ccttgtgaaacaaacctccggccccatcattgagatcggaccaggaagcggtgccctcactcacccgatggcccacttgg
ggagggcgataacggcagttgaagtggacgcaaaactagctgccaaactcacacaagaaacctcctcggcggcggtcgaa
gtggtccatgatgatttccttaacttccggttacccgccactccctgcgtcattgtgggaaacattccctttcacctcac
cactgccattcttcgaaagttgctgcatgcgccagcatggactgacgctgtactcctcatgcagtgggaagtcgctcgcc
gccgggccggggtaggcgcaagcacgatgatgacggctcagtggtccccatggttcacatttcacctgggttctcgggta
ccaaggactgctttccggccacagccaaacgttgacggggggatcttagtgatccgccgggtgggtgacccgaagattcc
gatagagcagcgcaaagcctttcaggcgatggtgcacaccgttttcactgcccggggacgcgggataggggaaattctcc
gaagggcagggttgttttcatcacgttcagaaacacaatcatggttgcgctcgcgaggaatcgaccccgcgaccctacct
cccagattgcacaccaacgactggatcgatctcttccaggtgactggttcctctctacctcaccatcgacccatttcacc
atcgggaagtagtcaacgacctcctcaacggaaaaaccgaagccggcggcgttaa

>>MEG_2855|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
atgtctgcatacggacacggccgtcacgagcatggccaaaattttctcaccaaccacaagatcatcaactccatcatcga
ccttgtgaaacaaacctccggccccatcattgagatcggaccaggaagcggtgccctcactcacccgatggcccacttgg
ggagggcgataacggcagttgaagtggacgcaaaactagctgccaaaatcacacaagaaacctcctcggcggcggtcgaa
gtggtccatgatgatttccttaacttccggttacccgccactccctgcgtcattgtgggaaacattccctttcacctcac
cactgccattcttcgaaagttgctgcatgcgccagcatggactgacgctgtactcctcatgcagtgggaagtcgctcgcc
gccgggccggggtaggcgcaagcacgatgatgacggctcagtggtccccatggttcacatttcacctgggttctcgggta
ccaaggtctgctttccggccacagccaaacgttgacggggggatcttagtgatccgccgggtgggtgacccgaagattcc
gatagagcagcgcaaagcctttcaggcgatggtgcacaccgttttcactgcccggggacgcgggataggggaaattctcc
gaaggcagggttgttttcatcacgttcagaaacacaatcatggttgcgctcgcgaggaatcgaccccgcgaccctacctc
ccagattgcacaccaacgactggatcgatctcttccaggtga

>>MEG_2856|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
atgtctacatacggatacggccgtcacgaacatggccaaaattttctcacagaccacaagatcatcaactccatcgtcga
tcttgtaaaacaaacctccggccccatcattgagatcgggccaggaagcggtgccctcactcacccgatatcccacttgg
ggagggcaataacggcagttgaggtagacgcaaaactagctgccaaactcacaaaaaagaccgcctcggcgtcggtcgaa
gtggtccatgatgatttcctcaacttcccgttacccgccactccctgcgtcattgtgggaaacattccctttcacctcac
cactgccattcttcgaaagttgttgcatgcgccggcatggactgacgctgtactcctcatgcagtgggaagtcgctcgcc
gccgggccggggtaggtgcaagcacnatgatgacggctcagtggtccccatggttcacgtttcaccttggttcccganta
ccaaggtctgctttccggccacagccaaacgttgacggggggatcttagtgatccgccgggtgggtgacccgaagatccc
gatagagcaacgcaaagcctttcaggcgatggtgcacaccgttttcaccgcccggggacgcgggataggggaaattctcc
gaagggcagggttgttttcatcacgttcagagacacaatcatggttgcgctcgcgaggaatcgaccccgcaaccctacct
cccagattgcacaccagcgactggatcgatctcttccaggtgactggttcctctccaccgcgccatcggcccatttcaca
atcgggaagtagtcaacgccctcctcaacggaaaaatcgaggccggcggcggtaa

>>MEG_2857|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
atgtctgcatacggacacggccgtcacgagcatggccaaaattttctcaccaaccacaagatcatcaactccatcatcga
ccttgtgaaacaaacctccggccccatcattgagatcggaccaggaagcggtgccctcactcacccgatggcccacttgg
ggagggcgataacggcagttgaagtggacgcaaaactagctgccaaaatcacacaagaaacctcctcggcggcggtcgaa
gtggtccatgatgatttccttaacttccggttacccgccactccctgcgtcattgtgggaaacattccctttcacctcac
cactgccattcttcgaaagttgctgcatgcgccagcatggactgacgctgtactcctcatgcagtgggaagtcgctcgcc
gccgggccggggtaggcgcaagcacgatgatgacggctcagtggtccccatggttcacatttcacctgggttctcgggta
ccaaggtctgctttccggccacagccaaacgttgacggggggatcttagtgatccgccgggtgggtgacccgaagattcc
gatagagcagcgcaaagcctttcaggcgatggtgcacaccgttttcactgcccggggacgcgggataggggaaattctcc
gaagggcagggttgttttcatcacgttcagaaacacaatcatggttgcgctcgcgaggaatcgaccccgcgaccctacct
cccagattgcacaccaacgactggatcgatctcttccaggtgactggttcctctctacctcaccatcgacccatttcacc
atcgggaagtagtcaacgacctcctcaacggaaaaaccgaagccggcggcgttaa

>>MEG_2858|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
atgtctgcatacggacacggccgtcacgagcatggccaaaattttttcaccaaccacaagatcatcaagtccatcatcga
ccttgtgaaacaaacctccggccccatcattgagatcggaccaggaagcggtgccctcactcacccgatggcccacttgg
ggagggcgataacggcagttgaagtggacgcaaaactagctgccaaaatcacacaagaaacctcctcggcggcggtcgaa
gtggtccatgatgatttccttaacttccggttacccgccactccctgcgtcattgtgggaaacattccctttcacctcac
cactgccattcttcgaaagttgctgcatgcgccagcatggactgacgctgtactcctcatgcagtgggaagtcgctcgcc
gccgggccggggtaggcgcaagcacgatgatgacggctcagtggtccccatggttcacatttcacctgggttctcgggta
ccaaggtctgctttccggccacagccaaacgttgacggggggatcttagtgatccgccgggtgggtgacccgaagattcc
gatagagcagcgcaaagcctttcaggcgatggtgcacaccgttttcactgcccggggacgcgggataggggaaattctcc
gaagggcagggttgttttcatcacgttcagaaacacaatcatggttgcgctcgcgaggaatcgaccccgcgaccctacct
cccagattgcacaccaacgactggatcgatctcttccaggtgactggttcctctctacctcaccatcgacccatttcacc
atcgggaagtagtcaacgacctcctcaacggaaaaaccgaagccggcggcgttaa

>>MEG_2859|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACAGGGCCGTCACGAGCATGGCCAAAATTTTCTCACCAACCACAAGATCATCAACTCCATCATCGA
CCTTGTGAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCCACTTGG
GGAGGGCGATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAAATCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGGTTACCCGCCACTCCCTGCGTCATTGTGGGAAACATTCCCTTTCACCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCAGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCCGGGGTAGGCGCAACGACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCTCGGGTA
CCAAGGTCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAGGGGAAATTCTCC
GAAGGCAGGGTTGTTTTCATCACGTTCAGAAACATAATCATGGTTGCGCTCGCGAGGAATCGACCCCGCGACCCTACCTC
CCAGATTGCTACACCAACGACTGGATCGATCTCTTCCAGGTGACTGGTTCCTCTCTACCTCACCATCGACCCATTTCACC
ATCGGGAAGTAGTCAACGACCTCCTCAACGGAAAAACCGAAGCCGGCGGCGTTAA

>>MEG_2860|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACACGGCCGTCACGAACATGGCCAAAATTTTCTCACCGACCACAAGATCATCAACTCCATCATCGA
CCTTGTAAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCTACTTGG
GGAGGGCAATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAACTCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGTTTACCCGCCACTCCCTGCGTCATTGTGGGAAATATTCCCTTTCATCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCGGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCTGGGGTAGGCGCAAGCACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCCCGGGTA
CCAAGGTCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAAGGGAAATTCTCC
GAAGGGCAGGGTTGTTTTCATCACGTTCAGAAACACAATCATGGTTGCACTCGCGAGGAATCGACCCTGCGACCCTACCT
CCCAGATTGCACACCAGCGACTGGATCGATCTCTTCCAGGTGACTGGTTCCTCTTCACCGCACCATCGACCAATTTCACC
ATCGGGAAGTAGTCAACGACCTCCTCAACGGAAAAACCGAAGCCGGCGGCGTTAA

>>MEG_2861|Drugs|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACACGGCCGTCACGAGCATGGCCAAAATTTTCTCACCAACCACAAGATCATCAACTCCATCATCGA
CCTTGTGAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCCACTTGG
GGAGGGCGATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAAATCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGGTTACCCGCCACTCCCTGCGTCATTGTGGGAAACATTCCCTTTCACCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCAGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCCGGGGTAGGCGCAAGCACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCTCGGGTA
CCAAGGCCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAGGGGAAATTCTCC
GAAGGCAGGGTTGTTTTCATCACGTTCAGAAACACAATCATGGTTGCGCTCGCGAGGAATCGACCCCGCGACCCTACCTC
CCAGATTGCACACCAACGACTGGATCGATCTCTTCCAGGTGA