MEGAResFrom MEG, the Microbial Ecology Group

ERMX

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

Other Groups in 23S rRNA methyltransferases

Sequences

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>MLS|ermX_4_NC_005206|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACACGGCCGTCACGAACATGGCCAAAATTTTCTCACCGACCACAAGATCATCAACTCCATCATCGA
CCTTGTAAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCTACTTGG
GGAGGGCAATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAACTCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGTTTACCCGCCACTCCCTGCGTCATTGTGGGAAATATTCCCTTTCATCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCGGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCTGGGGTAGGCGCAAGCACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCCCGGGTA
CCAAGGTCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAAGGGAAATTCTCC
GAAGGGCAGGGTTGTTTTCATCACGTTCAGAAACACAATCATGGTTGCACTCGCGAGGAATCGACCCTGCGACCCTACCT
CCCAGATTGCACACCAGCGACTGGATCGATCTCTTCCAGGTGACTGGTTCCTCTTCACCGCACCATCGACCAATTTCACC
ATCGGGAAGTAGTCAACGACCTCCTCAACGGAAAAACCGAAGCCGGCGGCGTTAA

>CARD|phgb|AF024666|2207-2969|ARO:3000596|ErmX|MLS|23S_rRNA_methyltransferases|ERMX
TCACCTGGAAGAGATCGATCCAGTCGTTGGTGTGCAATCTGGGAGGTAGGGTCGCGGGGTCGATTCCTCGCGAGCGCAAC
CATGATTGTGTTTCTGAACGTGATGAAAACAACCCTGCCTTCGGAGAATTTCCCCTATCCCGCGTCCCCGGGCAGTGAAA
ACGGTGTGCACCATCGCCTGAAAGGCTTTGCGCTGCTCTATCGGAATCTTCGGGTCACCCACCCGGCGGATCACTAAGAT
CCCCCCGTCAACGTTTGGCTGTGGCCGGAAAGCAGGCCTTGGTACCCGAGAACCCAGGTGAAATGTGAACCATGGGGACC
ACTGAGCCGTCATCATCGTGCTTGCGCCTACCCCGGCCCGGCGGCGAGCGACTTCCCACTGCATGAGGAGTACAGCGTCA
GTCCATGCTGGCGCATGCAGCAACTTTCGAAGAATGGCAGTGGTGAGGTGAAAGGGAATGTTTCCCACAATGACGCAGGG
AGTGGCGGGTAACCGGAAGTTAAGGAAATCATCATGGACCACTTCGACCGCCGCCGAGGAGGTTTCTTGTGTGATTTTGG
CAGCTAGTTTTGCGTCCACTTCAACTGCCGTTATCGCCCTCCCCAAGTGGGCCATCGGGTGAGTGAGGGCACCGCTTCCT
GGTCCGATCTCAATGATGGGGCCGGAGGTTTGTTTCACAAGGTCGATGATGGAGTTGATGATCTTGTGGTTGGTGAGAAA
ATTTTGGCCATGCTCGTGACGGCCGTGTCCGTATGCAGACATC

>MLS|ermX_3_U21300|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACACGGCCGTCACGAGCATGGCCAAAATTTTCTCACCAACCACAAGATCATCAACTCCATCATCGA
CCTTGTGAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCCACTTGG
GGAGGGCGATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAAATCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGGTTACCCGCCACTCCCTGCGTCATTGTGGGAAACATTCCCTTTCACCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCAGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCCGGGGTAGGCGCAAGCACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCTCGGGTA
CCAAGGCCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAGGGGAAATTCTCC
GAAGGCAGGGTTGTTTTCATCACGTTCAGAAACACAATCATGGTTGCGCTCGCGAGGAATCGACCCCGCGACCCTACCTC
CCAGATTGCACACCAACGACTGGATCGATCTCTTCCAGGTGA

>MLS|ErmX|M36726|296-1150|855|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACAGGGCCGTCACGAGCATGGCCAAAATTTTCTCACCAACCACAAGATCATCAACTCCATCATCGA
CCTTGTGAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCCACTTGG
GGAGGGCGATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAAATCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGGTTACCCGCCACTCCCTGCGTCATTGTGGGAAACATTCCCTTTCACCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCAGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCCGGGGTAGGCGCAACGACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCTCGGGTA
CCAAGGTCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAGGGGAAATTCTCC
GAAGGCAGGGTTGTTTTCATCACGTTCAGAAACATAATCATGGTTGCGCTCGCGAGGAATCGACCCCGCGACCCTACCTC
CCAGATTGCTACACCAACGACTGGATCGATCTCTTCCAGGTGACTGGTTCCTCTCTACCTCACCATCGACCCATTTCACC
ATCGGGAAGTAGTCAACGACCTCCTCAACGGAAAAACCGAAGCCGGCGGCGTTAA

>MLS|ermX_2_X51472|MLS|23S_rRNA_methyltransferases|ERMX
ATGTCTGCATACGGACACGGCCGTCACGAGCATGGCCAAAATTTTCTCACCAACCACAAGATCATCAACTCCATCATCGA
CCTTGTGAAACAAACCTCCGGCCCCATCATTGAGATCGGACCAGGAAGCGGTGCCCTCACTCACCCGATGGCCCACTTGG
GGAGGGCGATAACGGCAGTTGAAGTGGACGCAAAACTAGCTGCCAAAATCACACAAGAAACCTCCTCGGCGGCGGTCGAA
GTGGTCCATGATGATTTCCTTAACTTCCGGTTACCCGCCACTCCCTGCGTCATTGTGGGAAACATTCCCTTTCACCTCAC
CACTGCCATTCTTCGAAAGTTGCTGCATGCGCCAGCATGGACTGACGCTGTACTCCTCATGCAGTGGGAAGTCGCTCGCC
GCCGGGCCGGGGTAGGCGCAAGCACGATGATGACGGCTCAGTGGTCCCCATGGTTCACATTTCACCTGGGTTCTCGGGTA
CCAAGGTCTGCTTTCCGGCCACAGCCAAACGTTGACGGGGGGATCTTAGTGATCCGCCGGGTGGGTGACCCGAAGATTCC
GATAGAGCAGCGCAAAGCCTTTCAGGCGATGGTGCACACCGTTTTCACTGCCCGGGGACGCGGGATAGGGGAAATTCTCC
GAAGGCAGGGTTGTTTTCATCACGTTCAGAAACACAATCATGGTTGCGCTCGCGAGGAATCGACCCCGCGACCCTACCTC
CCAGATTGCACACCAACGACTGGATCGATCTCTTCCAGGTGA