MEGAResFrom MEG, the Microbial Ecology Group

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ERMV

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

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Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_2851|Drugs|MLS|23S_rRNA_methyltransferases|ERMV
ATGGCCCGCCCCAGTCGCGTATCCCGCGCGCTCTCGCAGAACTTCCTCGCCGACCGCGCCGCCGCCGGACAGCTCGCCCG
GCTCGCCGCGCCCCACGGCCTCCCCGTCCCGCTGCTGCTCGAAGTCGGCGCGGGCAAAGGCGCGTTGACCGAGCTGCTCG
CCCCGCGCTGTCGCAGTCTCCTCGCCTACGAGATCGACCCACGGCTCGTCCCCGTCCTGCGCTCGCGCTTCGCGGACGCC
CCGCACGTCCGCGTCCTCGGCGAGGACTTCCTGCGCGCCAGGGCGCCGCGCACCCCGTTCTCCGTCGCCGGGAACGTCCC
CTTCTCCCGTACCGCCGCCGTCGTCGCGTGGTGTCTGCGGGCCCCGCACCTCACCGACGCCACCCTGCTCACCCAGCTGG
AGTACGCCCGCAGACGCACCGGCGACTACGGCAGCTGGACGCGGCTGACCGTGCTGACTTGGCCCCGCCACGAGTGGCGG
CTCGCCGGGCGGGTCGGGCGCCGCAGCTTCCGTCCCGTGCCCCGGGTGGACGCGGGGATCGTCCGTATCGAGCGGCGTCG
CACCCCGCTGCTCGCGCCCGGTGCCGACGCCGGCTGGCGGGAGCTGGTCGACCTCGGCTTCTCCGGGGCCGGCGGCTCCC
TGCACGCCTCGCTGCGGCGGGCCCGCCCGAGACGGCGGGTGGACGCGGCGTTCCGCGCGGCGGGGCTCGACCGGGACGTC
CTGGTGGGGGAGGTGCCGCCGTGGACGTGGCTGAGGCTGCACGAGGTGCTGGGCTCGTGA

>>MEG_2852|Drugs|MLS|23S_rRNA_methyltransferases|ERMV
AGGACCGCAGGCCATGGCCCGCCCCAGTCGCGTATCCCGCGCGCTCTCGCAGAACTTCCTCGCCGACCGCGCCGCCGCCG
GACAGCTCGCCCGGCTCGCCGCGCCCCACGGCCTCCCCGTCCCGCTGCTGCTCGAAGTCGGCGCGGGCAAAGGCGCGTTG
ACCGAGCTGCTCGCCCCGCGCTGTCGCAGTCTCCTCGCCTACGAGATCGACCCACGGCTCGTCCCCGTCCTGCGCTCGCG
CTTCGCGGACGCCCCGCACGTCCGCGTCCTCGGCGAGGACTTCCTGCGCGCCAGGGCGCCGCGCACCCCGTTCTCCGTCG
CCGGGAACGTCCCCTTCTCCCGTACCGCCGCCGTCGTCGCGTGGTGTCTGCGGGCCCCGCACCTCACCGACGCCACCCTG
CTCACCCAGCTGGAGTACGCCCGCAGACGCACCGGCGACTACGGCAGCTGGACGCGGCTGACCGTGCTGACTTGGCCCCG
CCACGAGTGGCGGCTCGCCGGGCGGGTCGGGCGCCGCAGCTTCCGTCCCGTGCCCCGGGTGGACGCGGGGATCGTCCGTA
TCGAGCGGCGTCGCACCCCGCTGCTCGCGCCCGGTGCCGACGCCGGCTGGCGGGAGCTGGTCGACCTCGGCTTCTCCGGG
GCCGGCGGCTCCCTGCACGCCTCGCTGCGGCGGGCCCGCCCGAGACGGCGGGTGGACGCGGCGTTCCGCGCGGCGGGGCT
CGACCGGGACGTCCTGGTGGGGGAGGTGCCGCCGTGGACGTGGCTGAGGCTGCACGAGGTGCTGGGCTCGTGA

>>MEG_2853|Drugs|MLS|23S_rRNA_methyltransferases|ERMV
CCCGAGTTCAAGGACAAGGTCGCCACCCCGGCCTTCCAGGAGTACTACAGCGGCGCCATCGGCCTGTCCGAGCTGCGGAC
CCGCCTGGAACGCGACGGCAACCTGGTGCTCGCCCGCTACCAGCGCTGACGTAAATCCCTTTGCGCGCGACGCGGGCACC
TGCCTAGCGTGCCGTCCATGGCAGCGAACAACGCGATCACGAACTCCGGTCTCGGCCGGGGCTGTGCGCACTCCGTACGG
ATGCGCCGTGGCCCCGGAGCCCTGACCGGCCCGGGGAGCCACACCGCCCGCTGATCGCGCGCGCGGACCGCTGTCTCCTC
CCTTCTCTCTCCTGTCTTCCGGTCAGGGCCTTCGGCTGCCCTTCTCCCTCTCCACGGAAGACAAGGACCGCAGGCCATGG
CCCGCCCCAGTCGCGTATCCCGCGCGCTCTCGCAGAACTTCCTCGCCGACCGCGCCGCCGCCGGACAGCTCGCCCGGCTC
GCCGCGCCCCACGGCCTCCCCGTCCCGCTGCTGCTCGAAGTCGGCGCGGGCAAAGGCGCGTTGACCGAGCTGCTCGCCCC
GCGCTGTCGCAGTCTCCTCGCCTACGAGATCGACCCACGGCTCGTCCCCGTCCTGCGCTCGCGCTTCGCGGACGCCCCGC
ACGTCCGCGTCCTCGGCGAGGACTTCCTGCGCGCCAGGGCGCCGCGCACCCCGTTCTCCGTCGCCGGGAACGTCCCCTTC
TCCCGTACCGCCGCCGTCGTCGCGTGGTGTCTGCGGGCCCCGCACCTCACCGACGCCACCCTGCTCACCCAGCTGGAGTA
CGCCCGCAGACGCACCGGCGACTACGGCAGCTGGACGCGGCTGACCGTGCTGACTTGGCCCCGCCACGAGTGGCGGCTCG
CCGGGCGGGTCGGGCGCCGCAGCTTCCGTCCCGTGCCCCGGGTGGACGCGGGGATCGTCCGTATCGAGCGGCGTCGCACC
CCGCTGCTCGCGCCCGGTGCCGACGCCGGCTGGCGGGAGCTGGTCGACCTCGGCTTCTCCGGGGCCGGCGGCTCCCTGCA
CGCCTCGCTGCGGCGGGCCCGCCCGAGACGGCGGGTGGACGCGGCGTTCCGCGCGGCGGGGCTCGACCGGGACGTCCTGG
TGGGGGAGGTGCCGCCGTGGACGTGGCTGAGGCTGCACGAGGTGCTGGGCTCGTGAATCCGGATCACAGAGCAGCCGGCG
TCATGAATTCAGGTTGCACGAGACGTATCGTCTCGCCTATGGTCGAGCCCATGACCACTCCCGCACACATCGCCATGTTC
TCCGTCGCCGCCCACGGGCA