MEGAResFrom MEG, the Microbial Ecology Group

ERMR

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

Other Groups in 23S rRNA methyltransferases

Sequences

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>>MEG_2843|Drugs|MLS|23S_rRNA_methyltransferases|ERMR
ATGGCAGGTCCGCAAGACCGTCCGCGAGGGCGCGGACCCTCCTCCGGTCGCCCGCAGCGGCCGGTGGGCGGCCGCAGCCA
GCGCGACCGCGACCGGCGGGTCCTCGGCCAGAACTTCCTGCGCGACCCGGCGACCATCCGGCGCATCGCCGACGCCGCCG
ACGTCGACCCCGACGGGCTCGTCGTCGAGGCGGGTCCCGGCGAAGGGCTGCTCACCCGCGAGCTCGCCCGACGCGCCGGG
CGGGTACGCACCTACGAGCTGGACCAGCGCCTCGCGCGACGACTCTCGACCGACCTGGCCCAGGAGACGAGCATCGAGGT
CGTCCACGCCGACTTCCTGACCGCGCCTCACCCCGAGGAGCCGTTCCAGTTCGTCGGCGCGATCCCCTACGGCATCACCT
CCGCCATCGTCGACTGGTGCCTGACCGCCCCGACCCTGACGTCGGCGACCCTCGTGACCCAGCAGGAGTTCGCGCGCAAG
CGGACGGGTGACTACGGACGGTGGACGGCCCTCACCGTCACCACGTGGCCGACCTTCGAGTGGCAGTACGTCGCCAAGGT
CGACCGCACGCTGTTCACACCGGTGCCGCGCGTGCACTCCGCGATCATGCGGCTGCGCCGCCGCCCACAGCCCCTCCTGC
GCGACGCGGCGGCGAGGTCGCGCTTCGCGGACATGGTGGAGATCGGCTTCGTCGGCAAGGGCGGCAGCCTCTACCGGTCG
CTGACCCGGGAGTGGCCGCGCTCGAAGGTCGACAGCGCGTTCGCGCGCGCCGACGTCCACCACGACGAGATCGTCGCCTT
CGTGCACCCCGACCAGTGGATCACGCTGTTCCAGCTCCTCGACGGGTCCCGTGGCGGCGCCGCGCGCGGACCGGGCGACC
AGCGGGGGCGGCGCGGCCGCCCAGGCGGAGGCCCCCGGCCGGACGGTCGCGCGGGCGGCGGCCCGCGCCGCGACGCGGGC
GGGCGCCGCACGGGTGACGGACGCGGAGGTCGCCCCCGTCCCCCGCGCGGCGGCCAGGCCTAG

>>MEG_2844|Drugs|MLS|23S_rRNA_methyltransferases|ERMR
ATGAACAAAAAAAATATAAAAGATAGTCAAAACTTTATTACTTCAAAGCATCATATAAATGAAATTTTGAGAAATGTACA
TTTAAATACAAATGATAATATTATTGAGATTGGTTCAGGGAAAGGTCATTTCTCGTTTGAATTAGCTAAAAGGTGTAATT
ATGTAACCGCCATTGAAATAGATCCTAAATTATGTAGGATAACTAAAAACAAACTTATTGAATATGAGAACTTCCAGGTT
ATCAATAAAGATATTTTACAATTTAAGTTTCCTAAAAATAAGTCATATAAGATATTTGGAAATATACCCTACAATATAAG
TACAGATATAATTCGAAAAATTGTTTTTGAAAGCACAGCTACAGAAAGTTATTTAATAGTGGAATATGGATTTGCTAAAA
GGTTGCTAAATACAAATCGTTCACTAGCACTATTTTTAATGACAGAAGTTGATATATCCATATTAAGTAAAATCCCTAGA
GAATACTTTCATCCAAAACCTAGAGTTAATAGCTCGTTAATTGTATTAAAAAGACACCCTTCAAAAATATCACTCAAAGA
TAGAAAACAATATGAAAATTTTGTTATGAAATGGGTTAACAAAGAATACATAAAACTATTTTCCAAAAACCAATTTTATC
AAGCCTTAAAATATGCAAGAATTGACGATTTAAACAATATTAGCTTTGAACAATTCTTGTCTCTTTTCAATAGCTATAAA
TTATTTAATAGATAA