MEGAResFrom MEG, the Microbial Ecology Group

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ERMD

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

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Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_2823|Drugs|MLS|23S_rRNA_methyltransferases|ERMD
atgaagaaaaaaaatcataagtacagaggaaaaaagttaaaccgcggggaatatccgaatttttccggacagcatttgat
gcataataaaaaattaattgaagaaattgtggatcgggcaaatattagcatagacgatacggttttagagttaggagcgg
gaaaaggtgctttgacaactatgctaagtcaaaaagccggtaaggtattggcagtggaaaacgattctaaattcgttgct
atactcacacgtaaaacagcacagcatccaaatacgaaaattattcatcaagatatcatgaagattcatttaccaaaaga
aaagtttgtggtggtctctaatattccctatgccatcacaactcccatcatgaaaatgctcttgaacaatcctgcaagcg
gatttcaaaaagggatcatcgtaatggaaaaaggggctgctaaacgtttcacatcaaaattcattaaaaattcctatgtt
ttagcttggagaatgtggtttgatattggcattgtcagagaaatatcgaaagagcatttttctccccctccaaaagtgga
ctcggcaatggtcagaataacacgaaaaaaagacgcgcctctatcacataaacattacattgcgtttcttgggcttgccg
aatatgcgctaaaggagccgcaagcccctttctgtgttgctttacgcggaatttttactccgcgtcaaatgaaacactta
agaaaaagtctaaaaattaacaatgaaaaaaccgttggaacgctcaccgaaaaccaatgggcggttatttttaacacgat
gactcaatatgtgatgcaccacaaatggccaagagcaaataagcgaaaacccggagaaatataa

>>MEG_2824|Drugs|MLS|23S_rRNA_methyltransferases|ERMD
atgaagaaaaaaaatcataagtacagaggaaaaaagttaaaccgcggggaatctccgaatttttccggacagcatttgat
gcataataaaaaattaattgaagaaattgtggatcgggcaaatattagcatagacgatacggttttagagttaggagcgg
gaaaaggggctttgacaactgtgctaagtcaaaaagccggtaaggtattggcagtggaaaacgattctaaattcgttgat
atactcacacgtaaaacggcacagcattcaaatacgaaaattattcatcaagatatcatgaagattcatttaccaaaaga
aaagtttgtggtggtctctaatattccctatgccatcacaacccccatcatgaaaatgcttttgaacaatcctgcaagcg
gatttcaaaaagggatcatcgtaatggaaaaaggggctgctaaacgtttcacatcaaaattcattaaaaattcctatgtt
ttagcttggagaatgtggtttgatattggcattgtcagagaaatatcgaaagagcatttttctccccctccaaaagtgga
ctcggcaatggtcagaataacacgaaaaaaagacgcgcctctatcacataaacattatattgcgtttcggggacttgccg
aatacgcgctaaaggagccgaatatccctctctgtgttgctttacgcggaatttttaccccgcgtcaaatgaaacacttg
agaaaaagtctaaaaatcaacaatgaaaaaaccgttggaacgctcaccgaaaaccaatgggcggtcatttttaacacgat
gactcagtatgtaatgcatcacaaatggccaagagcaaataagcgaaaacccggagaaatataa

>>MEG_2825|Drugs|MLS|23S_rRNA_methyltransferases|ERMD
ATGAAGAAAAAAAATCATAAGTACAGAGGAAAAAAGTTAAACCGCGGGGAATCTCCGAATTTTTCCGGACAGCATTTGAT
GCATAATAAAAAATTAATTGAAGAAATTGTGGATCGGGCAAATATTAGCATAGACGATACGGTTTTAGAGTTAGGAGCGG
GAAAAGGGGCTTTGACAACTGTGCTAAGTCAAAAAGCCGGTAAGGTATTGGCAGTGGAAAACGATTCTAAATTCGTTGAT
ATACTCACACGTAAAACAGCACAGCATTCAAATACGAAAATTATTCATCAAGATATCATGAAGATTCATTTACCAAAAGA
AAAGTTTGTGGTGGTCTCTAATATTCCCTATGCCATCACAACTCCCATCATGAAAATGCTCTTGAACAATCCTGCAAGCG
GATTTCAAAAAGGGATCATCGTAATGGAAAAAGGGGCTGCTAAACGTTTCACATCAAAATTCATTAAAAATTCCTATGTT
TTAGCTTGGAGAATGTGGTTTGATATTGGCATTGTCAGAGAAATATCGAAAGAGCATTTTTCTCCCCCTCCAAAAGTGGA
CTCGGCAATGGTCAGAATAACACGAAAAAAAGACGCGCCTCTATCACATAAACATTATATTGCGTTTCGGGGACTTGCCG
AATACGCGCTAAAGGAGCCGAATATCCCTCTCTGTGTTCGTTTACGCGGAATTTTTACCCCGCGTCAAATGAAACACTTA
AGAAAAAGTCTAAAAATCAACAATGAAAAAACCGTTGGAACGCTCACCGAAAACCAATGGGCGGTTATTTTTAACACGAT
GACTCAATATGTAATGCATCACAAATGGCCAAGAGCAAATAAGCGAAAACCCGGAGAAATATAA