MEGAResFrom MEG, the Microbial Ecology Group

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ERM32

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

  • http://cid.oxfordjournals.org/content/34/4/482.full

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Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>>MEG_2775|Drugs|MLS|23S_rRNA_methyltransferases|ERM32
ATGCGGAAGAACGTCGTGCGATATCTGCGCTGTCCGCACTGCGCAGCCCCTCTGCGGTCATCCGACCGCACCCTCCGCTG
CGAAAACGGGCACACCTTCGACGTCGCCCGGCAGGGCTATGTGAATCTGCTCAGACGCCCGACGAAGCTCGCCGCCGACA
CCACCGACATGGTCGCCGCCCGGGCCGCGCTGCTGGACAGCGGGCATTACGCGCCGCTGACCGAGCGGCTGGCCGGGACG
GCCGGGCGCGCGGCGGGCGCCGGGGCACCGGACTGCGTCGTGGACATCGGCGGGGGCACCGGTCACCATCTCGCCCGTGT
CCTGGAGGAGTTCGAGGACGCCGAGGGACTCCTGCTGGACATGTCCAAGCCGGCCGTGCGCAGGGCCGCCCGCGCCCATC
CCCGGGCCAGCTCCGCCGTCGCCGACGTATGGGACACACTTCCGCTGCGGGACGGGGCCGCCGCGATGGCCCTCAACGTC
TTCGCCCCGCGCAACCCGCCGGAGATCCGCAGGATCCTCCGCCCCGGCGGCACCCTGCTGGTCGTCACGCCCCAGCAGGA
CCACCTCGCCGAACTCGTGGACGCGCTGGGGCTGTTGCGCGTACGGGACCACAAGGAGGGCCGGCTGGCCGAACAGCTCG
CGCCGCACTTCGAGGCCGTCGGGCAGGAGCGGCTGCGGACCACTCTCCGCCTCGATCACGACGCGCTCGGCCGGGTGGTC
GCCATGGGGCCCAGTTCCTGGCACCAGGACCCGGATGAACTGGCGCGGCGGATCGCGGAGTTGCCCGGCATCCACGAGGT
CACGCTCTCGGTCACCTTCACCGTCTGCCGCCCTCTGCCCTGA

>>MEG_2776|Drugs|MLS|23S_rRNA_methyltransferases|ERM32
ATGCGGAAGAACGTCGTGCGATATCTGCGCTGTCCGCACTGCGCAGCCCCTCTGCGGTCATCCGACCGCACCCTCCGCTG
CGAAAACGGGCACACCTTCGACGTCGCCCGGCAGGGCTATGTGAATCTGCTCAGACGCCCGACGAAGCTCGCCGCCGACA
CCACCGACATGGTCGCCGCCCGGGCCGCGCTGCTGGACAGCGGGCATTACGCGCCGCTGACCGAGCGGCTGGCCGGGACG
GCCCGGCGCGCGGCGGGCGCCGGGGCACCGGACTGCGTCGTGGACATCGGCGGGGGCACCGGTCACCATCTCGCCCGTGT
CCTGGAGGAGTTCGAGGACGCCGAGGGACTCCTGCTGGACATGTCCAAGCCGGCCGTGCGCAGGGCCGCCCGCGCCCATC
CCCGGGCCAGCTCCGCCGTCGCCGACGTATGGGACACACTTCCGCTGCGGGACGGGGCCGCCGCGATGGCCCTCAACGTC
TTCGCCCCGCGCAACCCGCCGGAGATCCGCAGGATCCTCCGCCCCGGCGGCACCCTGCTGGTCGTCACGCCCCAGCAGGA
CCACCTCGCCGAACTCGTGGACGCGCTGGGGCTGTTGCGCGTACGGGACCACAAGGAGGGCCGGCTGGCCGAACAGCTCG
CGCCGCACTTCGAGGCCGTCGGGCAGGAGCGGCTGCGGACCACTCTCCGCCTCGATCACGACGCGCTCGGCCGGGTGGTC
GCCATGGGGCCCAGTTCCTGGCACCAGGACCCGGATGAACTGGCGCGGCGGATCGCGGAGTTGCCCGGCATCCACGAGGT
CACGCTCTCGGTCACCTTCACCGTCTGCCGCCCTCTGCCCTGA