MEGAResFrom MEG, the Microbial Ecology Group

ERM

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

Other Groups in 23S rRNA methyltransferases

Sequences

Download Sequences

>CARD|phgb|AY154657|0-1161|ARO:3000601|Erm38|MLS|23S_rRNA_methyltransferases|ERM
ATGTGTCCACACCACATCACGGCCGGCACGAGCTCGGCCAGAACTTCCTGTCCGATCGGCGCGTCATCGCCGATATCGTC
GAAATCGTCTCGCGCACAAACGGTCCGATCATCGAGATCGGGGCGGGCGACGGCGCGCTGACCATACCCTTGCAACGACT
CGCCCGCCCGCTCACCGCCGTCGAGGTCGACGCGCGGCGCGCGCGGCGGTTGGCGCAGCGCACCGCGAGATCCGCCCCGG
GGCCTGCCTCGCGGCCCACCGAGGTCGTCGCCGCCGACTTCCTGCGCTACCCACTGCCCCGCTCACCCCACGTGGTCGTG
GGCAACCTGCCGTTCCACCTCACCACCGCGATCCTGCGGCGACTGCTGCACGGTCCGGGCTGGACCACGGCCGTGCTGCT
CATGCAGTGGGAGGTGGCCCGCCGACGCGCCGCGGTGGGCGGCGCCACCATGATGACCGCCCAGTGGTGGCCGTGGTTCG
AATTCGGCCTTGCCCGAAAGGTTTCCGCGGCGAGCTTCACGCCGCGGCCCGCGGTCGACGCCGGACTGCTCACCATCACG
CGCCGCAGCCGGCCGCTGGTCGACGTCGCGGACCGGGCGCGTTACCAGGCGCTGGTGCACCGCGTGTTCACCGGACGCGG
ACACGGCATGGCGCAGATCCTGCAACGGTTGCCCACGCCGGTGCCCCGCACTTGGTTGCGGGCCAACGGGATAGCACCGA
ACTCCCTGCCCCGCCAGTTGTCCGCGGCGCAGTGGGCGGCGCTGTTCGAGCAGACGCGTCTAACTGGTGCCCAACGGGTC
GATCGTCCACGCGATGTACAGCACGGCCGCGCTCACCGTCGCCGTGGTGGCGAAGTCGATCGCCCGGCTACGCACCACAA
GCAGACCGGCCCGGTCGTCGGTCAGCGCCAACCGCAGCGCGGCCGCGACGCCGACGCCGATCCCGATGACCAGCGCACCG
CGCCGCCAGTAACCCGCCACCACCAGGGCGAACGCCGCGATGAAGATCAGGCCGACCACCAGGATCGGCCATTGACCGGC
GAACACCTTGCGGGCGAATTCCTTTGGCGTCACGCCAGTTTCGACTCTTCGGCTTCGACGACGTTGGTCAGCAGGAAGGC
GCGGGTCAACGGGCCCACGCCACCGGGGTTGGGCGACACGTGA

>CARD|phgb|AY234334|0-846|ARO:3000600|Erm34|MLS|23S_rRNA_methyltransferases|ERM
ATGACGAAAAAAATGAACAAGTATAATGGGAAAAAACTTAGCCGTGGAGAACCTCCCAATTTTAGCGGTCAGCATTTTAT
GCACAATAAACGGCTACTGAAGGAAATTGTTGATAAAGCTGACGTCTCTGTTCGTGATACGGTTTTAGAGCTGGGAGCAG
GAAAAGGCGCGTTGACGACGATTTTAAGCGAACGCGCGGACCGGGTTCTAGCCGTCGAGTATGACCAAAAATGTATTGAA
GCGCTGCAATGGAAACTAGTTGGGTCAAAAAACGTGTCCATTCTCCATCAAGATATTATGAAGGTGGCATTGCCAACGGA
ACCGTTTGTTGTTGTTTCCAACATCCCTTATTCGATCACAACGGCAATCATGAAAATGCTGTTAAACAATCCAAAAAACA
AACTACAACGAGGGGCAATTGTAATGGAGAAAGGAGCAGCAAAGCGGTTTACAAGCGTTTCGCCGAAAGACGCTTATGTG
ATGGCTTGGCATATGTGGTTTGACATCCACTATGAAAGGGGAATTTCCAGAAGTTCATTTTCGCCGCCGCCGAAAGTCGA
TTCTGCCCTTGTCCGCATTGTCCGCAAACAGCATCCCCTTTTTCCATATAAAGAGGCGAAAGCGATGCATGACTTTTTAT
CGTACGCACTAAACAACCCTAGAGCACCCCTTGATCAGGTATTACGAGGAATTTTTACCGCCCCTCAAGCAAAAAAAGTG
CGGCAGGCAATCGGCGTCAAACCTGAGACACCAGTGGCCATGCTTCATGCCAGGCAGTGGGCGATGGTTTGTGACGCGAT
GGTTCGGCATGTTCCAAAAGTGTATTGGCCAAGGCGAAAGAGATAA

>CARD|phgb|AF079138|153-1122|ARO:3000598|Erm31|MLS|23S_rRNA_methyltransferases|ERM
ATGGCATTTTCCCCGCAGGGCGGCCGACACGAGCTCGGTCAGAACTTCCTCGTCGACCGGTCAGTGATCGACGAGATCGA
CGGCCTGGTGGCCAGGACCAAGGGTCCGATACTGGAGATCGGTCCGGGTGACGGCGCCCTGACCCTGCCGCTGAGCAGGC
ACGGCAGGCCGATCACCGCCGTCGAGCTCGACGGCCGGCGCGCGCAGCGCCTCGGTGCCCGCACCCCCGGTCATGTGACC
GTGGTGCACCACGACTTCCTGCAGTACCCGCTGCCGCGCAACCCGCATGTGGTCGTCGGCAACGTCCCCTTCCATCTGAC
GACGGCGATCATGCGGCGGCTGCTCGACGCCCAGCACTGGCACACCGCCGTCCTCCTCGTCCAGTGGGAGGTCGCCCGGC
GCCGGGCCGGCGTCGGCGGGTCGACGCTGCTGACGGCCGGCTGGGCGCCCTGGTACGAGTTCGACCTGCACTCCCGGGTC
CCCGCGCGGGCCTTCCGTCCGATGCCGGGCGTGGACGGAGGAGTACTGGCCATCCGGCGGCGGTCCGCGCCGCTCGTGGG
CCAGGTGAAGACGTACCAGGACTTCGTACGCCAGGTGTTCACCGGCAAGGGGAACGGGCTGAAGGAGATCCTGCGGCGGA
CCGGGCGGATCTCGCAGCGGGACCTGGCGACCTGGCTGCGGAGGAACGAGATCTCGCCGCACGCGCTGCCCAAGGACCTG
AAGCCCGGGCAGTGGGCGTCGCTGTGGGAGCTGACCGGCGGCACGGCCGACGGATCCTTCGACGGTACGGCGGGCGGTGG
CGCGGCCGGATCGCACGGGGCGGCTCGGGTCGGGGCCGGTCACCCGGGCGGCCGGGTGTCCGCGAGCCGGCGGGGCGTGC
CGCAGGCGCGGCGCGGCCGGGGGCATGCGGTACGGAGCTCCACGGGGACCGAGCCGAGGTGGGGCAGGGGGCGGGCGGAG
AGCGCGTGAG

>593|AF319779.2|AF319779|MLS|23S_rRNA_methyltransferases|ERM
ATGACAAAAAAGAAATTGCCCGTTCGTTTTACGGGTCAGCACTTTACTATTGACAAAGTGCTTATTAAAGATGCAATAAA
AGAATCAAATATAAATCAACACGATACAGTTTTAGATATTGGAGCTGGTAAGGGTTTTCTAACTGTTCATCTCTTAAAAA
ATGTCGATAAAGTTATTGCCATTGAAAACGATGTTGCATTAAGTCAACATTTGCGCAAAAAATTCATTCACGCTCAAAAC
GTTCAAGTGGTTAGTTGTGATTATAGAAATTTTGTGGTTCCGAAAGTTCCATTTAAAGTAGTTTCAAATATTCCTTTTGG
TATTACATCTGATATTTTTAGTAGTCTGATGTTTGAAAATGTCGAATATTTTCTATGCGGTTCAATTATCCTTCAGTCAG
AACCGGCAAAAAAATTGTTTTCAAGTAAGGTTTATAACCCATTGACAGTACTTTATCATACCTATTATGATTTGAAATTC
CTGTATGAGATAAATCCTGAAAGTTTTTTGCCACCACCAACTGTCAAATCAGCACTTTTGAGAATTGAAAGAAAACAGAT
TTCATTAGATATTGGGCTTAAGGTTAAGTACTTAAATTTTGTTTCGTATATGTTACAAAAACCTGATTTAACAGTCAAAA
CAGCTATGAAGTCTATTTTTAGAAAAAAACAAGTTAGGTCAATTTCAGAAAAATTTGGAGTTGACCTTAACTCCAAAATT
GTCTGTTTGACTCCAAATCAATGGAAGAATTGTTTTTTAGAAATGCTCGAAGTTGTTCCTGAAAAGTTTCATCCGTCATA
A

>CARD|phgb|AF079138|1282-2293|ARO:3001265|Erm30|MLS|23S_rRNA_methyltransferases|ERM
CTAACGGCCCGTGCGGCGTCCGTACGACGAGCCTCGCGCGCCCTGGCGGCCCTTGGTCTGCCGGACCTGTGCGCGGGGTG
CGCAGGGTTCGCCGCCGCGCGTGGGGCCGTATCTGCGGCTCCCGGGCACGGCGGCCCTGCTCGTCTCCGAGTCATAGTCC
CTGCCGCCGGCGCCACCGCCCTGGCCCGGCATGCGCGTGCCGGGCGCCCCCGGCGCGTAACTCGGCTGGGAGGCCTGGAA
AAGGGCGATCCATTGGGTGAGCGTGAGGTCCTTCGGCAGTCCGCCGTCCGGAATTCCGTGGCGGTCGGCGAGGGAACGGT
AGGTCCGCTTGGGGATGTGGCGCCGGAGGATCTCCGCGAGGCCCCGTCCGGGGCCGGTGAAGACGGCTTCGGCGAAGTTC
TGGAAGGCGCGGCTCGCGCTCTCGGGCAGCAGGGGCTGGGGGCGTCGCCTGATCGTCAGGACGCCGCCGTCGACGCGGGG
CATCGGACGGAACGACGAGGCGCGGACGCGGTCGTGGACCGCGAACTCGTACCAGGGGGCCCAGGAGGTCGTGAGGAGCG
ATCCGCCGCTGCGACCGGCGCGTTTGCGGGCGACCTCCCACTGCACTATCAGGGCCGCCGACTGCCAGTTCGTCGATTCC
AGGAGACTCCGGAGAATCTGGGTCGTGATGCCGAAGGGAACGTTTCCGACGACGGTGTCGATATCGCGCGGAATGCGGAA
GTCGAGGAAATCACCCTGGAATACGGTGACCCTCTCCCCTTCGAATTTCCGCCGCACATGCGCGGCCCAGTGCGGGTCCA
TCTCCACGACCGTCACGGTGTCGAAGGAGCGCACCAACTCCTCGGTTATCGCGCCCTTTCCGGGGCCGATTTCGAGAACG
TTCCTACCGTCCCCCTCGACATGCGTGACGAGATTGCGCACGGCTCTGTCGTCCTGAAGGAAGTTCTGGCCTAATTCGCG
GCGAAGGGTGTCGCGGTCCGCTCGCCTCGGTATGGAGTCGCGCATTGCCATG

>CARD|phgb|D14532|1038-1974|ARO:3001306|ErmW|MLS|23S_rRNA_methyltransferases|ERM
ATGTCATCAATCCGGCGCCGGCACGCCGCCGCTTCGCTCGACACCCCTGCCGTGGGCGGCAGGCACGAACTCGGTCAGAA
CTTCCTCGTCGACCGAGGTGTATGCACAAGGATCGCCGAGGTCGTCTCCTCGACGACGGCCCATCCGGTCCTCGAACTGG
GCGCCGGTGACGGTGCCATCACCCGGGCCCTGGTCGCGGCGAATCTCCCGGTCACCGCGCTGGAACTCGACCCCCGGCGG
GTCCGGCGGCTCCAGCGGACCTTCGCCGACGGGGTCACCGTCGTGCACGGGGACATGCTCCGGTACGACTTCGGGCCGTA
CCCGCACCACGTGGTGTCGACCGTGCCGTTCTCCATCACCACGCCGCTGCTCCGGCGCCTGATCGGCCAGCGGTTCTGGC
ACACCGCGGTGCTGTTGGTGCAGTGGGAGGTGGCCCGTAAGCGGGCCGGTGTGGGCGGCACCACGATGCTCACCGCAGCC
AGTTGGCCGTGGTACGAGTTCACCCTGGTGGAGCGGGTGCCGAAGACCTCGTTCGACCCGGTGCCGAGCGTCGACGGCGG
CATCCTCGTCATCGAGCGTCGATCCGCGCCGCTGCTCGACGACCGCTGCGTGGGTGACTACCAGAACCTGGTACGCGAGG
TGTACACCGGTCCCGGTCGTGGTCTGGCCGCGATTCTCCGTACCCGTCTGCCCGGTCGTGAGGTGGACGCCTGGCTCCGC
CGCGAGCGGGTGGACCCGGCGGCCCTGCCCCGCGACCTCAAGGCCGGGCACTGGGCATCCCTCTACCGGCTCTACCGGGA
GGTGGGTACTCGGCCCGCCCCTGCCGGCCGGTCCGTCCGGGCCCGGCCCGGATCCGTCGGCCCCGACCGCTCGCTCCCTC
CGCGCGGCCTGCGATCCGGTCCGCCGAGGGCTCGACGACGTGGTGGAGGCGCCTGAT

>CARD|phgb|AF462611|0-846|ARO:3000605|Erm36|MLS|23S_rRNA_methyltransferases|ERM
ATGCCCACTTACCGTGGCGGCCGACATGAGCACGGCCAGAACTTCCTCACTGACCACACCACGATCGACCGGCTCTCACG
GCTGGTAGGCGACTCGACCGGTCCGATCGTCGAGATCGGCCCGGGCCAGGGCAGGCTCACAAGAGAGCTGCAGAAGCTCG
GCCGGTCCCTGACTGCTGTCGAGATCGACAGCCGGCTGGCGGACCGACTTGCATCGGCCAGTCAGTTCCGCGAGCAGAAA
CACGTAACCGTCGTCAACGCAGACTTCCTTCACTGGCCGCTACCGACCACTCCGTATGTGGTGGTCGGCAACGTTCCGTT
CCACCTGACCACAGCCATCCTGCGCAGACTGCTGCACGATGGAGCATGGACCCAGGTGGTCCTGCTCGTGCAGTGGGAAG
TGGCCCGCCGGCGTGCCGGCATCGGTGGTAGCAGCATGATGACCGCGCAGTGGTGGCCTTGGATCGACTTCAGCTTGCAC
GGGCGCGTGCCCCGGTCGGCGTTCAAGCCAGCCCCGAGCGTGGACGGTGGCCTCTTGGAGATGACTCGTCGTCCGGACCC
ATTGCTCAGCCCAGACGCGAGAGAGTCCTACCGACAGTTCGTCCATGACGTTTTCACCAGTAGGGGCAGGGGTATCGGCG
AGATCCTGGCTAACGTATCCAGCTCACTCGGAAAGCGGGGAGCGCTCCAGTTGTTGAAGAGCGAGGGGATTCGCTCCTCG
TCCCTGCCCAAAGATCTCTCAGCGGAGCAGTGGGCTCGCCTCTTTACCAGCGCGTCGCCTACGAAGAGTGCCAAAACCGG
AAGGAACGCACACCCCGCCCACTCCGCACGGCGGCAAGGTCGATGA

>CARD|phgb|AY487229|2152-2893|ARO:3000602|Erm39|MLS|23S_rRNA_methyltransferases|ERM
GTGTCTTCAGTTCATCACGGCCGGCATGAGAACGGCCAGAATTTTCTGCGCGACCGTCGAGTGGTCGGCGACATCGTGAG
GATGGTCTCGCACACAGCGGGTCCCATCGTCGAGATCGGGGCCGGAGACGGCGCCCTCACCCTGCCGTTACAGCGGCTGG
GCCGACCGTTGACCGCCATCGAGATCGACCTCCACCGTGCCCGACGGCTCGCCGACCGAACCACTGCCGAGGTGATCGCA
ACCGACTTCCTGCGGTACCGGCTGCCGCGCACGCCGCACGTGGTGGTGGGCAACCTGCCGTTCCATCTGACCACCGCCAT
CCTCCGGCGCCTACTGCACGAGAACGGCTGGACCGATGCGATCCTGTTGGTGCAGTGGGAGGTGGCTCGACGGCGGGCCG
GTGTCGGCGGCGCCACCATGATGACCGCCCAGTGGTGGCCGTGGTTCGAATTCGGCCTGGCGCGAAAGGTTTCGGCCGAC
GCGTTCCGGCCGCGGCCGAGTGTGGATGCCGGGCTGCTGACCATTCAGCGCCGAGCTGAGCCGCTACTCCCGTGGGCCGA
CCGTCGTGCGTATCAGGCGCTGGTCCACAGGGTTTTCACCGGGCGCGGGCGTGGTCTGGCCCAGATTCTGCGGCCCCACG
TGCACCCACGGTGGCTGTCTGCCAACGGAATTCACCCGTCGGCTCTGCCCAGAGCGCTGACGGCTCGACAGTGGGTGGCG
TTGTTCGATGCCGCCGGCTAGC

>CARD|phgb|HE650138|2186-2918|ARO:3003205|Erm43|MLS|23S_rRNA_methyltransferases|ERM
ATGAATAACAAAAATCCCAAAGATACGCAGAACTTTATAACCTCTAAGAAATGTATAAATGAAATATTAAAAAATATTAT
TATTACAGCAGATGATAACATTGTTGAAATTGGAACTGGGAAAGGTCATTTTACGAAAGCTTTATCAAAAGTAGTTAAGT
CTGTAATTGGCGTAGAAATCGATAAGTCTTTATATTATAACTTGAAAAAGGATAGTAAACTACAAGATAATATACAACTT
ATTAATCAAGATATATTAAATTTTCAATTCCCTGATAATAAAGATTATAAAATTTTTGGTAGTATTCCTTATAATATTAG
TACTGAAATTATTAAAAAAATACTGTATGAGAGTAAAGCAGAATACAATTATTTAATTGTAGAATTAGGATTTGCTAAAC
GGATTCAAGATAAAAATAAAGCGTTAAGCCTACTATTATTGCCTAAAATGGATGTTGAAATCTTGAAAGTAATTCCTAAC
AAATATTTTCATCCCAAACCTAAAGTAGAATCGGCATTAATATTATTAAAAAAACATAAACCTTTAATTTCGGCAAAAGA
TGAAAAAAATTATCAATTCTTTGTATATAAGTGGGTAAACAAAGAATATAAGAAATTGTTTACAAAAAACCAGTTTAAGA
AAGCATTAAAAAATGCAAATGTACAAAACTTAAATAAAATATCGAAACAACAATTTATCTCTATTTTTTATAGTTATAAA
TTATTTAATTAA

>CARD|phgb|AM180355|2319373-2320111|ARO:3000375|ErmB|MLS|23S_rRNA_methyltransferases|ERM
TTATTTCCTCCCGTTAAATAATAGATAACTATTAAAAATAGACAATACTTGCTCATAAGTAACGGTACTTAAATCGTTTA
CTTTGGCGTATTTCATTGCTTGATGAAACTGATTTTTAGTAAACAGTTGACGATATTCTCGATTGACCCATTTTGAAACA
AAGTACGTATATAGTTTCCAATATTTATCTGGAACATCTGTGGTATGGCGGGTAAGTTTTATTAAGGCACTGTTTACTTT
TGGTTTAGGATGAAAGCATTCAGCTGGCAGCTTAAGCAATTGCTTAATCGAGACTTGAGTGTGCAAGAGCAACCCTAGTG
TTCGGTGAATATCCAAGGTACGCTTGTAGAATCCTTCTTCAACAATCAGATAGATGTCAGACGCACGGCTTTCAAAAACC
ACTTTTTTAATAATTTGTGTGCTTAAATGGTAAGGAATACTCCCAACAATTTTATACCTCTGTTTGTTAGGGAATTGAAA
CTGTAGAATATCTTGGTGAATTAAAGTGACACGAGTATTCAGTTTTAATTTTTCTGACGATAAGTTGAATAGATGACTGT
CTAATTCAATAGACGTTACCTGTTTACTTATTTTAGCCAGTTTCGTCGTTAAATGCCCTTTACCTGTTCCAATTTCGTAA
ACGGTATCGGTTTCTTTTAAATTCAATTGTTTTATTATTTGGTTGAGTACTTTTTCACTCGTTAAAAAGTTTTGAGAATA
TTTTATATTTTTGTTCATG