MEGAResFrom MEG, the Microbial Ecology Group

CHRB

Target modification is a common mechanism of resistance to antibiotics. The 23S methyltransferases transfer a methyl group to the 23S rRNA component of the bacterial ribosome, preventing the action of the MLS group of antibiotics.

References

Other Groups in 23S rRNA methyltransferases

Sequences

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>CARD|phgb|AY509120|22652-23495|ARO:3001302|chrB|MLS|23S_rRNA_methyltransferases|CHRB
CTACGCCGACAACCGGTAGGCGGAGAGCCGCACGGAGAGCGTGACCCGAGTCGGCGCCGGCAGCCGCTGGATCGTCTCCA
GATCCCGCTGCGCGTCACGGTGCCAGGCATTGGGCCCCATGCCGACCAGGTGCGCCAGAGCCTGGTGGTCGAGAGCCATG
GTCCGGGTCAACTCCTCCGTGGCGACGGCCGAGAAGTGCGGAGCGAGCTGCTCCGCGAGACGCGACTCCTTGCCTTCGTC
CACCTGCAGCAGGCCGAGGGCGCCGATCACCTCCCGCAGGTGATCGGGCAGAGGAGTGACAACCAGGAGAACGCCACGGG
GATGGAGAACGCGATGCAGTTCAGGACCGTTGCGGGGAGCGAACGTGTTGATCACCATGCCGGCTGCGGCATCCCGCAGC
GGAAGCGTCTGCCAGGCGTCGGTCACCGCGGCCGCGATCCGCGGATGCGCCTTCGCGGCACGCCGCACGGCGTACTTGGA
GATGTCCAGCAGCAGGCCCTGGGCATCGGGGAACGCTTCCATGACCCCGGCGTGATAGTGGCCCGTCCCCCCACCGATGT
CGACCACACAGCCGGGCACGGCCGGATCGGCCGTCCGCCGCGCCAGATCGACCAGCGCATCCATCACGGGGTCGTAGTGA
CCCGCCGACAGGAATGCGTCCCGGGCCTCCACCATTTCCTTGGTGTCGGCCCGCAGCTTCGTCGCCCTGGGAAGCAGATT
CACATAACCCTGCTTCGCGATGTCGAAGGAGTGTCCGGCGGGGCAGAAAAGTGCGCGGTCGCCCTGAGCCAGCGAAGCAC
CGCAGTGCGGGCAGGCGAGGTAGCGCACGATCCTGTTGAGCATG