MEGAResFrom MEG, the Microbial Ecology Group

VanI-type resistance protein

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The core resistance proteins are typically VanHAX and encode the D-Lac/Ser dehydrogenase, D-ala-D-lac/ser ligase, and dipeptidase, respectively. The VanI resistance cluster is characterized by its lack of VanH-like D-lactate dehydrogenase and so is unique. Its terminal product is D-ala-D-lac.

References

Other Mechanisms in Glycopeptides

Groups

Sequences

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