MEGAResFrom MEG, the Microbial Ecology Group

VanG-type accessory protein

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The accessory proteins are not essential for resistance but are known to enhance resistance in some bacteria. Other accessory genes, such as vanW, have unknown function at this time. The VanG resistance cluster is inducible and characterized by low-level resistance to vancomycin and susceptibility to teicoplanin. Its terminal product is D-ala-D-ser.



Other Mechanisms in Glycopeptides



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