MEGAResFrom MEG, the Microbial Ecology Group

VanD-type accessory protein

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The accessory proteins are not essential for resistance but are known to enhance resistance in some bacteria. Other accessory genes, such as vanW, have unknown function at this time. The VanD resistance cluster is similar to VanA and VanB in that it is acquired, but its gene content and phenotype differ. It is constitutively expressed due to a mutation/frameshift in the VanRS genes. Its terminal product is D-ala-D-lac.



Other Mechanisms in Glycopeptides



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