MEGAResFrom MEG, the Microbial Ecology Group

VanC-type regulator

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The regulator proteins include VanRS (and optionally VanU). These genes are part of a sensor-kinase two-component system. The VanC resistance cluster is intrinsic to Enterococcus gallinarum and other Entrococci; it is characterized by low resistance to vancomycin and susceptibility to teicoplanin. Its terminal product is D-ala-D-ser.

References

  • http://cid.oxfordjournals.org/content/42/Supplement_1/S25.full,http://www.readcube.com/articles/10.1038/ja.2013.117

Other Mechanisms in Glycopeptides

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