MEGAResFrom MEG, the Microbial Ecology Group

VanA-type accessory protein

The vancomycin resistance gene clusters contain three general categories of genes, the core resistance proteins (VanHAX), the accessory proteins (VanJKWYZ and MurF2), and the sensor-regulator genes (VanRS). The accessory proteins are not essential for resistance but are known to enhance resistance in some bacteria. Other accessory genes, such as vanW, have unknown function at this time. The VanA gene cluster is acquired, inducible and characterized by high resistance. Its terminal product is D-ala-D-lac.

References

Other Mechanisms in Glycopeptides

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Sequences

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