MEGAResFrom MEG, the Microbial Ecology Group

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FUSB

Though the exact mechanism is unknown, the protein encoded by fusB is known to bind Elongation Factor G (EF-G), which is the target of fusidic acid. This suggests that the product of fusB in some way prevents the binding of EF-G by fusidic acid, therefore causing resistance.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/16390458

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Other Groups in Ribosomal zinc-binding protein

Sequences

Download Sequences

>>MEG_3066|Drugs|Fusidic_acid|Ribosomal_zinc-binding_protein|FUSB
atgaaaacaatgatttatcctcaccaatataattatatcagatcggttattttaagattgaaaaatgtatataaaacggt
aaatgataaagaaaccgtcaaagttattcaatcggaaacctataatgatattagtgagatttttggtcatatagatgacg
atattgaagaatctttaaaagtattaatgaacatcagattatcaaacaaagaaattgaagcaatacttaataaattttta
gaatatgtagtaccttttgaactacctagtccgcaaaaacttcagaaagtatttaagaaagttaaaaaaataaaaatacc
tcaatttgaagaatatgatttgaaggtaagttcatttgtaggatggaatgaacttgcatcaaatcggaaatatataatat
attacgatgaaaaaaaacaattaaaaggactttatggagaaatttctaatcaggttgtaaaggggttctgcacaatttgt
aataaagaatctaatgtttcattattcatgaaaaagtcaaaaaccaattcggatggtcaatatgtaaaaaaaggtgacta
tatatgtcgagatagcattcattgtaataaacaattaacagatattaatcagttttataattttattgataaactagatt
aa

>>MEG_3067|Drugs|Fusidic_acid|Ribosomal_zinc-binding_protein|FUSB
ATGAAAACAATGATTTATCCTCACCAATATAATTATATCAGATCGGTTATTTTAAGATTGAAAAATGTATATAAAACGGT
AAATGATAAAGAAACCGTCAAAGTTATTCAATCGGAAACCTATAATGATATTAATGAGATTTTTGGTCATATAGATGACG
ATATTGAAGAATCTTTAAAAGTATTAATGAACATCAGATTATCAAACAAAGAAATTGAAGCAATACTTAATAAATTTTTA
GAATATGTAGTACCTTTTGAACTACCTAGTCCGCAAAAACTTCAGAAAGTATTTAAGAAAGTTAAAAAAATAAAAATACC
TCAATTTGAAGAATATGATTTGAAGGTAAGTTCATTTGTAGGATGGAATGAACTTGCATCAAATCGGAAATATATAATAT
ATTACGATGAAAAAAAACAATTAAAAGGACTTTATGGAGAAATTTCTAATCAGGTTGTAAAGGGGTTCTGCACAATTTGT
AATAAAGAATCTAATGTTTCATTATTCATGAAAAAGTCAAAAACCAATTCGGATGGTCAATATGTAAAAAAAGGTGACTA
TATATGTCGAGATAGCATTCATTGTAATAAACAATTAACAGATATTAATCAGTTTTATAATTTTATTGATAAACTAGATT
AA