MEGAResFrom MEG, the Microbial Ecology Group

Notice: Trying to access array offset on value of type null in /home/meglabuser/megares.meglab.org/vendor/doctrine/annotations/lib/Doctrine/Common/Annotations/DocParser.php on line 967

GYRB

GyrA and B are the two components of the bacterial DNA gyrase (topoisomerase IIa). Mutations in these proteins can cause resistance to fluoroquinolones via evasion of the mechanism of action. Since the aminocoumarins also affect GyrB, resistance to the aminocoumarins can also be mediated through mutations in gyrB.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC245234/

Notice: Trying to access array offset on value of type null in /home/meglabuser/megares.meglab.org/vendor/doctrine/annotations/lib/Doctrine/Common/Annotations/DocParser.php on line 967

Other Groups in Fluoroquinolone-resistant DNA topoisomerases

Sequences

Download Sequences

>>MEG_3238|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGTCGAATTCTTATGACTCCTCCAGTATCAAAGTCCTGAAAGGGCTGGATGCGGTGCGTAAGCGCCCGGGTATGTATAT
CGGCGACACGGATGACGGCACCGGTCTGCACCACATGGTATTCGAGGTGGTAGATAACGCTATCGACGAAGCGCTCGCAG
GTCACTGTAAAGATATCGTCGTGACTATTCACGCCGATAACTCCGTGTCCGTAACGGATGATGGCCGTGGCATTCCGACC
GGGATTCACCCGGAAGAAGGCGTCTCGGCGGCGGAAGTGATCATGACCGTTCTGCACGCGGGCGGTAAATTTGACGATAA
CTCCTATAAAGTCTCCGGCGGTCTGCACGGCGTGGGCGTCTCGGTAGTCAACGCTCTGTCGCAAAAACTGGAACTGGTTA
TCCAGCGAGATGGCAAAATTCACCGTCAGATCTACGAGCACGGCGTGCCGCAGGCACCCCTGGCCGTCACTGGCGATACC
GATAAAACCGGCACGATGGTACGTTTCTGGCCGAGCCACGAAACCTTCACCAACGTCACTGAATTTGAATATGAGATCCT
GGCGAAACGCCTGCGTGAACTGTCATTCCTGAACTCAGGCGTCTCCATCCGCCTGCGCGACAAGCGCGATGGCAAAGAAG
ATCATTTCCACTACGAAGGCGGCATCAAGGCGTTTGTTGAATATCTGAACAAGAATAAAACGCCGATCCACCCGAATATC
TTCTATTTCTCCACCGAAAAAGACGGTATCGGCGTGGAAGTAGCGCTGCAGTGGAACGATGGTTTCCAGGAAAACATCTA
CTGCTTTACCAACAACATTCCGCAGCGCGACGGCGGTACTCACCTTGCAGGCTTCCGTGCGGCGATGACCCGTACGCTGA
ACGCCTACATGGACAAAGAAGGCTACAGCAAAAAAGCCAAAGTCAGCGCCACCGGCGACGATGCCCGTGAAGGTCTGATT
GCGGTGGTTTCCGTAAAAGTACCGGATCCGAAATTCTCCTCACAGACCAAAGATAAGCTGGTCTCTTCCGAGGTGAAATC
GGCGGTAGAACAGCAGATGAACGAACTGCTGAGCGAATACCTGCTGGAAAACCCATCTGACGCGAAAATCGTCGTCGGCA
AAATTATCGACGCCGCGCGTGCGCGTGAAGCGGCGCGTCGCGCCCGTGAAATGACCCGTCGTAAAGGCGCGCTCGATTTA
GCCGGTCTGCCGGGCAAACTGGCGGACTGTCAGGAACGCGACCCGGCGCTGTCCGAACTGTACCTGGTGGAAGGGGACTC
CGCGGGCGGCTCTGCGAAGCAGGGGCGTAACCGCAAGAACCAGGCGATTCTGCCGCTGAAAGGTAAAATCCTTAACGTCG
AGAAAGCGCGCTTCGACAAGATGCTTTCCTCCCAGGAAGTGGCGACGCTGATCACCGCGCTGGGCTGCGGTATCGGTCGC
GACGAGTACAACCCGGACAAGCTGCGCTATCACAGCATCATCATCATGACCGATGCGGACGTCGACGGCTCGCACATCCG
TACGCTGCTGTTGACCTTCTTCTATCGTCAGATGCCGGAAATTGTCGAGCGTGGCCACGTCTACATTGCGCAGCCGCCGC
TGTACAAAGTGAAGAAAGGTAAGCAGGAACAGTACATTAAAGACGACGAAGCGATGGATCAGTACCAGATTTCCATCGCG
CTTGACGGTGCGACTCTGCACGCGAACGCTCATGCGCCGGCGCTATCCGGCGAAGCGTTAGAAAAACTGGTCTCTGAATA
TAACGCCACGCAGAAAATGATTGGTCGTATGGAGCGTCGCTTCCCGAAAGCGCTGCTCAAAGAGCTGGTGTATCAGCCAA
CTCTGACCGAAGCCGATCTTTCTGATGAGCAGACTGTAACGCGCTGGGTGAATGCGCTGATTACCGAGCTGAACGAGAAA
GAGCAGCACGGCAGTCAGTGGAAGTTCGATGTTCATACTAATACGGAACAGAATCTGTTCGAGCCGATCGTTCGCGTGCG
TACGCATGGCGTGGATACCGATTATCCGTTGGATCACGAGTTTGTGACCGGCGCGGAATATCGTCGTATCTGCACGCTGG
GCGAGAAGCTGCGTGGTCTGATTGAAGAGGACGCGTTTATCGAACGCGGCGAGCGTCGCCAGCCGGTAACCAGCTTCGAG
CAGGCGCTGGAGTGGCTGGTGAAAGAATCACGTCGCGGTCTGGCTATCCAGCGTTATAAAGGTCTGGGTGAAATGAACCC
GGATCAGCTGTGGGAAACCACCATGGACCCGGAAAGCCGCCGTATGCTGCGCGTGACCGTCAAAGATGCAATTGCTGCCG
ACCAGCTGTTCACTACGCTGATGGGTGATGCCGTTGAGCCGCGTCGTGCCTTTATCGAGGAGAACGCCCTGAAAGCAGCG
AATATCGATATTTAA

>>MEG_3239|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
GTGGCTGCCCAGAGGAAGGCCCAAGACGAATATGGCGCTGCGTCCATCACTATTCTTGAAGGGCTGGAGGCCGTTCGCAA
ACGTCCCGGTATGTACGTCGGGTCAACTGGTGAGCGTGGTCTCCACCATCTGATATGGGAAGTGGTGGACAACTCAGTAG
ATGAGGCGATGGCCGGTTATGCTACGCAAGTTGATGTGCGGTTATTCGACGACGGTAGTGTCGAGGTCGCCGATAACGGT
CGTGGTATTCCGGTGGCAGTGCATGCTACGGGGGTACCGACTGTTGACGTAGTTATGACCCAATTACATGCCGGCGGTAA
ATTCGGTGGTAAAGATAGCGGTTATAACGTCAGTGGTGGTTTGCATGGGGTAGGTGTGTCGGTGGTTAACGCATTGTCCA
CCAGGGTCGAGGTCGACATCAAACGTGACGGCTATGAATGGTCACAGTTTTACGACAAGGCTGTGCCGGGCATTCTTAAG
CAAGGCGAAGCTACTGAGGCGACGGGAACGACGATTAGATTTTGGGCAGATCCTGACATTTTCGAAACCACAAAGTATGA
CTTTGGGACGGTGGCGCGCCGAATTCAAGAAGTGGCTTTCTTGAACAAGGGTTTGACGATCAATCTTGTTGACGAACGGG
TGAAGCAGGACGAAGTTGTCGACGATGTCGTCAGCGATACAGCCGAGGCTCCTGTGGCTATGACCGTTGAAGAAAAGTCA
ACGGAGTCGAGTGCGCCGCACAAGGTTAGACACCGTACGTTCCACTACCCCGGAGGCCTGGTGGACTTCGTCAAGCACAT
CAACCGGACTAAGACTCCTATTCAACAGAGCATTATCGATTTTGATGGCAAAGGTGCCGGTCACGAGGTTGAAGTTGCGA
TGCAGTGGAACGGCGGCTATTCGGAATCAGTGCATACCTTTGCGAACACGATTAACACCCATGAAGGCGGCACCCACGAA
GAAGGTTTCCGTAGCGCTTTGACATCAGTGGTGAACAAGTACGCTAAGGATAAAAAACTACTCAAAGACAAGGATCCCAA
CCTAACTGGCGACGATATCCGTGAAGGTCTGGCGGCGGTTATCTCGGTTAAGGTCAGTGAACCACAGTTTGAGGGTCAGA
CCAAAACAAAGCTGGGGAACACCGAAGTTAAGTCATTCGTGCAGAGGGTCTGTAATGAGCAACTTATTCACTGGTTTGAA
GCCAATCCAGTAGATGCGAAAGCGGTTGTGAATAAGGCGATATCGTCGGCACAAGCCCGAATAGCTGCACGTAAAGCACG
AGAGTTAGTGCGTCGAAAAAGTGCCACCGATCTTGGTGGACTTCCTGGAAAACTTGCCGATTGCCGCTCTACTGATCCTC
GAAGTTCTGAACTGTATGTAGTGGAAGGTGATTCGGCTGGTGGTTCAGCAAAGAGTGGCCGTGATTCGATGTTTCAGGCA
ATCCTTCCGTTACGTGGCAAGATCATAAATGTTGAAAAGGCACGTATTGACCGAGTGCTAAAGAACACCGAAGTTCAAGC
AATTATTACGGCATTGGGTACTGGAATCCATGATGAATTCGATATCTCCAGGCTGCGTTATCACAAAATTGTTTTGATGG
CCGACGCTGACGTTGACGGCCAACATATCTCGACGCTGTTGTTGACTTTGTTATTTCGGTTCATGCGACCACTCATCGAG
CATGGGTACGTGTTTTTAGCGCAGCCGCCACTTTACAAATTGAAGTGGCAACGTATGGATCCGGAATTTGCTTACTCCGA
TAGCGAGCGCGACGGCTTATTAGAGACCGGGCTTAAGCTTGGCAAGAAAATCAACAAAGAGGATGGTATCCAACGTTATA
AAGGTTTAGGTGAAATGGATGCCAAGGAGTTGTGGGAAACCACCATGGACCCGTCGGTGCGAGTTTTGCGTCAAGTAACA
CTGGATGACGCGGCGGCTGCTGACGAGTTATTCTCTATTCTGATGGGTGAGGACGTCGATGCACGCCGTAGCTTTATCAC
CCGTAATGCCAAGGATGTTCGTTTCCTGGATGTCTAG

>>MEG_3240|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGAACGATTCTAATAAAGAAAATAAATACACCGCTGAAAGTATTAAAGTACTTGAAGGATTAGAAGCGGTACGAAAACG
TCCTGGTATGTATATTGGTTCAACTCAATCAGAAGGTTTGCACCATATGATTTGAGAAATTGTTGATAACTCAATCGATG
AAGCAATGGGTGGTTTTGCAACAGTTGTTAAAGTTATTATAAAAAAAGATGGAGTAATACGAGTTGAAGATGATGGACGT
GGAATTCCAGTTGGAATTCATGAAAAAACTGGTTTATCAGGTGTTGAAACTGTATTAACTGTGTTGCATGCTGGAGGTAA
ATTTGATAATGATAGTTACAAAGTCTCTGGTGGATTACATGGTGTTGGTGCATCTGTTGTTAATGCTTTAAGTAAAAACT
TTAAAGTTTGAGTTAATAAAAATTATGTTCAACATTACGTTGAATTTATTAATGGTGGACATGCTATTGAACCATTAAAA
ATAATTAACGACAAAGATATCAAAGAAAAAGGAACAACAATTGAGTTTATTCCTGACTTTGAAATCATGGAAGAAAATGA
ATGAGATGAGCTAAAAATAATGGCTCGTTTAAAACAATTAGCTTACCTTAATAAAGGTGTTAATATCGAATTTGAATCAG
AAATGACTAATCGTAAAGAAAAATGACATTACGAAGGTGGTTTAAAAGAGTATATAGCTGATTTAAACGCTGAAAAAGAA
CCATTATTTGATGCTATTGTTTACGGTGAAGAAGAAAAAGAAGTTAAAGTTCCAGGTCACAATGATCAAACTTATAACAT
TAAATGTGAAGTAGCATTTCAATACAATAATTCGTACAACAATTCAACACACTCATTCTGTAATAACATTAATACTACAG
AAGGTGGAACACACGAAGAAGGTTTTAAATTAGCGATTACACGTTTATTAAACAAATATGCAATCGATAAAAAGTATTTA
AAAGACACTGATGATAAAATCACTAAAGAAGACGTGAGCGAAGGGTTAACAGCGATTATTTCTATTAAGCACCCTAACCC
TCAATATGAAGGTCAAACAAAGAAAAAATTAGGAAATAGTGAAGTTCGTCCTTATGTTAATGAAATTACTTCTATAATTT
TCGAAAAATTCTTAAATGAAAATCCAGAAGAATCAAAAAAAATTGTTGCTAAAGTTATGCAAGCCGCTGAGGCACGTCGT
CGTTCTCATGAAGCGCGTGAAGCTACAAGACGAAAATCACCATTTGAATCAAATTCATTACCAGGTAAATTAGCTGATTG
TTCAAATCGTGATTCAAGTGTTACAGAAATTTATATTGTCGAAGGGGATTCAGCTGGTGGATCAGCAAAAACTGGTCGTG
AACGTGAATTCCAAGCAATTTTACCATTGCGTGGAAAAATTATTAATGTTGAAAAAGCAAAAATTGACAAGATTTTCGCT
AATGAAGAAATTCAAAACATGATTACTGCTTTTGGAGCAGGAATAGGGCCTGAATTTAATATTGAAAAATTAAGATATTC
AAAAATTATTATTATGACCGATGCCGATGTCGATGGTAGCCATATTCGAATCTTGTTATTAACATTCTTTTATCGATACA
TGTTACCATTGATTCAAAATGGTAATGTTTATATTGCTCAACCACCACTTTATAAAGTGAGTTATGGTAAAACAATTAAA
TATGCATATTCTGATCAAGAATTAGAAAAAATTAAATCAACATTGTTGAATACAAAATATAACATTCAACGTTATAAAGG
GTTAGGGGAGATGAATCCTGATCAATTATGAGAAACAACAATGGATCCTAAAAATCGTCTTTTATTAAAAGTTAATATTG
AAGATGCGGCAATCGCTGATAAAACATTTTCTTTATTAATGGGTGATGATGTAACACCACGAAAAGAATTTATTGAAAAA
AATGCAAAATATGTAAAGAATATTGATGCTTAA

>>MEG_3241|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGATGCAAGAAAAAAAGCAAACTTATGATGAAAATCAAATACAAGTATTAGAAGGTCTTGAAGCTGTTAGAAAAAGACC
TGGAATGTATATTGGAAGTACTAGTTCTAGGGGGCTTCATCATTTAGTGTATGAGATAGTTGATAATAGCATAGATGAGG
CATTGGCAGGATATTGCGATAAAATAAATGTAATTATACATAAAGATAATTCTATAACAGTTACGGATAATGGTAGAGGA
ATGCCTGTTGGAATGCACCATAAAATGAAGAAACCAACTGTAGAAGTTATAATGACTATACTACATGCAGGAGGGAAATT
TGGTGGTGGAGGATACAAAGTTTCCGGCGGACTTCATGGAGTTGGAGCATCAGTTGTAAATGCTTTATCTGAAATCTGTG
AAGTTGAAGTAAAAAGAGAAAGCCATATATGGAGACAGGTATTTAAAAGAGGAAAAGTAGCAAGCGGACTTGACATAATA
GGTGATAGTGAGGAGCACGGAACAAAAATTCACTTTAAACCAGATGCAGAAATATTTGATGAAATAGAATATGATTATGA
TACATTGGCTCAAAGGCTTAGAGAATTGGCATTTTTAAACAAGGGTATAAAAATAAGGTTAGAAGATGAGAGAGATGATA
AAGAAGAAATATTTCACTATGAAGGTGGAATAAAGTCCTTTGTAACTTATCTTAATAGAAATAAACAACCAATTCATAAA
GAGCCTATATACGTAGAAGGCAAAAAAGATGACTACTCTGTAGAAATTGCTATTCAATACAATGATGGGTATACTGAAAA
TATTTTTGCTTTTGCTAATAACATAGATACAGTAGAAGGTGGAACTCATTTAGCTGGATTTAAGTCAGCACTTACTAGAG
TATTTAATGATTATGCAAAAAAATTTGGTATATTAAAAGAAAATGATAAGAACCTATCAGGAGAAGATATAAGGGAAGGC
CTTACTGCAGTTATATCTGTAAAACTTGTAGACCCTCAATTTGAAGGCCAGACGAAAACAAAACTAGGAAATAGTGAAGT
GCGTGGTATAGTTGACAGCATAATGGGAGAGTCCTTAAATAATTTTTTACAGGAAAATCCTCAAGTAGCAAAGATGATAC
TTGATAAATCACTTATGGCATCACGTGCTAGAGAAGCGGCAAGAAAAGCAAGAGAGCTTACAAGACGTAAATCTATACTT
GAAAATACTTCTCTTCCAGGAAAATTAGCAGATTGTTCATCTAAAGATCCTTCTGAATGTGAAATATATTTAGTCGAGGG
TGATTCTGCAGGTGGATCTGCAAAACAAGGTAGAAATAGAAAATTTCAAGCTATACTTCCGCTACGTGGTAAAATAATGA
ATGTTGAGAAACAAAGGCTTGACAAAATACTTGGCTATGAAGAAATAAGAGCTATGATAACGGCATTTGGAGCAGGTATA
GGAAAAGACTTTGATGTAAATAAAATAAGATACAATAAAATAATAATAATGACAGATGCAGATGTAGATGGTGCGCACAT
AAGAACATTATTACTTACTTTTTTCTTCAGATATATGAAGGAACTTGTTGAAAAATGTCACGTTTATATAGCTCAACCAC
CTTTATATAGAGTAGCTAAAGGGAAGAAGGAATACTACGCATATTCAGATGATGAATTAGATGTATTGCTTACTGAAATA
GGTGGGAAAGACAGTAATGTAGATATACAAAGATATAAAGGACTTGGAGAAATGGATTCAGAGCAACTTTGGGATACTAC
AATGAATCCTGAAACAAGGACTCTTATTCAAGTAAATGTAGAGGACACTATGGCTGCTGATGAAATCTTTACTATACTTA
TGGGTGACAAGGTAGAACCTCGTAGAAATTTTATACAAGAAAATGCTAAAAAAGTTGTAAACTTAGATATATAA

>>MEG_3242|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGTCGAATACCTATGACTCCTCAAGTATCAAAGTATTAAAAGGGCTGGACGCGGTGCGTAAACGCCCGGGAATGTACAT
TGGTGATACCGATGACGGAACCGGTTTACACCACATGGTCTTCGAGGTTGTTGACAACGCTATCGACGAAGCCCTCGCCG
GTTACTGTAAAGACATCATTGTGACCATTCACAATGATAATTCAGTCTCCGTACAGGATGACGGTCGCGGTATCCCGACC
GGGATCCATGAAGAAGAAGGCGTCTCCGCCGCAGAAGTTATCATGACTGTTCTGCACGCCGGCGGGAAGTTCGATGATAA
CTCCTATAAAGTCTCAGGCGGCCTGCACGGCGTCGGGGTCTCTGTTGTTAACGCCCTGTCTGAAAAACTGGAACTGGTTA
TCCGCCGTGACGGCAAAGTTCACGAGCAGATTTACCGCCACGGTGAACCGCAGGATCGCCTGACTGTTGTCGGCGAAACC
GATAAAACCGGGACACGCGTGCGTTTCTGGCCGAGCATGGACACCTTCAAAGGCGAGACTGAATTCCAGTACGACATTCT
GGCAAAACGCCTGCGCGAACTCTCCTTCCTGAACTCCGGTGTATCGATCCGTCTGATCGATAAACGCGACGGCAAAGAAG
ATCACTTTCACTACGAAGGCGGTATCAAAGCATTCGTGGAATATTTAAGCCGCGCCAAAACTTCGATTCATAACAACGTT
TTCTATTTCTCCACTGAGAAAGACGATATCGGCGTGGAAATCTCCATGCAGTGGAATGACTCCTTCCAGGAAAACGTATA
CTGCTTCACCAACAACATTCCGCAGCGCGACGGTGGTGCTCACCTCGCCGGTTTCCGCGCCGCCATGACCCGTACCCTCA
ACAGCTATATTGAGAAAGAAGGGCTGAATAAAAAATCCAAAGTCAGCACCACCGGGGACGATGCCCGTGAAGGACTGGTG
GCGGTCATTTCCGTCAAAGTGCCGGATCCGAAATTCTCCTCCCAGACTAAAGACAAGCTGGTCTCTTCCGAAGTGAAAAC
GGCGGTTGAAACCCTGATGAACGAAAAGCTGTCTGAATATCTGGATGAAAACCCGAACGACACCAAAATCATTGTCGGCA
AAATTATTGATGCCGCACGCGCCCGTGAAGCTGCACGCCGTGCCCGTGAAATGACCCGCCGTAAAGGCGCGCTGGATTTA
GCCGGTCTGCCGGGTAAACTGGCGGATTGTCAGGAACGCGACCCGGCCTTCTCCGAACTGTACTTAGTGGAAGGGGACTC
TGCGGGCGGCTCTGCAAAACAGGGGCGTAACCGTAAGAACCAGGCTATCCTGCCGCTGAAAGGTAAAATCCTGAACGTTG
AGAAGGCGCGTTTTGATAAAATGCTGGCTTCTCAGGAAGTTGCCACCCTGATCACCGCACTCGGCTGCGGTATCGGCCGC
GACGAATACAACCCGGACAAACTGCGCTATCACAGCATCATCATCATGACCGATGCCGACGTCGATGGTTCACACATCCG
TACCCTGTTACTGACTTTCTTCTACCGTCAGATGCCGGAAATCATTGAGCGCGGTTATGTGTATATCGCACAGCCGCCGC
TGTATAAAGTGAAAAAAGGCAAGCAGGAACAGTATATTAAAGATGACGAAGCGATGGAGCAGTATCAGGTCTCTATCGCA
CTGGATGGCGCGGCACTGTATGTAAACGAAAATGCAGCTCCGATTCAGGGCGAACATCTGGAAAAACTGCTGCACGAATA
CAACGGCGCACACAAAATTATCCGCCGTTTAGAGCGTCTCTATCCGCTGGCACTGTTAAACAGCCTGGTCTACCAGCCGA
AACTGGAAGAATCCGCGCTGCTGAACAAAACCGAGGTGGAAGCCTGGGCACAGAGCCTGACAGAGCGCCTGACCCGTCAT
GAAGAGCACGGCAGCACCTACAGCTACCGTATTGCGGAAAACAAAGAGCGCCAGCTGTTTGAGCCGGTACTGACTATCCG
TACCCACGGTGTGGATACTGACTACAATCTGGATTTCGATTTTGTTCACGGCAGCGAATATGCCCGTATCTCCAAACTGG
GTGAGCTTATCCGTGGTCTGATTGAAGAAGGTGCTTATGTTGTCCGTGGTGAACGCCGTCAGAACGTCAGCAACTTTGAG
CAGGCACTGGACTGGCTGATGAAAGAATCACGCCGTGGTCTGGCTGTACAGCGCTATAAAGGGCTGGGTGAAATGAACCC
GGAACAGCTGTGGGAAACCACAATGAACCCGGAAACCCGCCGTATGTTGCAGGTCACGGTAAAAGATGCGATTGCAACGG
ATCAGTTATTCACCACACTGATGGGTGATGATGTTGAACCGCGCCGTGCCTTTATCGAAGAGAATGCCCTGAAAGCGGCA
AACATCGACGTATAA

>>MEG_3243|Drugs|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
GTGGCTGCCCAGAAAAAGAAGGCCCAAGACGAATACGGCGCTGCGTCTATCACCATTCTCGAAGGGCTGGAGGCCGTCCG
CAAACGTCCCGGCATGTACATTGGCTCGACCGGTGAGCGCGGTTTACACCATCTCATTTGGGAGGTGGTCGACAACGCGG
TCGACGAGGCGATGGCCGGTTATGCAACCACAGTGAACGTAGTGCTGCTTGAGGATGGCGGTGTCGAGGTCGCCGACGAC
GGCCGCGGCATTCCGGTCGCCACCCACGCCTCCGGCATACCGACCGTCGACGTGGTGATGACACAACTACATGCCGGCGG
CAAGTTCGACTCGGACGCGTATGCGATATCTGGTGGTCTGCACGGCGTCGGCGTGTCGGTGGTTAACGCGCTATCCACCC
GGCTCGAAGTCGAGATCAAGCGCGACGGGTACGAGTGGTCTCAGGTTTATGAGAAGTCGGAACCCCTGGGCCTCAAGCAA
GGGGCGCCGACCAAGAAGACGGGGTCAACGGTGCGGTTCTGGGCCGACCCCGCTGTTTTCGAAACCACGGAATACGACTT
CGAAACCGTCGCCCGCCGGCTGCAAGAGATGGCGTTCCTCAACAAGGGGCTGACCATCAACCTGACCGACGAGAGGGTGA
CCCAAGACGAGGTCGTCGACGAAGTGGTCAGCGACGTCGCCGAGGCGCCGAAGTCGGCAAGTGAACGCGCAGCCGAATCC
ACTGCACCGCACAAAGTTAAGAGCCGCACCTTTCACTATCCGGGTGGCCTGGTGGACTTCGTGAAACACATCAACCGCAC
CAAGAACGCGATTCATAGCAGCATCGTGGACTTTTCCGGCAAGGGCACCGGGCACGAGGTGGAGATCGCGATGCAATGGA
ACGCCGGGTATTCGGAGTCGGTGCACACCTTCGCCAACACCATCAACACCCACGAGGGCGGCACCCACGAAGAGGGCTTC
CGCAGCGCGCTGACGTCGGTGGTGAACAAGTACGCCAAGGACCGCAAGCTACTGAAGGACAAGGACCCCAACCTCACCGG
TGACGATATCCGGGAAGGCCTGGCCGCTGTGATCTCGGTGAAGGTCAGCGAACCGCAGTTCGAGGGCCAGACCAAGACCA
AGTTGGGCAACACCGAGGTCAAATCGTTTGTGCAGAAGGTCTGTAACGAACAGCTGACCCACTGGTTTGAAGCCAACCCC
ACCGACGCGAAAGTCGTTGTGAACAAGGCTGTGTCCTCGGCGCAAGCCCGTATCGCGGCACGTAAGGCACGAGAGTTGGT
GCGGCGTAAGAGCGCCACCGACATCGGTGGATTGCCCGGCAAGCTGGCCGATTGCCGTTCCACGGATCCGCGCAAGTCCG
AACTGTATGTCGTAGAAGGTGACTCGGCCGGCGGTTCTGCAAAAAGCGGTCGCGATTCGATGTTCCAGGCGATACTTCCG
CTGCGCGGCAAGATCATCAATGTGGAGAAAGCGCGCATCGACCGGGTGCTAAAGAACACCGAAGTTCAGGCGATCATCAC
GGCGCTGGGCACCGGGATCCACGACGAGTTCGATATCGGCAAGCTGCGCTACCACAAGATCGTGCTGATGGCCGACGCCG
ATGTTGACGGCCAACATATTTCCACGCTGTTGTTGACGTTGTTGTTCCGGTTCATGCGGCCGCTCATCGAGAACGGGCAT
GTGTTTTTGGCACAACCGCCGCTGTACAAACTCAAGTGGCAGCGCAGTGACCCGGAATTCGCATACTCCGACCGCGAGCG
CGACGGTCTGCTGGAGGCGGGGCTGAAGGCCGGGAAGAAGATCAACAAGGAAGACGGCATTCAGCGGTACAAGGGTCTAG
GTGAAATGGACGCTAAGGAGTTGTGGGAGACCACCATGGATCCCTCGGTTCGTGTGTTGCGTCAAGTGACGCTGGACGAC
GCCGCCGCCGCCGACGAGTTGTTCTCCATCCTGATGGGCGAGGACGTCGACGCGCGGCGCAGCTTTATCACCCGCAACGC
CAAGGATGTTCGGTTCCTGGATGTCTAA