MEGAResFrom MEG, the Microbial Ecology Group

GYRB

GyrA and B are the two components of the bacterial DNA gyrase (topoisomerase IIa). Mutations in these proteins can cause resistance to fluoroquinolones via evasion of the mechanism of action. Since the aminocoumarins also affect GyrB, resistance to the aminocoumarins can also be mediated through mutations in gyrB.

References

Other Groups in Fluoroquinolone-resistant DNA topoisomerases

Sequences

Download Sequences

>CARD|pvgb|Z70722|4202-6296|ARO:3003304|Mycobacterium|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
GTGACTGCTGCGGTAACTGGACCGCTCACATGTAACCTCAAGGAGAGCATTCAGACCGTGGCTGCCCAGAGGAAGGCCCA
AGACGAATATGGCGCTGCGTCCATCACTATTCTTGAAGGGCTGGAGGCCGTTCGCAAACGTCCCGGTATGTACGTCGGGT
CAACTGGTGAGCGTGGTCTCCACCATCTGATATGGGAAGTGGTGGACAACTCAGTAGATGAGGCGATGGCCGGTTATGCT
ACGCAAGTTGATGTGCGGTTATTCGACGACGGTAGTGTCGAGGTCGCCGATAACGGTCGTGGTATTCCGGTGGCAGTGCA
TGCTACGGGGGTACCGACTGTTGACGTAGTTATGACCCAATTACATGCCGGCGGTAAATTCGGTGGTAAAGATAGCGGTT
ATAACGTCAGTGGTGGTTTGCATGGGGTAGGTGTGTCGGTGGTTAACGCATTGTCCACCAGGGTCGAGGTCGACATCAAA
CGTGACGGCTATGAATGGTCACAGTTTTACGACAAGGCTGTGCCGGGCATTCTTAAGCAAGGCGAAGCTACTGAGGCGAC
GGGAACGACGATTAGATTTTGGGCAGATCCTGACATTTTCGAAACCACAAAGTATGACTTTGGGACGGTGGCGCGCCGAA
TTCAAGAAGTGGCTTTCTTGAACAAGGGTTTGACGATCAATCTTGTTGACGAACGGGTGAAGCAGGACGAAGTTGTCGAC
GATGTCGTCAGCGATACAGCCGAGGCTCCTGTGGCTATGACCGTTGAAGAAAAGTCAACGGAGTCGAGTGCGCCGCACAA
GGTTAGACACCGTACGTTCCACTACCCCGGAGGCCTGGTGGACTTCGTCAAGCACATCAACCGGACTAAGACTCCTATTC
AACAGAGCATTATCGATTTTGATGGCAAAGGTGCCGGTCACGAGGTTGAAGTTGCGATGCAGTGGAACGGCGGCTATTCG
GAATCAGTGCATACCTTTGCGAACACGATTAACACCCATGAAGGCGGCACCCACGAAGAAGGTTTCCGTAGCGCTTTGAC
ATCAGTGGTGAACAAGTACGCTAAGGATAAAAAACTACTCAAAGACAAGGATCCCAACCTAACTGGCGACGATATCCGTG
AAGGTCTGGCGGCGGTTATCTCGGTTAAGGTCAGTGAACCACAGTTTGAGGGTCAGACCAAAACAAAGCTGGGGAACACC
GAAGTTAAGTCATTCGTGCAGAGGGTCTGTAATGAGCAACTTATTCACTGGTTTGAAGCCAATCCAGTAGATGCGAAAGC
GGTTGTGAATAAGGCGATATCGTCGGCACAAGCCCGAATAGCTGCACGTAAAGCACGAGAGTTAGTGCGTCGAAAAAGTG
CCACCGATCTTGGTGGACTTCCTGGAAAACTTGCCGATTGCCGCTCTACTGATCCTCGAAGTTCTGAACTGTATGTAGTG
GAAGGTGATTCGGCTGGTGGTTCAGCAAAGAGTGGCCGTGATTCGATGTTTCAGGCAATCCTTCCGTTACGTGGCAAGAT
CATAAATGTTGAAAAGGCACGTATTGACCGAGTGCTAAAGAACACCGAAGTTCAAGCAATTATTACGGCATTGGGTACTG
GAATCCATGATGAATTCGATATCTCCAGGCTGCGTTATCACAAAATTGTTTTGATGGCCGACGCTGACGTTGACGGCCAA
CATATCTCGACGCTGTTGTTGACTTTGTTATTTCGGTTCATGCGACCACTCATCGAGCATGGGTACGTGTTTTTAGCGCA
GCCGCCACTTTACAAATTGAAGTGGCAACGTATGGATCCGGAATTTGCTTACTCCGATAGCGAGCGCGACGGCTTATTAG
AGACCGGGCTTAAGCTTGGCAAGAAAATCAACAAAGAGGATGGTATCCAACGTTATAAAGGTTTAGGTGAAATGGATGCC
AAGGAGTTGTGGGAAACCACCATGGACCCGTCGGTGCGAGTTTTGCGTCAAGTAACACTGGATGACGCGGCGGCTGCTGA
CGAGTTATTCTCTATTCTGATGGGTGAGGACGTCGATGCACGCCGTAGCTTTATCACCCGTAATGCCAAGGATGTTCGTT
TCCTGGATGTCTAGT

>CARD|pvgb|NC_011374|104283-106236|ARO:3003305|Ureaplasma|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGAACGATTCTAATAAAGAAAATAAATACACCGCTGAAAGTATTAAAGTACTTGAAGGATTAGAAGCGGTACGAAAACG
TCCTGGTATGTATATTGGTTCAACTCAATCAGAAGGTTTGCACCATATGATTTGAGAAATTGTTGATAACTCAATCGATG
AAGCAATGGGTGGTTTTGCAACAGTTGTTAAAGTTATTATAAAAAAAGATGGAGTAATACGAGTTGAAGATGATGGACGT
GGAATTCCAGTTGGAATTCATGAAAAAACTGGTTTATCAGGTGTTGAAACTGTATTAACTGTGTTGCATGCTGGAGGTAA
ATTTGATAATGATAGTTACAAAGTCTCTGGTGGATTACATGGTGTTGGTGCATCTGTTGTTAATGCTTTAAGTAAAAACT
TTAAAGTTTGAGTTAATAAAAATTATGTTCAACATTACGTTGAATTTATTAATGGTGGACATGCTATTGAACCATTAAAA
ATAATTAACGACAAAGATATCAAAGAAAAAGGAACAACAATTGAGTTTATTCCTGACTTTGAAATCATGGAAGAAAATGA
ATGAGATGAGCTAAAAATAATGGCTCGTTTAAAACAATTAGCTTACCTTAATAAAGGTGTTAATATCGAATTTGAATCAG
AAATGACTAATCGTAAAGAAAAATGACATTACGAAGGTGGTTTAAAAGAGTATATAGCTGATTTAAACGCTGAAAAAGAA
CCATTATTTGATGCTATTGTTTACGGTGAAGAAGAAAAAGAAGTTAAAGTTCCAGGTCACAATGATCAAACTTATAACAT
TAAATGTGAAGTAGCATTTCAATACAATAATTCGTACAACAATTCAACACACTCATTCTGTAATAACATTAATACTACAG
AAGGTGGAACACACGAAGAAGGTTTTAAATTAGCGATTACACGTTTATTAAACAAATATGCAATCGATAAAAAGTATTTA
AAAGACACTGATGATAAAATCACTAAAGAAGACGTGAGCGAAGGGTTAACAGCGATTATTTCTATTAAGCACCCTAACCC
TCAATATGAAGGTCAAACAAAGAAAAAATTAGGAAATAGTGAAGTTCGTCCTTATGTTAATGAAATTACTTCTATAATTT
TCGAAAAATTCTTAAATGAAAATCCAGAAGAATCAAAAAAAATTGTTGCTAAAGTTATGCAAGCCGCTGAGGCACGTCGT
CGTTCTCATGAAGCGCGTGAAGCTACAAGACGAAAATCACCATTTGAATCAAATTCATTACCAGGTAAATTAGCTGATTG
TTCAAATCGTGATTCAAGTGTTACAGAAATTTATATTGTCGAAGGGGATTCAGCTGGTGGATCAGCAAAAACTGGTCGTG
AACGTGAATTCCAAGCAATTTTACCATTGCGTGGAAAAATTATTAATGTTGAAAAAGCAAAAATTGACAAGATTTTCGCT
AATGAAGAAATTCAAAACATGATTACTGCTTTTGGAGCAGGAATAGGGCCTGAATTTAATATTGAAAAATTAAGATATTC
AAAAATTATTATTATGACCGATGCCGATGTCGATGGTAGCCATATTCGAATCTTGTTATTAACATTCTTTTATCGATACA
TGTTACCATTGATTCAAAATGGTAATGTTTATATTGCTCAACCACCACTTTATAAAGTGAGTTATGGTAAAACAATTAAA
TATGCATATTCTGATCAAGAATTAGAAAAAATTAAATCAACATTGTTGAATACAAAATATAACATTCAACGTTATAAAGG
GTTAGGGGAGATGAATCCTGATCAATTATGAGAAACAACAATGGATCCTAAAAATCGTCTTTTATTAAAAGTTAATATTG
AAGATGCGGCAATCGCTGATAAAACATTTTCTTTATTAATGGGTGATGATGTAACACCACGAAAAGAATTTATTGAAAAA
AATGCAAAATATGTAAAGAATATTGATGCTTAA

>CARD|pvgb|NC_003197|4038854-4041269|ARO:3003307|Salmonella|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
TTAAATATCGATATTCGCTGCTTTCAGGGCGTTCTCCTCGATAAAGGCACGACGCGGCTCAACGGCATCACCCATCAGCG
TAGTGAACAGCTGGTCGGCAGCAATTGCATCTTTGACGGTCACGCGCAGCATACGGCGGCTTTCCGGGTCCATGGTGGTT
TCCCACAGCTGATCCGGGTTCATTTCACCCAGACCTTTATAACGCTGGATAGCCAGACCGCGACGTGATTCTTTCACCAG
CCACTCCAGCGCCTGCTCGAAGCTGGTTACCGGCTGGCGACGCTCGCCGCGTTCGATAAACGCGTCCTCTTCAATCAGAC
CACGCAGCTTCTCGCCCAGCGTGCAGATACGACGATATTCCGCGCCGGTCACAAACTCGTGATCCAACGGATAATCGGTA
TCCACGCCATGCGTACGCACGCGAACGATCGGCTCGAACAGATTCTGTTCCGTATTAGTATGAACATCGAACTTCCACTG
ACTGCCGTGCTGCTCTTTCTCGTTCAGCTCGGTAATCAGCGCATTCACCCAGCGCGTTACAGTCTGCTCATCAGAAAGAT
CGGCTTCGGTCAGAGTTGGCTGATACACCAGCTCTTTGAGCAGCGCTTTCGGGAAGCGACGCTCCATACGACCAATCATT
TTCTGCGTGGCGTTATATTCAGAGACCAGTTTTTCTAACGCTTCGCCGGATAGCGCCGGCGCATGAGCGTTCGCGTGCAG
AGTCGCACCGTCAAGCGCGATGGAAATCTGGTACTGATCCATCGCTTCGTCGTCTTTAATGTACTGTTCCTGCTTACCTT
TCTTCACTTTGTACAGCGGCGGCTGCGCAATGTAGACGTGGCCACGCTCGACAATTTCCGGCATCTGACGATAGAAGAAG
GTCAACAGCAGCGTACGGATGTGCGAGCCGTCGACGTCCGCATCGGTCATGATGATGATGCTGTGATAGCGCAGCTTGTC
CGGGTTGTACTCGTCGCGACCGATACCGCAGCCCAGCGCGGTGATCAGCGTCGCCACTTCCTGGGAGGAAAGCATCTTGT
CGAAGCGCGCTTTCTCGACGTTAAGGATTTTACCTTTCAGCGGCAGAATCGCCTGGTTCTTGCGGTTACGCCCCTGCTTC
GCAGAGCCGCCCGCGGAGTCCCCTTCCACCAGGTACAGTTCGGACAGCGCCGGGTCGCGTTCCTGACAGTCCGCCAGTTT
GCCCGGCAGACCGGCTAAATCGAGCGCGCCTTTACGACGGGTCATTTCACGGGCGCGACGCGCCGCTTCACGCGCACGCG
CGGCGTCGATAATTTTGCCGACGACGATTTTCGCGTCAGATGGGTTTTCCAGCAGGTATTCGCTCAGCAGTTCGTTCATC
TGCTGTTCTACCGCCGATTTCACCTCGGAAGAGACCAGCTTATCTTTGGTCTGTGAGGAGAATTTCGGATCCGGTACTTT
TACGGAAACCACCGCAATCAGACCTTCACGGGCATCGTCGCCGGTGGCGCTGACTTTGGCTTTTTTGCTGTAGCCTTCTT
TGTCCATGTAGGCGTTCAGCGTACGGGTCATCGCCGCACGGAAGCCTGCAAGGTGAGTACCGCCGTCGCGCTGCGGAATG
TTGTTGGTAAAGCAGTAGATGTTTTCCTGGAAACCATCGTTCCACTGCAGCGCTACTTCCACGCCGATACCGTCTTTTTC
GGTGGAGAAATAGAAGATATTCGGGTGGATCGGCGTTTTATTCTTGTTCAGATATTCAACAAACGCCTTGATGCCGCCTT
CGTAGTGGAAATGATCTTCTTTGCCATCGCGCTTGTCGCGCAGGCGGATGGAGACGCCTGAGTTCAGGAATGACAGTTCA
CGCAGGCGTTTCGCCAGGATCTCATATTCAAATTCAGTGACGTTGGTGAAGGTTTCGTGGCTCGGCCAGAAACGTACCAT
CGTGCCGGTTTTATCGGTATCGCCAGTGACGGCCAGGGGTGCCTGCGGCACGCCGTGCTCGTAGATCTGACGGTGAATTT
TGCCATCTCGCTGGATAACCAGTTCCAGTTTTTGCGACAGAGCGTTGACTACCGAGACGCCCACGCCGTGCAGACCGCCG
GAGACTTTATAGGAGTTATCGTCAAATTTACCGCCCGCGTGCAGAACGGTCATGATCACTTCCGCCGCCGAGACGCCTTC
TTCCGGGTGAATCCCGGTCGGAATGCCACGGCCATCATCCGTTACGGACACGGAGTTATCGGCGTGAATAGTCACGACGA
TATCTTTACAGTGACCTGCGAGCGCTTCGTCGATAGCGTTATCTACCACCTCGAATACCATGTGGTGCAGACCGGTGCCG
TCATCCGTGTCGCCGATATACATACCCGGGCGCTTACGCACCGCATCCAGCCCTTTCAGGACTTTGATACTGGAGGAGTC
ATAAGAATTCGACATC

>CARD|pvgb|NC_020418|545199-547614|ARO:3003306|Morganella|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
TTATACGTCGATGTTTGCCGCTTTCAGGGCATTCTCTTCGATAAAGGCACGGCGCGGTTCAACATCATCACCCATCAGTG
TGGTGAATAACTGATCCGTTGCAATCGCATCTTTTACCGTGACCTGCAACATACGGCGGGTTTCCGGGTTCATTGTGGTT
TCCCACAGCTGTTCCGGGTTCATTTCACCCAGCCCTTTATAGCGCTGTACAGCCAGACCACGGCGTGATTCTTTCATCAG
CCAGTCCAGTGCCTGCTCAAAGTTGCTGACGTTCTGACGGCGTTCACCACGGACAACATAAGCACCTTCTTCAATCAGAC
CACGGATAAGCTCACCCAGTTTGGAGATACGGGCATATTCGCTGCCGTGAACAAAATCGAAATCCAGATTGTAGTCAGTA
TCCACACCGTGGGTACGGATAGTCAGTACCGGCTCAAACAGCTGGCGCTCTTTGTTTTCCGCAATACGGTAGCTGTAGGT
GCTGCCGTGCTCTTCATGACGGGTCAGGCGCTCTGTCAGGCTCTGTGCCCAGGCTTCCACCTCGGTTTTGTTCAGCAGCG
CGGATTCTTCCAGTTTCGGCTGGTAGACCAGGCTGTTTAACAGTGCCAGCGGATAGAGACGCTCTAAACGGCGGATAATT
TTGTGTGCGCCGTTGTATTCGTGCAGCAGTTTTTCCAGATGTTCGCCCTGAATCGGAGCTGCATTTTCGTTTACATACAG
TGCCGCGCCATCCAGTGCGATAGAGACCTGATACTGCTCCATCGCTTCGTCATCTTTAATATACTGTTCCTGCTTGCCTT
TTTTCACTTTATACAGCGGCGGCTGTGCGATATACACATAACCGCGCTCAATGATTTCCGGCATCTGACGGTAGAAGAAA
GTCAGTAACAGGGTACGGATGTGTGAACCATCGACGTCGGCATCGGTCATGATGATGATGCTGTGATAGCGCAGTTTGTC
CGGGTTGTATTCGTCGCGGCCGATACCGCAGCCGAGTGCGGTGATCAGGGTGGCAACTTCCTGAGAAGCCAGCATTTTAT
CAAAACGCGCCTTCTCAACGTTCAGGATTTTACCTTTCAGCGGCAGGATAGCCTGGTTCTTACGGTTACGCCCCTGTTTT
GCAGAGCCGCCCGCAGAGTCCCCTTCCACTAAGTACAGTTCGGAGAAGGCCGGGTCGCGTTCCTGACAATCCGCCAGTTT
ACCCGGCAGACCGGCTAAATCCAGCGCGCCTTTACGGCGGGTCATTTCACGGGCACGGCGTGCAGCTTCACGGGCGCGTG
CGGCATCAATAATTTTGCCGACAATGATTTTGGTGTCGTTCGGGTTTTCATCCAGATATTCAGACAGCTTTTCGTTCATC
AGGGTTTCAACCGCCGTTTTCACTTCGGAAGAGACCAGCTTGTCTTTAGTCTGGGAGGAGAATTTCGGATCCGGCACTTT
GACGGAAATGACCGCCACCAGTCCTTCACGGGCATCGTCCCCGGTGGTGCTGACTTTGGATTTTTTATTCAGCCCTTCTT
TCTCAATATAGCTGTTGAGGGTACGGGTCATGGCGGCGCGGAAACCGGCGAGGTGAGCACCACCGTCGCGCTGCGGAATG
TTGTTGGTGAAGCAGTATACGTTTTCCTGGAAGGAGTCATTCCACTGCATGGAGATTTCCACGCCGATATCGTCTTTCTC
AGTGGAGAAATAGAAAACGTTGTTATGAATCGAAGTTTTGGCGCGGCTTAAATATTCCACGAATGCTTTGATACCGCCTT
CGTAGTGAAAGTGATCTTCTTTGCCGTCGCGTTTATCGATCAGACGGATCGATACACCGGAGTTCAGGAAGGAGAGTTCG
CGCAGGCGTTTTGCCAGAATGTCGTACTGGAATTCAGTCTCGCCTTTGAAGGTGTCCATGCTCGGCCAGAAACGCACGCG
TGTCCCGGTTTTATCGGTTTCGCCGACAACAGTCAGGCGATCCTGCGGTTCACCGTGGCGGTAAATCTGCTCGTGAACTT
TGCCGTCACGGCGGATAACCAGTTCCAGTTTTTCAGACAGGGCGTTAACAACAGAGACCCCGACGCCGTGCAGGCCGCCT
GAGACTTTATAGGAGTTATCATCGAACTTCCCGCCGGCGTGCAGAACAGTCATGATAACTTCTGCGGCGGAGACGCCTTC
TTCTTCATGGATCCCGGTCGGGATACCGCGACCGTCATCCTGTACGGAGACTGAATTATCATTGTGAATGGTCACAATGA
TGTCTTTACAGTAACCGGCGAGGGCTTCGTCGATAGCGTTGTCAACAACCTCGAAGACCATGTGGTGTAAACCGGTTCCG
TCATCGGTATCACCAATGTACATTCCCGGGCGTTTACGCACCGCGTCCAGCCCTTTTAATACTTTGATACTTGAGGAGTC
ATAGGTATTCGACATC

>CARD|pvgb|AL450380|5228-7265|ARO:3003304|Mycobacterium|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
GTGGCTGCCCAGAGGAAGGCCCAAGACGAATATGGCGCTGCGTCCATCACTATTCTTGAAGGGCTGGAGGCCGTTCGCAA
ACGTCCCGGTATGTACGTCGGGTCAACTGGTGAGCGTGGTCTCCACCATCTGATATGGGAAGTGGTGGACAACTCAGTAG
ATGAGGCGATGGCCGGTTATGCTACGCAAGTTGATGTGCGGTTATTCGACGACGGTAGTGTCGAGGTCGCCGATAACGGT
CGTGGTATTCCGGTGGCAGTGCATGCTACGGGGGTACCGACTGTTGACGTAGTTATGACCCAATTACATGCCGGCGGTAA
ATTCGGTGGTAAAGATAGCGGTTATAACGTCAGTGGTGGTTTGCATGGGGTAGGTGTGTCGGTGGTTAACGCATTGTCCA
CCAGGGTCGAGGTCGACATCAAACGTGACGGCTATGAATGGTCACAGTTTTACGACAAGGCTGTGCCGGGCATTCTTAAG
CAAGGCGAAGCTACTGAGGCGACGGGAACGACGATTAGATTTTGGGCAGATCCTGACATTTTCGAAACCACAAAGTATGA
CTTTGGGACGGTGGCGCGCCGAATTCAAGAAGTGGCTTTCTTGAACAAGGGTTTGACGATCAATCTTGTTGACGAACGGG
TGAAGCAGGACGAAGTTGTCGACGATGTCGTCAGCGATACAGCCGAGGCTCCTGTGGCTATGACCGTTGAAGAAAAGTCA
ACGGAGTCGAGTGCGCCGCACAAGGTTAGACACCGTACGTTCCACTACCCCGGAGGCCTGGTGGACTTCGTCAAGCACAT
CAACCGGACTAAGACTCCTATTCAACAGAGCATTATCGATTTTGATGGCAAAGGTGCCGGTCACGAGGTTGAAGTTGCGA
TGCAGTGGAACGGCGGCTATTCGGAATCAGTGCATACCTTTGCGAACACGATTAACACCCATGAAGGCGGCACCCACGAA
GAAGGTTTCCGTAGCGCTTTGACATCAGTGGTGAACAAGTACGCTAAGGATAAAAAACTACTCAAAGACAAGGATCCCAA
CCTAACTGGCGACGATATCCGTGAAGGTCTGGCGGCGGTTATCTCGGTTAAGGTCAGTGAACCACAGTTTGAGGGTCAGA
CCAAAACAAAGCTGGGGAACACCGAAGTTAAGTCATTCGTGCAGAGGGTCTGTAATGAGCAACTTATTCACTGGTTTGAA
GCCAATCCAGTAGATGCGAAAGCGGTTGTGAATAAGGCGATATCGTCGGCACAAGCCCGAATAGCTGCACGTAAAGCACG
AGAGTTAGTGCGTCGAAAAAGTGCCACCGATCTTGGTGGACTTCCTGGAAAACTTGCCGATTGCCGCTCTACTGATCCTC
GAAGTTCTGAACTGTATGTAGTGGAAGGTGATTCGGCTGGTGGTTCAGCAAAGAGTGGCCGTGATTCGATGTTTCAGGCA
ATCCTTCCGTTACGTGGCAAGATCATAAATGTTGAAAAGGCACGTATTGACCGAGTGCTAAAGAACACCGAAGTTCAAGC
AATTATTACGGCATTGGGTACTGGAATCCATGATGAATTCGATATCTCCAGGCTGCGTTATCACAAAATTGTTTTGATGG
CCGACGCTGACGTTGACGGCCAACATATCTCGACGCTGTTGTTGACTTTGTTATTTCGGTTCATGCGACCACTCATCGAG
CATGGGTACGTGTTTTTAGCGCAGCCGCCACTTTACAAATTGAAGTGGCAACGTATGGATCCGGAATTTGCTTACTCCGA
TAGCGAGCGCGACGGCTTATTAGAGACCGGGCTTAAGCTTGGCAAGAAAATCAACAAAGAGGATGGTATCCAACGTTATA
AAGGTTTAGGTGAAATGGATGCCAAGGAGTTGTGGGAAACCACCATGGACCCGTCGGTGCGAGTTTTGCGTCAAGTAACA
CTGGATGACGCGGCGGCTGCTGACGAGTTATTCTCTATTCTGATGGGTGAGGACGTCGATGCACGCCGTAGCTTTATCAC
CCGTAATGCCAAGGATGTTCGTTTCCTGGATGTCTAGT

>CARD|pvgb|AP009048|3760295-3762710|ARO:3003303|Escherichia|Fluoroquinolones|Fluoroquinolone-resistant_DNA_topoisomerases|GYRB|RequiresSNPConfirmation
ATGTCGAATTCTTATGACTCCTCCAGTATCAAAGTCCTGAAAGGGCTGGATGCGGTGCGTAAGCGCCCGGGTATGTATAT
CGGCGACACGGATGACGGCACCGGTCTGCACCACATGGTATTCGAGGTGGTAGATAACGCTATCGACGAAGCGCTCGCGG
GTCACTGTAAAGAAATTATCGTCACCATTCACGCCGATAACTCTGTCTCTGTACAGGATGACGGGCGCGGCATTCCGACC
GGTATTCACCCGGAAGAGGGCGTATCGGCGGCGGAAGTGATCATGACCGTTCTGCACGCAGGCGGTAAATTTGACGATAA
CTCCTATAAAGTGTCCGGCGGTCTGCACGGCGTTGGTGTTTCGGTAGTAAACGCCCTGTCGCAAAAACTGGAGCTGGTTA
TCCAGCGCGAGGGTAAAATTCACCGTCAGATCTACGAACACGGTGTACCGCAGGCCCCGCTGGCGGTTACCGGCGAGACT
GAAAAAACCGGCACCATGGTGCGTTTCTGGCCCAGCCTCGAAACCTTCACCAATGTGACCGAGTTCGAATATGAAATTCT
GGCGAAACGTCTGCGTGAGTTGTCGTTCCTCAACTCCGGCGTTTCCATTCGTCTGCGCGACAAGCGCGACGGCAAAGAAG
ACCACTTCCACTATGAAGGCGGCATCAAGGCGTTCGTTGAATATCTGAACAAGAACAAAACGCCGATCCACCCGAATATC
TTCTACTTCTCCACTGAAAAAGACGGTATTGGCGTCGAAGTGGCGTTGCAGTGGAACGATGGCTTCCAGGAAAACATCTA
CTGCTTTACCAACAACATTCCGCAGCGTGACGGCGGTACTCACCTGGCAGGCTTCCGTGCGGCGATGACCCGTACCCTGA
ACGCCTACATGGACAAAGAAGGCTACAGCAAAAAAGCCAAAGTCAGCGCCACCGGTGACGATGCGCGTGAAGGCCTGATT
GCGGTCGTTTCCGTGAAAGTGCCGGACCCGAAATTCTCCTCCCAGACCAAAGACAAACTGGTTTCTTCTGAGGTGAAATC
GGCGGTTGAACAGCAGATGAACGAACTGCTGGCAGAATACCTGCTGGAAAACCCAACCGACGCGAAAATCGTGGTTGGCA
AAATTATCGATGCTGCCCGTGCCCGTGAAGCGGCGCGTCGCGCGCGTGAAATGACCCGCCGTAAAGGTGCGCTCGACTTA
GCGGGCCTGCCGGGCAAACTGGCAGACTGCCAGGAACGCGATCCGGCGCTTTCCGAACTGTACCTGGTGGAAGGGGACTC
CGCGGGCGGCTCTGCGAAGCAGGGGCGTAACCGCAAGAACCAGGCGATTCTGCCGCTGAAGGGTAAAATCCTCAACGTCG
AGAAAGCGCGCTTCGATAAGATGCTCTCTTCTCAGGAAGTGGCGACGCTTATCACCGCGCTTGGCTGTGGTATCGGTCGT
GACGAGTACAACCCGGACAAACTGCGTTATCACAGCATCATCATCATGACCGATGCGGACGTCGACGGCTCGCACATTCG
TACGCTGCTGTTGACCTTCTTCTATCGTCAGATGCCGGAAATCGTTGAACGCGGTCACGTCTACATCGCTCAGCCGCCGC
TGTACAAAGTGAAGAAAGGCAAGCAGGAACAGTACATTAAAGACGACGAAGCGATGGATCAGTACCAGATCTCTATCGCG
CTGGACGGCGCAACGCTGCACACCAACGCCAGTGCACCGGCATTGGCTGGCGAAGCGTTAGAGAAACTGGTATCTGAGTA
CAACGCGACGCAGAAAATGATCAATCGTATGGAGCGTCGTTATCCGAAAGCAATGCTGAAAGAGCTTATCTATCAGCCGA
CGTTGACGGAAGCTGACCTTTCTGATGAGCAGACCGTTACCCGCTGGGTGAACGCGCTGGTCAGCGAACTGAACGACAAA
GAACAGCACGGCAGCCAGTGGAAGTTTGATGTTCACACCAATGCTGAGCAAAACCTGTTCGAGCCGATTGTTCGCGTGCG
TACCCACGGTGTGGATACTGACTATCCGCTGGATCACGAGTTTATCACCGGTGGCGAATATCGTCGTATCTGCACGCTGG
GTGAGAAACTGCGTGGCTTGCTGGAAGAAGATGCGTTTATCGAACGTGGCGAGCGTCGTCAGCCGGTAGCCAGCTTCGAG
CAGGCGCTGGACTGGCTGGTGAAAGAGTCCCGTCGCGGCCTCTCCATCCAGCGTTATAAAGGTCTGGGCGAGATGAACCC
GGAACAGCTGTGGGAAACCACTATGGACCCGGAAAGTCGTCGTATGCTGCGCGTTACCGTTAAAGATGCGATTGCTGCCG
ACCAGTTGTTCACCACGCTGATGGGCGACGCCGTTGAACCGCGCCGTGCGTTTATTGAAGAGAACGCCCTGAAAGCGGCG
AATATCGATATTTAAT