MEGAResFrom MEG, the Microbial Ecology Group

Fluoroquinolone-resistant DNA topoisomerases

Resistance to the fluoroquinolone class of antibiotics can be caused by direct mutation of their target, the DNA topoisomerases II and IV. These mutations are often specific to various bacterial species, though they commonly occur in homologous regions, termed the quinolone-resistance determining regions (QRDR). Known resistance mutations must be detected in order for these genes to be suspected as resistant genes.

References

Other Mechanisms in Fluoroquinolones

Groups

Sequences

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