Fluoroquinolones
The fluoroquinolone class of antibiotics target the bacterial DNA topoisomerases II (gyrase) and IV, converting them into a product that is toxic to the bacterial cell. Common drugs in this class include ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, etc.
References
- http://www.ncbi.nlm.nih.gov/pubmed/24576155
Mechanisms
- Fluoroquinolone ABC efflux pump
- Fluoroquinolone resistance phosphotransferase
- Fluoroquinolone-resistant DNA topoisomerases
- Quinolone active efflux
- Quinolone resistance protein Qnr