MEGAResFrom MEG, the Microbial Ecology Group

APH6

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(6) phosphotransferases modify the 6 hydroxyl group.

References

Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>AGly|Aph6-Ia|AY971801|1-924|924|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGAGTTCGTCGGACCACATCCACGTCCCGGACGGCCTGGCCGAGTCGTACAGCAGAAGCGGTGGCGAGGAAGGGCGCGC
CTGGATCGCCGGACTTCCCGCTCTCGTCGCGCGATGCGTCGACCGCTGGGAGCTGAAGAGGGACGGCGGCGTCCGCTCCG
GTGAGGCCTCCCTCGTGGTGCCGGTGCTGCGTGCTGACGGCACCCGGGCGGCGCTCAAACTCCAGATGCCCCGGGAAGAG
ACGACGGCCGCGCTGATCGGCCTGCGAGCCTGGGGCGGGGACGGCATGGTGCGGCTGCTCGACCACGACGAGGAGAGCAG
CACGATGCTGCTGGAACGCCTGGACGGTTCGCGGACGCTGGCGTCGGTCGAGGACGACGACGAGGCCATGGGCGTCCTCG
CCGGGCTGCTGAACCGGCTGCACTCCGTTCCGGCACCTCCGGGGCTGCGGGGTCTGGGAGAGATCGCCGGCGCCATGGTG
GAGGAAGTTCCCTCCGCTGTCGACTCGTTGGCGGATCCGGAGGACCGTAGCCGGTTGCGCGGCTGGGCGTCGGCCGTGGC
CGAGCTGGTGGGCGAGCCCGGTGACCGCGTCCTGCACTGGGACCTGCACTACGAGAACGTGCTGGCCGCCGAGCGCGAAC
CGTGGCTGGCCATCGACCCCGAGCCGCTGGTCGGCGACCCGGGGTTCGACCTGTGGCCGGCCCTGGACACCGGTTGGGAG
CGGATCGAGGCCACCGGTGACGCGCGGCGGGTGGTCCGGCGGCGCTTCGACCTGCTGACGGAAGCGCTGGAGCTGGACCG
CGGGAGGGCGGCCGGGTGGACCCTGGCCCGGCTCCTGCAGAACACCCTGTGGGACATCGAGGACGGGCTGACGGCGATCG
CCCCCTCCCAGATCGCCGTGGCCGAAGCGCTGGCGAAGCCCTGA

>1479|HF953351.1|HF953351|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGTTCATGCCGCCTGTTTTTCCTGCTCATTGGCACGTTTCGCAACCTGTTCTCATTGCGGACACCTTTTCCAGCCTCGT
TTGGAAAGTTTCATTGCCAGACGGGACTCCTGCAATCGTCAAGGGATTGAAACCTATAGAAGACATTGCTGATGAACTGC
GCGGGGCCGACTATCTGGTATGGCGCAATGGGAGGGGAGCAGTCCGGTTGCTCGGTCGTGAGAACAATCTGATGTTGCTC
GAATATGCCGGGGAGCGAATGCTCTCTCACATCGTTGCCGAGCACGGCGACTACCAGGCGACCGAAATTGCAGCGGAACT
AATGGCGAAGCTGTATGCCGCATCTGAGGAACCCCTGCCTTCTGCCCTTCTCCCGATCCGGGATCGCTTTGCAGCTTTGT
TTCAGCGGGCGCGCGATGATCAAAACGCAGGTTGTCAAACTGACTACGTCCACGCGGCGATTATAGCCGATCAAATGATG
AGCAATGCCTCGGAACTGCGTGGGCTACATGGCGATCTGCATCATGAAAACATCATGTTCTCCAGTCGCGGCTGGCTGGT
GATAGATCCCGTCGGTCTGGTCGGTGAAGTGGGCTTTGGCGCCGCCAATATGTTCTACGATCCGGCTGACAGAGACGACC
TTTGTCTCGATCCTAGACGCATTGCACAGATGGCGGACGCATTCTCTCGTGCGCTGGACGTCGATCCGCGTCGCCTGCTC
GACCAGGCGTACGCTTATGGGTGCCTTTCCGCAGCTTGGAACGCGGATGGAGAAGAGGAGCAACGCGATCTAGCTATCGC
GGCCGCGATCAAGCAGGTGCGACAGACGTCATACTAG

>AGly|Aph6-I|X01702|485-1285|801|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGGAGCGCTGGCGCCTGCTGCGCGACGGCGAGCTGCTCACCACCCACTCGAGCTGGATACTTCCCGTCCGCCAGGGGGA
CATGCCGGCGATGCTGAAGGTCGCGCGCATTCCCGATGAAGAGGCCGGTTACCGCCTGTTGACCTGGTGGGACGGGCAGG
GCGCCGCCCGAGTCTTCGCCTCGGCGGCGGGCGCTCTGCTCATGGAGCGCGCGTCCGGGGCCGGGGACCTTGCACAGATA
GCGTGGTCCGGCCAGGACGACGAGGCTTGCAGGATCCTCTGCGACACCGCCGCTCGTCTGCACGCGCCGCGGTCCGGACC
GCCGCCCGATCTCCATCCGCTACAGGAATGGTTCCAGCCGCTTTTCCGGTTGGCCGCTGAGCACGCGGCACTTGCGCCCG
CCGCCAGCGTAGCGCGCCAACTTCTGGCGGCGCCGCGCGAGGTGTGCCCGCTCCACGGCGACCTGCACCACGAGAACGTG
CTCGACTTCGGCGACCGCGGCTGGCTGGCCATCGACCCGCACGGACTGCTCGGCGAGCGCACCTTCGACTATGCCAACAT
CTTCACGAATCCCGATCTCAGCGACCCCGGTCGCCCGCTTGCGATCCTGCCGGGCAGGCTGGAGGCTCGACTCAGCATTG
TGGTCGCGACGACCGGGTTTGAGCCCGAACGGCTTCTTCGCTGGATCATTGCATGGACGGGCTTGTCGGCAGCCTGGTTC
ATCGGCGACGGCGACGGCGAGGGCGAGGGCGCTGCGATTGATCTGGCCGTAAACGCCATGGCACGCCGGTTGCTTGACTA
G

>AGly|NC_004973.1.1149626|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGTTCATGCCGCCTGTTTTTCCTGCTCATTGGCACGTTTCGCAACCTGTTCTCATTGCGGACACCTTTTCCAGCCTCGT
TTGGAAAGTTTCATTGCCAGACGGGACTCCTGCAATCGTCAAGGGATTGAAACCTATAGAAGACATTGCTGATGAACTGC
GCGGGGCCGACTATCTGGTATGGCGCAATGGGAGGGGAGCAGTCCGGTTGCTCGGTCGTGAGAACAATCTGATGTTGCTC
GAATATGCCGGGGAGCGAATGCTCTCTCACATCGTTGCCGAGCACGGCGACTACCAGGCGACCGAAATTGCAGCGGAACT
GATGGCGAAGCTGTATGCCGCATCTGAGGAACCCCTGCCTTCTGCCCTTCTCCCGATCCGGGATCGCTTTGCAGCTTTGT
TTCAGCGGGCGCGCGATGATCAAAACGCAGGTTGTCAAACTGACTACGTCCACGCGGCGATTATAGCCGATCAAATGATG
AGCAATGCCTCGGAACTGCGTGGGCTACATGGCGATCTGCATCATGAAAACATCATGTTCTCCAGTCGCGGCTGGCTGGT
GATAGATCCCGTCGGTCTGGTCGGTGAAGTGGGCTTTGGCGCCGCCAATATGTTCTACGATCCGGCTGACAGAGACGACC
TTTGTCTCGATCCTAGACGCATTGCACAGATGGCGGACGCATTCTCTCGTGCGCTGGACGTCGATCCGCGTCGCCTGCTC
GACCAGGCGTACGCTTATGGGTGCCTTTCCGCAGCTTGGAACGCGGATGGAGAAGAGGAGCAACGCGATCTAGCTATCGC
GGCCGCGATCAAGCAGGTGCGACAGACGTCATACTAG

>AGly|Aph6-Ib|X05648|382-1305|924|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGAGCACGTCAAAACTGGTGGAGATCCCGGAACCCCTGGCGGCGTCGTACGCCCGCGCCTTCGGCGAGGAGGGACAGGC
ATGGATCGCCGCCCTGCCCGCGCTGGTCGAGGAATTACTGGACCGCTGGGAGCTGACGGCGGACGGCGCCTCCGCGTCGG
GCGAGGCCTCCCTCGTGCTGCCGGTGCTGCGCACCGACGGCACCCGCGCCGTCCTCAAGCTCCAGCTGCCCAGGGAGGAG
ACCTCCGCCGCCATCACCGGACTGCGCACCTGGAACGGGCACGGCGTCGTGCGGCTGCTCGACCACGACCCGCGCAGCAG
CACCATGCTCCTGGAGCGGCTGGACGCGTCCCGCACGCTGGCCTCGGTCGAGGACGACGACGCCGCCATGGGCGTACTCG
CCGGGCTGCTGGCCCGGCTGGTGTCCGTCCCCGCGCCGCGGGGGCTGCGCGGCCTCGGCGACATCGCCGGCGCCATGCTG
GAGGAGGTGCCGCGGGCGGTCGCGGCGCTGGCCGACCCGGCCGACCGGCGGCTGCTGAACGACTGGGCGTCGGCGGTGGC
CGAACTGGTCGGCGAACCCGGCGACCGGATGCTGCACTGGGACCTGCACTACGGCAACGTCCTCGCCGCCGAGCGCGAAC
CCTGGCTCGCCATCGACCCCGAACCGCTCGCCGGTGACCCCGGCTTCGACCTGTGGCCCGCCCTGGACAGCCGGTGGGAC
GACATCGTCGCACAGCGGGACGTCGTACGCGTCGTGCGACGCCGCTTCGACCTGCTGACCGAGGTCCTCGGCCTGGACCG
GGCACGGGCGGCCGGCTGGACGTACGGCAGGCTGCTGCAGAACGCCCTGTGGGACATCGAGGACGGCAGTGCCGCCCTCG
ACCCCGCCGCCGTCACGCTCGCACAGGCGCTGCGGGGCCACTGA

>AGly|Aph9-Ib|U70376|3618-4541|996|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGGACACGTCAAAAGCGATCGAGGTCCCGGAACACCTGGCGGCGTCGTACAGCAGGGGATTCGGCGAGGAAGGGAGGGC
CTGGATCGCTGCGCTGCCGACTCTCGCCGCGGCATTCCTGGACAGGTGGGAACTGCGGCGCGATGGTGCGGCCCGGGCAG
GGGAAGCCTCGCTGGTACTGCCGGTGTTACGCCAGGACGGTACCCGCGCGGTCCTCAAGCTCCAGATGCCCCGGGAAGAG
ACCACTGCGGCCCTCATCGGCCTGTGCACATGGAACGGTGCCGGCACGGTACGGCTGCTCGACCACGATCCCCACAGCAG
CACCATGCTCCTGGAGCGGCTGGACAGCGCCCGCACCTTGGCCTCACTCGAGGACGACGACGTCGCGATGGGAATCCTCG
CCGAACTGCTGGCGCGGCTCGTCAGCGTCCCCGCCCCCCGGGAACTGCGCCGCCTCAAAGACATCGCCGCCGACATGCTG
GAGCGGGTACCGCGCGCGGTCACGGCCCTGGCCGACCCGGCCGACCGGCAGTTGTTGCGTGGCTGGGCGGCGGCCGTCGC
CGAACTGATCGAGGAACCCGGCGACCAGATGCTGCACTGGGACCTGCACTACGACAACGTGCTGGCCGCGGAGCGTGAGC
CGTGGCTCGCCATCGACCCCGAACCGCTCGCAGGGGACCCCGGTTTCGACCTGTGGCCGGCCCTGGACAGCCGGTGGGAC
GACATCGTCGCCACGGGCGACACCCGGCGTGTGGTGCGGCGCCGGTTCGACCTGCTCACCGGGGTCCTCGGTCTGGACCG
CGGGCGTGCGGCCGGCTGGACGCTGGGGCGGCTGCTGCAGAACGAGCTGTGGGACATCGAGGGCGGTGGCTCCGCCCTCG
CCCCGTCCTCGGTCGCGATGGCGGAGGCGCTCCAGAACCGTTGA

>AGly|strB_3_AF024602|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGTTCATGCCGCCTGTTTTTCCTGCTCATTGGCACGTTTCGCAACCTGTTCTCATTGCGGACACCTTTTCCAGCCTCGT
TTGGAAAGTTTCATTGCCAGACGGGACTCCTGCAATCGTCAAGGGATTGAAACCTATAGAAGACATTGCTGATGAACTGC
GCGGGGCCGACTATCTGGTATGGCGCAATGGGAGGGGAGCAGTCCGGTTGCTCGGTCGTGAGAACAATCTGATGTTGCTC
GAATATGCCGGGGAGCGAATGCTCTCTCACATCGTTGCCGAGCACGGCGACTACCAGGCGACCGAAATTGCAGCGGAACT
AATGGCGAAGCTGTATGCCGCATCTGAGGAACCCCTGCCTTCTGCCCTTCTCCCGATCCGGGATCGCTTTGCAGCTTTGT
TTCAGCGGGCGCGCGATGATCAAAACGCAGGTTGTCAAACTGACTACGTCCACGCGGCGATTATAGCCGATCAAATGATG
AGCAATGCCTCGGAACTGCGTGGGCTACATGGCGATCTGCATCATGAAAACATCATGTTCTCCAGTCGCGGCTGGCTGGT
GATAGATCCCGTCGGTCTGGTCGGTGAAGTGGGCTTTGGCGCCGCCAATATGTTCTACGATCCGGCTGACAGAGACGACC
TTTGTCTCGATCCTAGACGCATTGCACAGATGGCGGACGCATTCTCTCGTGCGCTGGACGTCGATCCGCGTCGCCTGCTC
GACCAGGCGTACGCTTATGGGTGCCTTTCCGCAGCTTGGAACGCGGATGGAGAACAGGAGCAACGCGATCTAGCTATCGC
GGCCGCGATCAAGCAGGTGCGACAGACGTCATACTAG

>AGly|Sph|AY037297|3548-2706|801|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGAGTGTGTCTTCCCGTTTTCCGCCTGAGGTCACTGCGTGGATGGAGCGCTGGCGCCTGCTGCGCGACGGCGAGCTGCT
CACCACCCACTCGAGCTGGATACTTCCCGTCCGCCAGGGGGACATGCCGGCGATGCTGAAGGTCGCGCGCATTCCCGATG
AAGAGGCCGGTTACCGCCTGTTGACCTGGTGGGACGGGCAGGGCGCCGCCCGAGTCTTCGCCTCGGCGGCGGGCGCTCTG
CTCATGGAGCGCGCGTCCGGGGCCGGGGACCTTGCACAGATAGCGTGGTCCGGCCAGGACGACGAGGCTTGCAGGATCCT
CTGCGACACCGCCGCTCGTCTGCACGCGCCGCGGTCCGGACCGCCGCCCGATCTCCATCCGCTACAGGAATGGTTCCAGC
CGCTTTTCCGGTTGGCCGCTGAGCACGCGGCACTTGCGCCCGCCGCCAGCGTAGCGCGCCAACTTCTGGCGGCGCCGCGC
GAGGTGTGCCCGCTCCACGGCGACCTGCACCACGAGAACGTGCTCGACTTCGGCGACCGCGGCTGGCTGGCCATCGACCC
GCACGGACTGCTCGGCGAGCGCACCTTCGACTATGCCAACATCTTCACGAATCCCGATCTCAGCGACCCCGGTCGCCCGC
TTGCGATCCTGCCGGGCAGGCTGGAGGCTCGACTCAGCATTGTGGTCGCGACGACCGGGTTTGAGCCCGAACGGCTTCTT
CGCTGGATCATTGCATGGACGGGCTTGTCGGCAGCCTGGTTCATCGGCGACGGCGACGGCGAGGGCGAGGGCGCTGCGAT
TGATCTGGCCGTAAACGCCATGGCACGCCGGTTGCTTGACTAG

>AGly|AF313472.2|gene16|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGTTCATGCCGCCTGTTTTTCCTGCTCATTGGCACGTTTCGCAACCTGTTCTCATTGCGGACACCTTTTCCAGCCTCGT
TTGGAAAGTTTCATTGCCAGACGGGACTCCTGCAATCGTCAAGGGATTGAAACCTATAGAAGACATTGCTGATGAACTGC
GCGGGGCCGACTATCTGGTATGGCGCAATGGGAGGGGAGCAGTCCGGTTGCTCGGTCGTGAGAACAATCTGATGTTGCTC
GAATATGCCGGGGAGCGAATGCTCTCTCACATCGTTGCCGAGCACGGCGACTACCAGGCGACCGAAATTGCAGCGGAACT
AATGGCGAAGCTGTATGCCGCATCTGAGGAACCCCTGCCTTCTGCCCTTCTCCCGATCCGGGATCGCTTTGCAGCTTTGT
TTCAGCGGGCGCGCGATGATCAAAACGCAGGTTGTCAAACTGACTACGTCCACGCGGCGATTATAGCCGATCAAATGATG
AGCAATGCCTCGGAACTGCGTGGGCTACATGGCGATCTGCATCATGAAAACATCATGTTCTCCAGTCGCGGCTGGCTGGT
GATAGATCCCGTCGGTCTGGTCGGTGAAGTGGGCTTTGGCGCCGCCAATATGTTCTACGATCCGGCTGACAGAGACGACC
TTTGTCTCGATCCCAGACGCATTGCACAGATGGCGGACGCATTCTCTCGTGCGCTGGACGTCGATCCGCGTCGCCTGCTC
GACCAGGCGTACGCTTATGGGTGCCTTTCCGCAGCTTGGAACGCGGATGGAGAAGAGGAGCAACGCGATCTAGCTATCGC
GGCCGCGATCAAGCAGGTGCGACAGACGTCATACTAG

>AGly|Y00459.1|gene3|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH6
ATGAGTTCGTCGGACCACATCCACGTCCCGGACGGCCTGGCCGAGTCGTACAGCAGAAGCGGTGGCGAGGAAGGGCGCGC
CTGGATCGCCGGACTTCCCGCTCTCGTCGCGCGATGCGTCGACCGCTGGGAGCTGAAGAGGGACGGCGGCGTCCGCTCCG
GTGAGGCCTCCCTCGTGGTGCCGGTGCTGCGTGCTGACGGCACCCGGGCGGCGCTCAAACTCCAGATGCCCCGGGAAGAG
ACGACGGCCGCGCTGATCGGCCTGCGAGCCTGGGGCGGGGACGGCATGGTGCGGCTGCTCGACCACGACGAGGAGAGCAG
CACGATGCTGCTGGAACGCCTGGACGGTTCGCGGACGCTGGCGTCGGTCGAGGACGACGACGAGGCCATGGGCGTCCTCG
CCGGGCTGCTGAACCGGCTGCACTCCGTTCCGGCACCTCCGGGGCTGCGGGGTCTGGGAGAGATCGCCGGCGCCATGGTG
GAGGAAGTTCCCTCCGCTGTCGACTCGTTGGCGGATCCGGAGGACCGTAGCCGGTTGCGCGGCTGGGCGTCGGCCGTGGC
CGAGCTGGTGGGCGAGCCCGGTGACCGCGTCCTGCACTGGGACCTGCACTACGAGAACGTGCTGGCCGCCGAGCGCGAAC
CGTGGCTGGCCATCGACCCCGAGCCGCTGGTCGGCGACCCGGGGTTCGACCTGTGGCCGGCCCTGGACACCGGTTGGGAG
CGGATCGAGGCCACCGGTGACGCGCGGCGGGTGGTCCGGCGGCGCTTCGACCTGCTGACGGAATCGCTGGAGCTGGACCG
CGGGAGGGCGGCCGGGTGGACCCTGGCCCGGCTCCTGCAGAACACCCTGTGGGACATCGAGGACGGGCTGACGGCGATCG
CCCCCTCCCAGATCGCCGTGGCCGAAGCGCTGGCGAAGCCCTGA