MEGAResFrom MEG, the Microbial Ecology Group

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APH4

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(4) phosphotransferases modify the 4 hydroxyl group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>>MEG_1082|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH4
ATGAAAAAGCCTGAACTCACCGCGACGTCTGTCGAGAAGTTTCTGATCGAAAAGTTCGACAGCGTCTCCGACCTGATGCA
GCTCTCGGAGGGCGAAGAATCTCGTGCTTTCAGCTTCGATGTAGGAGGGCGTGGATATGTCCTGCGGGTAAATAGCTGCG
CCGATGGTTTCTACAAAGATCGTTATGTTTATCGGCACTTTGCATCGGCCGCGCTCCCGATTCCGGAAGTGCTTGACATT
GGGGAATTCAGCGAGAGCCTGACCTATTGCATCTCCCGCCGTGCACAGGGTGTCACGTTGCAAGACCTGCCTGAAACCGA
ACTGCCCGCTGTTCTGCAGCCGGTCGCGGAGGCCATGGATGCGATCGCTGCGGCCGATCTTAGCCAGACGAGCGGGTTCG
GCCCATTCGGACCGCAAGGAATCGGTCAATACACTACATGGCGTGATTTCATATGCGCGATTGCTGATCCCCATGTGTAT
CACTGGCAAACTGTGATGGACGACACCGTCAGTGCGTCCGTCGCGCAGGCTCTCGATGAGCTGATGCTTTGGGCCGAGGA
CTGCCCCGAAGTCCGGCACCTCGTGCACGCGGATTTCGGCTCCAACAATGTCCTGACGGACAATGGCCGCATAACAGCGG
TCATTGACTGGAGCGAGGCGATGTTCGGGGATTCCCAATACGAGGTCGCCAACATCTTCTTCTGGAGGCCGTGGTTGGCT
TGTATGGAGCAGCAGACGCGCTACTTCGAGCGGAGGCATCCGGAGCTTGCAGGATCGCCGCGGCTCCGGGCGTATATGCT
CCGCATTGGTCTTGACCAACTCTATCAGAGCTTGGTTGACGGCAATTTCGATGATGCAGCTTGGGCGCAGGGTCGATGCG
ACGCAATCGTCCGATCCGGAGCCGGGACTGTCGGGCGTACACAAATCGCCCGCAGAAGCGCGGCCGTCTGGACCGATGGC
TGTGTAGAAGTACTCGCCGATAGTGGAAACCGACGCCCCAGCACTCGTCCGAGGGCAAAGGAATAG

>>MEG_1083|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH4
ATGCTGCAAACTTCTAAAAAAAAATCTGGGCACGATGAAAGTTGGGCTAACGCTGACGCTCACAAATGGCGTGGCGAAAG
GAAGCGAGACAATCGGAAAATTGTTCTCTCGGGCACCACAAAGCTGTTGTTTGTCGCTGAAGAACAATTCCAACTGATTC
CGCCGCCTTCCTATTGCGTCAGCCTTGTACCTAAGCTGCCGAGTAACGTCACTCAACCTCTCTTTGAATACTGCTTTGCT
CCGCGAATACTTTTCTTCTATGCGCTCAAGAAAATGACACAGCACACCAAGCTCTGCAAACTTTCTTCGCTCATCTGGCG
CGAAATGTGGGCCATTTCTTCTCGCCTGCAATGGCAATGCGTCTGTGCGGCGAGGAGAATCACGATGCGGAATGGGGGCT
GGAAGTTCATAGAGATGCTGAGTTGTTGGAGCGACATGGTACATAAGCATGAGTCTGTCCTGATTTCCACCCTCCCGTCT
TTCATCAACTTTCTCGTCGGACCCTTCCGATCGGCGGGCGCAGAACCAGGCGGTATGCACCGTAGGGTGGACCCACCGCG
GCCACTGTCGCCAGCCTTGATCGAGGCCTTCGACGGGGTCATGCAGCTCTCGGGCGCCCCCTCTCGTGGGGTCACACCAA
CCCCACGAGGGCCAGATGCTTTGGGCCGGATAACAGATAGCCGCGGGGGGTCCGAGGCTGGCTATAGGTTTAATATGTGT
AATCGGGCAGTACCATCGGCCGCGCTCCCGATTGGGGAAGTGCTTGACATTGGGGAATTCAGCGGGAAGCGGACCTACCT
GGCCGCCGTGCACAGGGCCCGCGAGCAAGACCTGCCTGAAACCGAACTGCCCGCTGTTCTGCAGCCCTGCACGGGCATGG
CACATGCGATCGCTGCGGCCGATCTTAGCCACACGAGCGGGTTCGCCCCATTCGGACCGCAAGGAATGGGTCAAGAGACT
CCATGGCGTGATAAGCGCGATTGCTATTTCGATCCCCAGGTGTATTATTGGCTCTCTCAAATGGGCGACACCCTACGGGC
GTCCGTCGCGCAGGGTTTCGAAAAGCGGATGCTTTGGGCCGAGGACTGCCCCGAAGCCCGGCACCTCCGGATTCACGTAA
AGGGGTCCAACGCTGCCCTGCCGGAACCCGGCCCCAAAACGTGGGCGGGGGACGGGAGCCAAGCGGTGTGGGCAGGCCGG
CTGCGTCCCACCCAGGATTCCCGGTACGTGGTCGCCAGCATCTTCCCCTGGAGGCCGTGGTGA