MEGAResFrom MEG, the Microbial Ecology Group

APH4

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(4) phosphotransferases modify the 4 hydroxyl group.

References

Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>CARD|phgb|V01499|230-1256|ARO:3002655|APH4-Ia|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH4
ATGAAAAAGCCTGAACTCACCGCGACGTCTGTCGAGAAGTTTCTGATCGAAAAGTTCGACAGCGTCTCCGACCTGATGCA
GCTCTCGGAGGGCGAAGAATCTCGTGCTTTCAGCTTCGATGTAGGAGGGCGTGGATATGTCCTGCGGGTAAATAGCTGCG
CCGATGGTTTCTACAAAGATCGTTATGTTTATCGGCACTTTGCATCGGCCGCGCTCCCGATTCCGGAAGTGCTTGACATT
GGGGAATTCAGCGAGAGCCTGACCTATTGCATCTCCCGCCGTGCACAGGGTGTCACGTTGCAAGACCTGCCTGAAACCGA
ACTGCCCGCTGTTCTGCAGCCGGTCGCGGAGGCCATGGATGCGATCGCTGCGGCCGATCTTAGCCAGACGAGCGGGTTCG
GCCCATTCGGACCGCAAGGAATCGGTCAATACACTACATGGCGTGATTTCATATGCGCGATTGCTGATCCCCATGTGTAT
CACTGGCAAACTGTGATGGACGACACCGTCAGTGCGTCCGTCGCGCAGGCTCTCGATGAGCTGATGCTTTGGGCCGAGGA
CTGCCCCGAAGTCCGGCACCTCGTGCACGCGGATTTCGGCTCCAACAATGTCCTGACGGACAATGGCCGCATAACAGCGG
TCATTGACTGGAGCGAGGCGATGTTCGGGGATTCCCAATACGAGGTCGCCAACATCTTCTTCTGGAGGCCGTGGTTGGCT
TGTATGGAGCAGCAGACGCGCTACTTCGAGCGGAGGCATCCGGAGCTTGCAGGATCGCCGCGGCTCCGGGCGTATATGCT
CCGCATTGGTCTTGACCAACTCTATCAGAGCTTGGTTGACGGCAATTTCGATGATGCAGCTTGGGCGCAGGGTCGATGCG
ACGCAATCGTCCGATCCGGAGCCGGGACTGTCGGGCGTACACAAATCGCCCGCAGAAGCGCGGCCGTCTGGACCGATGGC
TGTGTAGAAGTACTCGCCGATAGTGGAAACCGACGCCCCAGCACTCGTCCGAGGGCAAAGGAATAGA

>CARD|phgb|X74325|645-1908|ARO:3002656|APH4-Ib|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH4
ATGCTGCAAACTTCTAAAAAAAAATCTGGGCACGATGAAAGTTGGGCTAACGCTGACGCTCACAAATGGCGTGGCGAAAG
GAAGCGAGACAATCGGAAAATTGTTCTCTCGGGCACCACAAAGCTGTTGTTTGTCGCTGAAGAACAATTCCAACTGATTC
CGCCGCCTTCCTATTGCGTCAGCCTTGTACCTAAGCTGCCGAGTAACGTCACTCAACCTCTCTTTGAATACTGCTTTGCT
CCGCGAATACTTTTCTTCTATGCGCTCAAGAAAATGACACAGCACACCAAGCTCTGCAAACTTTCTTCGCTCATCTGGCG
CGAAATGTGGGCCATTTCTTCTCGCCTGCAATGGCAATGCGTCTGTGCGGCGAGGAGAATCACGATGCGGAATGGGGGCT
GGAAGTTCATAGAGATGCTGAGTTGTTGGAGCGACATGGTACATAAGCATGAGTCTGTCCTGATTTCCACCCTCCCGTCT
TTCATCAACTTTCTCGTCGGACCCTTCCGATCGGCGGGCGCAGAACCAGGCGGTATGCACCGTAGGGTGGACCCACCGCG
GCCACTGTCGCCAGCCTTGATCGAGGCCTTCGACGGGGTCATGCAGCTCTCGGGCGCCCCCTCTCGTGGGGTCACACCAA
CCCCACGAGGGCCAGATGCTTTGGGCCGGATAACAGATAGCCGCGGGGGGTCCGAGGCTGGCTATAGGTTTAATATGTGT
AATCGGGCAGTACCATCGGCCGCGCTCCCGATTGGGGAAGTGCTTGACATTGGGGAATTCAGCGGGAAGCGGACCTACCT
GGCCGCCGTGCACAGGGCCCGCGAGCAAGACCTGCCTGAAACCGAACTGCCCGCTGTTCTGCAGCCCTGCACGGGCATGG
CACATGCGATCGCTGCGGCCGATCTTAGCCACACGAGCGGGTTCGCCCCATTCGGACCGCAAGGAATGGGTCAAGAGACT
CCATGGCGTGATAAGCGCGATTGCTATTTCGATCCCCAGGTGTATTATTGGCTCTCTCAAATGGGCGACACCCTACGGGC
GTCCGTCGCGCAGGGTTTCGAAAAGCGGATGCTTTGGGCCGAGGACTGCCCCGAAGCCCGGCACCTCCGGATTCACGTAA
AGGGGTCCAACGCTGCCCTGCCGGAACCCGGCCCCAAAACGTGGGCGGGGGACGGGAGCCAAGCGGTGTGGGCAGGCCGG
CTGCGTCCCACCCAGGATTCCCGGTACGTGGTCGCCAGCATCTTCCCCTGGAGGCCGTGGTGAA