MEGAResFrom MEG, the Microbial Ecology Group

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APH2-DPRIME

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(2'') phosphotransferases modify the 2 double prime hydroxyl group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>>MEG_1008|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
atgattgatttggacgtagaaatatatcagcatttgaatgaacagataaaaataaataaactctgctatttgtcatcagg
tgatgatagcgatacttttttatgtaatgaacaatatgttgtgaaagttccaaaacgagattctgttagatttgctcaga
aacgagagtttgaattgtatcggtttttagaaaattgtaatttatcttatcagacccctgcggtagtatatcaaagtgac
cgatttaatattatgaaatatattaaaggggaacgtattacttatgagcagtatcataagttgagtgaaaaggaaaagga
tgcccttgcatatgatgaagctacgtttttgaaagagttacattctatagagattgattgttctgtcagtttgttttcag
atgctctggtgaataagaaagataagtttttgcaagataaaaaattacttataagtattttggaaaaggagcagctgttg
actgatgagatgttggaacatatcgaaacaatatatgaaaacatatcaagcaatgctgttatatttaactatatcccttg
tttggtacataatgatttcagtgcaaataacttgatttttagaaataatagactgtttggagttattgattttggcgatt
ttaatgtaggtgacccggataatgattttttatgcttgctggattgtagtacagatgatttcgggaaagaatttggcagg
aaggtattaaaatactatcagcataaggcgccggaagtagcagaaagaaaagcagagcttaatgatgtgtattggtcgat
agaccaaatcatttatggttatgaaagaaaagatagggaaatgttgattaagggtgtttctgaattgctacagacacaag
cagagatgtttatattttag

>>MEG_1009|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
atggatataaaaaagattatagaagaaaaatgcaagatagttgttgatagtataaagttgattggcgaggggtatgacag
taaagcatacattgtaaataatgaatatgtttttaaaattaaatttagtgctaataagaaaaaaggatatgaaaaagaaa
aagcaatatatgatttcttaaacaaaaaattaaatacaacaataaatattcctaatattgaatattcatatataagtgat
gatatatctatattggggtataaggaaattaaaggaacttttttaacaccagagatttattttactttatcaaaagagaa
acaagatttgttgaaacaagatattgctatgtttttaaaacaaatgcacaatttagattatagtgaaataagttcatata
cgatagacaataaacaaaatgttttagaagaatatcaattactaaaagaaacaatatatgatagttttactgatattgaa
aaacaatatgtagaaaattttatgcaaatattacataatacgactatatttgatggcagaaaatgtttatgtcataatga
ttttagttgtaatcatttattacttgatgataatagattagttggagtaattgattttggagattctggaattatagatg
agtattgtgattttatatatttattagaagatagtaaagaagaaattggtgtatcttttggagaagatatattaagatta
tacggaaatattgatatttcaaaagcaaaagaatatcaagatgtagtagaacaatattatcctattgaaactattgtata
tggtattaaaaataataaacctgattttatagaaaaaggtagaaaagagatttatataagaacacacaaagaagaaaaat
taaggaagtga

>>MEG_1010|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
atggatattagaaaaacaatagaagaaaaatgcaatatagtgattgaaagcattaaattgattggagaaggatacgatag
taaagcatatatagtaaataatgaatatgtttttaaaataaagtttagtgctaataagaaaaaaggttatgaaaaagaaa
aagcagtatatgattttttgaataaaaaattacatacttctgtaaatattcctaatatagagtattcatacataagtgat
gaaatatctatattaggttataaagaaattaaaggaacatttttaacaccagaaatctatttttcaatgtcattggaaca
acaagatttattaaaacaagatattgcaatgtttttacgacaaatgcacgatttagattttgatgaaataagttcatata
caatagataataagcaaaatgttttagaagaatatcaattattacgagaaacaatttatgagagtcttactgatatagaa
aagcaatatatagaagaatttatgcaaagactatatagtacaactatatttgatggcaaaaaatgtttgtgtcataatga
ttttagttgtaatcatttattgttagatgataataataggttagttggagtaattgattttggagattctggaataattg
atgaatactgtgattttatatatttattagaagatagtgaagaagaaataggagtttcttttggagaagatatacttaaa
ctttatggaaatattgatatttcaaaagcaaaagaatatcaggatgtagtagaacaatattatcctatcgaaactattgt
atatggtgtaaaaaataatagagatgattttattgaaaaaggaagaaaagaaatctatttaagaacaagaaaagatgaaa
agacaaggaagtga

>>MEG_1011|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGTTAACTTGGACGCTGAGATATATGAGCACTTAAATAAACAGATAAAAATAAATGAACTCCGTTATTTATCGTCCGG
CGATGATAGTGATACTTTTTTGTGTAATGAACAATATGTTGTGAAAGTTCCTAAACGAGATTCTGTTAGAATTTCTCAGA
AACGAGAGTTTGAATTGTATCGTTTTTTAGAAAACTGTAAGCTATCTTATCAAATCCCTGCGGTAGTGTATCAAAGTGAC
CGATTTAATATTATGAAATATATTAAAGGGGAACGTATTACTTATGAGCAGTATCATAAGTTGAGTGAAAAGGAAAAGGA
TGCCCTTGCATATGATGAAGCGACGTTTTTGAAAGAGTTACATTCCATAGAGATTGATTGTTCTGTCAGTTTGTTTTCAG
ATGCTCTGGTGAATAAGAAAGATAAGTTTTTGCAAGATAAAAAATTACTTATAAGTATTCTGGAAAAGGAGCAGCTGTTA
ACTGATGAGATGTTGGAACATATCGAAACAATATATGAAAACATATTAAACAATGCTGTTTTATTTAAATATACCCCTTG
TTTGGTACATAATGATTTCAGTGCAAATAACATGATTTTTAGAAATAATAGACTGTTTGGAGTTATTGATTTTGGCGATT
TTAATGTAGGTGACCCGGATAATGATTTTTTGTGCTTGCTGGATTGTAGTACAGATGATTTCGGGAAAGAATTTGGCAGG
AAGGTATTAAAATACTATCAGCATAAGGCGCCGGAAGTAGCAGAAAGAAAAGCAGAGCTTAATGATGTATATTGGTCGAT
AGACCAAATTATTTATGGTTATGAAAGAAAAGATAGGGAAATGTTGATTAAGGGTGTTTCTGAATTGCTACAAACACAAG
CAGAGATGTTTATATTTTAG

>>MEG_1012|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGAGAACTTATACTTTCGACCAGGTAGAAAAGGCAATAGAGCAGTTATATCCTGATTTTACTATCAATACAATAGAGAT
TTCAGGAGAAGGCAATGACTGTATTGCATATGAAATAAACAGGGATTTCATTTTTAAATTTCCAAAGCATTCAAGAGGAT
CTACTAATCTTTTTAATGAAGTAAATATACTCAAAAGAATCCACAATAAATTACCCCTCCCCATTCCGGAGGTGGTTTTT
ACAGGAATGCCATCAGAAACGTACCAAATGTCTTTCGCAGGTTTTACAAAAATTAAAGGAGTACCATTGACACCTCTTCT
ACTCAATAATCTGCCGAAGCAATCTCAAAATCAGGCAGCTAAGGACCTGGCCCGATTTCTAAGTGAACTTCACAGCATAA
ACATCTCTGGATTCAAAAGTAATCTGGTATTAGATTTTCGAGAGAAGATAAATGAAGATAATAAAAAAATCAAAAAGTTA
CTATCCAGGGAATTAAAGGGTCCCCAGATGAAGAAAGTGGATGATTTTTACAGGGATATTCTAGAGAACGAAATCTACTT
CAAATACTATCCTTGTCTTATTCATAACGATTTTAGCAGTGATCATATTTTATTTGATACCGAAAAAAATACTATTTGTG
GAATAATCGATTTTGGAGATGCAGCTATTTCTGATCCCGACAATGATTTTATAAGTTTGATGGAAGATGATGAAGAATAC
GGCATGGAATTTGTATCAAAAATATTGAACCATTACAAACATAAGGATATACCGACAGTTTTGGAAAAATATAGGATGAA
AGAAAAATACTGGTCGTTCGAAAAGATTATCTATGGAAAGGAATATGGTTATATGGATTGGTATGAAGAGGGATTAAATG
AAATCAGAAGCATTAAAATTAAATAG

>>MEG_1013|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGTTAACTTGGACGCTGAGATATATGAGCACTTAAATAAACAGATAAAAATAAATGAACTCCGTTATTTATCGTCCGG
CGATGATAGTGATACTTTTTTGTGTAATGAACAATATGTTGTGAAAGTTCCTAAACGAGATTCTGTTAGAATTTCTCAGA
AACGAGAGCTTGAATTGTATCGTTTTTTAGAAAACTGTAAGCTATCTTATCAAATCCCTGCGGTAGTGTATCAAAGTGAC
CGATTTAATATTATGAAATATATTAAAGGGGAACGTATTACTTATGAGCAGTATCATAAGTTGAGTGAAAAGGAAAAGGA
TGCCCTTGCATATGATGAAGCGACGTTTTTGAAAGAGTTACATTCCATAGAGATTGATTGTTCTGTCAGTTTGTTTTCAG
ATGCTCTGGTGAATAAGAAAGATAAGTTTTTGCAAGATAAAAAATTACTTATAAGTATTCTGGAAAAGGAGCAGCTGTTA
ACTGATGAGATGTTGGAACATATCGAAACAATATATGAAAACATATTAAGCAATGCTGTTTTATTTAAATATACCCCTTG
TTTGGTACATAATGATTTCAGTGCAAATAACATGATTTTTAGAAATAATAGACTGTTTGGAGTTATTGATTTTGGCGATT
TTAATGTAGGTGACCCGGATAATGATTTTTTGTGCTTGCTGGATTGTAGTACAGATGATTTCGGGAAAGAATTTGGCAGG
AAGGTATTAAAATACTATCAGCATAAGGCGCCGGAAGTAGCAGAAAGAAAAGCAGAGCTTAATGATGTATATTGGTCGAT
AGACCAAATCATTTATGGTTATGAAAGAAAAGATAGGGAAATGTTGATTAAGGATGTTTCTGAATTGCTACAAACACAAG
CAGAGATGTTTATATTTTAG

>>MEG_1014|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGATATAAAAAAGATAATAGAAGAAAAATGCAATATAGTTGTTGATAGTATAAAGTTGATTGGTGAGGGTTATGACAG
CAAAGCATACATTGTAAATAATGAATATGTTTTCAAAATCAAATTTAGTGCTAATAAGAAAAAAGGGTATGAAAAAGAAA
AAGCAATATATGATTTTCTAAACAAAAAATTAAATACAAATATTAAAATACCAAATATAGAATATTCATATATAAGTGAA
GAATTATCTATTTTAGGATATAAAGAAATTAAAGGAACTTTTTTAACACCAGAAATATATTTTGCCTTATCAAAAGAAAA
GCAAGAATTATTAAAGCAAGATATTGCTATGTTTTTAAGACAAATGCACGATTTAGATTATAGTGAAATAAGTTCATATA
CGATAGACAATAAACAAAATGTTTTAGAAGAATATCAATTACTTAAAGAAACAATATATGATAGTCTTACTGATATTGAA
AAACAATATGTAGAAGAATTTATGCAAAGATTAAATAGTACAACTATATTTGATGGTAAAAAATGCTTATGCCATAATGA
TTTTAGTTGTAATCATTTATTACTTGATGATGAAAATAGATTATGTGGTGTAATAGATTTTGGAGATTCTGGAATTATAG
ATGAATACTGTGATTTCATATATTTGCTAGAAGATAGTGAAGAAGAAATTGGCGTGTCTTTTGGAGAAGATATATTAAGA
TTATACGGAAATATTGATATTTCAAAAGCAAAGGAATATCAAGATGTTGTAGAACAATATTATCCAATAGAAACTATTGT
ATATGGTATTAAAAATAATAGACCTGATTTTATAGAAAAAGGTAGAAAAGAGATTTATATAAGAACTCGCAAAGATGAAA
AATTAAGGAAGTGA

>>MEG_1015|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGACAACTTATACTTTCGACCAGGTAGAAGAGGCAATAGAGCAGTTATATCCTGATTTTACTATCAATACAATAGAGAT
TTCAGGAGAAGGCAATGACTGTATTGCATATGAAATAAACGGGAATTTTATTTTTAAATTTCCAAAGCATTCAAGAGCTT
CGATTAATCTCTTGAATGAAGTAACCGTACTCAAAACAATCCACAATGAATTATCACTACCCATTCCCGAGGTGGTTTTT
ACAGGAATGCCATCAGAAATGTGCCAAATGTCTTTCGCAGGTTTTACAAAAATTAAAGGAGTACCTTTGACACCTCTTCT
ACTCAAAAATCTGCCGAAGCAATCTCAAGATCAGGCAGCTAAGGACCTGGCCCGATTTTTAAGTGAACTTCACAGCATAA
ATATCTCTGGATTCAAAAGTAATCTGGTATTAGATTTTCGAGAGAAGATAAATGAAGATAATAAAAAAATCAAAAAGTTA
CTATCCAGGGAATTAAAGGGTCACCAGATGAAGAAAGTGGATGATTTTTACAGGGATATTCTAGACAACGAAATCTACTT
CAAATACTATCCTTGTCTTATTCATAACGATTTCAGCAGCGATCATATTTTATTTGATACCGAAAAAAATACCATTTGTG
GAATAATCGATTTTGGAGATGCAGCTATTTCTGATCCCGACAATGATTTTATAAGTTTGATGGAAGATGATGAAGAGTAC
GGCATGGAATTCGTATCAAAAATATTGAACCATTACAAACATAAGGATATACCGACAGTTTTGGAAAAATATATGATGAA
AGAAAAATACTGGTCGTTCGAAAAGATTATCTATGGAAAGGAATATGGTTATATGGATTGGTATGAAGAGGGATTAAATG
AAATCAGAAGCATTAAAATTAAATAG

>>MEG_1016|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGCTAAAATGAGAATATCACCGGAATTGAAAAAACTGATCGAAAAATACCGCTGCGTAAAAGATACGGAAGGAATGTC
TCCTGCTAAGGTATATAAGCTGGTGGGAGAAAATGAAAACCTATATTTAAAAATGACGGACAGCCGGTATAAAGGGACCA
CCTATGATGTGGAACGGGAAAAGGACATGATGCTATGGCTGGAAGGAAAGCTGCCTGTTCCAAAGGTCCTGCACTTTGAA
CGGCATGATGGCTGGAGCAATCTGCTCATGAGTGAGGCCGATGGCGTCCTTTGCTCGGAAGAGTATGAAGATGAACAAAG
CCCTGAAAAGATTATCGAGCTGTATGCGGAGTGCATCAGGCTCTTTCACTCCATCGACATATCGGATTGTCCCTATACGA
ATAGCTTAGACAGCCGCTTAGCCGAATTGGATTACTTACTGAATAACGATCTGGCCGATGTGGATTGCGAAAACTGGGAA
GAAGACACTCCATTTAAAGATCCGCGCGAGCTGTATGATTTTTTAAAGACGGAAAAGCCCGAAGAGGAACTTGTCTTTTC
CCACGGCGACCTGGGAGACAGCAACATCTTTGTGAAAGATGGCAAAGTAAGTGGCTTTATTGATCTTGGGAGAAGCGGCA
GGGCGGACAAGTGGTATGACATTGCCTTCTGCGTCCGGTCGATCAGGGAGGATATCGGGGAAGAACAGTATGTCGAGCTA
TTTTTTGACTTACTGGGGATCAAGCCTGATTGGGAGAAAATAAAATATTATATTTTACTGGATGAATTGTTTTAG

>>MEG_1017|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGAAACAAAATAAACTTCACTATACCACAATGATAATGACTCAGTTCCCAGATATAAGCATACAATCCGTCGAGTCGCT
TGGTGAGGGCTTTAGGAATTACGCGATCCTCGTCAATGGAGATTGGGTTTTTCGTTTTCCCAAGAGTCAACAAGGTGCAG
ACGAATTGAACAAAGAAATCCAATTGCTACCTCTGTTGGTCGGTTGTGTTAAGGTGAATATTCCACAGTATGTATATATC
GGAAAGCGAAGTGATGGAAATCCCTTCGTGGGCTACCGTAAAGTCCAAGGCCAAATCTTGGGTGAAGACGGGATGGCCGT
TTTTCCCGATGATGCAAAAGATCGACTGGCGCTGCAACTTGCTGAGTTCATGAATGAGCTAAGCGCATTTCCTGTTGAAA
CTGCCATATCAGCCGGGGTTCCTGTTACAAACCTGAAAAATAAAATTCTCTTGCTATCGGAAGCTGTGGAGGATCAGGTG
TTCCCTCTTCTTGATGAGTCTTTAAGGGACTATCTCACGCTGCGCTTCCAATCCTATATGACTCATCCGGTATATACACG
ATATACGCCGAGACTAATTCACGGCGATTTGTCACCTGATCATTTTTTGACGAATTTGAATTCACGTCAGACCCCATTAA
CAGGCATTATCGATTTTGGTGATGCCGCAATAAGTGATCCCGATTATGATTATGTATACCTTTTGGAAGATTGCGGCGAG
CTGTTTACTCGGCAAGTGATGGCTTATAGAGGCGAGGTTGACTTGGATACTCACATCAGAAAAGTCTCCTTGTTCGTAAC
GTTCGATCAAGTCAGTTACCTGTTAGAAGGCTTAAGGGCAAGGGATCAGGACTGGATTTCTGAAGGGTTAGAGCTTTTGG
AAGAGGATAAGGCCAACAATTTTGGTGCGAACAGTGCTTAA

>>MEG_1018|Drugs|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGTGTGAATTTAGTAGTCCGCAAATTCCAATAACGGATATTGAGAATGCCATGGAACGGATCGGAAGTCCGGTGAGAGA
ACTCCGCCGCTTGGATGCGGGGGATGACAGCGAAGTGCTGCTTTGCAATGGGCTGTTTGTCATCAAAATCCCCAAACGGC
CATCTGTGCGCGTGACACAGCAAAGAGAATTTGCAGTATACTCCTTTCTCAAACAGTATGATTTACCTGCCTTGATTCCG
GAAGTGATTTTTCAATGCAGCGAATTTAATGTTATGTCGTTTATCCCCGGAGAAAACTTTGGCTTTCAAGAATATGCTTT
GCTTTCAGAAAAGGAAAAAGAAGCGCTTGCTTCAGATATGGCGATATTTTTGCGGAGATTGCATGGTATATCGGTGCCGC
TTTCAGAGAAACCGTTCTGTGAAATCTTCGAAGATAAACGCAAAAGATATTTGGAAGACCAAGAACAGCTGCTTGAAGTG
CTCGAAAACCGAAAACTCTTGAATGCACCACTCCAGAAAAATATCCAGACGATATACGAGCATATCGGTCAGAATCAGGA
ACTGTTTAACTATGCGGCCTGTTTAGTTCACAATGATTTTAGCTCTTCCAATATGGTGTTCAGACATAATCGTCTGTATG
GCGTGATCGATTTTGGAGATGTAATTGTCGGCGATCCGGACAATGATTTTTTATGCCTTCTGGATTGCAGCATGGATGAC
TTTGGGAAAGATTTCGGGCGAAAGGTTTTAAGGCATTATGGCCATCGGAATCCACAATTAGCAGAAAGAAAAGCAGAAAT
CAATGATGCTTACTGGCCGATACAGCAAGTCCTGCTTGGTGTTCAGAGAGAAGATCGGTCGCTTTTCTGTAAGGGATACC
GTGAACTTCTAGCCATAGACCCAGATGCTTTCATTTTATAA