MEGAResFrom MEG, the Microbial Ecology Group

APH2-DPRIME

Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification. Aph(2'') phosphotransferases modify the 2 double prime hydroxyl group.

References

Other Groups in Aminoglycoside O-phosphotransferases

Sequences

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>AGly|CP004067.1|gene46|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGTGTGAATTTAGTAGTCCGCAAATTCCAATAACGGATATTGAGAATGCCATGGAACGGATCGGAAGTCCGGTGAGAGA
ACTCCGCCGCTTGGATGCGGGGGATGACAGCGAAGTGCTGCTTTGCAATGGGCTGTTTGTCATCAAAATCCCCAAACGGC
CATCTGTGCGCGTGACACAGCAAAGAGAATTTGCAGTATACTCCTTTCTCAAACAGTATGATTTACCTGCCTTGATTCCG
GAAGTGATTTTTCAATGCAGCGAATTTAATGTTATGTCGTTTATCCCCGGAGAAAACTTTGGCTTTCAAGAATATGCTTT
GCTTTCAGAAAAGGAAAAAGAAGCGCTTGCTTCAGATATGGCGATATTTTTGCGGAGATTGCATGGTATATCGGTGCCGC
TTTCAGAGAAACCGTTCTGTGAAATCTTCGAAGATAAACGCAAAAGATATTTGGAAGACCAAGAACAGCTGCTTGAAGTG
CTCGAAAACCGAAAACTCTTGAATGCACCACTCCAGAAAAATATCCAGACGATATACGAGCATATCGGTCAGAATCAGGA
ACTGTTTAACTATGCGGCCTGTTTAGTTCACAATGATTTTAGCTCTTCCAATATGGTGTTCAGACATAATCGTCTGTATG
GCGTGATCGATTTTGGAGATGTAATTGTCGGCGATCCGGACAATGATTTTTTATGCCTTCTGGATTGCAGCATGGATGAC
TTTGGGAAAGATTTCGGGCGAAAGGTTTTAAGGCATTATGGCCATCGGAATCCACAATTAGCAGAAAGAAAAGCAGAAAT
CAATGATGCTTACTGGCCGATACAGCAAGTCCTGCTTGGTGTTCAGAGAGAAGATCGGTCGCTTTTCTGTAAGGGATACC
GTGAACTTCTAGCCATAGACCCAGATGCTTTCATTTTATAA

>CARD|phgb|CP004067|43007-43928|ARO:3002669|APH2-DPRIME-Ig|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
TTATAAAATGAAAGCATCTGGGTCTATGGCTAGAAGTTCACGGTATCCCTTACAGAAAAGCGACCGATCTTCTCTCTGAA
CACCAAGCAGGACTTGCTGTATCGGCCAGTAAGCATCATTGATTTCTGCTTTTCTTTCTGCTAATTGTGGATTCCGATGG
CCATAATGCCTTAAAACCTTTCGCCCGAAATCTTTCCCAAAGTCATCCATGCTGCAATCCAGAAGGCATAAAAAATCATT
GTCCGGATCGCCGACAATTACATCTCCAAAATCGATCACGCCATACAGACGATTATGTCTGAACACCATATTGGAAGAGC
TAAAATCATTGTGAACTAAACAGGCCGCATAGTTAAACAGTTCCTGATTCTGACCGATATGCTCGTATATCGTCTGGATA
TTTTTCTGGAGTGGTGCATTCAAGAGTTTTCGGTTTTCGAGCACTTCAAGCAGCTGTTCTTGGTCTTCCAAATATCTTTT
GCGTTTATCTTCGAAGATTTCACAGAACGGTTTCTCTGAAAGCGGCACCGATATACCATGCAATCTCCGCAAAAATATCG
CCATATCTGAAGCAAGCGCTTCTTTTTCCTTTTCTGAAAGCAAAGCATATTCTTGAAAGCCAAAGTTTTCTCCGGGGATA
AACGACATAACATTAAATTCGCTGCATTGAAAAATCACTTCCGGAATCAAGGCAGGTAAATCATACTGTTTGAGAAAGGA
GTATACTGCAAATTCTCTTTGCTGTGTCACGCGCACAGATGGCCGTTTGGGGATTTTGATGACAAACAGCCCATTGCAAA
GCAGCACTTCGCTGTCATCCCCCGCATCCAAGCGGCGGAGTTCTCTCACCGGACTTCCGATCCGTTCCATGGCATTCTCA
ATATCCGTTATTGGAATTTGCGGACTACTAAATTCACACATC

>AGly|Aph2-Ib|AF207840|272-1171|900|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGTTAACTTGGACGCTGAGATATATGAGCACTTAAATAAACAGATAAAAATAAATGAACTCCGTTATTTATCGTCCGG
CGATGATAGTGATACTTTTTTGTGTAATGAACAATATGTTGTGAAAGTTCCTAAACGAGATTCTGTTAGAATTTCTCAGA
AACGAGAGTTTGAATTGTATCGTTTTTTAGAAAACTGTAAGCTATCTTATCAAATCCCTGCGGTAGTGTATCAAAGTGAC
CGATTTAATATTATGAAATATATTAAAGGGGAACGTATTACTTATGAGCAGTATCATAAGTTGAGTGAAAAGGAAAAGGA
TGCCCTTGCATATGATGAAGCGACGTTTTTGAAAGAGTTACATTCCATAGAGATTGATTGTTCTGTCAGTTTGTTTTCAG
ATGCTCTGGTGAATAAGAAAGATAAGTTTTTGCAAGATAAAAAATTACTTATAAGTATTCTGGAAAAGGAGCAGCTGTTA
ACTGATGAGATGTTGGAACATATCGAAACAATATATGAAAACATATTAAACAATGCTGTTTTATTTAAATATACCCCTTG
TTTGGTACATAATGATTTCAGTGCAAATAACATGATTTTTAGAAATAATAGACTGTTTGGAGTTATTGATTTTGGCGATT
TTAATGTAGGTGACCCGGATAATGATTTTTTGTGCTTGCTGGATTGTAGTACAGATGATTTCGGGAAAGAATTTGGCAGG
AAGGTATTAAAATACTATCAGCATAAGGCGCCGGAAGTAGCAGAAAGAAAAGCAGAGCTTAATGATGTATATTGGTCGAT
AGACCAAATTATTTATGGTTATGAAAGAAAAGATAGGGAAATGTTGATTAAGGGTGTTTCTGAATTGCTACAAACACAAG
CAGAGATGTTTATATTTTAG

>AGly|Aph2-dprime-Ie|AY939911|3536-4441|906|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGACAACTTATACTTTCGACCAGGTAGAAGAGGCAATAGAGCAGTTATATCCTGATTTTACTATCAATACAATAGAGAT
TTCAGGAGAAGGCAATGACTGTATTGCATATGAAATAAACGGGAATTTTATTTTTAAATTTCCAAAGCATTCAAGAGCTT
CGATTAATCTCTTGAATGAAGTAACCGTACTCAAAACAATCCACAATGAATTATCACTACCCATTCCCGAGGTGGTTTTT
ACAGGAATGCCATCAGAAATGTGCCAAATGTCTTTCGCAGGTTTTACAAAAATTAAAGGAGTACCTTTGACACCTCTTCT
ACTCAAAAATCTGCCGAAGCAATCTCAAGATCAGGCAGCTAAGGACCTGGCCCGATTTTTAAGTGAACTTCACAGCATAA
ATATCTCTGGATTCAAAAGTAATCTGGTATTAGATTTTCGAGAGAAGATAAATGAAGATAATAAAAAAATCAAAAAGTTA
CTATCCAGGGAATTAAAGGGTCACCAGATGAAGAAAGTGGATGATTTTTACAGGGATATTCTAGACAACGAAATCTACTT
CAAATACTATCCTTGTCTTATTCATAACGATTTCAGCAGCGATCATATTTTATTTGATACCGAAAAAAATACCATTTGTG
GAATAATCGATTTTGGAGATGCAGCTATTTCTGATCCCGACAATGATTTTATAAGTTTGATGGAAGATGATGAAGAGTAC
GGCATGGAATTCGTATCAAAAATATTGAACCATTACAAACATAAGGATATACCGACAGTTTTGGAAAAATATATGATGAA
AGAAAAATACTGGTCGTTCGAAAAGATTATCTATGGAAAGGAATATGGTTATATGGATTGGTATGAAGAGGGATTAAATG
AAATCAGAAGCATTAAAATTAAATAG

>AGly|aph2-dprime-Ib_1_AF337947|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGGTTAACTTGGACGCTGAGATATATGAGCACTTAAATAAACAGATAAAAATAAATGAACTCCGTTATTTATCGTCCGG
CGATGATAGTGATACTTTTTTGTGTAATGAACAATATGTTGTGAAAGTTCCTAAACGAGATTCTGTTAGAATTTCTCAGA
AACGAGAGCTTGAATTGTATCGTTTTTTAGAAAACTGTAAGCTATCTTATCAAATCCCTGCGGTAGTGTATCAAAGTGAC
CGATTTAATATTATGAAATATATTAAAGGGGAACGTATTACTTATGAGCAGTATCATAAGTTGAGTGAAAAGGAAAAGGA
TGCCCTTGCATATGATGAAGCGACGTTTTTGAAAGAGTTACATTCCATAGAGATTGATTGTTCTGTCAGTTTGTTTTCAG
ATGCTCTGGTGAATAAGAAAGATAAGTTTTTGCAAGATAAAAAATTACTTATAAGTATTCTGGAAAAGGAGCAGCTGTTA
ACTGATGAGATGTTGGAACATATCGAAACAATATATGAAAACATATTAAGCAATGCTGTTTTATTTAAATATACCCCTTG
TTTGGTACATAATGATTTCAGTGCAAATAACATGATTTTTAGAAATAATAGACTGTTTGGAGTTATTGATTTTGGCGATT
TTAATGTAGGTGACCCGGATAATGATTTTTTGTGCTTGCTGGATTGTAGTACAGATGATTTCGGGAAAGAATTTGGCAGG
AAGGTATTAAAATACTATCAGCATAAGGCGCCGGAAGTAGCAGAAAGAAAAGCAGAGCTTAATGATGTATATTGGTCGAT
AGACCAAATCATTTATGGTTATGAAAGAAAAGATAGGGAAATGTTGATTAAGGATGTTTCTGAATTGCTACAAACACAAG
CAGAGATGTTTATATTTTAG

>AGly|Aph2-dprime-Id|AF016483|131-1036|906|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGAGAACTTATACTTTCGACCAGGTAGAAAAGGCAATAGAGCAGTTATATCCTGATTTTACTATCAATACAATAGAGAT
TTCAGGAGAAGGCAATGACTGTATTGCATATGAAATAAACAGGGATTTCATTTTTAAATTTCCAAAGCATTCAAGAGGAT
CTACTAATCTTTTTAATGAAGTAAATATACTCAAAAGAATCCACAATAAATTACCCCTCCCCATTCCGGAGGTGGTTTTT
ACAGGAATGCCATCAGAAACGTACCAAATGTCTTTCGCAGGTTTTACAAAAATTAAAGGAGTACCATTGACACCTCTTCT
ACTCAATAATCTGCCGAAGCAATCTCAAAATCAGGCAGCTAAGGACCTGGCCCGATTTCTAAGTGAACTTCACAGCATAA
ACATCTCTGGATTCAAAAGTAATCTGGTATTAGATTTTCGAGAGAAGATAAATGAAGATAATAAAAAAATCAAAAAGTTA
CTATCCAGGGAATTAAAGGGTCCCCAGATGAAGAAAGTGGATGATTTTTACAGGGATATTCTAGAGAACGAAATCTACTT
CAAATACTATCCTTGTCTTATTCATAACGATTTTAGCAGTGATCATATTTTATTTGATACCGAAAAAAATACTATTTGTG
GAATAATCGATTTTGGAGATGCAGCTATTTCTGATCCCGACAATGATTTTATAAGTTTGATGGAAGATGATGAAGAATAC
GGCATGGAATTTGTATCAAAAATATTGAACCATTACAAACATAAGGATATACCGACAGTTTTGGAAAAATATAGGATGAA
AGAAAAATACTGGTCGTTCGAAAAGATTATCTATGGAAAGGAATATGGTTATATGGATTGGTATGAAGAGGGATTAAATG
AAATCAGAAGCATTAAAATTAAATAG

>419|U51479.1|EGU51479|Aminoglycosides|Aminoglycoside_O-phosphotransferases|APH2-DPRIME
ATGAAACAAAATAAACTTCACTATACCACAATGATAATGACTCAGTTCCCAGATATAAGCATACAATCCGTCGAGTCGCT
TGGTGAGGGCTTTAGGAATTACGCGATCCTCGTCAATGGAGATTGGGTTTTTCGTTTTCCCAAGAGTCAACAAGGTGCAG
ACGAATTGAACAAAGAAATCCAATTGCTACCTCTGTTGGTCGGTTGTGTTAAGGTGAATATTCCACAGTATGTATATATC
GGAAAGCGAAGTGATGGAAATCCCTTCGTGGGCTACCGTAAAGTCCAAGGCCAAATCTTGGGTGAAGACGGGATGGCCGT
TTTTCCCGATGATGCAAAAGATCGACTGGCGCTGCAACTTGCTGAGTTCATGAATGAGCTAAGCGCATTTCCTGTTGAAA
CTGCCATATCAGCCGGGGTTCCTGTTACAAACCTGAAAAATAAAATTCTCTTGCTATCGGAAGCTGTGGAGGATCAGGTG
TTCCCTCTTCTTGATGAGTCTTTAAGGGACTATCTCACGCTGCGCTTCCAATCCTATATGACTCATCCGGTATATACACG
ATATACGCCGAGACTAATTCACGGCGATTTGTCACCTGATCATTTTTTGACGAATTTGAATTCACGTCAGACCCCATTAA
CAGGCATTATCGATTTTGGTGATGCCGCAATAAGTGATCCCGATTATGATTATGTATACCTTTTGGAAGATTGCGGCGAG
CTGTTTACTCGGCAAGTGATGGCTTATAGAGGCGAGGTTGACTTGGATACTCACATCAGAAAAGTCTCCTTGTTCGTAAC
GTTCGATCAAGTCAGTTACCTGTTAGAAGGCTTAAGGGCAAGGGATCAGGACTGGATTTCTGAAGGGTTAGAGCTTTTGG
AAGAGGATAAGGCCAACAATTTTGGTGCGAACAGTGCTTAA